Traditional and Novel Adsorbents for Antibiotics Removal from Wastewater describes, in detail, the importance of removing antibiotics from aqueous systems, along with new information on their variation, solubility, toxicology and allowable concentration in groundwater. The book covers adsorption as an applicable method, highlighting its advantages and disadvantages. It investigates various adsorbents ranging from traditional activated carbons, modified forms of clays, metal oxides, polymer resins, and more advanced materials such as graphene-based, MOF, nano-matrices, and composite materials as potential sorbents for the adsorption of antibiotics from aqueous solutions. In addition, the book covers biological microorganisms that have been used to remove antibiotics from wastewater and presents biopolymers, biowaste and living cells potentially and practically suitable for this purpose. For all adsorbents, the book explains preparation methods, main properties, modification techniques to increase antibiotic removal efficiency, mechanisms in antibiotic removal, advantages and limitations. It also presents adsorption-desorption in batch and continuous mode, optimized operating parameters, kinetic and equilibrium adsorption, and regeneration studies.

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.