Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

The 'Advances in Plant Biopesticides' comprises 19 chapters on different important issues of developing biopesticides from promising botanicals and its phytomolecules based on the research reviews in the area concern. The book is written by reputed scientists and professors of both developed and developing countries namely Australia, Canada, Czech Republic, Egypt, Greece, India, Kenya, Thailand, Turkey, United Kingdom, and USA represented by almost 53 contributors. The book is organized and presented in such a form that the readers can acquire and enhance their knowledge in plant biopesticide bioresources, its application in different areas to manage pests and diseases of field crops, stored products with status of exploring in Africa, non-target effects on beneficial arthropods, control of arthropods of veterinary and vectors of communicable diseases, efficacy in controlling honeybee mite pests, prospect of applying new tools to enhance the efficacy of plant biopesticides through use of nanotechnology, most important plant derived active principle as source of biopesticides, possible mode of action of phytochemicals against arthropods, limitation, production status, consumption, formulation, registration and quality regulation of plant biopesticides and have been cited by important scientific references. Most importantly, the book also highlights a unique example for developing biopesticides based on the research on Annonaceae as potential source of plant biopesticide, exploiting phytochemicals for developing green technology for sustainable crop protection strategies to withstand climate change with example in Africa, and overview in developing insect resistance to plant biopesticides. Most of the chapter contributing authors are internationally reputed researchers and possess experiences of more than three to four decades in the area of plant biopesticides. The contributing and corresponding authors of the book - Advances in Plant Biopesticides proposed and identified by the editor (Dwijendra Singh) include distinguished professors and reputed scientists from different continents of the world namely MB Isman (Canada), Nadia Z Dimetry (Egypt), Zeaur R Khan (Kenya), John A Pickett (UK), Gadi VP Reddy (USA), S Gopalakrishnan (India), Anand Prakash (India), Chirantan Chattopadyay (India), Christos G Athanassiou (Greece), Philip C. Stevenson (UK), S Raguraman (India), S Ghosh (India), Mir S Mulla (USA), Apiwat Tawatsin (Thailand), Dwijendra Singh (India), K Sahayaraj (India), Suresh Walia (India), T Shivanandappa (India), Roman Pavela (Czeck Republic), Errol Hasan (Australia), Ayhan Gokce (Turkey), SK Raza (India), and their colleague co-contributors. This book would certainly provide the updated knowledge to global readers on plant biopesticides as one of the important reference source and would stimulate to present and future researchers, scientists, student, teachers, entrepreneurs, and government & non-government policy makers interested to develop new & novel environmentally safe plant biopesticides world over.

This edited book serves as a vital resource on the contributions of microorganisms to advances in nanotechnology, establishing their applications in diverse areas of biomedicine, environment, biocatalysis, food and nutrition, and renewable energy. It documents the impacts of microorganisms in nanotechnology leading to further developments in microbial nanobiotechnology. This book appeals to researchers and scholars of microbiology, biochemistry and nanotechnology.

Nanotechnology is expected to bring revolutionary changes in a variety of fields. This volume describes nanoparticles and their biomedical applications, and covers metal nanoparticles, metal oxide nanoparticles, rare earth based nanoparticles and graphene oxide nanoparticles. It elaborates on a number of biomedical applications, including therapeutic applications. It addresses the topic of green synthesis, in view of increasing health and environmental concerns.

This review series covers trends in modern biotechnology.
All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http: //link.springer.de/series/abe/

Gellan Gum as a Biomedical Polymer details key topics and fundamental aspects of gellan gum and its biomedical applications in drug delivery, proteins and peptides delivery, cell delivery, tissue engineering, wound dressings and enzyme immobilizations in developing high quality products. Sections introduce gellan gum, its source, production and gelation mechanism, discuss biomedical materials, and provides ways it can be used for biomedical applications. The book also examines the used of gellan gum as pharmaceutical excipients for drug delivery. Future developments and challenges round out the book’s coverage. With contributions for an international group of experts, this book is a useful reference for scientists, researchers and those in industry engaged in biomedical product development using natural polysaccharides.

