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Books > Medicine > Other branches of medicine > Pharmacology > General

Role of Essential Oils in the Management of COVID-19 (Hardcover): Ahmed Al-Harrasi, Saurabh Bhatia, Tapan Behl;, Deepak... Role of Essential Oils in the Management of COVID-19 (Hardcover)
Ahmed Al-Harrasi, Saurabh Bhatia, Tapan Behl;, Deepak Kaushik, Md. Khalid Anwer, …
R4,384 Discovery Miles 43 840 Ships in 12 - 17 working days

1. Present more scientific insights that will be helpful for both scientists and healthcare professionals to control, diagnose, and treat COVID-19 2. Useful Scientist, academicians, physicians, aroma therapists, medical practitioners, researchers those are working in development of therapeutics for COVID-19 and other infectious diseases (especially virologists, pathologist, pharmacologist, pulmonologists, ayurvedic practitioners, molecular biologists, essential oil practitioners are consultant/educators), pharmacognosist 3. Demonstrates the role of essential oils and their chemical components in the management of COVID-19

Non-Invasive Monitoring of Transdermal Drug Delivery (Hardcover): Pasquale Arpaia, Umberto Cesaro, Nicola Moccaldi, Isabella... Non-Invasive Monitoring of Transdermal Drug Delivery (Hardcover)
Pasquale Arpaia, Umberto Cesaro, Nicola Moccaldi, Isabella Sannino
R3,913 Discovery Miles 39 130 Ships in 12 - 17 working days

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Asian Medical Industries - Contemporary Perspectives on Traditional Pharmaceuticals (Hardcover): Stephan Kloos, Calum Blaikie Asian Medical Industries - Contemporary Perspectives on Traditional Pharmaceuticals (Hardcover)
Stephan Kloos, Calum Blaikie
R3,937 Discovery Miles 39 370 Ships in 12 - 17 working days

Offers a new perspective on "traditional" Asian medicines Provides original insights into "traditional" Asian pharmaceutical industries Broad-ranging, multidisciplinary and comparative research on Asian medicine in China, India, Japan, Mongolia, and Nepal Relevant to scholars, students, health professionals, and policy makers Includes extensive bibliographies of essential but little-known scholarship on Asian medicines from Asia

Opioid Therapy in Infants, Children, and Adolescents (Hardcover, 1st ed. 2020): Ravi D. Shah, Santhanam Suresh Opioid Therapy in Infants, Children, and Adolescents (Hardcover, 1st ed. 2020)
Ravi D. Shah, Santhanam Suresh
R1,979 Discovery Miles 19 790 Ships in 10 - 15 working days

Opioid analgesics are among the most effective medications for pain management but are associated with serious and increasing public health problems, including abuse, addiction, and death from overdose. Currently, there is an opioid epidemic in the United States with the rate of prescription opioid-related overdose deaths quadrupling over the last 15 years. Pediatric patients are particularly vulnerable to the devastating consequences of opioid misuse. Adolescents who are prescribed opioids are at a higher risk for abusing illicit drugs later in life. Clinicians managing pediatric pain must account for such issues while still delivering effective analgesia to young patients who suffer from both acute and chronic pain. Opioid Therapy in Children and Adolescents is designed to explore the unique aspects of opioid therapy in pediatric patients. An introductory framework provides historical context and describes the epidemiology of the opioid crisis with focus on pediatric implications. Subsequent chapters focus on pediatric opioid pharmacology, safe opioid prescribing practices, and non-opioid alternatives to managing pediatric pain states, including multimodal analgesic strategies, interdisciplinary approaches, and complementary medicine. Mitigation strategies against pediatric opioid diversion and misuse are addressed to help clinicians develop practice changes that protect pediatric patients from opioid-related morbidity and mortality. Clinical case examples are also utilized throughout the text to provide grounding for each chapter and a context within which to examine pertinent issues. This first of its kind book provides a comprehensive approach that will guide clinicians to appropriately and safely prescribe opioid analgesics to pediatric patients suffering from pain. It is an invaluable resource for pediatricians, family practitioners, anesthesiologists, pediatric oncologists, and other clinicians who manage pediatric pain.

