Biopharmaceuticals, the term for genetically engineered therapeutic proteins, monoclonal antibodies, and nucleic acid-based products, have become an increasing part of the pharmaceutical armament. While this category of drugs accounts for approximately 25% of all new drugs coming to market, very few references exist that review these commercially available products. Until now, accessing data on the list of currently approved biopharmaceuticals has been laborious and patchy. Directory of Approved Biopharmaceutical Products brings together key information on various aspects of these compounds, presenting a brief summary of each biopharmaceutical currently approved for medical use. Each summary includes the scientific and trade name, year and regions approved, approved indications, manufacturer, marketing right, method of manufacture, scientific overview, and therapeutic properties. Based on information gathered from regulatory agencies and pharmaceutical manufacturers, the book presents the most comprehensive data currently available in a single, convenient volume. This comprehensive and consistent approach will save professionals in the pharmaceutical industry hours spent trawling the literature - and provides a singular resource for future reference.

Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug's interaction with endogenous chemicals. In Drug Synergism and Dose-Effect Data Analysis, noted pharmacologist, mathematician, and author Ronald J. Tallarida finally brings these methods to light. Drawing on statistical theory and methods but keeping the special needs of the pharmacologist in mind, he begins his treatment with dose-response relations, the statistical analysis of the data, and the models that describe them. He also offers the only modern presentation of probit and logit analysis and provides detailed calculation methods not found in typical statistics books. Numerous examples accompany a presentation that clearly illustrates the calculations and experimental design considerations for modern drug analysis. You'll find the conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need to perform, with confidence, the quantitative analysis of dose response data.

This volume provides a single-source of reviews for all the important colloidal drug delivery systems, including nanoparticles, liposomes, niosomes, microemulsions and ointments. Over 1000 bibliographic citations, as well as tables, drawings, equations and photographs, are provided. Arranged in order of increasing physical complexity, this work analyzes developments in the field.

For hundreds of years cannabis has been used as a therapeutic medicine around the world. Cannabis was an accepted medicine during the second half of the 19th century, but its use declined because single agent pain medications were advocated by physicians who demanded standardization of medicines. It was not until 1964 when the chemical structure of THC (delta 9-tetrahydrocannabinol) was elucidated and its pharmacological effects began to be understood. Numerous therapeutic effects of cannabis have been reviewed, but cannabis-based medicines are still an enigma because of legal issues. Many patients could benefit from cannabinoids, terpenoids and flavonoids found in Cannabis sativa L. These patients suffer from medical conditions including chronic pain, chronic inflammatory diseases, neurological disorders, and other debilitating illnesses. As more states are legalizing medical cannabis, prescribers need a reliable source which provides clinical information in a succinct format. This book focuses on the science of cannabis as an antioxidant and anti-inflammatory supplement. It discusses cannabis uses in the human body for bone health/osteoporosis; brain injury and trauma; cancer; diabetes; gastrointestinal conditions; mental health disorders; insomnia; pain; anxiety disorders; depression; migraines; eye disorders; and arthritis and inflammation. There is emphasis on using the whole plant - from root to raw leaves and flowers discussing strains, extraction and analysis, and use of cannabis-infused edibles. Features: Provides an understanding of the botanical and biochemistry behind cannabis as well as its use as a dietary supplement. Discusses endocannabinoid system and cannabinoid receptors. Includes information on antioxidant benefits, pain receptors using cannabinoids, and dosage guidelines. Presents research on cannabis treatment plans, drug-cannabis interactions and dosing issues, cannabis vapes, edibles, creams, and suppositories. Multiple appendices including a glossary of cannabis vocabulary, how to use cannabis products, a patient guide and recipes as well as information on cannabis for pets.

The tea plant, Camellia sinensis, is of particular importance to humans, and the consumption of tea has a long history of over 2000 years. Currently, tea is one of the most popular beverages worldwide. In recent years the subject of tea has attracted a great deal of attention. As well as the use of tea in traditional medicine, modern biochemical research has shown the potential application of tea and tea products to disease prevention and therapy. The goal of this book is to cover all relevant aspects including botanical identification, processing and major categories of tea, physiological and pharmacological effects, and experimental therapeutic effects. The therapeutic applications of tea based on traditional Chinese medicine are also included. The contributors are renowned experts from botanical, agricultural, chemical, biochemical, and medical circles. Tea: Bioactivity and Therapeutic Potential will be an invaluable reference source for physicians and all professionals in pharmaceutical, agricultural, and food research and development industries as well as anyone who is interested in the potential medical applications of tea.