This edited book is focusing on the novel and innovative procedures in tissue culture for large scale production of plantation and horticulture crops. It is bringing out a comprehensive collection of information on commercial scale tissue culture with the objective of producing high quality, disease-free and uniform planting material. Developing low cost commercial tissue culture can be one of the best possible way to attain the goal of sustainable agriculture. Tissue culture provides a means for rapid clonal propagation of desired cultivars, and a mechanism for somatic hybridization and in vitro selection of novel genotypes. Application of plant tissue culture technology in horticulture and plantation crops provides an efficient method to improve the quality and nutrition of the crops. This book includes a description of highly efficient, low cost in vitro regeneration protocols of important plantation and horticulture crops with a detailed guideline to establish a commercial plant tissue culture facility including certification, packaging and transportation of plantlets. The book discusses somatic embryogenesis, virus elimination, genetic transformation, protoplast fusion, haploid production, coculture of endophytic fungi, effects of light and ionizing radiation as well as the application of bioreactors. This book is useful for a wide range of readers such as, academicians, students, research scientists, horticulturists, agriculturists, industrial entrepreneurs, and agro-industry employees.

This second edition volume expands on the previous edition with updated chapters in model systems and new crops. The book contains protocols for plastid engineering in leaves, tissue culture cells, and the shoot apex of plants, as well as for marker excision from the plastid genome and engineering Rubisco, the key enzyme of photosynthesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Chloroplast Biotechnology: Methods and Protocols, Second Edition is a valuable resource for researchers who wish to enter the field, and for practitioners looking for insights of applications in agriculture, industrial biotechnology and healthcare.

The book comprehensively covers the different topics of graphene based biopolymer and nanocomposites, mainly synthesis methods for the composite materials, various characterization techniques to study the superior properties and insights on potential advanced applications.The book will address and rectify the complications of using plastics that are non-degradable and has abhorrent impact on environment. The limitations of properties of biopolymer can be vanquished by employing graphene as a nanomaterial. Outstanding properties of graphene in accordance with biopolymer can be utilized to develop applications like water treatment, tissue engineering, photo-catalysts, super-absorbents. This is a useful reference source for both engineers and researchers working in composite materials science as well as the students attending materials science, physics, chemistry, and engineering courses.

Somatic hybrids through the fusion of plant protoplasts have widened the genetic variability of cultivated plants. As "Somatic Hybridization in Crop Improvement I", published in 1994, this volume describes how this discipline can contribute to the improvement of crops. It comprises 24 chapters dealing with interspecific and intergeneric somatic hybridization and cybridization. It is divided into four sections:I. Cereals: Barley, rice, and wheat.II. Vegetables and Fruits: Arabidopsis, Asparagus, Brassica, chicory, Citrus, Cucumis, Diospyros, Ipomoea, and various Solanaceous species, e.g., tomato, potato, and eggplant.III. Medicinal and Aromatic Plants: Atropa, Dianthus, Nicotiana, and Senecio.IV. Legumes/Pasture Crops: Alfalfa.This book is tailored to the needs of advanced students, teachers and researchers in the fields of plant breeding, genetic engineering, and plant tissue culture.

This book provides a comprehensive overview of FDA (Federal Drug Administration) procedures. It simplifies the complexities involved in getting FDA clearance by using an integrated approach of clinical, engineering, and business aspects. It includes both medical devices and drug development. This involves understanding the structure of the FDA, its purpose, and its initiatives. This book also examines what is needed for designing clinical trials and addressing recalls and failures. It uses case studies to further illustrate the integrated method stressed throughout this work.