Phytochemistry of Piper betle Landraces (Paperback): Vikas Bajpai, Nikhil Kumar, Brijesh, Kumar Phytochemistry of Piper betle Landraces (Paperback)
Vikas Bajpai, Nikhil Kumar, Brijesh, Kumar
R1,745 Discovery Miles 17 450 Ships in 12 - 17 working days

Piper betle (betel vine) a pan-Asiatic, tropical plant, which can also grow under mild subtropical areas, is essentially grown for leaves which are chewed with array of additives besides slaked lime. The plant is cultivated widely in India and its surrounding areas. Phytochemistry of Piper betel landraces presents a brief on the distribution, historical and cultural aspects, and properties ascribed to this plant in the ancient texts. Phytochemical and pharmacological information has also been included to underscore the importance of this plant in the present time. A detailed account on metabolic profiling employing modern methods is included, such as real-time, direct analysis of the flight mass spectrometric method and chemometric analysis for characterization of the available biodiversity and signatures specific to gender and geographical location. It was also possible to identify the gender of unknown landraces, with the help of principal component analysis. Features: Elaborates on the chemical diversity within Piper betle. Piper betle leaves have mouth freshening antimicrobial compounds. Use of chemical signatures for the identification of different Piper betle landraces, their gender and geographical locations.

Phytochemistry of Tinospora cordifolia (Paperback): Brijesh, Kumar, Vikas Bajpai, Nikhil Kumar Phytochemistry of Tinospora cordifolia (Paperback)
Brijesh, Kumar, Vikas Bajpai, Nikhil Kumar
R1,747 Discovery Miles 17 470 Ships in 12 - 17 working days

Tinospora cordifolia stem is used as a tonic, vitalizer, and as a remedy for metabolic disorders to treat allergies, diabetes, dysentery, jaundice, heart diseases, leprosy, rheumatoid arthritis, skin diseases, and urinary disorders. It shows anti-inflammatory, analgesic, antipyretic actions and immunosuppressive effects. This book focuses on providing gender and geographical location-based differences in the phytoconstituents of T. cordifolia by the liquid chromatography mass spectrometric method. These methods have potential use in the quality control of T. cordifolia and the screening of herbal preparations. Features: Compilation of ayurvedic features of one of the most important plants of the Indian system of medicines. Useful for all ayurvedic practitioners, researchers, faculty, students, and herbal product manufacturers. Application of advance hyphenated LC-MS techniques for variation study in phytoconstituents.

The Future of Pharmaceuticals - A Nonlinear Analysis (Hardcover): Sarfaraz K. Niazi The Future of Pharmaceuticals - A Nonlinear Analysis (Hardcover)
Sarfaraz K. Niazi
R8,371 Discovery Miles 83 710 Ships in 12 - 17 working days

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

Quantitative Drug Safety and Benefit Risk Evaluation - Practical and Cross-Disciplinary Approaches (Hardcover): William Wang,... Quantitative Drug Safety and Benefit Risk Evaluation - Practical and Cross-Disciplinary Approaches (Hardcover)
William Wang, Melvin Munsaka, James Buchanan, Judy Li
R3,925 Discovery Miles 39 250 Ships in 12 - 17 working days

Covers four pillars of safety statistics: cross-disciplinary scientific engagement, effective and efficient operational process, visual analytics, and intelligent data architecture Links safety monitoring to benefit risk evaluation Presents an emerging topic that links to ICH E19 and TransCelerate safety efforts

Organelle and Molecular Targeting (Hardcover): Lara Scheherazade Milane, Mansoor M. Amiji Organelle and Molecular Targeting (Hardcover)
Lara Scheherazade Milane, Mansoor M. Amiji
R6,018 Discovery Miles 60 180 Ships in 12 - 17 working days

