Printing Peptide Arrays with a Complementary Metal Oxide Semiconductor Chip, by Felix F. Loeffler, Yun-Chien Cheng, Bastian Muenster, Jakob Striffler, Fanny C. Liu, F. Ralf Bischoff, Edgar Doersam, Frank Breitling, Alexander Nesterov-Mueller. Protein Engineering as a Tool for the Development of Novel Bio production Systems, by Uwe T. Bornscheuer. Compartmentalization and Metabolic Channeling for Multienzymatic Biosynthesis: Practical Strategies and Modeling Approaches, by U. Jandt, C. You, Y. H.-P. Zhang, A.-P. Zeng. Cell-Free Systems: Functional Modules for Synthetic and Chemical Biology, by Marlitt Stech, Andreas K. Brodel, Robert B. Quast, Rita Sachse, Stefan Kubick. New Bio production Systems: From Molecular Circuits to Novel Reactor Concepts in Cell-Free Biotechnology, by Steffen Rupp. Cell-free Biosystems in the Production of Electricity and Bioenergy, by Zhiguang Zhu, Tsz Kin Tam, Y.-H. Percival Zhang. In Vitro Multi enzymatic Reaction Systems for Biosynthesis, by Ines Ardao, Ee Taek Hwang, An-Ping Zeng. Directed Multistep Biocatalysis Using Tailored Permeabilized Cells, by Steffen Krauser, Christian Weyler, Lisa Katharina Blass, Elmar Heinzle."

Inspired by the leading authority in the field, the Centre for Process Systems Engineering at Imperial College London, this book includes theoretical developments, algorithms, methodologies and tools in process systems engineering and applications from the chemical, energy, molecular, biomedical and other areas. It spans a whole range of length scales seen in manufacturing industries, from molecular and nanoscale phenomena to enterprise-wide optimization and control. As such, this will appeal to a broad readership, since the topic applies not only to all technical processes but also due to the interdisciplinary expertise required to solve the challenge.
The ultimate reference work for years to come.

Originally published in 1967, this title reveals how the missionaries, so often misguided and short-sighted, were in fact pioneers of modernization, science and freedom. The structure of the book allows for comparative analysis and the volume illustrates how some of the social consequences of action through the schools could be foreseen. In addition light is thrown on the results of Imperial rule during the nineteenth century and on the nature of the impact of Western education in Asia and Africa.

In this monograph, the authors demonstrate how the integration of adaptability, operability, and re-configurability in the design of complex systems is indispensable for the further digitization of engineering systems in smart manufacturing. Globalization of the customer base has resulted in distributed and networked manufacturing systems. However, current design methods are not suitable to address variations in product design, changes in production scale, or variations in product quality necessitated by dynamic changes in the market. Adaptability, operability, and re-configurability are key characteristics that are necessary to address the limitations of the current methods used to design networked manufacturing systems. In recent years, the digital transformation driving Industry 4.0 has had an enormous impact on globally distributed manufacturing. Digitalisation, the integration of digital technology into networked engineered systems, is increasingly being adopted to respond to changes in the market. This is achieved by means of (a) the concurrent design of adaptable systems, (b) addressing flexibility in design parameters, (c) conducting an operability analysis, and (d) employing a reconfiguration strategy to address faults and variances in product quality and re-establish connectivity among the elements in the system. The design of manufacturing systems in the age of Industry 4.0 is addressed in this monograph. The authors introduce the concept of a 'smart platform' and a computational framework for the digitalization of networked manufacturing systems. They also suggest how the framework and techniques in this monograph are applicable beyond the manufacturing domain for architecting networked engineered systems in other industries such as chemical processes and health care, that are being transformed through the adoption of the Industry 4.0 construct.

Drives and Control for Industrial Automation presents the material necessary for an understanding of servo control in automation. Beginning with a macroscopic view of its subject, treating drives and control as parts of a single system, the book then pursues a detailed discussion of the major components of servo control: sensors, controllers and actuators. Throughout, the mechatronic approach a synergistic integration of the components is maintained, in keeping with contemporary practice.

