Written by two urologists and a genitourinary physician, this impeccably researched text provides the reader with a comprehensive overview of sexual health, exploring a range of topics such as: sexually transmitted infections; contraception; urological conditions; genital dermatoses; sexual dysfunction; novel therapeutic options. With a clear, symptom-based format, this is an ideal quick reference guide for the consulting room and the ward.

Offering an authoritative collection of chapters from clinicians and researchers in the United States, Canada, and Europe, this reference comprehensively covers the latest understanding in the etiology, pathophysiology, diagnosis, and treatment of sexual dysfunction.

Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

APPRAISAL AND REVALIDATION SERIES The new Appraisal and Revalidation Series helps doctors demonstrate their competence to the standard expected by the General Medical Council and to the standard expected if they are recognised as having 'special clinical interests'. It helps doctors gather evidence of their performance for appraisal and revalidation portfolios. This fifth book in the series examines the practical ways to identify learning and service needs within the areas of substance abuse palliative care musculoskeletal conditions and prescribing practice. It also provides guidance on how to collect data to demonstrate learning competence performance and service delivery standards. All general practitioners and those with special clinical interests and primary care organisation leads will find this book essential reading. For more information on other titles in this series please click here

"I say that this is a dirty, filthy book, and the test of it is that no human being would allow that book on his table, no decently educated English husband would allow even his wife to have it...." Such was the uncompromising pronouncement of Sir Hardinge Gifford, Her Majesty's Solicitor General, who in 1877 prosecuted Charles Bradlaugh and Annie Besant for publishing Dr. Charles Knowlton's Fruits of Philosophy.

Knowlton's work was the first American medical handbook on contraception. It had become an incredibly popular book among Britons who believed the neo-Malthusian dictum that the only solution to poverty in Britain was a limit on the growth of its population. They saw effective birth control measures as a way to make such a limit practicable. In 1877, its publisher was hauled into court and pleaded guilty to printing obscene material. Bradlaugh and Besant tested the right of official harassment by bringing out an edition of the Fruits of Philosophy that bore an introduction explaining their motives. The pair was arrested and charged with violating the Obscene Publications Act of 1857.

Their arrest, trial, conviction, and eventual acquittal constitute a landmark in the history of the world birth control movement. The enormous publicity accorded the principals and their cause brought the subject of family planning into the homes of nearly every Briton who read the newspapers' sensational coverage. What followed thereafter is telling: a dramatic, steady decline in the English birthrate. By their simple act of publishing Knowlton's short book, Bradlaugh and Besant helped establish England's pioneering role in the dissemination, democratization, and implementation of birth controlinformation.

This volume contains the writings of Charles Knowlton and Annie Besant on reproductive physiology and birth control and an account of the Bradlaugh-Besant trial. Included also are two of Besant's own pamphlets on birth control, and a comprehensive introductory essay that establishes a context for understanding neo-Malthusianism and the advocacy of birth control in nineteenth-century England. One of a small handful of books that helped stimulate a women's movement in the West, it will interest sociologists and gender studies specialists as well as the general reader interested in the history of birth control.

The potential impact of work being conducted in genomics, proteomics, and metabolomics upon clinical practice for gynecologists is immense but not yet completely appreciated. This groundbreaking text from international experts examines the newest topics on the perinatal agenda and gives clinicians a real look into the future via the newest methodologies.

This book stems from the author's clinical experience working with infertile women in psychotherapy and psychoanalysis. It highlights the crucial importance of integrative work of psychotherapists and psychoanalysts with reproductive medical specialists in assisted reproductive technology (ART).

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes

Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms. To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level. Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation. The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics. "

This timely resource offers extensive discussions on the pharmacological, environmental, endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproductive and Developmental Toxicology -provides an overview of the basic biology and physiology of organ systems affected by toxicants -furnishes detailed examples of developmental toxicology -analyzes germ cell toxicity and infertility -covers the developmental effects of neurotoxicity -considers periods of exposure and long-term toxicological consequences -explains how gonadal processes may be susceptible to toxicants in other reproductive organ systems -and more! With over 3700 bibliographic citations and more than 100 photographs, drawings, and tables, Reproductive and Developmental Toxicology is a useful reference for toxicologists; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; obstetricians/gynecologists; pediatricians; pharmacists and pharmacologists; physiologists; geneticists; poison control specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

The first and second editions of this successful textbook have been highly praised for their lucid and detailed coverage of abstract algebra. In this third edition, the author has carefully revised and extended his treatment, particularly the material on rings and fields, to provide an even more satisfying first course in abstract algebra.

An analysis of cell death in reproductive physiology. It examines topics such as the control of apoptosis in the uterus during decidualization and stern cell factor regulation of apoptosis in mouse primordial germ cells.

