This self contained book presents a comprehensive overview of the past, present and future of the galactose regulon of yeast, the classical model system of molecular biologists. The book starts with a brief historical overview on yeast research. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. Contemporary topics including genomics, evolution, binary and graded responses, and stochasticity are all addressed.

This updated and expanded second edition reviews numerous aspects of the marine microbiome and its possible industrial applications. The marine microbiome is the total of microorganisms and viruses in the ocean and seas and in any connected environment, including the seafloor and marine animals and plants. In the first part of the book, diversity, origin and evolution of the marine microorganisms and viruses are discussed. The microbes presented originate from all three domains of life: Bacteria, Archaea, and Eukarya. The second part sheds some light on the different communities: it describes marine habitats and how their inhabitants control biogeochemical cycles. The third part finally examines the microbial ocean as a global system and evaluates methods of utilizing marine microbial resources. Adopting a translational approach, the book connects academic research with industrial applications, making it a fascinating read and valuable resource for microbiologists from both domains.

Advances in Applied Microbiology, Volume 120 continues the comprehensive reach of this widely read and authoritative review source in microbiology, providing invaluable references and information on a variety of areas relating to the topics of microbiology.

The Flax Genome is a comprehensive compilation of most recent studies focused on reference genome, genetic resources and molecular diversity, breeding, QTL mapping, gene editing tools, functional genomics and metabolomics, molecular breeding via genomic selection, and genomic resources. The flax genome reference sequences and the new genome assemblies are presented. A list of flax QTL and candidate genes associated with more than 35 traits, including yield and agronomic, seed quality and fatty acid composition, fibre quality and yield, abiotic stress, and disease resistance traits, are summarized. A QTL- based genomic selection strategy and genome-editing tools are systematically introduced. In addition, huge amounts of flax genomic resources generated in the last decade are summarized. The book contains 13 chapters with about 390 pages authored by globally reputed researchers in the relevant fields to this crop The book is intended to be useful to students, teachers, and researchers interested in traditional and molecular breeding, pathology, molecular genetics and breeding, bioinformatics and computational biology, and functional genomics

Animal cell technology has undergone a rapid transformation over the last decade from a research tool and highly specialised technology to a central resource for innovation in pharmaceutical research and development. These proceedings of the 14th Meeting of the European Society for Animal Cell Technology (Vilamoura, Portugal, May 1996) bring up to date the historical perspective of animal cell technology for the benefit of society, `From Vaccines to Genetic Medicine', and will charter this vital technology for the years to come. Strong contributions are grouped in the traditional ESACT areas of 'Cell and Physiology Engineering' dealing with cell state, including genetics, and its environment, and 'Animal Cell Process Engineering' covering integration of bioreaction with bioseparation coupled with on-line monitoring to improve protein production and consistency. Extensive coverage of metabolic engineering on synthesis, folding, assembly, transiting and secretion is dealt with in the session on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. Two traditional but expanding areas of animal cell technology relevance are highlighted in the broad sessions of 'Animal Cells as Tools for Discovery and Testing' and 'Animal Cell Vaccines: Present and Future'. Two sessions finally cover the more recent domains of animal cell technology work - 'Tissue Engineering and Biomedical Devices' and 'Cells and Vectors for Genetic Medicine' - where one can foresee a very bright future.

This book discusses the various aspects of sustainable packaging edibles in food industry. It is divided into five main parts. The first section of the book addresses details of edible films, various sources, origin, scope and functions. Second section covers different sustainable alternatives such as seed gums, fruits and vegetable peels, sea weeds, fruits wastes, dairy by products & anti-oxidant edible packaging. This book also discusses about methods of improvements of mechanical properties of packaging edibles & their food applications, testing methods, innovations, limitations, challenges and nano edibles. It provides insights about the large quantity of wastes and by-products generated by food processing industries. Disposal of these wastes is a big problem due to their high biochemical oxygen demand (BOD) & chemical oxygen demand (COD) which causes severe problem of pollution to the environment. These wastes contain large amounts of proteins, carbohydrates, lipids, minerals, various bioactive compounds and have eco-friendly packaging potential. The book emphasizes on the fact that recycling these wastes as packaging edibles are sustainable and economical. As a world foreseeing food technology revolution, this book explores the unique topics in food packaging which possesses mammoth commercial applications and environmental potential. Due to its immense scope, this book is highly useful for researchers, food scientists, students and food packaging industry experts.

