The enormous increase in our knowledge and understanding of diabetes mellitus in recent years has resulted in new management strategies for greatly enhancing care in diabetic pregnancy. Clinicians responsible for the care of women with diabetes need to keep abreast of these advances. Diabetes and Pregnancy: An International Approach to Diagnosis and Management is a comprehensive, yet practical guide to the present state of knowledge regarding diabetic pregnancy. It summarizes published literature, and offers clear and valuable information on the practicalities of providing special care before, during and after pregnancy. This volume will be indispensable to all members of the health care team involved in the care of pregnant diabetic women and their babies, including obstetricians, neonatologists, diabetes physicians, specialist nurses, midwives as well as general practitioners.

This introductory textbook examines the issues of human reproduction common to a variety of advanced school and beginning university courses. It covers in detail the physiology of the human reproductive system, the production of gametes, fertilisation, pregnancy, birth, lactation and contraception. Sensitive issues such as infertility, abortion and embryo research are discussed with careful consideration of the moral and ethical issues involved.

This book, by two of the most distinguished figures in fertility and reproduction research, answers all the most common questions about menaupause and andropause, and hormone resupplement therapy (HRT) for menopausal women. It offers explanations of all aspects of this subject, presenting balanced and reliable information about benefits, risks, and prospects for this field. Segal invented Norplant, the first long-term implantable contraceptive, and as the leader of Reproductive Biology at the Population Council, he orchestrated and coordinated the research and trials leading to basically every new contraceptive introduced over a period of about 25 years. Mastroianni did more than anyone else to develop in vitro fertizilation as a viable treatment option, and was for many years the chairman of the largest department of obstetrics and gynecology, and the director of the most successful IVF clinic. This book is unique in including coverage of the climacteric in men.

This book offers a comprehensive roadmap for determining when and how to regulate risky reproductive technologies on behalf of future children. First, it provides three benchmarks for determining whether a reproductive practice is harmful to the children it produces. This framework synthesizes and extends past efforts to make sense of our intuitive, but paradoxical, belief that reproductive choices can be both life-giving and harmful. Next, it recommends a process for reconciling the interests of future children with the reproductive liberty of prospective parents. The author rejects a blanket preference for either parental autonomy or child welfare and proposes instead a case-by-case inquiry that takes into account the nature and magnitude of the proposed restrictions on procreative liberty, the risk of harm to future children, and the context in which the issue arises. Finally, he applies this framework to four past and future medical treatments with above average risk, including cloning and genetic engineering. Drawing lessons from these case studies, Peters criticizes the current lack of regulatory oversight and recommends both more extensive pre-market testing and closer post-market monitoring of new reproductive technologies. His moderate, pragmatic approach will be widely appreciated.

Within 10 chapters this book addresses the whole gamut of questions that may arise in the context of pregnancy resulting from assisted reproduction. Incidence of abortion, extrauterine pregnancy or chromosomal abnormalities, pregnancy complications, problems regarding mode of delivery and the health status of children at birth are covered as well as the further development of the children and the social structure of the families. Topics such as follow-up of families in lesbian relationships and following gamete donations are also discussed.

This volume, and its companion volume on the oocyte, provide an authoritative and wide-ranging account of the gametes, and their reproductive role and function in humans. Acknowledged authorities from around the world provide a detailed and timely account of the spermatozoon. The volume starts with an evolutionary perspective before focusing on the molecular and cellular biology of the sperm cell, and its structure and function. The development and maturation of sperm are described, as is their movement and transport in the male and female genital tract. Practical issues such as sperm storage and assisted contraception are fully covered. The causes of male infertility are also an important theme. The volume concludes with a thought-provoking chapter on ethical considerations. The volume will be an essential source of information for all clinicians and scientists with an interest in human reproduction.