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Biotechnology - the Science, the Products, the Government, the Business (Paperback): Ronald P. Evens Biotechnology - the Science, the Products, the Government, the Business (Paperback)
Ronald P. Evens
R1,051 Discovery Miles 10 510 Ships in 12 - 17 working days

The over-riding premise for biotechnology in this book is bringing novel products to market to substantially advance patient care and disease mitigation. Biotechnology, over its relatively brief existence of 40 years, has experienced a mercurial growth. The vast educational need for biotechnology information in this rapidly burgeoning field is a basic rationale here. However a more prominent underpinning is that, bringing biotech products to market for patient care involves success in the following four areas of engagement simultaneously - scientific advances for healthcare technologies, novel and varied products for untreated diseases, regulatory authorities, and biotech companies. Features Comprehensive coverage of biotechnology science topics used in development and manufacturing Addresses all the scientific technologies within biotechnology responsible for products on the market and the pipeline Presents business issues such as marketing and sales of the products, as well as companies engaged, and how biotech business has evolved

Natural Polymers for Pharmaceutical Applications - Volume 1: Plant-Derived Polymers (Paperback): Amit Kumar Nayak, Md Saquib... Natural Polymers for Pharmaceutical Applications - Volume 1: Plant-Derived Polymers (Paperback)
Amit Kumar Nayak, Md Saquib Hasnain, Dilipkumar Pal
R2,525 Discovery Miles 25 250 Ships in 12 - 17 working days

This new volume, Natural Polymers for Pharmaceutical Applications, Volume 1: Plant-Derived Polymers, presents some of the latest research on the applications of natural polymers in drug delivery and therapeutics for healthcare benefits. Polymers and their applications from several plants are discussed in depth, including tamarind gum, gum Arabic, natural carbohydrate polymer gum tragacanth, pectin, guar gum and its derivatives, locust bean gum, sterculia gum, okra gum, and others. The use of the polymers derived from plants as potential pharmaceutical excipients is expanding day by day because of their stability in the biological system, drug-releasing capability, drug-targeting abilities, as well as their bioavailability.

Natural Polymers for Pharmaceutical Applications - Volume 2: Marine- and Microbiologically Derived Polymers (Paperback): Amit... Natural Polymers for Pharmaceutical Applications - Volume 2: Marine- and Microbiologically Derived Polymers (Paperback)
Amit Kumar Nayak, Md Saquib Hasnain, Dilipkumar Pal
R2,525 Discovery Miles 25 250 Ships in 12 - 17 working days

Many polymers derived from various marine sources and microorganisms possess some important biological properties such as biocompatibility, biodegradability, and bioadhesivity that make them attractive as pharmaceutical excipients in various pharmaceutical dosage forms. Moreover, these polymers can be modified physically and/or chemically to improve their biomaterial properties. In this volume, Natural Polymers for Pharmaceutical Applications, Volume 2: Marine- and Microbiologically Derived Polymers, looks at how these polymers have been explored and exploited for pharmaceutical uses, such as in tablets, microparticles, nanoparticles, ophthalmic preparations, gels, emulsions, suspensions, etc. Some commonly used marine- and microbiologically derived polymers used as pharmaceutical excipients include alginates, agar-agar, gellan gum, carrageenan; chitosan, xanthan gum, and others. The book focuses on important recent advances from experts around the world on marine-derived polysaccharides and pharmaceutical applications of alginates, agar-agar, gellan gum, carrageenan, chitosan derivatives, xanthan gum.

Natural Polymers for Pharmaceutical Applications - Animal-Derived Polymers (Paperback): Amit Kumar Nayak, Dilipkumar Pal, Md... Natural Polymers for Pharmaceutical Applications - Animal-Derived Polymers (Paperback)
Amit Kumar Nayak, Dilipkumar Pal, Md Saquib Hasnai
R2,516 Discovery Miles 25 160 Ships in 12 - 17 working days

In recent years, many animal-derived polymers have emerged as an attractive category of naturally derived polymers because of their advantageous physicochemical, chemical, and biological properties. The important biological properties of these natural polymers derived from animals are biocompatibility and biodegradation. These polymers are generally composed of repeated units of amino acids. Moreover, these polymers can be modified physically and/or chemically to improve their biomaterial properties. Natural Polymers for Pharmaceutical Applications, Volume 3: Animal-Derived Polymers looks at how these polymers can be exploited as pharmaceutical excipients in various pharmaceutical dosage forms, like microparticles, nanoparticles, ophthalmic preparations, gels, implants, etc. The commonly used animal-derived polymers used as pharmaceutical excipients are hyaluronic acid (hyaluronan), albumin, collagen, gelatin, chondroitin, etc.