This informative volume presents a valuable overview of the therapeutic aspects as well as applications of antioxidants. It discusses the basic mechanisms of therapy-based oxidative damage and categorization of nutritional antioxidants and covers the sources of antioxidants as well as their extraction and quantification. The volume considers the controversies of the usefulness or disadvantages of antioxidant supplementation in relation to adaptation and performance and also looks at the effectiveness of bioactives and antioxidant-based therapies for specific health issues, such as anemia, infectious diseases, urinary tract infections, Parkinson's diseases, and diabetes. The book discusses the sensing of oxidative stress and the effectiveness of antioxidant treatment, followed by an introduction to several biomarkers to estimate the bioefficacy of dietary/supplemental antioxidants in various forms. Also considered are free radicals that can cause "oxidative stress," a process that can trigger cell damage, and how antioxidant molecules have been shown to counteract oxidative stress in laboratory experiments.

Health and medical uses of ginseng is broad due to its adaptogenic properties, it is an effective tonic. Ginseng can be used to improve mental and physical performance, reduce stress, and increase longevity. This book covers the properties and uses of four varieties of ginseng in the world with focus on American and Asian types of ginseng. This books discusses healing properties of ginseng, growing ginseng plants, chemical, nutritional, medical and pharmacological properties, detoxification, longevity and proper usage of the root. Features * Discusses four types of ginseng, chemical compositions, clinical and pharmacological uses * Presents various clinical uses of ginseng, covering more than 40 diseases and conditions * Covers traditional Chinese medicine related history of the use of ginseng in China, and the discovery of both Asian and American ginseng. * Teaches users how to use different kinds of ginseng for health maintenance * Discusses ginseng use in cold, flu prevention, cancer, diabetes, low energy/lethargy, and erectile dysfunction

Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Demonstrating that quite the opposite is true, Computational Pharmacokinetics outlines the fundamental concepts and models of PK from a mathematical perspective based on clinically relevant parameters. After an introductory chapter, the book presents a noncompartmental approach to PK and discusses the numerical analysis of PK data, including a description of an absorption process through numerical deconvolution. The author then builds a simple physiological model to better understand PK volumes and compares this model to other methods. The book also introduces compartmental models, discusses their limitations, and creates a general-purpose type of model. The final chapter looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling. With both a solid discussion of theory and the use of practical examples, this book will enable readers to thoroughly grasp the computational factors of PK modeling.

Medicinal Plants: Culture, Utilization and Phytopharmacology covers over 400 species. Each chapter gathers valuable information from a wide variety of sources, and supplies it to the user in convenient table format, arranged alphabetically by scientific name, followed by the common name. Data topics include: major constituents (active ingredients) and medicinal values of plants; toxicity or hazardous components; essential oils; value-added products and possible uses; cultivation and harvesting; diseases and insects found in medicinal plants. Three appendices (alphabetical listing of plants by common name, followed by the scientific name; essential oils and their derivation; active ingredients and their sources) provide handy cross-references to the Tables.

Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort to establish a function for GHB. Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects has brought together the combined expertise of many of the leading authorities on the biochemistry, physiology and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.

Providing a significant cross-fertilization of ideas across several disciplines, Enhancement in Drug Delivery offers a unique comprehensive review of both theoretical and practical aspects of enhancement agents and techniques used for problematic administration routes. It presents an integrated evaluation of absorption enhancers and modes for promoting absorption that is especially valuable to those involved with the development of pharmaceutical, cosmetic, bioengineered, and medical products, as well as graduate students looking to study this intriguing field and those professionals involved with patents and regulatory issues. Organized by routes of administration, the book is divided into eight major sections: oral, rectal, buccal/sublingual, dermal/transdermal, nasal, vaginal/uterine, ocular, and brain. It offers fundamental as well specialized information including current findings on- * Surfactant use to accelerate macromolecule input * Targeted gastrointestinal delivery and enhanced absorption of lipophilic drugs * Permeation issues in rectal absorption * Chemical means of enhancement * Carriers for enhanced delivery to and across the skin * Methods associated with breaching the skin * Promoted buccal and sublingual absorption * Emerging ocular, nasal, vaginal, and uterine delivery systems * Carriers for overcoming the blood brain barrier Those investigators primarily involved with one specific route of delivery will be able to learn of helpful concepts and find additional stimulat