This volume, and its companion volume on the spermatozoon, provide an authoritative and wide ranging account of the gametes and their reproductive role and function in humans. Acknowledged authorities from around the world contribute a detailed and timely account of the oocyte. The volume starts with an evolutionary perspective before focusing on the molecular and cellular biology of the oocyte and its structure and function. The development and maturation of the oocyte is fully dealt with to include the endocrine and paracrine regulation of ovarian function. Practical issues such as oocyte storage and ovarian stimulation are also fully covered. The causes of female infertility are also an important theme. The volume concludes with a thought provoking chapter on ethical considerations. The volume will be an essential source of information for all clinicians and scientists with an interest in human reproduction.

Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

There is renewed interest in lifestyle medicine - the focus on food, physical activity, stress management, high-quality connections, restorative sleep, and avoidance of toxic substances - in the prevention, treatment, and sometimes reversal of chronic disease, but very little information exists on its application for improving specific women's health issues across the lifespan. Consequently, there is a growing need among health professionals who care for women for a textbook that addresses evidence-based lifestyle solutions to manage the health challenges they face every day in their offices. This book begins with a review of the fundamentals of Lifestyle Medicine through the lens of a woman's lifespan. It provides information about lifestyle interventions to improve gynecologic and sexual health and to manage and sometimes reverse gynecologic diseases. It clarifies the importance of lifestyle and behaviors before and during pregnancy to address infertility, reduce adverse pregnancy outcomes, and to lower non-communicable diseases in children along with emerging epigenetic evidence. The use of Lifestyle Medicine to prevent and manage breast and gynecologic cancers, enhance health as part of cancer survivorship, and decrease the risk or reduce many of the symptoms and diseases experienced during menopause including vasomotor symptoms and osteoporosis are also discussed. Additionally, the text covers cardiovascular disease, diabetes, autoimmune disorders, dementia and mental health from the perspective of gender specific differences. This book provides practical resources on implementing the components of lifestyle medicine. Some of the topics covered include models of care for women and families, reimbursement, health coaching and behavioral change, community engagement and health equity for under-resourced settings. The electronic version of the book presents supplemental material featuring in-depth reading, as well as online and digital resources for implementing Lifestyle Medicine. The book is an evidence-based source of information on women's health issues for health professionals already practicing lifestyle medicine, as well as an entry level textbook for those new to the field of lifestyle medicine. The collective expertise of each of the editors along with content provided by leaders within the American College of Lifestyle Medicine fills a much-needed void within the specialty of Lifestyle Medicine and is for providers of women's health globally. Features: Provides a basic overview of Lifestyle Medicine (nutrient-rich diet, exercise, stress resilience, sleep, and high-quality connections) in the care of women across the lifespan. Provides lifestyle-focused treatment recommendations for specific women health issues. Includes strategies for implementing Lifestyle Medicine with vulnerable populations and in communities. Summarizes key points at the close of each chapter and includes supplemental material with in-depth reading. Features additional resources for implementing lifestyle medicine into practice. "This women's health book is evidence based and comprehensive. There is nothing like it. Women need up to date information about physical activity, nutrition, sleep, stress resilience, social connection and substance use. In addition, there is a desire to better understand the power of these pillars throughout a woman's life including pregnancy, menopause and the golden years. This book fills that need." Elizabeth Pegg Frates, MD, DipABLM, FACLM, President Elect of the American College of Lifestyle Medicine "Healthy aging begins at pre-conception. Evidence overwhelmingly shows that it's we women who-through our lifestyle behavior choices-can take far greater control of our own health destinies, as well as the health destinies of our children and generations to come. We cannot underestimate the power of what we eat, how we move, and what we think in regard to our optimal health or lack thereof. This book is a must-read for all medical professionals!" Susan Benigas, Executive Director of the American College of Lifestyle Medicine Lifestyle Medicine is the science of taking core principles and customizing how they're applied to each individual and each situation to achieve positive health behavior change. This book sets the evidence based foundation for how that process happens, and why it needs to happen, with the most important segment of health consumers - women. It is the next for all who are passionate about changing how health care is delivered." Wayne S. Dysinger, MD, MPH, Physician, Founder and Chair, Lifestyle Medical "Lifestyle factors have a powerful role in chronic disease prevention, underscoring the profound control we have over our health. Improving Women's Health Across the Lifespan applies lifestyle medicine to women's health, empowering women and their clinicians with the tools to transform their lives, and fostering a legacy of health for future generations." JoAnn E. Manson, MD, MPH, DrPH, Professor of Medicine and the Michael and Lee Bell Professor of Women's Health, Harvard Medical School Chief, Division of Preventive Medicine Brigham and Women's Hospital, Professor, Harvard Chan School of Public Health

