Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

CRC Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants is a unique catalog that includes more than 15,000 phytochemical constituents from over 1,000 higher plant species. This volume covers all of the generally-recognized-as-safe (GRAS) herbs and at least 250 important food and medicinal plants. Each entry features the scientific name, one or more common names, a listing of phytochemical constituents, a single datum or range of quantitative data (wet-weight to dry-weight in parts per million), two-letter abbreviation identifying the plant part, and three-letter abbreviation(s) indicating the source(s) of the data.

The extraordinary amount of data compiled into an easy-to-use tabular format makes the CRC Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants a volume useful to all pharmacologists, toxicologists, nutritionists, pharmacognicists, and food scientists.

Sage, the Genus Salvia is one of the most famous and used herbs in the world. This volume, containing over twenty chapters written by leading experts in the field, presents a comprehensive coverage on all aspects of Salvia. Topics covered include the presentation of the most known Salvia species (approximately 400 of them), the distribution of the genus, its chemotaxonomy, ecophysiology, cultivation technology and breeding methods, information on the extraction, isolation, characterisation and structure of a large number of bioactive components, the various pharmacological properties of the species, the share of Salvia products in aromatherapy and the natural cosmetics market, biotechnological techniques, and commercial aspects.

This comprehensive volume on Salvia should be of interest to everyone involved in medicinal and aromatic plant applications and research.

Master key scientific principles to prepare for certification and practice as a Pharmacy Technician. Pharmacology for Pharmacy Technicians, 3rd Edition, is a comprehensive, yet approachable text written specifically for your needs and offering complete coverage of the principles of pharmacology and the way drugs work within the body's systems. Concepts are supplemented throughout with patient scenarios, anatomy and physiology refreshers, drug monographs with pill photos, and a number of other learning aids to help you comprehend this subject matter. With its companion workbook, this learning package provides the essential foundation necessary to launch a successful and rewarding career in Pharmacy Technology! Comprehensive, updated content is built to address the specific needs of Pharmacy Technician education. Mini drug monographs in every body system and drug classification chapter contain valuable drug information and pill photos for quick reference. Summary drug tables with generic/brand name, usual dose and dosing schedule, and warning labels offer at-a-glance access to information about specific drugs. Helpful Tech Notes enhance your understanding of the practical knowledge needed in the pharmacy setting and help you relate new concepts to practical use. Tech Alerts offer critical reminders and warnings to help you learn to identify and avoid common pharmacy errors. Technician's Corner critical thinking exercises prepare you for on-the-job situations by providing you with a set of facts and asking you to reach a conclusion. Updated drug information ensures you're familiar with the latest drug approvals and therapeutic considerations. Key terminology list with definitions feature visual highlights within chapter discussions, and alphabetized list in the glossary. UPDATED! Drug information reflects the latest dosage and prescription guidelines. NEW! Coverage of advancements in the areas of vaccines, HIV/AIDS, cancer, and diabetes provide you with the latest information for these chronic conditions. NEW! Additional artwork supports foundational and body-system pharmacology content. IMPROVED! Streamlined incorporation of med term and A&P content into chapters.

The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology -covers oral, transdermal, parenteral, and implantable delivery of drugs -discusses modification methods to achieve desired release kinetics -highlights constraints of system design for practical clinical application -analyzes diffusion equations and mathematical modeling -considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents -evaluates polymers as drug delivery carriers -describes peptide, protein, micro-, and nanoparticulate release systems -examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices -and more!

This up-to-date reference book compiles the recent developments, innovations, and perspectives on second and third-generation bioplastics. It discusses the main commercialized bioplastics, such as polylactic acid (PLA) and polyhydroxyalkanoates (PHAs). Chapters include the use of alternative raw materials and innovations in bioplastic production processes to reduce costs and decrease environmental impacts. It covers bioplastic production from lignocellulosic biomass, sugars, or oils produced by microbes and municipal waste material. It also includes techno-economic aspects. The book is meant for researchers and industry experts in biotechnology, environmental sciences, and applied microbiology.

The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

Filled with strategies to minimize the adverse effects of injectable drugs, this book provides the scientific background and techniques required to evaluate parenteral formulations with respect to their potential to cause pain, irritation, and muscle damage. Using a unique, interdisciplinary approach, the book's editors and contributors represent the areas of pharmaceutics, physiology, anatomy, toxicology, and product formulation. The chapters cover topics such as muscle damage with injectables, in vitro and in vivo cystolic enzyme release, histological and morphological methods, assessing pain, cosolvents in injectables, biodegradable microparticles, and more.

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource.

