This thesis presents original research on how to seamlessly integrate electronics with living biological systems. Jia Liu has used silicon nanowires as active sensors to investigate biological signals at the cellular level. He has also designed nanoelectronic networks into flexible, three-dimensional (3D) and macroporous architectures, which mimic the structure of tissue scaffolds for in vitro 3D integrations with synthetic tissues and in vivo implantation by means of syringe injection. Importantly, the results demonstrate 3D interpenetrations of nanoelectronic networks with neural networks, 3D mapping of tissue activity and long-term implantation with minimal immunoresponses. Further, the book discusses potential applications for pharmacological studies, brain activity mapping and nanoelectronics enabled therapies. The findings presented here have gained wide recognition, including a top research ranking by Chemical & Engineering News and being listed among Scientific American's 10 world changing ideas in 2015.

8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent. Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals.

Smart Nanomaterials to Combat the Spread of Viral Infections comprises nanotechnology-based approaches with detailed preventive and treatment methodology for enabling their application in antiviral systems. This book discusses the role of metal nanoparticles in the treatment of and prevention of viral infections and nanotechnology advancements in antiviral coatings to combat affected surfaces. It also covers the use of nanomaterials for the efficient intracellular delivery of antiviral agents to disinfect and treat viral infections. This is a timely coverage of how nanotechnologies and materials as well as the utilization of artificial intelligence and Internet of things-based smart nano-systems are used to control and manage viral infections during the COVID-19 pandemic. Advances in smart research and future antimicrobial applications round out the book. This book provides a comprehensive overview of smart nanomaterials and advanced nano-system applications to researchers and academics in virology, microbiology, chemistry, material science, nanotechnology, and biotechnology as well as those in industries interested in their virucidal properties to prevent viral infections.

This book presents latest work in the field of plant biotechnology regarding high-efficiency micropropagation for commercial exploitation at low labor and equipment costs. The book consists of 18 chapters on establishing advanced culture systems, techniques as well as latest modification protocols on a variety of crops. It also discusses new methods such as nylon film culture system, light-emitting diode and wireless light-emitting diode system, stem elongation, wounding manipulation and shoot tip removal, in vitro hydroponic and microponic culture system, thin cell layer culture system etc. Plant cell tissue has been developed more than fifty years ago. Since then applications of in vitro plant propagation expanded rapidly all around the world and played as an important role in agricultural and horticultural systems. This book will be of interest to teachers, researchers, scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences.

Global industrial growth has resulted in numerous pollutants being introduced into the environment. It has additionally caused decreased water availability for agricultural activity in developing countries, which, in turn, has compelled farmers to use wastewater irrigation. In advanced agricultural systems, farmers are adapting various strategies to achieve a higher yield and thus sustain crop productivity. Consequent to the introduction of contaminants in the environment, soil pollutants have become a critical issue. Selection of disease-resistant, high-yielding crop varieties, and extensive fertilizer applications are quite common among farming communities. This book provides insight into environmental pollutants with special reference to their interference with plant nutrition. It additionally discusses the physiological aspects of plant nutrition. This book enhances current knowledge of the effects of pollutants on plant growth and physiology.

This book will expound the latest information on the current state of persimmon genomics and transcriptomics, with a particular focus on the latest findings and analysis in relation to the most important agronomic traits. The genus Diospyros contains about 400 species distributed all continents of the globe. Most of Diospyros species are distributed in the tropical and subtropical regions, while cultivated persimmon or simply kaki (Diospyros kaki) originates in East Asia and has been grown in China, Japan and Korea for many years. World production of persimmon has been increasing continuously since 1990s, with China being the most producer. Outside Asia, kaki production has been rapidly increasing in Spain in recent years. Because kaki is mostly hexaploid (2n = 6x =90) and its genome size is quite large with the flow cytometric analysis estimation of about 900 Mb, genetic and molecular studies in persimmon are quite complicated. Diploid close relatives of kaki, D. lotus and D. oleifera have been recently used as model species of kaki. Utilizing these species, molecular basis of several economically molecular basis of important traits such as sexuality and astringency has been studied, giving important information for kaki breeding.