This important new volume in the series Cambridge Reviews in Human Reproduction provides a wide-ranging and authoritative account of the uterus and its physiological role in fertility, normal pregnancy and delivery. Acknowledged authorities from around the world provide a detailed and timely account of uterine physiology. The volume encompasses a wealth of material including cell and developmental biology, structure, function, anatomy and endocrinology, and then goes on to cover clinically important issues such as the cervix during pregnancy, measurement of uterine contractions and initiation of labour. It will prove of particular value to those involved in the management of women with pre-term labour, as well as those concerned with the development of new procedures for the prevention or amelioration of this condition.

A complete guide to the side-effects and treatments - both conventional and alternative - for endometriosis, from a respected name in the field who also suffers from endometriosis.

Endometriosis is a debilitating reproductive and immunological disease that affects 7-10 million American women each year. The disease occurs when the same kind of tissue that lines the walls of the uterus grows outside the uterus in the pelvic cavity or some other area of the body, usually significantly affecting the woman's fertility and often causing pelvic pain. And as with any condition that affects fertility, the results are often emotional and psychological as well as physical.

As someone who suffers from endometriosis, and who has connections to a wide network of healthcare professionals, Morris is the perfect person to guide sufferers through diagnosis, treatment and living well with the condition. Like the previous titles in our successful Living Well series, this book will offer a holistic approach to living with the disease. The author will offer strategies for coping with the psychological aspects of endometriosis, including how best to tell others about the condition; treatment options including alternative and complementary treatment plans; dealing with infertility; and weighing the hysterectomy option. The author will draw on her relationship with fellow sufferers as well as medical professionals to help readers, making this the most comprehensive guide to endometriosis available.

Kerry-Ann Morris was diagnosed with endometriosis in 1999. Since then she has become one of the most active members of the endometriosis community, and has started an outreach website for the disease.She has relationships with many fellow sufferers and experts in the medical community, making her the perfect author for a book on holistic treatment.

This concise 1993 volume proposes a standardized approach to the investigation of infertility. The volume provides clear guidelines and a logical sequence of steps which will quickly lead the clinician or physician to an accurate diagnosis of the underlying cause of infertility. This standardized approach to the management of infertility will lead to more efficient, systematic and economic care for the infertile couple. The diagnostic charts, which may be photocopied, provide an unambiguous route to diagnosis of the underlying cause of infertility, whilst the text fully explains and describes the essential clinical tests. The volume summarizes the results gained from the study of more than 10,000 infertile couples, who were investigated as part of the WHO's programme to counter the widespread personal distress caused by infertility. It is hoped that the standardized approach presented here will go some way towards countering this major problem.

Since the late nineteenth century, medicine has sought to foster the birth of healthy children by attending to the bodies of pregnant women, through what we have come to call prenatal care. Women, and not their unborn children, were the initial focus of that medical attention, but prenatal diagnosis in its present form, which couples scrutiny of the fetus with the option to terminate pregnancy, came into being in the early 1970s. Tangled Diagnoses examines the multiple consequences of the widespread diffusion of this medical innovation. Prenatal testing, Ilana Löwy argues, has become mainly a risk-management technology—the goal of which is to prevent inborn impairments, ideally through the development of efficient therapies but in practice mainly through the prevention of the birth of children with such impairments. Using scholarship, interviews, and direct observation in France and Brazil of two groups of professionals who play an especially important role in the production of knowledge about fetal development—fetopathologists and clinical geneticists—to expose the real-life dilemmas prenatal testing creates, this book will be of interest to anyone concerned with the sociopolitical conditions of biomedical innovation, the politics of women’s bodies, disability, and the ethics of modern medicine.