Drugs in Sport (Hardcover, 8th edition): David Mottram, Neil Chester Drugs in Sport (Hardcover, 8th edition)
David Mottram, Neil Chester
R4,107 Discovery Miles 41 070 Ships in 12 - 17 working days

The book comprehensively addresses all substances and methods prohibited by WADA It strikes a balance between scientific evidence and practical examples It is a key volume to both someone wishing to explore the topic, or academics looking for specific details and case studies. the book highlights athletes who may have been banned for substances, allowing students to engage in additional case study research

RNA Delivery Function for Anticancer Therapeutics (Hardcover): Loutfy H. Madkour RNA Delivery Function for Anticancer Therapeutics (Hardcover)
Loutfy H. Madkour
R5,446 Discovery Miles 54 460 Ships in 12 - 17 working days

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Ethical Issues in Cardiovascular Medicine (Hardcover): David M. Zientek, Mark J. Cherry Ethical Issues in Cardiovascular Medicine (Hardcover)
David M. Zientek, Mark J. Cherry
R3,912 Discovery Miles 39 120 Ships in 12 - 17 working days

This book provides an exploration of the ethics of cardiology practice. It provides a variety of frameworks for analyzing ethical issues that arise in cardiovascular medicine. Cardiovascular medicine-the diagnosis and treatment of congenital and acquired diseases of the heart, major arteries, and veins-has seen rapid change in diagnosis, treatment, and the organization of practice in the last half of the twentieth and the beginning of the twenty first century. The complexity of these developments has resulted in increasing subspecialization, and many practitioners are challenged to stay abreast with the latest developments in cardiology. These changes also bring with them various ethical challenges. The chapters in this volume are divided by five broad areas of practice: beginning-of-life, end-of-life, transplantation and allocation of expensive or scarce resources, professionalism, and research. The case-based approach presented across the volume provides a perspective that will allow readers to reason through current and future ethical issues as they arise in this rapidly changing field. Ethical Issues in Cardiovascular Medicine will be of interest to researchers working in bioethics, clinical ethics, and the philosophy of medicine, as well as practicing physicians, nurses, and students who work in cardiovascular medicine.

Nanotherapeutics - From Laboratory to Clinic (Paperback): Ezharul Hoque Chowdhury Nanotherapeutics - From Laboratory to Clinic (Paperback)
Ezharul Hoque Chowdhury
R1,431 Discovery Miles 14 310 Ships in 12 - 17 working days

The emergence of nanotherapeutics is attributable to the integration of nanotechnology, recombinant DNA technology, and synthetic organic chemistry with medicine for treating critical human diseases in a more efficient and specific molecular approach than therapy with conventionally-designed and formulated drugs. Nanotherapeutics: From Laboratory to Clinic comprehensively discusses the current shortcomings for delivery of classical (small) drugs, macromolecular therapeutics, and recombinant vaccine via the common intravascular and extravascular routes. The book describes the synthetic/chemical engineering methods as well as recombinant, hybridoma, and phage display technologies to fabricate different types of nanoparticulate carriers and drugs. It also reveals the diversified approaches undertaken by harnessing nanotechnology to overcome the multistep extracellular and intracellular barriers and to facilitate the development of novel strategies for therapeutic delivery and imaging. The author elaborates on the preclinical and clinical trials of potential nanoparticle-based products in animal models and patients and the approval/commercialization of nanotherapeutics, addressing all relevant human diseases. A focus on the above issues in a concise but illustrative manner fills the gap between the laboratory findings originating from the research on identification of cellular and systemic barriers of classical and macromolecular drugs along with development of strategies for fabrication and testing of nanotherapeutics, and the clinical outcomes emanating from the testing of the selected potential nanotherapeutics on patients of particular diseases. The book also fills a gap in the existing literature between the design and development of diversified nanotherapeutics for various purposes and the investigation and evaluation of potential barriers and resultant therapeutic efficacy of those nano-medicine formulations.