The authors holistic approach does not preclude the reader from learning in a step-by-step fashion each chapter contains material that can be studied separately without compromising understanding. Drives are described in several chapters organized according to the way they are usually classified in industry, each comprised of its actuators and sensors. The controller is discussed alongside. Topics of recent and current interest piezoelectricity, digital communications and future trends are detailed in their own dedicated chapters.

Drives and Control for Industrial Automation is primarily written for engineers and researchers interested in the applications of sensors, actuators and control systems in the automated environment. The discussion is thorough with the basics laid out succinctly but in sufficient detail to be useful to non-expert readers so students will also find this monograph a profitable source of information."

This book focuses on basic fundamental and applied aspects of micro-LED, ranging from chip fabrication to transfer technology, panel integration, and various applications in fields ranging from optics to electronics to and biomedicine. The focus includes the most recent developments, including the uses in large large-area display, VR/AR display, and biomedical applications. The book is intended as a reference for advanced students and researchers with backgrounds in optoelectronics and display technology. Micro-LEDs are thin, light-emitting diodes, which have attracted considerable research interest in the last few years. They exhibit a set of exceptional properties and unique optical, electrical, and mechanical behaviors of fundamental interest, with the capability to support a range of important exciting applications that cannot be easily addressed with other technologies. The content is divided into two parts to make the book approachable to readers of various backgrounds and interests. The first provides a detailed description with fundamental materials and production approaches and assembly/manufacturing strategies designed to target readers who seek an understanding ofof essential materials and production approaches and assembly/manufacturing strategies designed to target readers who want to understand the foundational aspects. The second provides detailed, comprehensive coverage of the wide range of device applications that have been achieved. This second part targets readers who seek a detailed account of the various applications that are enabled by micro-LEDs.

Structure formation in crystallizing polymers, as occurring during processing, has not been treated so far in a coherent form. This fact explains, why this monograph is written as the ?rst book devoted to this subject. A quarter of a century ago the underdevelopment of this subject was obvious. Trial and error dominated. In fact, other apposite subjects as polymer melt rheology or heat transfer, had reached high levels. A great number of books has been devoted to them. Mold ?lling of amorphous polymers and the solidi?cation of these polymers by vitri?cation can nowadays be simulated numerically with a high degree of accuracy. In the solidi?ed sample even residual stresses and corresponding birefringence effects can accurately be 1 calculated . However, semicrystalline polymers, which form the majority of industrial po- mers, have been excluded from these considerations for good reasons. In fact, great uncertainties existed about the formation of quality determining crystalline str- tures. In particular, polyole?ns suffered from this shortcoming. In 1983 this fact instigated the polymer research group at the Johannes Kepler University in Linz to start with pertinent activities. The urgency of this kind of studies becomes evident, if advantages and hitches of these polymers are considered. 1. Versatility of processing: Injection molding into a great variety of shapes and sizes, from thin walled beakers to garden chairs, not to forget pipe and pro?le extrusion, cable coating, ?ber spinning, ?lm blowing. 2. Product qualities: Ductility, low density, good electric insulation, corrosion resistance, surface quality.

Design for Manufacturability and Statistical Design: A Comprehensive Approach presents a comprehensive overview of methods that need to be mastered in understanding state-of-the-art design for manufacturability and statistical design methodologies. Broadly, design for manufacturability is a set of techniques that attempt to fix the systematic sources of variability, such as those due to photolithography and CMP. Statistical design, on the other hand, deals with the random sources of variability. Both paradigms operate within a common framework, and their joint comprehensive treatment is one of the objectives of this book and an important differentation.