Post-Authorization Safety Studies of Medicinal Products: The PASS Book bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid signal detection, as well as novel and advanced design and analysis approaches for causal interference from observational data. This book serves as an important reference for pharmacovigilance scientists and pharmacoepidemiologists who are searching for the appropriate study design to answer safety research questions. Readers will be able to effectively and efficiently design and interpret findings from post-authorization safety studies with the goal of improving the benefit-risk balance of a drug in order to optimize patient safety.

Handbook of Excipients The Handbook of Pharmaceutical Excipients is internationally recognised as the world's most authoritative source of information on pharmaceutical excipients. It is the definitive comprehensive guide to uses, properties and safety of excipients providing scientists and researchers with a one stop resource when researching an excipient. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. Extensive content updates in the new edition include: - Over 420 fully referenced excipient monographs, many including IR, Raman, and NIR spectra - 13 new monographs including several amino acids and hydrated silicon dioxide - 250 existing monographs reviewed - New chapters providing support to the formulator, such as excipient selection for orally inhaled and also injectable formulations. Unique Benefits - The world's authoritative source of information on pharmaceutical excipients - International Scope: Recognized globally as the authority on the uses, properties and safety of excipients. - Written by over 170 expert pharmaceutical scientists - One stop resource when researching an excipient Contents - Biological Effects of Pharmaceutical Excipients - The Selection of Excipients for Injectable Formulations - The Selection of Excipients for Orally Inhaled Dosage Forms - The History of Excipients - The Use of Counterions and Coformers in the Creation of Salt and Co-Crystal forms of Active Pharmaceutical Ingredients (APIs) - Over 420 Monographs benefiting from a standardized, easy-to-use template including: - Pharmacopoeial information from the UK, Europe, Japan and the United States where relevant - non-proprietary names and synonyms - chemical name and structure, CAS Registry number, empirical formula, molecular weight - functional category, applications and incompatibilities - material description and typical excipient properties - safety, stability, storage and handling information - method of drug manufacture - related substances - primary references - editorial comments - author details and revision date

Records cataloging the healing powers of natural substances - plants, minerals, and animal byproducts - date back more than 4,000 years. There is no denying the effectiveness of traditional Chinese medicine, yet - until recently - the roots of this knowledge were largely lost in superstition and folklore. However, the use of herbs as an alternative medical treatment for many illnesses has increased steadily over the last decade, particularly since such herbs are categorized as "Natural Food Products" and are not yet subject to strict control by the FDA. Reports published in 1996 indicate that more than 10% of the US population has used herbal remedies.

This book does not debate the value of Eastern or Western medicine but brings together Chinese herbal lore and Western scientific methods in a current, comprehensive treatise on the pharmacology of Chinese herbs. This second edition of The Pharmacology of Chinese Herbs presents the chemical composition, pharmacological action, toxicity, and therapeutic value of 473 herbs.

The book:
o Classifies herbs according to their therapeutic value
o Informs how active ingredients in herbs may adversely interact with other herbs or drugs
o Evaluates which herbs have the potential for more investigation and possible use as drugs
o Describes the pharmacological action of each herb based on recent scientific study and describes each herb according to Chinese pharmacopoeia and folk medicine
o Provides a review of Chinese medical history
o Presents information on how to use modern chemical techniques for enhancing or modifying herbal ingredients into better agents with more strength and activity


What's New in the Second Edition
Discussions on:
o Herbs and their specific effects on the immune system
o Herbs and fertility/infertility
o Anti-cancer herbs
o Anti-HIV herbs
o Anti-malarial herbs
o Ginseng and ginsenosides
o Anti-Alzheimer herbs
o Herbs affecting the nervous system

An established textbook that provides you with full coverage of the physicochemical principles essential to the modern pharmacist and pharmaceutical scientist. This sixth edition has a broad chemical and physicochemical base and covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body. Now with more clinical examples, new questions and extra case studies.

Despite the growing interest in biodiversity as a source of valuable new products and biochemical information, there have been very few systematic efforts to estimate the value of preserving biological resources for this purpose. Drugs of Natural Origin gives you a detailed model of the value of wild biological resources for pharmaceutical research and development. Author Anthony Artuso presents several decision models and analytical techniques that you can use to assess the economics of biochemical prospecting efforts whether you re part of a private corporation, nonprofit research institute, developing country government, or international organization.Drugs of Natural Origin explores the policy options available to developing countries and international organizations to tap into the emerging market for biological resources in such a way as to provide both incentives for conservation of biodiversity and new opportunities for economic development. You ll find evaluations of a range of proactive strategies that can be used to protect and enhance developing countries'biological resources. In addition, you ll learn about a bioeconomic model that incorporates the potential biochemical and genetic value of a diverse ecosystem into land use planning and development.Developing country and international policymakers will find Drugs of Natural Origin a useful tool for determining how best to conserve biodiversity, while sustainably developing biological resources. This book outlines a comprehensive and integrated set of policy measures, research and development initiatives, and financing arrangements that could increase biochemical research activity while providing incentives for conservation of biodiversity and a potential path for sustainable development.Managers of pharmaceutical R&D programs will use the decision models developed in Drugs of Natural Origin to plan, evaluate, and continually refine their R&D programs. The book s theoretic framework provides you with an analytical tool for systematically evaluating critical decisions at each stage of the R&D process. Thus, you learn to incorporate both subjective assessments and quantitative data into a comprehensive framework for R&D decisionmaking.