This book highlights the uses for underutilized crops, presenting the state-of-the-art in terms of genome sequencing for over 30 crops, previously understudied and under-researched. In a changing climate and with significant pressure on the land, it is the ideal time to be discussing novel crops, with significant biotic and abiotic tolerances and/or rich nutrient profiles for consumers. Previously, the only species with sequenced genomes were high-profile internationally recognized crops, but in the current era genomes are being sequenced for dozens of crops, including those previously classified as underutilized, now being investigated. This book covers food crops, from fruits to tubers, and from grasses to legumes, as well as crops with non-food applications. Some of these crops have draft genomes, and others have polished genomes with extensive resequencing panels. Each chapter tells the story of an individual crop or crop group, written by experts, focusing on the genome data available, revealing more about crop domestication and genetic variation, and the current and future prospects given that this data is now becoming available. It also highlights how even small sequencing projects can provide draft genome sequences suitable for gene discovery, comparative genomics, and identification of molecular markers for understanding these crops further.

Nanobiotechnology Applications in Plant Protection: Volume 2 continues the important and timely discussion of nanotechnology applications in plant protection and pathology, filling a gap in the literature for nano applications in crop protection. Nanobiopesticides and nanobioformulations are examined in detail and presented as powerful alternatives for eco-friendly management of plant pathogens and nematodes. Leading scholars discuss the applications of nanobiomaterials as antimicrobials, plant growth enhancers and plant nutrition management, as well as nanodiagnostic tools in phytopathology and magnetic and supramagnetic nanostructure applications for plant protection. This second volume includes exciting new content on the roles of biologically synthesized nanoparticles in seed germination and zinc-based nanostructures in protecting against toxigenic fungi. Also included is new research in phytotoxicity, nano-scale fertilizers and nanomaterial applications in nematology and discussions on Botyris grey mold and nanobiocontrol. This book also explores the potential effects on the environment, ecosystems and consumers and addresses the implications of intellectual property for nanobiopesticides. Further discussed are nanotoxicity effects on the plant ecosystem and nano-applications for the detection, degradation and removal of pesticides.

The book is a comprehensive treatment of the field, covering fundamental theoretical principles and new technological advancements, state-of-the-art device design, and reviewing examples encompassing a wide range of related sub-areas. In particular, the first area focuses on the recent development of novel wearable and implantable antenna concepts and designs including metamaterial-based wearable antennas, microwave circuit integrated wearable filtering antennas, and textile and/or fabric material enabled wearable antennas. The second set of topics covers advanced wireless propagation and the associated statistical models for on-body, in-body, and off-body modes. Other sub-areas such as efficient numerical human body modeling techniques, artificial phantom synthesis and fabrication, as well as low-power RF integrated circuits and related sensor technology are also discussed. These topics have been carefully selected for their transformational impact on the next generation of body-area network systems and beyond.

Before the concept of history began, humans undoubtedly acquired life benefits by discovering medicinal and aromatic plants (MAPs) that were food and medicine. Today, a variety of available herbs and spices are used and enjoyed throughout the world and continue to promote good health. The international market is also quite welcoming for MAPs and essential oils. The increasing environment and nature conscious buyers encourage producers to produce high quality essential oils. These consumer choices lead to growing preference for organic and herbal based products in the world market. As the benefits of medicinal and aromatic plants are recognized, these plants will have a special role for humans in the future. Until last century, the production of botanicals relies to a large degree on wild-collection. However, the increasing commercial collection, largely unmonitored trade, and habitat loss lead to an incomparably growing pressure on plant populations in the wild. Therefore, medicinal and aromatic plants are of high priority for conservation. Given the above, we bring forth a comprehensive volume, "Medicinal and Aromatic Plants: Healthcare and Industrial Applications", highlighting the various healthcare, industrial and pharmaceutical applications that are being used on these immensely important MAPs and its future prospects. This collection of chapters from the different areas dealing with MAPs caters to the need of all those who are working or have interest in the above topic.