Antiviral and Antimicrobial Smart Coatings: Fundamentals and Applications provides a critical analysis of all types of smart antiviral and antimicrobial coatings currently being researched. The book opens with a discussion of the microbial and viral pathogens, including how to identify them and their interaction with surfaces. The next three sections look at the concept of smart coatings, specifically antibacterial, antifungal, and antiviral smart coatings, types, effects, and applications. The book concludes by discussing the methods and standards for characterization of coatings and then presents several real world case studies. A valuable resource for those working in the smart coatings field.

The main driving force behind the development of new applications for chitin and its derivative chitosan lies with the fact that these polysaccharides represent a renewable source of natural biodegradable polymers. Since chitin is the second most abundant natural polymer, academic as well as industrial scientists are faced with a great challenge to find new and practical applications for this material. This book provides an examination of the state of the art, and discusses new applications as well as potential products. Applications of Chitin and Chitosan deals almost exclusively with applications. Previous books in the field have devoted less than 30% of their material to commercial or medical uses.
In the past thirty years, substantial progress has been made on fundamental and applied research in chitosan technology. One of the driving forces behind this rapid development has been the decrease in the supply of natural resources. At the same time there has been an increased realization that there are abundant alternative bioresources. Two factors-economics and versatility-have also stimulated interest in chitosan's utilization in various fields. Chitin and chitosan derivatives have applications in fields that range from fertilizers to pharmaceuticals. Chitosan is no longer just a waste by-product from the seafood processing industry. This material is now being utilized by industry to solve problems and to improve existing products, as well as to create new ones.
Applications of Chitin and Chitosan is illustrated with over 100 photos, charts, graphs and figures and more than 40 tables.
Applications of Chitin and Chitosan will be of interest to industrial personnel involved in bioprocessing as well as bioengineering students, specialists in the biomedical and biopharmaceutical industry, biochemists, food engineers, environmentalists, and microbiologists and biologists who specialize in chitosan technology. Publication: Fall 1996.

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.

Green Sustainable Process for Chemical and Environmental Engineering and Science: Methods for Producing Smart Packaging covers the latest advances in the development and production of smart packaging. The book addresses issues related to the production of smart packaging, including marketing and environmental impacts of these new products. The book demonstrates how modern packaging goes beyond protecting food against physical, chemical, and biological damage, and that scientific advances now enable producing functional packaging that prolongs product quality, preserves physical and chemical properties, produces greater protection against transportation shocks, and makes food more compact and easily recycled.

Nanomaterials for Photodynamic Therapy takes a unique approach to this area, with a key focus on the use of nanomaterials and nanocarriers for photodynamic therapy (PDT). The book introduces the history and mechanism of action behind PDT, covering the variety of sensitizers currently available. Subsequent chapters review existing and emerging nanomaterials for PDT, including hydrogel nanocomposites, fullerenes, quantum dots, polymeric micelles, and more. Challenges and translational aspects of PDT are also discussed, touching on the issues and hindrances of drug resistant cancers. The book bridges the gap between the physics and clinical aspects of PDT, offering a unique nanomaterials-focused perspective. This book will prove useful for materials scientists, biomedical engineers, electrical and optical engineers, and pharmaceutical scientists interested in cancer treatment.

