ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation's oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Somatic hybrids through the fusion of plant protoplasts have widened the genetic variability of cultivated plants. As "Somatic Hybridization in Crop Improvement I", published in 1994, this volume describes how this discipline can contribute to the improvement of crops. It comprises 24 chapters dealing with interspecific and intergeneric somatic hybridization and cybridization. It is divided into four sections:I. Cereals: Barley, rice, and wheat.II. Vegetables and Fruits: Arabidopsis, Asparagus, Brassica, chicory, Citrus, Cucumis, Diospyros, Ipomoea, and various Solanaceous species, e.g., tomato, potato, and eggplant.III. Medicinal and Aromatic Plants: Atropa, Dianthus, Nicotiana, and Senecio.IV. Legumes/Pasture Crops: Alfalfa.This book is tailored to the needs of advanced students, teachers and researchers in the fields of plant breeding, genetic engineering, and plant tissue culture.

The biomaterials technology industry is already well established in the western world and is growing rapidly within Asian Pacific nations. It is often described as the 'next electronics industry', whilst the laser is described as a 'solution looking for a problem'. This book describes the use of the laser to solve a troublesome and costly problem in a rapidly growing global industry. The authors have spent many years conducting research using laser materials processing and wettability characteristics and have perfected a technique to improve the bio-compatibility of various bone-implant materials using laser irradiation. They have made pioneering discoveries on the subject and established some generic theories and principals that will have a wide range of applications in the biomaterials field.This book: introduces inter-disciplinary research work covering laser materials processing and surface modification of biomaterials for enhanced compatibility; includes highly scientific and novel research material; serves both as a practitioner guide and a reference book; and, covers an exciting and rapidly developing area of technology that is of keen interest to engineers and clinicians alike. "Laser Surface Treatment of Bio-Implant Materials" is rare in providing a reference source that describes specifically a mechanical engineering solution to a biotechnology problem. It serves as both a practitioner guide and a medium to high-level reference text book, and as such is a reference source for the engineer practising or looking to move into the biomaterials field, undergraduate and post graduate students and those conducting bio-related research in either academia or industry. It will prove useful to mechanical engineers, biotechnologists, biomechanical engineers, metallurgists, clinicians and even surgeons.

This book describes the development of genetic resources in amaranths, with a major focus on genomics, reverse, and forward genetics tools and strategies that have been developed for crop improvement. Amaranth is an ancient crop native to the New World. Interest in amaranths is being renewed, due to their adaptability, stress tolerance, and nutritional value. There are about 65 species in the genus, including Amaranthus caudatus L., A. cruentus L., and A. hypochondriacus L., which are primarily grown as protein-rich grains or pseudocereals. The genus also includes major noxious weeds (e.g., A. palmeri). The amaranths are within the Caryophyllales order and thus many species (e.g., A. tricolor) produce red (betacyanin) or yellow (betaxanthin) betalain pigments, which are chemically distinct from the anthocyanins responsible for red pigmentation in other plants. A. hypochondriacus, which shows disomic inheritance (2n = 32; n= 466 Mb), has been sequenced and annotated with 23,059 protein-coding genes. Additional members of the genus are now also been sequenced including weedy amaranths, other grain amaranths, and their putative progenitors.

In the age of data science, the rapidly increasing amount of data is a major concern in numerous applications of computing operations and data storage. Duplicated data or redundant data is a main challenge in the field of data science research. Data Deduplication Approaches: Concepts, Strategies, and Challenges shows readers the various methods that can be used to eliminate multiple copies of the same files as well as duplicated segments or chunks of data within the associated files. Due to ever-increasing data duplication, its deduplication has become an especially useful field of research for storage environments, in particular persistent data storage. Data Deduplication Approaches provides readers with an overview of the concepts and background of data deduplication approaches, then proceeds to demonstrate in technical detail the strategies and challenges of real-time implementations of handling big data, data science, data backup, and recovery. The book also includes future research directions, case studies, and real-world applications of data deduplication, focusing on reduced storage, backup, recovery, and reliability.