Does Echinacea fight the common cold? Does St. John's Wort (SJW) really counteract depression? What about chondroitin for joint health? Today's healthcare professionals are increasingly confronted with questions from patients who want to use herbal supplements to treat various conditions. A critical and scientific assessment of medicinal plant research by an internationally recognized researcher and writer in the field, Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals, Third Edition combines the scientific aspects of herbal medicine, phytomedicine, and pharmacognosy with the modern clinical trials that support the rationale for using plant products in healthcare. A Decade's Worth of Updates The original edition of this volume was authored by the late Professor Varro E. Tyler, a true giant in the field of pharmacognosy and pharmacy education. Following in Tyler's footsteps, Dennis V.C. Awang, co-editor of the journal Phytomedicine, recognized the need for a revised third edition, in light of how quickly the clinical literature surrounding the dietary supplement market is growing. Millions of consumers are demanding natural treatment options from their doctors and pharmacies in a variety of forms, from herbal teas to tinctures and capsules. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals, Third Edition effectively fosters understanding in patients and practitioners of the role that herbs and phytomedicinal products can play in both self-care and healthcare.

Sustained-Release Injectable Products focuses on the development process for sustained-release versions of drugs and delivery systems and administration routes. From the rationale and basic product development principles to regulatory issues and the approval process, expert contributions address virtually every aspect. They bring together common threads that apply to any sustained-release formulation, such as scale-up, safety, biocompatibility, analytical challenges, and quality assurance.

In the evolving practice of pharmacokinetics (PK), it is important to keep on top of the latest advances. John E. Murphy, Pharm.D., FASHP, FCCP, a well-known leader in the field of clinical pharmacokinetics, has updated and expanded his widely used textbook and reference. Clinical Pharmacokinetics, 7th Edition, includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations. Everything You Need to Know About PK Today Drugs, dosing, and therapeutic monitoring Drug concentration measurements New chapter on the impact of pharmacogenomics Neonatal, pediatric, obese, and geriatric dosing Dosing in renal disease and creatinine clearance estimation Drugs sorted by family and as single drugs The companion workbook Clinical Pharmacokinetics, 7th Edition: Workbook, designed to test skills for using equations and the application of pharmacokinetic parameters, contains questions and exercises with answers and detailed solutions to help gauge understanding. This title is sold as a compelte set containing the text and workbook. They are not available for sale separately.

Here is a comprehensive overview of the drugs that act on the central and peripheral nervous systems. This volume thoroughly describes the diseases associated with the nervous system and the drugs used for their treatment while also looking at the current status of these drugs and their future potential and challenges. Divided into three sections, the book first focuses on the drugs that affect the functions of the autonomic nervous system to produce therapeutic effects. These drugs may act presynaptically by manipulating the genesis, storage, and secretion, and by blocking the action of neurotransmitters. Some drugs may trigger or impede postsynaptic receptors. Section 2 focuses on drugs that affect the central nervous system, including antianxiety drugs, sedative and hypnotic drugs, antidepressant drugs, antipsychotic drugs, antiepileptic drugs, and many more. It covers the pharmacological management of various diseases, including Alzheimer's, Parkinson's, Huntington's, and others. The last section offers explanations of neurochemical interactions with the aim to develop drugs that have beneficial effects on neurochemical imbalances. This section demonstrates models to assess the transport of drugs across the blood-brain barrier and nanomedicine to treat brain disorders. This rich compilation provides thorough and extensive research updates on the important advances in neuropharmacological drugs and drug therapy from experienced and eminent academicians, researchers, and scientists from throughout the world.

Handbook of Psychosocial Interventions for Chronic Pain provides a cutting-edge and comprehensive review of interventions for chronic pain grounded in biopsychosocial frameworks. Each chapter gives readers the opportunity to solidify their knowledge of major approaches to chronic pain in an accessible format. Reflecting national efforts to reduce prescriptions for pain medications and increase access to interdisciplinary treatment approaches, the book also considers a wide range of person-level variables such as age, cultural factors, and comorbid mental health conditions. In this book, mental health and allied health professionals will find the tools they need to understand the real-world delivery of chronic pain treatments in a wide variety of settings.