While medical specialists in disaster mitigation, preparedness, and response are needed worldwide, the initial phase of disaster response is almost entirely dependent upon local resources-making it essential that all healthcare personnel have a working knowledge of the field and stand ready to integrate into the response system. Ciottone's Disaster Medicine, 3rd Edition, is the most comprehensive reference available to help accomplish these goals in every community. It thoroughly covers isolated domestic events as well as global disasters and humanitarian crises. Dr. Gregory Ciottone and more than 200 worldwide authorities share their knowledge and expertise on the preparation, assessment, and management of both natural and man-made disasters, including lessons learned by the responders to contemporary disasters such as the COVID-19 pandemic, Australian and western U.S. wildfires, European heatwaves, the Beirut explosion, recent hurricanes and typhoons, and the global refugee crisis. Part 1 offers an A-to-Z resource for every aspect of disaster medicine and management, while Part 2 features an exhaustive compilation of every conceivable disaster event, organized to facilitate quick reference in a real-time setting. Covers basic concepts such as identification of risks, organizational preparedness, equipment planning, disaster education and training, and more advanced concepts such as disaster risk reduction, health in complex emergencies, building local disaster resiliency, psychological impact of disasters on children, and more. Contains new decision trees throughout that help guide you through the decision-making process in difficult situations. Uses an easy-to-follow, templated approach to historical perspectives, overviews of current practice including pre-incident and post-incident actions, medical treatment of casualties, and potential pitfalls. Includes updated sections on man-made disasters, including mass casualties, active shooter situations, integrated response to terrorist attacks, and chemical/biological/radiological/nuclear/high-yield explosives disasters. Discusses the latest technologies, such as the use of mobile disaster applications, drone response systems, and virtual reality simulation training. Features thoroughly updated information on crisis leadership, practical applications of disaster epidemiology, disaster and climate change, and the integration of non-government agencies (NGOs) in disaster response-a critical topic for those responding to humanitarian needs overseas. Includes new chapters on Pandemic Preparedness and Response, Disaster Medicine in a Changing Climate, Disaster Response in Asia, Building Local Capacity and Disaster Resiliency, Civilian-Military Coordination in Disaster Response, Medical Simulation in Disaster Preparedness, Disaster Nursing, Crisis Meta-Leadership, Palliative Care in Disasters, Counter-Terrorism Medicine, SARS CoV (COVID-19 and SARS), and Disasters in Space Travel. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Metered Dose Inhaler Technology explores the technologies of pressurized metered dose inhalation (MDI) delivery systems and provides practical, easy-to-use guidance to effective product formulation. With contributions from an international panel of authors, the book addresses the global phase-out of chloroflurocarbon chemicals (CFCs), the generation of propellant systems to replace them, and their associated new medications and therapies. Topics include the manufacture of metered dose inhalers, particle size analysis in inhalation therapy, development and testing, pharmcokinetics and metabolism of propellants, toxicology, and more.

Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

With the use of crack on the rise in American cities, there is more need than ever to understand the biological, environmental, and social factors behind cocaine addiction, as well as the pharmacological properties of cocaine that make it such an addictive drug. The Neurobiology of Cocaine Addiction helps clinicians and researchers analyze research findings and their relevance to the clinical treatment of cocaine dependency. To do this, it looks at the whole spectrum of cocaine use, from trends in cocaine-involved deaths, hospital emergencies, arrests, and treatment admissions to the specific impact the drug has on brain function. The book reports on important findings from positron emission tomography (PET) and a "binge" pattern cocaine administration mode. This will enable you to improve your understanding of how cocaine alters the pleasure/reward system of the brain and creates new instinctual needs that displace the inherent instinctual needs of hunger and sex.By reading The Neurobiology of Cocaine Addiction, you will sharpen your knowledge of the basic actions of cocaine, the factors related to daily cocaine use, the neurobiological basis of addictive diseases, and drug-induced alterations in normal physiology. You will also learn about: the coexistence of cocaine and heroin addiction cocaine's disruption of the endogenous opioid system QEEG and how it can play a potentially useful role in drug development and planning hypotheses of sensitization in the pathophysiology of cocaine dependence factors that predict daily cocaine use among patients in a methadone maintenance program abnormalities in brain function that persist for up to six months after last cocaine use patterns of cocaine use the importance of prospective data analysis and the limitations of a self-selective study groupClinicians, researchers, psychiatrists, and other professionals in chemical dependency and narcotics rehabilitation will turn the last page of The Neurobiology of Cocaine Addiction with a better understanding of cocaine's addictive qualities and the characteristics of the individuals who become addicted to it. You will see what headway has been made in research at some of the nation's top laboratories, but you will also see what remains to be done. Hopefully, you will find where you can make a contribution either at the practical level, the research level, or both.