Digital Health: Mobile and Wearable Devices for Participatory Health Applications is a key reference for engineering and clinical professionals considering the development or implementation of mobile and wearable solutions in the healthcare domain. The book presents a comprehensive overview of devices and appropriateness for the respective applications. It also explores the ethical, privacy, and cybersecurity aspects inherent in networked and mobile technologies. It offers expert perspectives on various approaches to the implementation and integration of these devices and applications across all areas of healthcare. The book is designed with a multidisciplinary audience in mind; from software developers and biomedical engineers who are designing these devices to clinical professionals working with patients and engineers on device testing, human factors design, and user engagement/compliance.

Biocontrol and Secondary Metabolites: Applications and Immunization for Plant Growth and Protection covers established and updated research on emerging trends in plant defense signaling in, and during, stress phases. Other topics cover growth at interface as a sustainable way of life and the context of human welfare and conservation of fungi as a group of organisms. Further, the book explores induced systemic resistance using biocontrol agents and/or secondary metabolites as a milestone for sustainable agricultural production, thus providing opportunities for the minimization or elimination of the use of fungicides.

This volume discusses both the latest experimental research in bioelectrosynthesis and current applications. Beginning with an introduction into the "electrification of biotechnology" as well as the underlying fundamentals, the volume then discusses a wide range of topics based on the interfacing of biotechnological and electrochemical reaction steps. It includes contributions on the different aspects of bioelectrochemical applications for synthesis purposes, i.e. the production of fine and platform chemicals based on enzymatically or microbially catalyzed reactions driven by electric energy. The volume finishes with a summary and outlook chapter which gives an overview of the current status of the field and future perspectives. Edited by experts in the field, and authored by a wide range of international researchers, this volume assesses how research from today's lab bench can be developed into industrial applications, and is of interest to researchers in academia and industry.

- the book provides a unique overview of the NCBI resources, including BLAST (which are foundational to bioinformatics), and how to use them, making it a great introduction to bioinformatics and a great resource for those just starting in an industry lab - whereas many bioinformatics books try to cover every aspect of the topic and easily confuse readers, this is highly practical and focuses on key resources and tools, and how to use them - the companion website contains tutorials, R and Python codes, instructor materials including slides, exercises, and problems for students

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman's famous statement "What I cannot create, I do not understand."

The PCP's Bicentennial Edition Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics.

Intelligent Environmental Data Monitoring for Pollution Management discusses evolving novel intelligent algorithms and their applications in the area of environmental data-centric systems guided by batch process-oriented data. Thus, the book ushers in a new era as far as environmental pollution management is concerned. It reviews the fundamental concepts of gathering, processing and analyzing data from batch processes, followed by a review of intelligent tools and techniques which can be used in this direction. In addition, it discusses novel intelligent algorithms for effective environmental pollution data management that are on par with standards laid down by the World Health Organization.

Sustainable increase in agricultural production while keeping the environmental quality, agro-ecosystem function and biodiversity is a real challenge in current agricultural practices. Application of PGPR can help in meeting the expected demand for increasing agricultural productivity to feed the world's booming population. Global concern over the demerits of chemicals in agriculture has diverted the attention of researchers towards sustainable agriculture by utilizing the potential of Plant Growth Promoting Rhizobacteria (PGPR). Use of PGPR as biofertilizers, biopesticides, soil, and plant health managers has gained considerable agricultural and commercial significance. The book Plant Growth Promoting Rhizobacteria (PGPR): Prospects for Sustainable Agriculture has contributions in the form of book chapter from 25 eminent global researchers, that discusses about the PGPRs and their role in growth promotion of various crop plants, suppression of wide range of phytopathogens, their formulation, effect of various factors on growth and performance of PGPR, assessment of diversity of PGPR through microsatellites and role of PGPR in mitigating biotic and abiotic stress.This book will be helpful for students, teachers, researchers, and entrepreneurs involved in PGPR and allied fields. The book will be highly useful to researchers, teachers, students, entrepreneurs, and policymakers.

This book highlights current efforts and research on waste management, processing and valorization, particularly in Asia-Africa countries. Chapters 1-2 highlight the overview of plastic waste management and the production of waste plastic oil (WPO). Chapters 3-5 discuss the landfill characterization and application of incineration and composting for waste processing. A new achievement in adsorbent production is highlighted in Chapters 6 and 7 while Chapters 10 and 11 focus on sewage characteristic and its utilization using microalgae. Enzyme production using waste is covered by Chapters 10-12. Chapter 13-14 dedicated to the advances in production of bioenergy. The book concludes with a discussion on life cycle analysis for solid waste management (Chapter 15).