This volume provides a practical guide providing step-by-step protocol to explore vaccines for farm and companion animals, as well as for fish and insects. Divided into three volumes, Volume 2: Vaccines for Veterinary Diseases guides readers through veterinary vaccines, vaccines for poultry, vaccines for farm animals, and vaccines for veterinary parasites. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 2: Vaccines for Veterinary Diseases aims to be a useful practical guide to researchers to help further their study in this field.

This book is the ultimate assembly of recent research activities on molecular architectonics and nanoarchitectonics by authors who are worldwide experts. The book proposes new ways of creating functional materials at the nano level using the concepts of molecular architectonics and nanoarchitectonics, which are expected to be the next-generation approaches beyond conventional nanotechnology. All the contents are categorized by types of materials, organic materials, biomaterials, and nanomaterials. For that reason, non-specialists including graduate and undergraduate students can start reading the book from any points they would like. Cutting-edge trends in nanotechnology and material sciences are easily visible in the contents of the book, which is highly useful for both students and experimental materials scientists.

This book details the frontier technologies in the area of bovine reproduction. It describes the importance and significance of different technologies for improving reproduction efficiency in bovines. The book delineates the advancements in the technologies that are currently in use for faster multiplication of elite germ plasm including multiple ovulation and embryo transfer, ovum-pick-up, in vitro fertilization and embryo production, and semen sexing. Other emerging technologies, having potential for improving reproductive efficiency in bovines, including stem cells are also discussed with special reference to spermatogonial stem cells. Simple but effective tools having a great scope for day-to-day application in bovine farms for effective reproductive management like ultrasonography and thermal imaging are also covered in this book. The chapters on sperm transcriptomics, proteomics, metabolomics provide current developments in these areas and use of integrated approach for identification of fertility biomarkers. The chapters also describe technological advancements for early pregnancy diagnosis and offspring sex pre-selection in bovines. Additionally, this book discusses different sperm selection procedures including application of nanotechnology to obtain superior spermatozoa for assisted reproduction. Futuristic technologies including genomic selection and transgenesis are also discussed in detail. Finally, the book also elucidates a comprehensive description of challenges perceived with bovine reproduction and how effectively these technologies can help in improving fertility in bovines.

The aim of the Technical Advisory Committee, in planning the c~:>Dtent of this meeting, was to illustrate the range of separation processes in which the use of membranes was practical and effective at an industrial scale. As Professor Strathmann reveals, the market for process equipment built around membranes is now worth about $5x1(f annually, and it seemed important to review this technology, and to point the direction of future technical advances. All but the most critical reader should find some items of interest. The Committee would admit to not fulftlling all of thier aims, although those delegates who attended the meeting in Edinburgh judged it a success. In the event it provided representative examples of processes from the food and beverage industry, from water treatment, and from the chemical industry, of which the removal of alcohol from fermented beverages, shipboard desalination and solvent recovery are three. The major uses of charged membranes and sterile processes are not covered, nor 9 is the largest market, $1.2x10 annually, for artificial kidney dialysis. However, it is interesting to see artificial kidney now finding an alternative use as a reactor for the production of monoclonal antibodies. We are also reminded by Professor Michel of the importance and efficiency of natural membranes in the kidney under conditions where fouling is crucial to their performance and enhances their selectivity.

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

This pioneering handbook serves as an essential tool for any biobanking entity to create, implement and continuously improve their Quality Management System (QMS). Written in a concise and highly readable manner all biobanking related QMS aspects, ranging from legal aspects to safety matters, are addressed according to the best knowledge in compliance with the dedicated Biobanks ISO standards. Following a practical approach by making use of FAQ and common practice sections this book guides the readers through this complex field in an easy-to understand way.The guidelines are convergent not only with ISO 20387:2018 Biotechnology - Biobanking - General requirements for biobanking but also with ISO 9001:2015, ISO 19011:2018, ISO 27000:2014, and ISO 27002:2013. Furthermore, they are compatible, among others with the recommendations of the Organization for Economic Cooperation and Development (OECD), IARC, and ISBER Best Practices. Aimed at both biobank employees and other stakeholders (e.g. public bodies, political bodies, hospitals, pharmaceutical industry, funders) at any level of experience the book serves as valuable source for self-education and teaching. The manual complies to the principles of responsibility, openness, and transparency and can be used by any biobanking unit regardless of the biological material the biobank operates with and independent of their associated biobank network. On behalf of a group of specialists and experts in the area of biobanking, regarding Quality Management Systems (QMS), Ethical, Legal and Societal Issues (ELSI) and IT solutions, the authors present with this book a significant achievement based on activities within the project, European Research Infrastructure BBMRI-ERIC "Quality Standards for Polish Biobanks" Handbook (QSPB).

"COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics technology" and "COVID-19" as a disease. The book covers the most recent understanding of COVID-19 and the applications of cutting-edge studies, making it accessible to a large multidisciplinary readership. The book explains how high-throughput technologies and systems biology might assist to solve the pandemic's challenges and deconstruct and appreciate the substantial contributions that omics technologies have made in predicting the path of this unforeseeable pandemic. Features: In-depth summary of clinical presentation, epidemiological impact, and long-term sequelae of COVID-19 pandemic. A systematic overview of omics-based approaches to the study of COVID-19 biology. Recent research results and some pointers to future advancements in methodologies used. Detailed examples from recent studies on COVID-19 encompassing different omics methodologies. A detailed description of methodologies and notes on the applications of state-of-the-art technologies. This book is intended for scientists who need to understand the biology of COVID-19 from the perspective of omics investigations, as well as researchers who want to employ omics-based technologies in disease biology.

Following an introduction to biogenic metal nanoparticles, this book presents how they can be biosynthesized using bacteria, fungi and yeast, as well as their potential applications in biomedicine. It is shown that the synthesis of nanoparticles using microbes is eco-friendly and results in reproducible metal nanoparticles of well-defined sizes, shapes and structures. This biotechnological approach based on the process of biomineralization exploits the effectiveness and flexibility of biological systems. Chapters include practical protocols for microbial synthesis of nanoparticles and microbial screening methods for isolating a specific nanoparticle producer as well as reviews on process optimization, industrial scale production, biomolecule-nanoparticle interactions, magnetosomes, silver nanoparticles and their numerous applications in medicine, and the application of gold nanoparticles in developing sensitive biosensors.

This edited book is a comprehensive compilation of principles, conventional and molecular approaches used to develop improved varieties and hybrids of major crops in light of their origin, evolution, taxonomy, production and productivity and need by human civilization. The book covers breeding prospects of all important food and commercial crops. It highlights the importance of breeding tools and techniques in ensuring food security. This book is of interest to teachers, researchers, agriculture scientists, capacity builders, and policymakers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, soil science, and environmental sciences. National and international agricultural scientists and policymakers will find this book useful.

Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.

Industrial Hemp: Food and Nutraceutical Applications is a comprehensive overview of different value chains for the industrial hemp industry. This excellent reference supports multi-disciplines and presents industrial hemp as a multi-purpose crop, with special attention paid to its food and nutraceutical applications. By combining and presenting multidisciplinary knowledge, readers will be introduced to recent progress in hemp production, processing, utilization and marketing. The book provides a systematic overview of alternative hemp applications, but also serves as a guide to the challenges needed for hemp revitalization to reach its fullness.

This book explores the connections between migration and terrorism and extrapolates, with the help of current research and case studies, what the future may hold for both issues. Migration and Radicalization: Global Futures looks at how migrants and terrorists have both been treated as Others outside the body politic, how growing migrant flows borne of a rickety state system cause both natives and migrants to turn violent, and how terrorist radicalization and tensions between natives and migrants can be reduced. As he contemplates potential global futures in the light of migration and radicalization, Gabriel Rubin charts a course between contemporary migration and terrorism scholarship, exploring their interactions in a methodologically rigorous but theoretically bold investigation.

This volume provides a practical guide providing step-by-step protocol to design and develop vaccines for human diseases. Divided into three volumes, Volume 1: Vaccines for Human Diseases guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 1: Vaccines for Human Diseases aims to be a useful practical guide to researchers to help further their study in this field.