Handbook of Pediatric Epilepsy Case Studies, Second Edition (Hardcover, 2nd edition): Maria Augusta Montenegro, Jong M. Rho Handbook of Pediatric Epilepsy Case Studies, Second Edition (Hardcover, 2nd edition)
Maria Augusta Montenegro, Jong M. Rho
R4,648 Discovery Miles 46 480 Ships in 12 - 17 working days

Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Fully updated, this new edition is organized chronologically, from neonate through adolescence, and the handbook is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training. Here the contributors review the recent flood of new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes and the volume is distilled into an easy-to-use guide. Fully updated text reviewing the latest research the pathophysiology, genetics, and treatment of the various epilepsy syndromes. Thorough, descriptions of the different syndromes commonly encountered in clinical practice across the pediatric range. Extensive resource section provided. Contributors describe why they chose each particular case, what they learned, and how it changed their practice. Access to a companion website, which offers digital graphics and videos on the topic

The Ups and Downs in Drug Design - Adventures in Medicinal Chemistry (Hardcover): Victor E. Marquez The Ups and Downs in Drug Design - Adventures in Medicinal Chemistry (Hardcover)
Victor E. Marquez
R8,062 Discovery Miles 80 620 Ships in 12 - 17 working days

Describes 'real life' examples in Medicinal Chemistry. Integrates the use of physical, chemical, and biological concepts that are important in drug design. Highlights the "ips" and "downs" that come with drug discovery. Aims to inspire students who may be struggling with the challenges and thought process in drug design. Intends to be an excellent companion text, illustrating real life experiences, for graduate and postgraduate students.

Metastatic Diseases - Novel Approaches in Diagnosis and Therapeutic Management (Hardcover): Sandeep Arora, Tapan Behl;, Sukhbir... Metastatic Diseases - Novel Approaches in Diagnosis and Therapeutic Management (Hardcover)
Sandeep Arora, Tapan Behl;, Sukhbir Singh, Neelam Sharma, Saurabh Gupta
R3,952 Discovery Miles 39 520 Ships in 12 - 17 working days

This insightful volume opens new horizons for exploring modern therapeutic entities and emerging targets for combating the deadly disease of cancer. The authors provide a review of cancer along with descriptions of its molecular level mechanisms and emphasize the role of promising new therapies, including herbal therapies, that can be utilized for the treatment of metastatic diseases. The chapters look at specific approaches that have been researched and developed and that have almost reached the standardization stage, such as intracellular mechanisms, particularly phosphoprotein-enriched astrocytes and transthyretin proteins; CXCR4; autophagy-inhibiting drugs; spatiotemporal genetic analysis; tyrosine kinase inhibitors; and more. Also considered are advances in diagnostic systems like intra vital microscopy and molecular imaging.

Biotechnological Approaches to Enhance Plant Secondary Metabolites - Recent Trends and Future Prospects (Hardcover): Mohd.... Biotechnological Approaches to Enhance Plant Secondary Metabolites - Recent Trends and Future Prospects (Hardcover)
Mohd. Shahnawaz
R3,913 Discovery Miles 39 130 Ships in 12 - 17 working days