This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.

This book explores recent advances in the microbial production of xylitol and its applications in food and medical sector. Xylitol is an important biomolecule from lignocellulose biorefinery which is produced from the xylose by chemical reactions or microbial fermentation methods. Currently, the demand of xylitol at commercial scale is being met through chemical methods. However, recent breakthroughs made in plant cell wall destruction, genetic engineering to develop the designer microorganisms, fermentation methods and media formulations and downstream processing have led the ways for sustainable production of xylitol at commercial scale in lignocellulose biorefineries. Microbial production of xylitol is preferred over the chemical processes as it is environmentally friendly, higher process efficiency with the desired product yield, and product recovery with minimum impurities. This book is a unique compilation of 11 book chapters written by experts in their respective fields. These chapters present critical insights and discuss the current progress and future progress in this area into fermentative xylitol production. Chapter 9 is licensed under the terms of the Creative Commons Attribution 4.0 International License. For further details see license information in the chapter.

This volume details techniques involved to study aquatic pathogens that cause infections, especially in fish. Chapters guide readers through a wide range of basic and advanced methods, viral and fungal pathogens, probiotic bacteria, treatment of pathogens using seaweed extract, medicinal plant extracts, and actinomycetes. Authoritative and cutting-edge, Aquaculture Microbiology aims to be a useful practical guide to researches to help further their study in this field. 

The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes."

This book will serve as a primer for readers to understand recent advances, applications, and current challenges in the field of Engineered Living Materials. The chapters cover core science and engineering research areas, including (1) advances in synthetic biology and genetic programmability for Engineered Living Materials, (2) functional Engineered Living Material for application in energy, electronics, and construction, and (3) novel manufacturing approaches for Engineered Living Materials at multiple scales. The emerging field of Engineered Living Materials represents a significant paradigm shift in materials design and synthesis, in which living cells are used to impart biologically active functionalities to manmade materials. The result is a genetically programmable augmentation of non-living matter to exhibit unprecedented life-like (i.e., living) capabilities. At the intersection of synthetic biology and materials science, the field of Engineered Living Materials exhibits unprecedented promise and potential to alter the way we synthesize new materials and design medical devices, fabrics, robotics, commodity polymers, and construction materials. Materials with attributes of living systems can be engineered with an ability to respond to their environment and designed to self-repair in response to physical or other stresses or detect the presence of specific stimuli, such as light, heat, pressure, or hazardous chemical compounds. Although nascent, scientists and researchers in the field of Engineered Living Materials have made marked advances in demonstrating a potential to revolutionize a multitude of science and engineering disciplines. This volume will define the current state of the art of Engineered Living Materials, and highlight grand opportunities and challenges that abound at the nexus of synthetic biology and materials science and engineering.

Explores the latest advances in virus particle assembly Details the different mechanisms biological motors use to move on their diverse substrates Demonstrates how knowledge of fundamental processes have been used to advance bio-nanotechnology Discusses the latest advances in DNA and RNA nanoparticle assembly and use Introduces the use of DNA/RNA nanoparticles for drug delivery

This volume details the most up-to-date cryo-EM techniques from leading researchers. Chapters are organized into four parts with emphasis on electron cryotomography, single particle analysis, and the crystal based cryo-EM methods of 2D electron crystallography, and MicroED for the study of 3D crystals. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CryoEM: Methods and Protocols aims to serve as an excellent resource on cryo-EM and can serve as the foundation for new researchers to this growing field in structural biology.

Mycology has an integral role to play in the development of the biotechnology and biomedical sectors. It has become a subject of increasing importance as new fungi and their associated biomolecules are identified. As this discipline comes to the forefront of research in these sectors, the requirement for a consolidation of available research approaches is required. The First Edition of this book has a few basic and applied protocols. With the Second Edition, this book provides consolidated information on recent developments and the most widely used mycological methods available in the fields of biochemistry, biotechnology and microbiology. The methods outlined offer clear and concise directions to the reader and covers both standard protocols and more applied mycological methods. This book provides useful information for undergraduates, post-graduates, and specialists and researchers studying fungal biology.