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Books > Medicine > Other branches of medicine > Pharmacology > General
Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data
in Adverse Drug Reactions was first published in 1977, and has been
continually published as a yearly update to the voluminous
encyclopedia Meyler's Side Effects of Drugs. Each Annual provides
clinicians and medical investigators with a reliable and critical
survey of new data and trends in the area of adverse drug reactions
and interactions, with an international team of specialists
contributing their expertise each year.
Cytochrome P450 Function and Pharmacological Roles in Inflammation
and Cancer, the latest volume in the Advances in Pharmacology
series, presents not only the function of cytochrome P450 but also
its pharmacological roles in inflammation and cancer.
Translational Immunology: Mechanisms and Pharmacologic Approaches
highlights and summarizes the most important advances in human
immunology, clinical translations, new tools to analyze therapeutic
targets, and new pharmacological approaches for autoimmunity,
inflammatory disorders, and cancer. The book is an essential
resource for those seeking to understand the potential
translational applications of burgeoning studies in human
immunology, helping readers make sense of the existing and emerging
scientific advances. The book grounds fundamental science in the
translational realm, providing insights from world renowned
researchers at the top of their game in their respective fields, in
both industry and academic settings. Readers will gain an
understanding of the rationale and mechanisms underlying current
and emerging pharmacologic approaches for interventional
immunology, the gaps therein, and new ideas for better and safer
therapeutic approaches, and physicians will glean information about
pharmacological limitations in altering disease progression and
complications. This reference on the translational realization of
the burgeoning findings in immunology provides a go-to reference
for experienced professional clinicians, researchers, industry
scientists, and those seeking more information on the field.
Advances in Structure and Activity Relationship of Coumarin
Derivatives covers the structural behavior of various coumarin
derivatives for various potential pharmaceutical applications.
Based on substitution targeted for active sites, the book takes a
rational approach for designing new and specific potent drugs,
optimizing existing ones, and developing novel reactions. This
focused primer describes the chemical structure and activity of
coumarin derivatives to explore the effects of different
substituents at specific positions, and their properties for
effective bioactivity.
Since the earliest dosage forms to modern drug delivery systems,
came a great development and growth of knowledge with respect to
drug delivery. Strategies to Modify the Drug Release from
Pharmaceutical Systems will address principles, systems,
applications and advances in the field.It will be principally a
textbook and a reference source of strategies to modify the drug
release. Moreover, the characterization, mathematical and
physicochemical models, applications and the systems will be
discussed.
Understanding the Basics of QSAR for Applications in Pharmaceutical
Sciences and Risk Assessment describes the historical evolution of
quantitative structure-activity relationship (QSAR) approaches and
their fundamental principles. This book includes clear,
introductory coverage of the statistical methods applied in QSAR
and new QSAR techniques, such as HQSAR and G-QSAR. Containing
real-world examples that illustrate important methodologies, this
book identifies QSAR as a valuable tool for many different
applications, including drug discovery, predictive toxicology and
risk assessment. Written in a straightforward and engaging manner,
this is the ideal resource for all those looking for general and
practical knowledge of QSAR methods.
In this issue of Immunology & Allergy Clinics, guest editor Dr.
Elizabeth J. Phillips brings her considerable expertise to the
topic of Drug Hypersensitivity. Top experts in the field cover key
topics such as perioperative anaphylaxis; telemedicine in drug
hypersensitivity; aspirin-exacerbated respiratory disease;
pediatric drug allergy; and more. Contains 15 relevant,
practice-oriented topics including excipient allergy; recognizing
drug hypersensitivity in skin of color; allergy to radiocontrast
dye; MRGRPX2 and its role in non-IgE-mediated mast cell activation;
and more. Provides in-depth clinical reviews on drug
hypersensitivity, offering actionable insights for clinical
practice. Presents the latest information on this timely, focused
topic under the leadership of experienced editors in the field.