Male infertility is a clinician-orientied book aimed at the clinician dealing with the infertile couple because rational, effective management is only possible if the couple are considered together. The aim of the work is to provide advice to the clinician and to give reference to the underlying science. This will not only enable clinicians to understand the underlying science but will also give scientists an insight to clinical work. This blend of science and clinical work is reflected in the contributors who are experts drawn from both fields.

Many health problems are unique to, more common in, or more severe in women than men. This book examines the underpinnings of these gender differences. Sections deal with biological (hormonal, anatomic, immunologic, and pregnancy-related), social, behavioural/psychological, and lifestyle influences. Chapters are heavily referenced, packed full with data, and they provide methodological insights that will guide future women's health research.

Fully revised for this fourth edition, the Oxford Handbook of Obstetrics and Gynaecology fully reflects new developments in the field. Featuring new sections on the outcomes of the MBRRACE report, abnormally adherent and invasive placenta, pregnancies in mothers of advanced age, assisted reproduction, and ovarian cancer screening, it provides a contemporary overview of this complex and important specialty. Written and reviewed by a team of highly experienced clinicians, academics, and trainees, this Handbook is a perfect starting point for preparation for postgraduate exams. Practical advice is presented with key evidence-based guidelines, supported by visual algorithms and top clinical tips. The previous edition was Highly Commended in the Obstetrics and Gynaecology category of the BMA Book Awards. The indispensable, concise, and practical guide to all aspects of obstetric and gynaecological medical care, diagnosis, and management, this fourth edition continues to be the must-have resource for all specialist trainees, junior doctors, and students, as well as a valuable aide memoire for experienced clinicians.

Essential Reproduction provides an accessible account of the fundamentals of reproduction within the context of cutting-edge knowledge and examples of its application. The eighth edition of this internationally best-selling title provides a multidisciplinary approach integrating anatomy, physiology, genetics, behaviour, biochemistry, molecular biology and clinical science, to give thorough coverage of the study of mammalian reproduction. Key features: Contains discussion of the latest on conceptual, informational and applied aspects of reproduction New pedagogical features such as clinical case studies at the end of each chapter Better use of boxed material to improve separation of narrative text from ancillary information Highlighted key words for ease of reference relate to summary of key points Introduction now split into two sections Expanded content in Fetal challenges, and Society and reproduction Substantial rearrangement and updating in Making sperm, Controlling fertility, and Restoring fertility

Fibrin sealant is used for numerous indications in gynecology, especially for the McIndoe Operation and Cohn biopsy, the Marshall-Marchetti-Krantz-Hirsch-Stoll-Operation, urethrocysopexy, or in vitro fertilization for embryo transfer. The use of fibrin sealant in urology has also been extended, especially in operations of the spermatic cord, reconstruction of the urethra and closing of nephrotomies.

Despite France and Belgium sharing and interacting constantly with similar culinary tastes, music and pop culture, access to Assisted Reproductive Technologies are strikingly different. Discrimination written into French law acutely contrasts with non-discriminatory access to ART in Belgium. The contributors of this volume are social scientists from France, Belgium, England and the United States, representing different disciplines: law, political science, philosophy, sociology and anthropology. Each author has attempted, through the prism of their specialties, to demonstrate and analyse how and why this striking difference in access to ART exists.

In Manufacturing Babies and Public Consent, Jose Van Dyck sketches a map of the public debate on new reproductive technologies as it has evolved in the USA and Britain since 1978. Many people have participated in heated discussions on test-tube babies and in vitro fertilization, particularly medical researchers and feminists. The new technologies have been both embraced as the cure to infertility and condemned as the exploitation of women's bodies. Reconstructing this debate, Van Dyck juxtaposes a variety of textual material, from scientific articles to newspaper articles and works of fiction.