It highlights the synthesis, classification, biological function, medicinal applications, and an overview of the recent advancements for the enhanced production of novel secondary metabolites in plants. It overviewed the role of induced mutation, salinity stress, Brassinosteroids impact to increase the secondary metabolic contents in plants and suggests increase in enzymatic activity in plants could be due to various point mutations which in turn could play a role at transcriptome levels. It discussed the significant role of endophytes to enhance the contents of plant secondary metabolites. Alternatively, it also suggests urgent need to set up the standard operating procedures using hydroponics system of cultivation for significant enhancement of secondary metabolite contents. It enlists various in vitro techniques to enhance plant secondary metabolites contents using plant tissue culture approaches. It systematically overviewed the state of art in biotechnological tools viz. CRISPER Cas9, and RNAi to enhance the plant secondary metabolite contents and recommend CRISPER Cas9 technology over the RNAi, ZFNs and TALENs because of its relatively simple and high precision method with easily programmable tool by changing the guide sequence of the sgRNA to any DNA sequence of interest with its capacity to recognize multiple targeted genes with very low off-target effects due to reduced CpG methylation.

Dihydropyrimidinones as Potent Anticancer Agents - Medicinal Chemistry Perspective (Paperback): Mashooq Ahmad Bhat, Muneeb U... Dihydropyrimidinones as Potent Anticancer Agents - Medicinal Chemistry Perspective (Paperback)
Mashooq Ahmad Bhat, Muneeb U Rehman, Amita Verma
R3,516 R3,187 Discovery Miles 31 870 Save R329 (9%) Ships in 12 - 17 working days

Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones, there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer. This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones.

Drug Discovery with Privileged Building Blocks - Tactics in Medicinal Chemistry (Paperback): Jie Jack Li, Minmin Yang Drug Discovery with Privileged Building Blocks - Tactics in Medicinal Chemistry (Paperback)
Jie Jack Li, Minmin Yang
R2,311 Discovery Miles 23 110 Ships in 12 - 17 working days

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.

Drug Discovery with Privileged Building Blocks - Tactics in Medicinal Chemistry (Hardcover): Jie Jack Li, Minmin Yang Drug Discovery with Privileged Building Blocks - Tactics in Medicinal Chemistry (Hardcover)
Jie Jack Li, Minmin Yang
R5,397 Discovery Miles 53 970 Ships in 12 - 17 working days

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.

Natural Products Chemistry of Botanical Medicines from Cameroonian Plants (Hardcover): Xavier Siwe-Noundou Natural Products Chemistry of Botanical Medicines from Cameroonian Plants (Hardcover)
Xavier Siwe-Noundou
R5,968 Discovery Miles 59 680 Ships in 12 - 17 working days

A contribution to the series on Natural Products Chemistry of Global Plants, Natural Products Chemistry of Botanical Medicines from Cameroon focuses on the sources and chemistry of natural products from plants in Cameroon, West Africa. The plants selected offer an opportunity to trace a route through history from ancient civilizations to the modern day, showing the important value to man of natural products in medicines and in foods. This book highlights how many of the extracts from Cameroon are today associated with important drugs, nutrition products, beverages, perfumes, cosmetics and pigments, as well as presenting their complex chemistry and structure. Key Features: Forms an important part of the series on Natural Products Chemistry of Global Plants, as Cameroon is a country with rich experience in the use of medicinal plants and with a wide diversity of botanical resources Addresses the current development of pharmacognosy research in Cameroon Provides readers with updated information on the chemistry and pharmacology of natural products with pharmaceutical potential Covers an extensive range of chemical, botanical and pharmacological diversities Xavier Siwe Noundou is a Scholar/Scientist based at Rhodes University in Grahamstown, South Africa. He has been a EU FP7 Marie Curie Fellow (2015-2016), Kaposvar University in Hungary (2015, 2016), Trakia Univesity in Bulgaria (2016), TWAS Fellow (2013), National Research Foundation South Africa Fellow (2014-2016). Dr Noundou works on Medicinal Chemistry focusing on Chemistry, Pharmacognosy and Nanotechnology. His main research interests include terrestrial natural products chemistry (from Cameroon and South Africa) and marine natural products chemistry (from the South African coastline): bioactive metabolites isolated as potential antiparasitic, antimicrobial, antiviral and antiproliferative candidates. He is author of more than forty scientific publications in his field of expertise.

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