This thesis reports on an innovative production-scheduling model for virtual computer-integrated manufacturing (VCIM) systems. It also describes a robust genetic algorithm for production scheduling in VCIM systems. The model, which is the most comprehensive of its kind to date, is not only capable of supporting collaborative shipment scheduling and handling multiple product orders simultaneously, but also helps cope with multiple objective functions under uncertainties. In turn, the genetic algorithm, characterised by an innovative algorithm structure, chromosome encoding, crossover and mutation, is capable of searching for optimal/suboptimal solutions to the complex optimisation problem in the VCIM production- scheduling model described. Lastly, the effectiveness of the proposed approach is verified in a comprehensive case study.

The scientific theme of the book is "Virtualisation - a multifaceted key enabler of Industry 4.0 from holonic to cloud manufacturing" which is addressed in the framework of cyber-physical system development. The book approaches cyber-physical systems for manufacturing with emergent digital technologies: Internet of Things, digital twins (based on the virtualization of production models embedded in the design, virtual commissioning, optimization and resilience of processes and fault tolerance of resources), big data, cloud control and computing, machine learning and cobots, that are applied in the book's chapters to industry and service sectors such as manufacturing, energy, logistics, construction and health care. The novelty of this approach consists in interpreting and applying the characteristics of RAMI4.0-the reference architecture model of the Industry 4.0 framework-as combinations of virtualized cyber-physical system elements and IT components in life cycle value stream models. The general scope of the book is to foster innovation in smart and sustainable manufacturing and logistics systems and in this context to promote concepts, methods and solutions for the digital transformation of manufacturing through service orientation in holonic and agent-based control with distributed intelligence. The book's readership is comprised by researchers and engineers working in the manufacturing value chain area who develop and use digital control solutions in the "Industry of the Future" vision. The book also addresses to master's and Ph.D. students enrolled in Engineering Sciences programs.

This book focusses on Industry 4.0 which is one of the most challenging trends for all categories of manufacturing enterprises. In this book, variety of mechatronic solutions are discussed to develop a manufacturing control system for small and medium-sized enterprises as they impose to improve their capabilities by integration into Industry 4.0 standards.

This book presents an analysis of the dynamics and the complexity of new product development projects which are organized according to the concept of concurrent engineering. The approach of the authors includes both a theoretical and an empirical treatment of the topic, based on the theory of design structure matrices. Readers will discover diverse perspectives and mathematical models, as well as an extensive discussion of two case studies.

This book approaches its subject matter by promoting concepts, methods and solutions for the digital transformation of manufacturing through service orientation in holonic and agent-based control with distributed intelligence. The scientific theme of the book concerns "Manufacturing as a Service", developed by virtualizing and encapsulating manufacturing resources, activities and controls into cloud networked services in an open perspective that spans models from shop floor resource allocation to enterprise infrastructure sharing. The papers included in the application space have a profound human dedication and aim at solving societal needs serving the partnership of the future-people and industry in the era of Society 5.0. The book's readership includes researchers and engineers working in manufacturing, supply chains and logistics areas who innovate, develop and use digital control solutions and students enrolled in Engineering and Service Science programs.

This book presents the proceedings of the 3rd Brazilian Technology Symposium (BTSym), which is a multi/trans/interdisciplinary event offering an excellent forum for presentations and discussions of the latest scientific and technological developments in various areas of research, with an emphasis on smart design and future technologies. It brings together researchers, students and professionals from the industrial and academic sectors to discuss current technological issues. Among the main topics covered in this book, we can highlight Artificial Neural Networks, Computational Vision, Security Applications, Web Tool, Cloud Environment, Network Functions Virtualization, Software-Defined Networks, IoT, Residential Automation, Data Acquisition, Industry 4.0, Cyber-Physical Systems, Digital Image Processing, Infrared Images, Patters Recognition, Digital Video Processing, Precoding, Embedded Systems, Machine Learning, Remote Sensing, Wireless Sensor Network, Heterogeneous Networks, Unmanned Ground Vehicle, Unmanned Aerial System, Security, Surveillance, Traffic Analysis, Digital Television, 5G, Image Filter, Partial Differential Equation, Smoothing Filters, Voltage Controlled Ring Oscillator, Difference Amplifier, Photocatalysis, Photodegradation, Cosmic Radiation Effects, Radiation Hardening Techniques, Surface Electromyography, Sickle cell disease methodology, MicroRNAs, Image Processing Venipuncture, Cognitive Ergonomics, Ecosystem services, Environmental, Power Generation, Ecosystem services valuation, Solid Waste and University Extension.

