Patients who are unable to achieve an adequate nutritional intake via their gut are at risk of malnutrition and its many associated problems. They may therefore require feeding directly into a vein. "Prescribing Adult Intravenous Nutrition" is an introductory text offering the inexperienced healthcare professional involved in nutritional support, a practical guide to the broad principles and practice of adult parenteral nutrition. "Prescribing Adult Intravenous Nutrition" describes: why nutritional care is so important; what should be given; what can go wrong; how to deal with any IVN related problems; and organizational aspects of nutritional care.

Presenting the work of international experts who discuss all aspects of probiotics and prebiotics, this volume reviews current scientific understanding and research being conducted in this area. The book examines the sources and production of probiotics and prebiotics. It explores their use in gastrointestinal disorders, infections, cancer prevention, allergies, asthma, and other disorders. It also discusses the use of these supplements in infant, elderly, and animal nutrition, and reviews regulations and safety issues.

Integrating Psychotherapy and Psychopharmacology: A Handbook for Clinicians is a practical guide for the growing number of mental-health practitioners searching for information on treatments that combine psychopharmacology, psychotherapy, and psychosocial rehabilitation. Research shows that combined approaches are among the most effective ways to treat an increasing number of psychiatric disorders. However, though these combined treatments are becoming the everyday practice of psychiatrists, psychologists, and other mental-health professionals, identifying the right treatment plan can be notoriously difficult, and clinicians are often left scrambling to answer questions about how to design and customize their treatment strategies. In Integrating Psychotherapy and Psychopharmacology, readers will find these questions fully addressed and the answers explained, and they'll come away from the book with a toolbox full of strategies for helping their patients improve symptoms, achieve remission, and stay well using a combination of drug and psychological treatments.

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines. This book supplies an in-depth discussion of drug-induced hepatoxicology, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced disease. It includes contributions international experts.

The use of drugs as remedies for various types of diseases has a long tradition; however, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possible toxicity. The aim of this handbook is to compile data from various authors, providing clinicians with data that will optimize their decision making in selecting effective, low-risk drug treatments. It also provides research workers, including physicians, pharmacists, and basic scientists, with a sound basis for increasing knowledge of the risk/benefit ratios of various drugs. Includes detailed assessments of the following types of drugs: Antihypertensive agents Diuretics Anti-diabetic drugs Anticonvulsant drugs Drugs for Parkinson's disease Antihistamines and antiserotonins Cytokines and immunomodulators Non-opioid analgesics and anti-inflammatory agents Antibacterial agents Antiviral agents Drugs used in reproductive endocrinology Systemic drugs for skin diseases Topical liposome drugs Topical glucocorticoids

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

Written in the same accessible manner as previous editions, the fifth edition of Karch's Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs. The Fifth Edition Now Features: Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch's Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse. Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Physicians of the 1990s cannot afford to spend valuable time combing through volumes of laborious discussions of tedious details on psychiatric drugs. Practical Handbook of Psychopharmacology is the most comprehensive, yet user-friendly guide to psychotropic medication available in any single source. Text is minimized and straight to the point, with critical clinical information given in two forms. First, highly useful tables with the relevant basic information on all major psychotropic drugs are provided. The book also contains clinical flowcharts or tabular practice guidelines that assist in making everyday decisions about the use of psychotropics. Unique chapters discuss the psychopharmacology of pain, personality disorders, aggression, and children/adolescents, while other chapters cover standard areas such as depression, mania, psychosis, and dementia.

While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines.Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"

The concept that the gut and brain are intricately linked is widely accepted not just within the lay community but increasingly within scientific and therapeutic circles as well. Terms such as "heartache" and "gut wrenching" are more than mere metaphor, they represent key fundamental aspects of human experience which all individuals will invariably endure from time to time. The relationship between the gut and brain is complex but fundamental to health and wellbeing. Increasing and compelling evidence supports the existence of a relationship between the health and status of the gut and the manifestation of significant psychopathology. Uniquely within the field of mental health and psychiatry, the role of gut flora and probiotics in both the understanding and treatment of mental illness represents an emerging science whether the potential for therapeutic intervention, through the use of probiotics, offers an opportunity to determine efficacy within a coherent evidence-based model of both action and pathology or, moreover, offers interventions that are comparatively benign compared to the side-effect profile associated with most drugs used to treat mental illness. Probiotics in Mental Health examines the role of probiotics in a range of clinical presentations associated with significant psychopathology and facilitates a reconsideration of how mental illness may be conceptualised within a coherent gut-brain model of health and wellbeing. Under the rubric of enhancing wellbeing rather than dwelling on illness and disease, this exciting new volume not only comprises the latest evidence in the field but also advocates an approach characterised by the understanding of mental disorder within an evidence-based model and the pursuit of mental health and wellbeing through the most benign of interventions.