Develop a healthier connection between worker and work with this practical introduction The United States Bureau of Labor Statistics estimates that 34% of all workdays lost each year are the result of work-related musculoskeletal disorders (WMSDs). These disorders result from a mismatch between a worker, their working conditions, and the task they perform. Improperly designed tasks or equipment, insufficient downtime between shifts or tasks, or even simple sitting position can all produce WMSDs. The key insights into preventing these disorders are produced by ergonomics, the scientific study of human bodies as they relate to objects, systems, and environments, especially work environments. Occupational Ergonomics: A Practical Approach aims to supply an ergonomic toolkit for creating healthier relationships between workers' bodies and their work. Beginning with a set of foundational ergonomic principles, it then details multiple assessment techniques in ways easily adapted to specific workplace situations. This balance of theory and practice has made Occupational Ergonomics an essential reference concerning human beings and the work they do. Readers of the second edition will also find: Up-to-date ergonomic research reflecting the latest clinical and workplace data. Entirely new chapters on Work Physiology, Total Worker Health, Return on Investment, and more. Major revisions to chapters on Elements of an Ergonomic Program, Workstation Design, Work-Related MSDs, How to Conduct an Assessments, and Office Ergonomics Detailed and updated case studies applying ergonomic assessment techniques to common workplace scenarios. Occupational Ergonomics is a must for workplace safety managers, safety coordinators, ergonomics program coordinators, facilities managers, and any professionals concerned with the work environment, and worker health and safety.

Plant secondary metabolites are plant-based natural products that display a variety of pharmacological effects. This book discusses the invaluable bioactivity and multifaceted potential of these compounds. The book describes the physico-chemical and biochemical aspects of the plant secondary metabolites along with the chemistry, therapeutics and future perspectives of these plant secondary metabolites. Moreover, the book also discusses about various sources of plant secondary metabolites, and the metabolite determination through various analytical techniques. It further describes the potential applications of plant secondary metabolites as anticancer and chemo preventive agents, their role as cosmetic ingredients and activity in skin cancer therapy. Further chapters emphasize upon the plethora of roles of plant secondary metabolites, including those as antivirals, anti-bacterial, anti-inflammatory drugs, cardioprotective agents etc. The book culminates with chapters on the impact of certain plant secondary metabolites in plant defence and human healthcare. This book is meant for researchers and students in the field of pharmacology and plant sciences. Moreover, this book is also useful for industry experts especially working in the field of herbal therapeutics.

This body of work represents the first volume of a book series covering the field of tissue engineering. Tissue engineering, which refers to a category of therapeutic or diagnostic products and processes which are based upon a combination of living cells and biomaterials, was defined as a field only a few years ago (1988). Tissue engineering is an inherently interdisciplinary field, combining bioengineering, life sciences and clinical sciences. The definition of this area of work as the field of tissue engineering brought together scientists from multiple backgrounds who already were working toward the achievement of similar goals. Why a book series exclusively devoted to tissue engineering? The field of tissue engineering is heterogeneous. The cells involved in tissue engineering can be autologous, allogeneic or xenogeneic. The biomaterials utilized can be either naturally occurring, synthetic or a combination of both. The appli cation of the technology can be either for acute or permanent purposes. An attempt to cover the field of tissue engineering in a single volume, with the degree of detail necessary for individuals with different scientific back grounds and disciplines, would be a difficult task to accomplish, particularly when this field is just emerging and changing rapidly. Therefore, addressing different technologies within the field of tissue engineering, in a comprehen sive manner, is the main mission of this series of volumes. A stellar group of scientists has been brought together to form the editorial board of the series."

Simulating for a crisis is far more than creating a simulation of a crisis situation. In order for a simulation to be useful during a crisis, it should be created within the space of a few days to allow decision makers to use it as quickly as possible. Furthermore, during a crisis the aim is not to optimize just one factor, but to balance various, interdependent aspects of life. In the COVID-19 crisis, decisions had to be made concerning e.g. whether to close schools and restaurants, and the (economic) consequences of a 3 or 4-week lock-down had to be considered. As such, rather than one simulation focusing on a very limited aspect, a framework allowing the simulation of several different scenarios focusing on different aspects of the crisis was required. Moreover, the results of the simulations needed to be easily understandable and explainable: if a simulation indicates that closing schools has no effect, this can only be used if the decision makers can explain why this is the case. This book describes how a simulation framework was created for the COVID-19 crisis, and demonstrates how it was used to simulate a wide range of scenarios that were relevant for decision makers at the time. It also discusses the usefulness of the approach, and explains the decisions that had to be made along the way as well as the trade-offs. Lastly, the book examines the lessons learned and the directions for the further development of social simulation frameworks to make them better suited to crisis situations, and to foster a more resilient society.