Nanotechnology has shown great potential in all spheres of life. With the increasing pressure to meet the food demands of rapidly increasing population, thus, novel innovation and research are required in agriculture. The principles of nanotechnology can be implemented to meet the challenges faced by agricultural demands. Major challenges include the loss of nutrients in the soil and nutrient-deficient plants, which result in a lower crop yield and quality. Subsequently, consumption of such crops leads to malnourishment in humans, especially in underprivileged and rural populations. One convenient approach to tackle nutrient deficiency in plants is via the use of fertilizers; however, this method suffers from lower uptake efficiency in plants. Another approach to combat nutrient deficiency in humans is via the use of supplements and diet modifications; however, these approaches are less affordably viable in economically challenged communities and in rural areas. Therefore, the use of nano-fertilizers to combat this problem holds the greatest potential. Additionally, nanotechnology can be used to meet other challenges in agriculture including enhancing crop yield, protection from insect pests and animals, and by use of nano-pesticides and nano-biosensors to carry out the remediation of polluted soils. The future use of nanomaterials in soil ecosystems will be influenced by their capability to interact with soil constituents and the route of nanoparticles into the environment includes both natural and anthropogenic sources. The last decade has provided increasing research on the impact and use of nanoparticles in plants, animals, microbes, and soils, and yet these studies often lacked data involving the impact of nanoparticles on biotic and abiotic stress factors. This book provides significant recent research on the use of nano-fertilizers, which can have a major impact on components of an ecosystem. This work should provide a basis to further study these potential key areas in order to achieve sustainable and safe application of nanoparticles in agriculture.

Provides clear instructions and step-by-step exercises to make learning the material easier for students. Emphasizes fundamental laboratory skills which prepare a student for the industry. Builds students' skills through an organized and systematic presentation of materials, procedures, and tasks. Updates reflect recent innovations and regulatory requirements to ensure students stay up to date. Supplies skills suitable for careers in forensic, clinical, quality control, environmental, and other testing laboratories.

This book presents basic principles and discusses the state-of-the-art methods of sperm sexing in livestock. It reviews the challenges and critical opinions on the conventional sperm sexing methods and characteristic features of spermatozoa of farm animals which could help to develop novel methods of sperm sexing. The book also presents principles and applications of flow cytometry for sperm separation. The chapters of the book elucidate methods and difficulties in developing sperm sexing methods. Notably, it covers recent research on immunological and nanotechnology-based sperm sexing methods. The book also provides information on the development of semen extenders. Towards the end, the book examines ethical and commercial aspects of sperm sexing. It is an ideal reference book for students, researchers and professionals working towards improving livestock production.

Like the previous nine volumes published between 1988 and 1996, "Medicinal" "and" "Aromatic" "Plants X" is unique in its approach. It comprises 22 chapters dealing with the distribution, importance, conventional propagation, micropropagation, tissue culture studies, and the in vitro production of important medicinal and pharmaceutical compounds in various species of "Actinidia," "Alkanna," "Arnebia," "Campanula," "Catharanthus," "Centella," "Chenopodium," "Cornus," "Cynara," "Ephedra," "Euglena," "Haplophyllum," "Morus," "Oenothera," "Otacanthus," "Oxalis," "Polypodium," "Rosmarinus," "Sesamum," "Solanum," "Taxus," and "Tephrosia." This book is tailored to the needs of advanced students, teachers, and research scientists in the field of pharmacy, plant tissue culture, phytochemistry, biochemical engineering and plant biotechnology.

East Asian medicine, biomedical research, and health care policy are framed by their own set of moral and cultural commitments. Chief among these is the influence of Confucian ideas. A rich portrayal is offered of the implications of Confucian moral and ontological understandings for medical decision-making, human embryonic stem cell research, and health care financing. What is offered is a multifaceted insight into what distinguishes East Asian bioethical reflections. This volume opens with an exploration of the Confucian recognition of the family as an entity existing in its own right and which is not reducible to its members or their interests. As the essays in this volume show, this recognition of the family supports a notion of family autonomy that contrasts with Western individualistic accounts of proper medical decision-making.