Linear Programming (LP) is perhaps the most frequently used optimization technique. One of the reasons for its wide use is that very powerful solution algorithms exist for linear optimization. Computer programs based on either the simplex or interior point methods are capable of solving very large-scale problems with high reliability and within reasonable time. Model builders are aware of this and often try to formulate real-life problems within this framework to ensure they can be solved efficiently. It is also true that many real-life optimization problems can be formulated as truly linear models and also many others can well be approximated by linearization. The two main methods for solving LP problems are the variants of the simplex method and the interior point methods (IPMs). It turns out that both variants have their role in solving different problems. It has been recognized that, since the introduction of the IPMs, the efficiency of simplex based solvers has increased by two orders of magnitude. This increased efficiency can be attributed to the following: (1) theoretical developments in the underlying algorithms, (2) inclusion of results of computer science, (3) using the principles of software engineering, and (4) taking into account the state-of-the-art in computer technology.
Theoretically correct algorithms can be implemented in many different ways, but the performance is dependent on how the implementation is done. The success is based on the proper synthesis of the above mentioned (1-4) components. Computational Techniques of the Simplex Method is a systematic treatment focused on the computational issues of the simplex method. It provides a comprehensive coverage of the most important and successful algorithmic and implementation techniques of the simplex method. It is a unique source of essential, never discussed details of algorithmic elements and their implementation. On the basis of the book the reader will be able to create a highly advanced implementation of the simplex method which, in turn, can be used directly or as a building block in other solution algorithms.

Composite insulators have been in service in electric power networks successfully for more than 40 years, and now up to the highest operating voltages. The present book extensively covers such insulators with a special focus on today's prevalent material, which is silicone rubber. It includes a detailed description of the electrical and mechanical characteristics of composite insulators, their material properties, their design as well as typical applications and service experience. Particular attention is given to the mechanical behavior of long rod and post insulators, insulated cross-arms, interphase spacers and hollow core apparatus insulators. The state of the art on manufacturing procedures and the selection and dimensioning of the necessary power arc and corona fittings is presented as well as evaluation tests of "old" insulators, i.e. insulators after many years in service. The closing chapter deals with an up to date overview of test procedures and IEC standards. The selection and the contents of the various subjects covered in this book are based on the authors' more than thirty years of experience with a renowned European manufacturer of composite insulators and string hardware. Their long and active participation in the relevant CIGRE and IEC working bodies adding to this experience. This book is therefore addressed to practicing engineers from electric utilities and the industry, as well as to academic professionals.

Bilevel programming problems are hierarchical optimization problems where the constraints of one problem (the so-called upper level problem) are defined in part by a second parametric optimization problem (the lower level problem). If the lower level problem has a unique optimal solution for all parameter values, this problem is equivalent to a one-level optimization problem having an implicitly defined objective function. Special emphasize in the book is on problems having non-unique lower level optimal solutions, the optimistic (or weak) and the pessimistic (or strong) approaches are discussed. The book starts with the required results in parametric nonlinear optimization. This is followed by the main theoretical results including necessary and sufficient optimality conditions and solution algorithms for bilevel problems. Stationarity conditions can be applied to the lower level problem to transform the optimistic bilevel programming problem into a one-level problem. Properties of the resulting problem are highlighted and its relation to the bilevel problem is investigated. Stability properties, numerical complexity, and problems having additional integrality conditions on the variables are also discussed. Audience: Applied mathematicians and economists working in optimization, operations research, and economic modelling. Students interested in optimization will also find this book useful.