This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors - both internationally respected anthropologists and new voices - demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals' and lay people's intimate encounters with policy. Authors look closely at core policy debates in the history of global maternal health across six different continents, including: Women's use of misoprostol for abortion in Burkina Faso The place of traditional birth attendants in global maternal health Donor-driven maternal health programs in Tanzania Efforts to integrate qualitative evidence in WHO maternal and child health policy-making Anthropologies of Global Maternal and Reproductive Health will engage readers interested in critical conversations about global health policy today. The broad range of foci makes it a valuable resource for teaching in medical anthropology, anthropology of reproduction, and interdisciplinary global health programs. The book will also find readership amongst critical public health scholars, health policy and systems researchers, and global public health practitioners.

1. 1 Historical Perspective In the nineteenth century, knowledge of the events leading to ovulation, fertilization, and implantation was very limited, so much so that Seiler (1832), in his book The Uterus and the Human Egg, wrote: ." . . in the left ovary the first signs of fertilization, namely a Graaf vesicle could be seen. The right ovary shows proof of a second successful copulation: a fresh scar from the ovulated egg and the beginning of a corpus luteum. " In fact all nineteenth century authors strictly divide the female cycle into two phases: the menstrual period and the intermenstruum (ct. Hitschmann and Adler 1908). The generally accepted histology of the endometrium in those days was that of the late proliferative phase. Deviations from this were considered to be pathological (Von Ebner 1902). As Gebhard (1899) expressly put it: "As a rule, it can be said that in the mature woman the endometrial glands run straight; an irregular course of the glands is to be regarded as pathological. " The same author describes the changes occurring during the secretory phase of the cycle as "endometritis glandularis" which he believed to arise from a local nutritional disturbance. The uterine stroma was believed to be lymphoid (Toldt 1877), and the uterine glands were compared to the crypts of Lieberkiihn (Von Ebner 1902).

In the mid-1990s, the international community pronounced prenatal sex selection via abortion an "act of violence against women" and "unethical." At the same time, new developments in reproductive technology in the United States led to a method of sex selection before conception; its US inventor marketed the practice as "family balancing" and defended it with the rhetoric of freedom of choice. In Gender before Birth, Rajani Bhatia takes on the double standard of how similar practices in the West and non-West are divergently named and framed. Bhatia's extensive fieldwork includes interviews with clinicians, scientists, biomedical service providers, and feminist activists, and her resulting analysis extends both feminist theory on reproduction and feminist science and technology studies. She argues that we are at the beginning of a changing transnational terrain that presents new challenges to theorized inequality in reproduction, demonstrating how the technosciences often get embroiled in colonial gender and racial politics.

Endorphins and other endogenous opioids appear to be the connecting link between reproductive functions and stress adaption of the human organism. This book contains the con- tributions of an international group of biologists, bioche- mists, and endocrinologists on the opioidergic control me- chanisms in reproduction and stress physiology. Main topics covered are: endogeneous opioids and the pituitary-gonadal system; ovarian endorphinsecretion; pregnancy-associated changes of plasma endorphin; and opioid control of the hypo- thalamo-pituitary-adrenal axis. Although all chapters give an excellent review on various studies in basic opioid re- search, there are numerous clinical implications mentioned in this book.

In the USA, severe psychiatric illness after childbirth strikes one woman for every 1000 births, or about 3500 women each year. An unrecorded number of new mothers experience lesser degrees of postpartum illness, and two distinct forms of severe illness can be distinguished. One form, called postpartum psychosis, is an agitated, very changeable condition, often characterized by confusion, hallucinations, delusions and sometimes episodes of violent behaviour. The other condition, major postpartum depression, begins two or three weeks after childbirth, and is characterized by confusion, depression of mood, and often with exhaustion, headache and digestive upset. Mixtures of the two severe disorders occur frequently. This volume contains a number of essays which support the position that postpartum disorders are primarily organic and are mainly disorders of hormonal deficit. They develop as the endocrine system falls back from the hyperactivity of pregnancy toward or beyond the levels of the prior non-pregnant state. Tremendous therapeutic opportunities exist or are imminent for both the organic and the psychological components of postpartum mental illness.