A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

The bioelectronic nose, the device which has a similar function to the human smell sensing system, can be realized by combining the olfactory cells or receptors with nanotechnology.In the last two decades, much has been learned about the smell sensing mechanism in biological systems. With knowledge about the biological olfactory system and the techniques for the expression of biological receptor proteins, we are able to utilize biological materials and systems to mimic the biological olfactory system. In addition to the advances in biological and biotechnological area, nanotechnology has progressed to a great degree. The bioelectronic nose is a good example of the integration of biotechnology and nanotechnology. This book describes basic biological sciences of the olfactory system, biotechnology for the production of olfactory biological elements, and nanotechnology for the development of various sensing devices. The purpose of this book is to provide the reader with a concept, basic sciences, fundamental technologies, applications, and perspectives of the bioelectronic nose."

This book discusses different approaches for successful pest-management through biotechnological interventions. Pest management is directly associated with the agricultural productivity. The book introduces the reader to various kinds of biopesticides that have been developed and are being developed for field application. Chemical pesticides have been widely used to control pests, and these induce pesticide resistance as well as other environmental problems. This book discusses the necessity to develop alternate pest control strategies, especially environment-friendly and target-specific biopesticides against destructive pests. The book describes important aspects such as microbial biopesticides, plant-based biopesticides, natural products that act against pests and the various other biotechnological advances and limitations of these biopesticides. It provides an in-depth knowledge of the latest research and development in the area of biopesticides. This informative book is meant for students and researchers in the fields of biotechnology, agriculture and applied microbiology.

This book is the first comprehensive compilation describing the importance of sandalwood in national and international markets, genetic resources, molecular markers, whole genome sequencing, and pathway genes involved in oil biosynthesis, aroma and fragrance. Application of various "omics" approaches in delineating genome architecture and annotation of genes is highlighted. This book comprises 10 chapters covered over 200 pages authored by the researchers involved in sandalwood genomics. The sandalwood, Santalum album is known for its unique fragrance and finest wood available for carving. Also, sandalwood is intertwined with Indian culture and it is the second most valuable and expensive tree in the world.

Smart Anticorrosive Materials: Trends and Opportunities covers new developments in nanoscale coatings and their current applications. The book addresses fundamental characteristics, synthesis, inhibition mechanisms and applications of green nanomaterials for educational (academic) as well as industrial purposes and provides a chronological overview of the growth of the field. The book concludes with discussions about commercialization, economics and environmental considerations. This will be an indispensable reference for scholars, chemical engineers, chemists and materials scientists working in R&D and academia who want to understand corrosion systems and modern advancements on smart coatings.

This book aims to cover the applications of nanotechnology against human infectious diseases. The chapters of the book discuss the role of nanotechnology in the efficient diagnosis and treatment of these diseases. It explicitly provides an overview of nanodiagnostics for infectious diseases from nanoparticles-based, nanodevice-based, and point-of-care platforms. The book also covers the state-of-the-art review of recent progress in biomimetic and bioengineered nanotherapies to treat infectious diseases. It also presents a nano carrier-based CRISPR/Cas9 delivery system for gene editing and its applications for developing interventional approaches against communicable diseases. Further, it reviews the recent developments in nanotechnology to engineer nanoparticles with desired physicochemical properties as a line of defense against multi-drug resistance micro-organisms. Cutting across the disciplines, this book serves as a guide for researchers in biotechnology, parasitology, and nanotechnology.

This edited book provides the first comprehensive overview on conventional and emerging processing technologies for the extraction and purification of proteins and/or peptides from plant sources with a special focus on subsequent product development. The book opens with an introduction to the most conventional processing technologies used in industry today: the alkaline extraction followed by isoelectric precipitation, and air classification. The book also focusses on novel extraction and purification technologies, covering the most recent green emerging technologies based on enzymatic processes, solvents, high-pressure processing, barometric membrane technologies, and microwave-assisted extraction, among others. The final chapters bridge the gap between the presented methods and product development and highlight how these technologies can alter protein functionality and nutritional quality of the extracted protein, and thereby, impact human health. In the context of rising consumer interest in foods from plant-protein ingredients and the United Nations targets for Sustainable Development Goal 12 on 'Responsible Consumption and Production', this book will provide an indispensable resource for students, engineers and researchers in academia and industry, working in the area of food science, food technology and plant-based product development.