This reference outlines the fundamental concepts and strategies for economic assessments for informed management decisions in industry. The book illustrates how to prepare capital cost and operating expense estimates, profitability analyses, and feasibility studies, and how to execute sensitivity and uncertainty assessments. From financial reports to opportunity costs and engineering trade-offs, Process Engineering Economics considers a wide range of alternatives for profitable investing and for projecting outcomes in various chemical and engineering fields. It also explains how to monitor costs, finances, and economic limitations at every stage of chemical project design, preparation, and evaluation.

The object of this book is to provide balanced coverage of the theory and practice of plating semiconductor devices. The principal concepts of plating are introduced and best practice discussed. The book is designed to help electroplaters achieve zero-defect' plating by providing an understanding of the plating chemistry and the handling of the plated parts.

The authors joined forces professionally when Kathy hired Shannon to be a member of her leadership team. This book describes the transformation they led to convert operations from traditional manufacturing to a lean enterprise. Kathy (executive leader responsible for profitability) and Shannon (transformation leader) share the finer points of a comprehensive change process, the challenges and triumphs, and the real emotion involved during their quest for success. Each describes the professional journey from their unique perspective and the highlights of an endearing friendship that was formed along the way. This story will inspire female leaders in any organization, showcasing an example of high-performing women thriving in an intense and fast-paced world. Kathy and Shannon are role models for those juggling intense, fulfilling careers, alongside life's complexities such as dual-career marriages and raising children. Their story provides a powerful case study of women supporting each other in the workplace to drive positive culture and significantly improved business results by leading with authenticity and inclusivity.

This monograph provides a field-proven approach to analyze industrial production with a cross-company scope as well as regarding all hierarchical system levels of manufacturing enterprises. The book exemplifies this approach in the context of aluminum die casting, and presents a set of measures which allow a 30 percent energy reduction along the value chain. The target audience primarily comprises researchers and experts in the field but the book may also be beneficial for graduate students.

Covering the complete design cycle of nanopositioning systems, this is the first comprehensive text on the topic. The book first introduces concepts associated with nanopositioning stages and outlines their application in such tasks as scanning probe microscopy, nanofabrication, data storage, cell surgery and precision optics. Piezoelectric transducers, employed ubiquitously in nanopositioning applications are then discussed in detail including practical considerations and constraints on transducer response. The reader is then given an overview of the types of nanopositioner before the text turns to the in-depth coverage of mechanical design including flexures, materials, manufacturing techniques, and electronics. This process is illustrated by the example of a high-speed serial-kinematic nanopositioner. Position sensors are then catalogued and described and the text then focuses on control.

Several forms of control are treated: shunt control, feedback control, force feedback control and feedforward control (including an appreciation of iterative learning control). Performance issues are given importance as are problems limiting that performance such as hysteresis and noise which arise in the treatment of control and are then given chapter-length attention in their own right. The reader also learns about cost functions and other issues involved in command shaping, charge drives and electrical considerations. All concepts are demonstrated experimentally including by direct application to atomic force microscope imaging.

Design, Modeling and Control of Nanopositioning Systems will be of interest to researchers in mechatronics generally and in control applied to atomic force microscopy and other nanopositioning applications. Microscope developers and mechanical designers of nanopositioning devices will find the text essential reading.

This book presents the proceedings of the 3rd International Conference of IFToMM ITALY, held online on September 9-11, 2020. It includes peer-reviewed papers on the latest advances in mechanism and machine science, discussing topics such as biomechanical engineering, computational kinematics, the history of mechanism and machine science, gearing and transmissions, multi-body dynamics, robotics and mechatronics, the dynamics of machinery, tribology, vibrations, rotor dynamics and vehicle dynamics. A valuable, up-to-date resource, it offers an essential overview of the subject for scientists and practitioners alike, and will inspire further investigations and research.

This book communicates the latest developments and thinking on the coaching subject worldwide. It presents insights into coaching in the management and engineering field on an international and transnational scale. The chapters contain innovative models, processes, strategies and uses, as well as the most recent research activities relating to coaching. This book highlights key issues and uses related to coaching for managers and engineers.