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 43 presents comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. The series encompasses review articles and database compilations that fall within a variety of categories, with this release focusing on Ganciclovir, Mirtazapine, Tolfenamic Acid, Mid-Infrared Spectroscopy of Pharmaceutical Solids, and the Validation of Chromatographic Methods of Analysis: Application for drugs that derived from herbs.

Updated and revised throughout. Second Edition explores the chromatographic methods used for the measurement of drugs, impurities, and excipients in pharmaceutical preparations--such as tablets, ointments, and injectables. Contains a 148-page table listing the chromatographic data of over 1300 drugs and related substances--including sample matrix analyzed, sample handling procedures, column packings, mobile phase, mode of detection, and more.

Provides a detailed survey of new therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit. The book emphasizes biological interventions based on the pathogenesis of autoimmunity, ranging from altering tolerance to modifying cytokines and changing lymphocyte function.

Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!

Multicultural Pharmaceutical Education spotlights methods and theory on how to increase representation of minorities in pharmacy schools and practice settings. Many of the ideas presented in this book are unique, and all provide an opportunity for institutions with few minority students to greatly improve their recruitment and retention efforts geared toward these students. The contributing authors, representing all levels of academia--deans, undergraduate students, vice provosts, executive directors, a National Professor of the Year, and faculty members--have all had experience in some aspect of minority pharmaceutical education. It is through their practical experiences that they offer suggestions and commentary on pharmacy programs of study. Historical accounts or examples of success that could be emulated at other institutions are included. With the help of Multicultural Pharmaceutical Education, colleges and universities and their faculty can forge ahead in attracting and retaining minority students to their pharmacy programs and into the world of pharmacy practice. Structured around four major areas (foundation, commitment, actuation, and conclusion), the authors remove the option of traditional excuses of failure in this important area of education. All those involved in pharmacy education should read this book whether deans, admissions counselors, professors, or students. Multicultural Pharmaceutical Education provides an easy-to-read, practical and theoretical approach to improving the opportunity and quality of education that minority students can achieve in pharmaceutical programs.

This new, and heavily revised, edition of Psychopharmacology, provides a comprehensive scientific study of the effects of drugs on the mind and behaviour. With the growing prevalence of psychiatric and behavioral disorders and the rapid advances in the development of new drug therapies, this textbook offers an essential understanding of the necessary details of drug action. The book presents its coverage in the context of the behavioral disorders they are designed to treat, rather than by traditional drug classifications, to strengthen understanding of the underlying physiology and neurochemistry, as well as the approaches to treatment. Each disorder from the major diagnostic categories is discussed from a historical context along with diagnostic criteria and descriptions of typical cases. In addition, what we presently know about the underlying pathology of each disorder is carefully described. Providing a solid foundation in psychology, neuroanatomy and physiology, the book also offers a critical examination of drug claims, as well as coverage of evidence-based alternatives to traditional drug therapies. Throughout, this text discusses how drug effectiveness is measured in both human and animal studies. Topics new to this edition include: a stronger emphasis on the environmental impacts on drug effectiveness; more on the mechanisms of adverse reactions to drugs and information on managing drug side effects; the risks and benefits of using "mood stabilizing drugs" to address behavior in youth with ADHD or ASD; and discussion of the research-to-practice gap in pharmacological care for children and adolescents. Accompanied by a robust companion website of instructor materials, this textbook is ideal for undergraduate and pre-professional students on courses in Psychopharmacology, Clinical Psychopharmacology, Drugs and Behavior. It is a valuable contribution to highlight the symbiotic relationship between psychopharmacology and the neural and behavioral sciences.

This up-to-date reference book discusses the synthesis, production, and application of various microbial enzymes and metabolites for health. Microorganisms like bacteria (lactic acid bacteria, Bacillus species), yeasts, and filamentous fungi have been globally exploited for their biotechnological applications. This book discusses ways to use them commercially. Chapters include the production of fibrinolytic enzymes, microbial lipases, bacteriocin production by lactic acid bacteria, and bioactives produced. It also covers microbial synthesis of alkaloids, terpenoids, and steroids. The book is useful for researchers, academicians, and industry experts in microbiology and biotechnology.