The second volume in the series Carbohydrate Chemistry: Proven Synthetic Methods, Volume 2 offers a collection of synthetic procedures valuable to the practice of synthetic carbohydrate chemistry. The series takes an important and unique approach in that all described procedures have been independently verified as reliable and reproducible. With editors and contributors who are highly respected scientists in the field, this book provides a widely useful reference for both researchers and students, exploring carbohydrate chemistry from both academic and industrial points of view. The book begins with an introductory section that offers tricks and tips collected by the series editor from many years of experience working in carbohydrate laboratories. The subsequent chapters present detailed protocols on both specific synthetic transformations and the preparation of common synthetic intermediates, with figures to aid in comprehension. Procedures are described for regioselective benzylidene ring opening reactions, oxidation reactions to provide uronic acids, stereoselective alpha-glucosylation reactions, and more. Protocols for synthetic intermediates of general utility include 3,4,6-tri-O-acetyl-d-galactal, phenyl 4,6-O-benzylidene-1-thio- -d-mannopyranoside, 1,2-anhydro-3,4,6-tri-O-benzyl- -d-mannopyranoside, and methyl N-acetylneuraminic acid, among many others. Each chapter presents in-depth experimental descriptions for the reported procedures, including reaction setup, reaction conditions, work-up procedures, and purification protocols. The chapters also provide detailed characterization of all products and intermediates as well as copies of the 1H NMR and 13C NMR of the described products and intermediates to indicate the purity of the obtained materials and to serve as a valuable reference for future practitioners. This book provides an important starting point to reliably access synthetic carbohydrate materials and as such offers a valuable resource for the synthetic organic chemistry community. Through the streamlined access of well-defined products it provides a thrust to the rapidly growing field of chemical glycobiology.

A comprehensive treatment of the science, technology, and regulation of rate-controlled administration of therapeutic agents, with coverage of the basic concepts, fundamental principles, biomedical rationales, and potential applications. This revised and updated edition (first in 1982) incorporates

Describes 'real life' examples in Medicinal Chemistry. Integrates the use of physical, chemical, and biological concepts that are important in drug design. Highlights the "ips" and "downs" that come with drug discovery. Aims to inspire students who may be struggling with the challenges and thought process in drug design. Intends to be an excellent companion text, illustrating real life experiences, for graduate and postgraduate students.

Pharmacy Registration Assessment Questions 3 follows on from the previous, highly popular Pharmacy Registration Assessment Questions. It features more than 400, entirely new, closed book and calculation questions. It can be used in conjunction with the previous volume or on its own. All the questions are in line with current GPhC guidance on the preregistration exam. This invaluable tool will not only help you familiarise yourself with the current style of questions, but will also enable you to revise ahead of your exams. Questions are based on print versions of BNF 76 and BNF for Children 2018-2019, alongside the most current treatment guidelines available at the time of writing the book. This book also includes questions featuring prescriptions, patient information and pictorial representation of conditions, replicating the type of questions you may encounter in the real exam. This revision aid gives you the opportunity to practice a variety of question styles ahead of the assessment including: - single best answer questions - extended matching questions - calculations This volume is written by a team of experienced authors who all work with pre-reg pharmacists every day and includes questions that are practical and will truly challenge you. In essence, this book is your handy guide to prepare for your exams. Nadia Bukhari is Senior Teaching Fellow in Pharmacy Practice & Pre-Registration Co-ordinator at the UCL School of Pharmacy. She is also the chairwoman for the Royal Pharmaceutical Society Pre-Registration conferences.

This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.

Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

The purpose of this book is to focus on major considerations in the clinical use of botanicals as an integrated therapy in current health care. The book uses an organ system approach to presenting clinical evidence on the use of botanicals for common conditions. The chapters include brief sections on background and pharmacognosy, preparation and dosing, safety, evidence and clinical application. In addition, several chapters highlight pharmacokinetic and pharmacogenomic considerations with botanicals in precision medicine and their use in special populations. Finally, a summary on the editors' perspective of "challenges and opportunities" is provided, which discusses the practice of botanicals as integrative therapies and where they are heading in the future.

Concepts, procedures and programs described in this book make it possible for readers to solve both simple and complex equilibria problems quickly and easily and to visualize results in both numerical and graphical forms. They allow the user to calculate concentrations of reactants and products for both simple and complicated situations. The user can spend less time doing calculations and more time thinking about what the results mean in terms of a larger problem in which she or he may be interested.