This is a comprehensive, up-to-date, authoritative research text and clinical reference work the menopause. It contains over 90 contributions covering every conceivable topic in the management of the menopause in women and related issues in the aging male. The book contains many illustrations and a wealth of references.

In the past, medical researchers and practicing clinicians have lacked a single, comprehensive resource on chromosome disorders, the cause of a wide variety of growth abnormalities and miscarriages. As new syndromes are being defined and known syndromes better described, patients with chromosomal abnormalities and their families are making greater demands on professionals for more extensive information. Consisting of more than 200 chromosomal aneuploidy syndromes, the Handbook of Chromosomal Syndromes is the most up-to-date reference to focus exclusively on clinical syndromes due to chromosomal abnormalities.

This fully illustrated guide is ideal for clinicians to use as a ready reference and for treatment and counseling of families and expectant parents facing abnormal prenatal tests. For each syndrome, this easy-to-use guide offers a complete description of clinical presentation, with illustrations, as well as information on behavioral aspects, life expectancy, diagnosis, and cytogenetics. Features of the text include:

• A section devoted to the nomenclature of chromosome abnormalities
• Pictorial material suitable to be shown to patient populations
• Descriptions of the phenotype in tabular and text form for quick and easy reference
• Ideograms for each entry
• A list of key references

Practicing clinicians–including primary care providers, pediatricians, and obstetricians–genetic counselors, researchers, and clinical and medical geneticists will find the Handbook of Chromosomal Syndromes to be an indispensable resource.

A geneticist tells the stories of men, women, and children whose genes have shaped their lives in unexpected ways.

It was while listening to a colleague tell the parents of a newborn girl that their daughter was going to die that a lifelong interest in genetic medicine was sparked in Dr Edwin Kirk. Warmth and gentleness tempered a direct, sure manner - this was the medicine he wanted to practise, where the most advanced science and the most deeply human meet. Twenty-five years later, Dr Kirk works both with patients and in the lab, and he spearheads a campaign that will change the way we think about having babies. His experience is without parallel, but it is his humour and insight that make all the difference.

Find out why Dr Kirk found himself among hundreds of people, each with a glass of poison in front of them - and how you might perform the same experiment yourself (without the poison). Learn how the realisation that a young boy wasn't short ended up saving the life of his mother - and how Angelina Jolie has saved the lives of many more. Sit in the room with Dr Kirk and his patients as they navigate the world of heartbreaking uncertainties, tantalising possibilities, and thorny questions of morality. In genetics, it is the particularities of an individual's history that matter, and here, in clear and considerate writing, those individual stories are given voice.

Female Puberty: A Comprehensive Guide for Clinicians is a practical reference, covering the full range of issues related to pubertal development. Developed to answer pointed clinical questions and to provide a thorough review of the literature, the book covers both the basics and the complexities of puberty, encompassing psychosocial development to pubertal nuances in highly specialized populations. Comprehensive in scope, this title offers concepts that are concisely conveyed and chapters that complement each other well. Complex subjects such as details of the hypothalamic-pituitary-ovarian axis are covered in a readily understandable manner and bullet points throughout the text serve as helpful reminders to the reader. An invaluable contribution to the literature, Female Puberty: A Comprehensive Guide for Clinicians will be of great interest to all health providers concerned with female reproductive health - including obstetrician gynecologists, reproductive endocrine specialists, pediatricians, pediatric specialists, family practitioners and allied health professionals.

Published in 1998, this book is a collected volume of papers from the first conference of the European Network for Biomedical ethics. The main subject of this conference is the ethical assessment of IVF in view of its concrete application as an infertility treatment and the consideration of possible alternatives for use. Twenty years after the introduction and the establishment of this therapy a more concrete evaluation of its medical indications, social conditions and consequences, the psychological consequences for the women involved and the parent-child relationship becomes possible. The legal and ethical evaluation of the reproduction technology as regards for example the legal and moral status of supernumery embyos in cryo-conservation has also to be considered in a European perspective. The ethical evaluation concentrates today on the new evolution that IVF technology takes in relation to the extension of diagnostics possibilities due to genetic research. Little work has been done on the connection between IVF and genetic diagnostics and therapy, so the medical and ethical evaluation of the connecting lines are also included in the book.