Integrating Psychotherapy and Psychopharmacology: A Handbook for Clinicians is a practical guide for the growing number of mental-health practitioners searching for information on treatments that combine psychopharmacology, psychotherapy, and psychosocial rehabilitation. Research shows that combined approaches are among the most effective ways to treat an increasing number of psychiatric disorders. However, though these combined treatments are becoming the everyday practice of psychiatrists, psychologists, and other mental-health professionals, identifying the right treatment plan can be notoriously difficult, and clinicians are often left scrambling to answer questions about how to design and customize their treatment strategies. In Integrating Psychotherapy and Psychopharmacology, readers will find these questions fully addressed and the answers explained, and they'll come away from the book with a toolbox full of strategies for helping their patients improve symptoms, achieve remission, and stay well using a combination of drug and psychological treatments.

Hugo Chavez won re-election in the 2012 Venezuelan presidential election, despite a closer margin between candidates than in previous elections. The results were puzzling for those who believed that Chavez's government had long ago reached its limits, while Chavez's supporters were struck by the growth of the opposition vote. Thus understanding the Venezuelan election of 2012 has proved to be challenging, with various recent studies focused upon it. Luis F. Angosto Ferrandez's book advances two ideas not previously discussed: the relationship between electoral behavior in Venezuela and contemporary Latin American geopolitics, and the way that relationship is projected through the candidates' appeal to narratives that situate Venezuela at the core of a heroic Latin American tradition and of a new regional process of integration. This edited volume first contextualizes and explains the results of the last re-election of Hugo Chavez in terms of its geopolitical conditionings and implications. Contributors tackle Latin American geopolitics by analyzing Venezuelan foreign policy and the country's role in continental projects of supra-national integration. Contributors also examine electoral strategy and tactics in order to show how the two main candidates built their campaign on emotional grounds as much on rational ones. This will be connected to the investigation of new narratives of national identification in contemporary Venezuela and how they may have practical implications in the design of policies addressing issues such as indigenous rights, community media and national security. Compiling state-of-the-art research on Latin American and Venezuelan politics, this book will appeal to academics and professionals who specialize in Latin American studies, international relations, democracy, and indigenous peoples.

Fluorescence of Living Plant Cells for Phytomedicine Preparations reveals how valuable medicinal compounds can be identified through the application of vital fluorescence in plant cells. The book explains the roles that fluorescent compounds play in plant physiology and promotes our knowledge of plant secretory cells and phytopreparations. Supported by vivid illustrations, the book reveals how actinic light - light that induces fluorescence in leaves and flowers - can be used in the identification of secretory cells within plant tissue that may be the repository of valuable medicinal compounds. The book demonstrates the potential of fluorescence in pharmacological analysis with detailed methods for applying fluorescence to identify these deposits of natural drugs. As such, this groundbreaking book contains methods of express-pharmaceutical analysis that could open new horizons in pharmacy and the cultivation of medicinal plants. Features Describes various fluorescence microscopy techniques for the localization of compounds contained in plants with pharmaceutical interest Provides an analysis of pharmaceutical material based on autofluorescence and histochemical reactions for numerous medicinal plant species Demonstrates practices for providing optimal growing conditions and improving the quality of the compounds Showing the readiness of plant raw material for pharmaceutical industry, this book will appeal to professionals in the pharmaceutical industry and students and researchers in the fields of phytochemistry, botany and pharmaceutical sciences.

Reverse Pharmacology: Phytocannabinoids, Banned and Restricted Herbals will serve as a tailormade reference guide for the manufacturers and practitioners of herbal drugs. Part A deals with Reverse Pharmacology & Nanophytomedicine and Part B with Phytocannabinoids and description of banned or restricted herbal drugs. Part B also includes chemical structures and unpublished material which are the salient features of this book. The work is an invaluable resource for professionals in the manufacturing of herbal and pharmaceutical products as well as those persons in regulatory affairs.

The use of biologics - drugs made from living organisms - has raised specific scientific, industrial, medical and legal issues. Examining the history of biologics necessitates the study of the pharmaceutical industry from a commercial and scientific perspective. The essays contained in this collection each deal with a case study of a biologic substance, or group of biologics, and its use during the twentieth century. The volume is divided into three sections dealing with drug production, the process of commercialization and the management of risks and controversies unique to biological agents in medicine.

Green synthesis is an emerging method for deriving nanoparticles present in natural plants for use in nanomedicine. Written by experts in the field, Green Synthesis in Nanomedicine and Human Health showcases the exciting developments of this specialty and its potential for promoting human health and well-being. This book gives practical information on novel preparation methods for identifying nanoparticles present in natural plants. It discusses applications of nanoparticles in combating communicable, non-communicable and vector-borne diseases. It also explores the potential for nanoparticles to combat antimicrobial resistance through improvements in treatment methods, diagnostics and drug delivery systems. Features scientific evidence of opportunities for integrating indigenous flora into nanomedicine to develop cost-effective therapeutic and diagnostic solutions for diseases, including cancer, tuberculosis, malaria and diabetes. Places green synthesis and nanomedicine in the African orthodox and traditional healthcare context. Provides policymakers with scientific evidence to inform policies for controlling or mitigating dangerous diseases. This book is essential reading for students, scientists, policymakers and practitioners of nanotechnology, and will appeal to anyone with an interest in integrating traditional African healthcare and Western medicine.

