During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of "cellular ingestion" is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation. Pathogens (e.g., HIV) exploit endocytic pathways to gain entry into cells, and defects in the endocytic machinery can lead to diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all of the major pathways of endocytosis and post-endocytic trafficking, and how they regulate cellular and organismal physiology. Contributors describe how cargo enters the cell via clathrin-mediated and clathrin-independent pathways, including caveolar endocytosis, micropinocytosis, cholesterol-sensitive endocytosis, phagocytosis, and the CLIC/GEEC pathway. They review the numerous machineries (e.g., Rab GTPases, tethering factors, and retromer) that transport cargo through endosomes and deliver it to lysosomes or recycle it back to the cell surface, and the signals and mechanisms governing these sorting decisions. Topics such as lysosomal dynamics, the biophysical challenges of bending membranes, and the evolution of endocytic systems are also covered. This volume also includes substantial discussion of the roles of endocytic trafficking in organismal development, physiology, and disease. It is thus an indispensable reference for cell biologists, but also neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process.

A fresh approach to visualization practices in the sciences that considers novel forms of imaging technology and draws on recent theoretical perspectives on representation. Representation in Scientific Practice, published by the MIT Press in 1990, helped coalesce a long-standing interest in scientific visualization among historians, philosophers, and sociologists of science and remains a touchstone for current investigations in science and technology studies. This volume revisits the topic, taking into account both the changing conceptual landscape of STS and the emergence of new imaging technologies in scientific practice. It offers cutting-edge research on a broad array of fields that study information as well as short reflections on the evolution of the field by leading scholars, including some of the contributors to the 1990 volume. The essays consider the ways in which viewing experiences are crafted in the digital era; the embodied nature of work with digital technologies; the constitutive role of materials and technologies-from chalkboards to brain scans-in the production of new scientific knowledge; the metaphors and images mobilized by communities of practice; and the status and significance of scientific imagery in professional and popular culture. Contributors Morana Alac, Michael Barany, Anne Beaulieu, Annamaria Carusi, Catelijne Coopmans, Lorraine Daston, Sarah de Rijcke, Joseph Dumit, Emma Frow, Yann Giraud, Aud Sissel Hoel, Martin Kemp, Bruno Latour, John Law, Michael Lynch, Donald MacKenzie, Cyrus Mody, Natasha Myers, Rachel Prentice, Arie Rip, Martin Ruivenkamp, Lucy Suchman, Janet Vertesi, Steve Woolgar

Erfahren Sie mehr uber die Physik des Fahrzeugbewegungszustand Translations-und Rotationsbewegungen Bahn, Geschwindigkeit, & Beschleunigung In diesem Buch erhalt der Leser Zugang zu echten wissenschaftlichen Daten in Bezug auf Fahrzeugbewegungszustand, um Forderung der Grafik-Lesen, Vergleich, Kontrast und Berechnung Fahigkeiten. Grafiken zeigen Daten aus den folgenden wissenschaftlichen Instrument: Videoanalyse Dieses Buch ermoglicht eine unabhangige Studie Studenten und Wohnen-Schule Familien realen Daten ohne aufwandige Datenerhebung analysieren. Diagramme zeigen Daten aus zwei ferngesteuerte Fahrzeuge, ein Auto und ein PKW, auf flachen und geneigten Flachen. Die Daten sind gerade und gekrummte Bewegung, Beschleunigung und Verzogerung, und ein paar Unfalle. Die in diesem Handbuch enthaltenen Labor Grafiken und Daten konnen fur die Unterrichtsplane von Lehrern und Eltern verwendet werden."