Authors synthesize and distill the latest research and practice
guidelines to create clinically significant, topic-based reviews.
Chinmedomics: The Integration of Serum Pharmacochemistry and
Metabolomics to Elucidate the Scientific Value of Traditional
Chinese Medicine uses new experimental techniques and research to
open doors in drug discovery and development related to traditional
Chinese medicine (TCM). This book features a unique approach that
combines chemometric analysis with metabolomics studies to
illuminate significant changes that have occurred in syndrome
states while simultaneously analyzing the efficacy of chemical
ingredients in herbal medicines. Chapters provide cutting-edge
information on traditional medicine, analytical technology, natural
products, metabolomics, bioinformatics and their applications. This
book provides a valuable resource for pharmacologists,
pharmaceutical scientists, medicinal plant researchers,
pharmacognosists and chemists working with TCM and highlights ways
to further research and advances in this area in the future.
Published continuously since 1944, the Advances in Protein
Chemistry and Structural Biology series has been the essential
resource for protein chemists. Each volume brings forth new
information about protocols and analysis of proteins. Each
thematically organized volume is guest edited by leading experts in
a broad range of protein-related topics.
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
offers a complete reference on the current international regulatory
guidelines and details best practice methodology for the three
standard animal models used to evaluate abuse potential: physical
dependence, self-administration and drug discrimination. This book
also includes chapters on alternative models and examples of when
you should use these alternatives. Case histories are provided at
the end of the book to show how the data generated from the animal
models play a pivitol role in the submission package for a new
drug. By incorporating all of this information into one book,
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
is your single resource for everything you need to know to
understand and implement the assessment of abuse liability.
Modern Applications of Plant Biotechnology in Pharmaceutical
Sciences explores advanced techniques in plant biotechnology, their
applications to pharmaceutical sciences, and how these methods can
lead to more effective, safe, and affordable drugs. The book covers
modern approaches in a practical, step-by-step manner, and includes
illustrations, examples, and case studies to enhance understanding.
Key topics include plant-made pharmaceuticals, classical and
non-classical techniques for secondary metabolite production in
plant cell culture and their relevance to pharmaceutical science,
edible vaccines, novel delivery systems for plant-based products,
international industry regulatory guidelines, and more. Readers
will find the book to be a comprehensive and valuable resource for
the study of modern plant biotechnology approaches and their
pharmaceutical applications.
The Practice of Medicinal Chemistry, Fourth Edition provides a
practical and comprehensive overview of the daily issues facing
pharmaceutical researchers and chemists. In addition to its
thorough treatment of basic medicinal chemistry principles, this
updated edition has been revised to provide new and expanded
coverage of the latest technologies and approaches in drug
discovery. With topics like high content screening, scoring,
docking, binding free energy calculations, polypharmacology, QSAR,
chemical collections and databases, and much more, this book is the
go-to reference for all academic and pharmaceutical researchers who
need a complete understanding of medicinal chemistry and its
application to drug discovery and development.
Progress in Medicinal Chemistry provides a review of eclectic
developments in medicinal chemistry. This volume includes chapters
covering recent advances in cancer therapeutics, fluorine in
medicinal chemistry, a perspective on the next generation of
antibacterial agents derived by manipulation of natural products, a
new era for Chagas Disease drug discovery? and imaging in drug
development.
Poor clinical trial designs result in failed studies wasting
research funds and limiting the advancement of cures for disorders.
Clinical Trial Design Challenges in Mood Disorders outlines classic
problems researchers face in designing clinical trials and
discusses how best to address them for the most definitive and
generalizable results. Traditional trial designs are included as
well as novel analytic techniques. The book examines information on
high placebo response, the generalizability of studies conducted in
the developing world, the duration of maintenance studies, and the
application of findings into clinical practice. With representation
from contributors throughout the world and from academia, industry,
regulatory agencies, and advocacy groups, this book will contribute
toward improved clinical trial design and valid, precise, and
reliable answers about what works better and faster for patients.
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