This book presents the applications of systems biology and synthetic biology in cancer medicine. It highlights the use of computational and mathematical models to decipher the complexity of cancer heterogeneity. The book emphasizes the modeling approaches for predicting behavior of cancer cells, tissues in context of drug response, and angiogenesis. It introduces cell-based therapies for the treatment of various cancers and reviews the role of neural networks for drug response prediction. Further, it examines the system biology approaches for the identification of medicinal plants in cancer drug discovery. It explores the opportunities for metabolic engineering in the realm of cancer research towards development of new cancer therapies based on metabolically derived targets. Lastly, it discusses the applications of data mining techniques in cancer research. This book is an excellent guide for oncologists and researchers who are involved in the latest cancer research.

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman's famous statement "What I cannot create, I do not understand."

The biomaterials technology industry is already well established in the western world and is growing rapidly within Asian Pacific nations. It is often described as the 'next electronics industry', whilst the laser is described as a 'solution looking for a problem'. This book describes the use of the laser to solve a troublesome and costly problem in a rapidly growing global industry. The authors have spent many years conducting research using laser materials processing and wettability characteristics and have perfected a technique to improve the bio-compatibility of various bone-implant materials using laser irradiation. They have made pioneering discoveries on the subject and established some generic theories and principals that will have a wide range of applications in the biomaterials field.This book: introduces inter-disciplinary research work covering laser materials processing and surface modification of biomaterials for enhanced compatibility; includes highly scientific and novel research material; serves both as a practitioner guide and a reference book; and, covers an exciting and rapidly developing area of technology that is of keen interest to engineers and clinicians alike. "Laser Surface Treatment of Bio-Implant Materials" is rare in providing a reference source that describes specifically a mechanical engineering solution to a biotechnology problem. It serves as both a practitioner guide and a medium to high-level reference text book, and as such is a reference source for the engineer practising or looking to move into the biomaterials field, undergraduate and post graduate students and those conducting bio-related research in either academia or industry. It will prove useful to mechanical engineers, biotechnologists, biomechanical engineers, metallurgists, clinicians and even surgeons.

This book offers a comprehensive review of the latest developments, challenges and trends in C1-based (one-carbon based) bioproduction, and it presents an authoritative account of one-carbon compounds as promising alternative microbial feedstocks. The book starts with a perspective on the future of C1 compounds as alternative feedstocks for microbial growth, and their vital role in the establishment of a sustainable circular carbon economy, followed by several chapters in which expert contributors discuss about the recent strategies and address key challenges regarding one or more C1 feedstocks. The book covers topics such as acetogenic production from C1 feedstocks, aerobic carboxydotrophic bacteria potential in industrial biotechnology, bioconversion of methane to value-added compounds, combination of electrochemistry and biology to convert C1 compounds, and bioprocesses based on C1-mixotrophy. Particular attention is given to the current metabolic engineering, systems biology, and synthetic biology strategies applied in this field.

Basics of proteins and proteomics techniques In-depth understanding of mass-spectrometry and quantitative proteomics An overview of interactomics and its application for translational research. Advancement in the field of proteomics and challenges in clinical applications.

Cancer Nanotheranostics, Volume 2 continues the discussion of the important work being done in this field of cancer nanotechnology. The contents of these two volumes are explained in detail as follows. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials, and nano-antibodies. This important second volume discusses nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nanoerythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, safety of nanobiomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics. Volume 2 is a vital continuation of this two-volume set. Together, these two volumes create a comprehensive and unique examination of this important area of research.

This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.

This book examines Ghana's use of the fingerprint biometric technology in order to further conversations about localization championed by technical communication scholars. Localization, in this case, refers to the extent to which users demonstrate their knowledge of use by subverting and reconfiguring the purpose of technology to solve local problems. Dorpenyo argues that the success of a technology depends on how it meets the users' needs and the creative efforts users put into use situations. In User Localization Strategies in the Face of Technological Breakdown, Dorpenyo advocates studying how users of technological systems construct knowledge about the technology and develop local strategies to solve technological breakdowns. By analyzing technical documents and interview transcripts, the author identifies and advances three user localization strategies: linguistic localization, subversive localization, and user-heuristic experience localization, and considers how biometric systems can become a tool of marginalization.