This important volume brings together findings in the psychological and medical treatment of sex offenders. It disseminates research from experts around the world in the field of sex offender treatment, making this knowledge available to researchers and clinicians everywhere. Professionals struggling to find effective methods for treating their patients will find Sex Offender Treatment a valuable tool for their daily work. Chapters in Sex Offender Treatment cover a variety of topics. Authors examine such areas as psychodynamic and psychiatric disorders associated with the sex offender, findings on pharmacologic interventions, treatment techniques and the public perception of sex offender treatment, and cautionary notes for those who provide therapy for sex offenders.Within these areas, some specific themes addressed include: types of personality disorders and implications for more effective treatment the effectiveness of antiandrogen treatment and the promising results of other pharmacotherapies techniques for developing insight in incest perpetrators a study of adult male incest offenders'perceptions of the treatment process an adolescent treatment program using a family communication approach hypotheses regarding sexual offenders and men who batter, using psychodynamic and feminist theory Full of practical strategies and useful information, Sex Offender Treatment is a book professionals will reach for again and again.

In Reproduction, Technology, and Rights, philosophers and ethicists debate the central moral issues and problems raised by today's revolution in reproductive technology. Leading issues discussed include the ethics of paternal obligations to children, the place of in vitro fertilization in the allocation of health care resources, and the ethical implications of such new technologies as blastomere separation and cloning. Also considered are how parents and society should respond to knowledge gained from prenatal testing and whether or not the right to abort should relieve men of the duty to support unwanted children.
Reproduction, Technology, and Rights illuminates the moral and ethical choices that our society faces because of advances in reproductive technology and helps to make those decisions better informed.

This book outlines the current understanding of how obesity affects female reproductive function across the lifespan. Topics include physiology of the menstrual cycle and early pregnancy, best practices in the delivery of contraceptive and prenatal care and healthcare policy that weighs the evidence in appropriate balance with principles that respect women's rights. Special attention is devoted to the idea that obesity's adverse effects are likely trans-generational; that is, children born to obese mothers are at increased risk for obesity, diabetes and cardiovascular disease later in life. Patients and their physicians need to be aware of the additional risks obesity confers in pregnancy and outline a plan of care that includes counseling preconceptionally, antepartum, intrapartum and postpartum in order to decrease morbidity. Obesity and Fertility provides advice for reproductive medicine physicians and gynecologists to help guide obese patients toward improved reproductive health and outcomes.

Prenatal Cocaine Exposures addresses the timely problem of maternal cocaine abuse and its effects on exposed infants, including growth retardation, learning, cardiovascular effects, and seizures. The impact of substance abuse on this and future generations presents an ongoing challenge to medical science. This comprehensive and authoritative volume reviews both animal and clinical studies to explain implications for treatment and long-term outcomes of early exposure.
Prenatal Cocaine Exposures investigates the specific role of cocaine in altering fetal development. Discussions of current studies and state-of-the-art techniques provide a basis for informed clinical decisions. Pediatricians, medical specialists, basic scientists, educators, and policy makers will all benefit from the comprehensive research gathered in this volume.

This book describes the principles and skills of counselling. It provides practical guidelines which show, by example, how to communicate effectively, how to offer counselling and support, and how to face and deal with difficult situations. Detailed attention is given to issues such as preparing women for surgery, breaking bad news, and providing information and support before, during and after childbirth. The book aims to increase the awareness of health workers by describing a broad range on women's experiences and reactions to their particular problems and health concerns, as well as the ways in which these are treated.

Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be better understood. In recent years, research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles is gaining greater appreciation. Ovarian Toxicology, Second Edition represents a compilation of chapters prepared by researchers who have substantially contributed to our understanding of the impact of xenobiotics and environmental factors on ovarian function. The second edition substantially updates newly investigated ovotoxicants as well as improved mechanistic insights that have emerged since the first edition. Topics include: Ovarian physiology and the metabolism of xenobiotics The effect of pesticides, heavy metals, phthalates, BPA, and cigarette smoking on the ovaries Ovarian cancer, including endocrine effects and new perspectives on chemoresistance Epidemiology and human health risk assessment for environmental chemicals and pharmaceuticals The first book to focus specifically on ovarian toxicology, this resource is ideal for scientists in academia, regulatory agencies, and industry who would benefit from a survey of the impact of xenobiotic chemicals on ovarian function.

How do men react to diagnosis of male infertility and how, if at all, are all their lives affected by it? Male infertility is commonplace yet the male experience of it has been woefully neglected. "Male Infertility - Men Talking" explores these issues by gathering together men's stories and seeing what common strands, if any, exist between them. Mary-Claire Mason explores the past and present medical management of male infertility as this forms an essential backdrop to the men's stories but the main emphasis is on how men's lives are affected. In the first half of this book, the discovery of sperm and the man's role in reproduction is considered together with a review of how the past affects the present medical management of male infertility and the problems that bedevil it. The male voice predominates in the second half, speaking of painful events and relationships with families and friends, their feeling of isolation, their medical experiences, the importance of biological fatherhood, and their hopes for the future.