There is a clear need for innovative technologies to improve the delivery of therapeutic and diagnostic agents in the body. Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. Nanomedicine in Drug Delivery gives an overview of aspects of nanomedicine to help readers design and develop novel drug delivery systems and devices that build on nanoscale technologies. Featuring contributions by leading researchers from around the world, the book examines: The integration of nanoparticles with therapeutic agents The synthesis and characterization of nanoencapsulated drug particles Targeted pulmonary nanomedicine delivery using inhalation aerosols The use of biological systems-bacteria, cells, viruses, and virus-like particles-as carriers to deliver nanoparticles Nanodermatology and the role of nanotechnology in the diagnosis and treatment of skin disease Nanoparticles for the delivery of small molecules, such as for gene and vaccine delivery The use of nanotechnologies to modulate and modify wound healing Nanoparticles in bioimaging, including magnetic resonance, computed tomography, and molecular imaging Nanoparticles to enhance the efficiency of existing anticancer drugs The development of nanoparticle formulations Nanoparticles for ocular drug delivery Nanoparticle toxicity, including routes of exposure and mechanisms of toxicity The use of animal and cellular models in nanoparticles safety studies With its practical focus on the design, synthesis, and application of nanomedicine in drug delivery, this book is a valuable resource for clinical researchers and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner. It explores a wide range of promising approaches for the diagnosis and treatment of diseases using cutting-edge nanotechnologies.

The book provides valuable information on wild plants and their ethnopharmacological properties, discussion on ethnobotany, phytotherapy, diversity, chemical and pharmacological properties including antifungal, anti-inflammatory and antiprotozal properties. The chapters include a wide range of case studies, giving updated evidence on importance of wild plant resources from different countries including Nepal, India, Brazil, Chile, Argentina, Colombia, Egypt, Peru, etc. In addition, some specific species are used to explain their potential properties. Discussing traditional usage and pharmacological properties of wild plants, this book is entirely different from other related publications and useful for the researchers working in the areas of conservation biology, botany, ethnobiology, ethnopharmacology, policy making, etc.

Drs. Stephen M. Stahl and Bret A. Moore have created an instant classic in Anxiety Disorders: A Guide for Integrating Psychopharmacology and Psychotherapy. Anxiety Disorders is a comprehensive reference for the psychiatry and psychology student, intern, or resident, early career psychiatrist or psychologist, and the busy clinician. It distills the most important information regarding combined treatments for anxiety and presents the material in an easily accessible, understandable, and readable format. Each chapter addresses a specific type of disorder: PTSD, panic, generalized anxiety, obsessive-compulsive and other disorders, and is authored by prominent clinicians with years of experience in providing integrated, individualized treatments. With its thorough exploration of psychopharmacological treatments, psychosocial treatments, and, crucially, the integration of the two, Anxiety Disorders is a text no 21st-century clinician or student can afford to be without.

This book offers an explanation of the specific ways that biocatalysis outperforms chemical catalysis by: utilizing ambient temperature and atmospheric pressure to minimize problems of isomerization, racemization, and epimerization; employing microbial cells and enzymes that can be immobilized and reused over many cycles; and overexpressing enzymes for greater economy and efficiency.

At the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential reference for the practising respiratory physician. Key features: The text builds upon basics with a review of basic sciences. The book covers imaging, varied drug-induced interstitial lung disease including pulmonary edema and diffuse alveolar hemorrhage, acute respiratory failure, pleural involvement and upper to lower airway disease A wide range of diseases are detailed from chemotherapy and radiation to biologic-induced lung disease, drug misuse, and special groups such as recipients of stem cell and solid organ transplants. A range of world class contributions from key opinion leaders. This book provides essential information for recognizing and managing drug-induced respiratory disease for all pulmonologists and respiratory care physicians. It will be of great interest to: critical care medicine specialists, hematologists, oncologists, cardiologists, allergists, rheumatologists, neurologists, internists, blood-bank specialists, pathologists and primary care physicians.

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities. In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure-activity relationships.

The book comprehensively addresses all substances and methods prohibited by WADA It strikes a balance between scientific evidence and practical examples It is a key volume to both someone wishing to explore the topic, or academics looking for specific details and case studies. the book highlights athletes who may have been banned for substances, allowing students to engage in additional case study research

Drs. Stephen M. Stahl and Bret A. Moore have created an instant classic in Anxiety Disorders: A Guide for Integrating Psychopharmacology and Psychotherapy. Anxiety Disorders is a comprehensive reference for the psychiatry and psychology student, intern, or resident, early career psychiatrist or psychologist, and the busy clinician. It distills the most important information regarding combined treatments for anxiety and presents the material in an easily accessible, understandable, and readable format. Each chapter addresses a specific type of disorder: PTSD, panic, generalized anxiety, obsessive-compulsive and other disorders, and is authored by prominent clinicians with years of experience in providing integrated, individualized treatments. With its thorough exploration of psychopharmacological treatments, psychosocial treatments, and, crucially, the integration of the two, Anxiety Disorders is a text no 21st-century clinician or student can afford to be without.

This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.