Protecting the reproductive potential of young patients undergoing cancer therapy is increasingly important. With modern treatment protocols, 80% of patients can be expected to survive. It has been estimated that up to one in 250 young adults will be a survivor of childhood cancer in the future; infertility, however, may be a consequence. As a wide range of fertility preservation methods are increasingly offered by clinicians, this systematic and comprehensive textbook dealing with the cryobiology, technology and clinical approach to this therapy will be essential reading to infertility specialists, embryologists, oncologists, cryobiologists, ObGyns, andrologists, and urologists with an interest in fertility preservation. Fertility Cryopreservation reviews all the techniques of this increasingly important field within reproductive medicine. It covers the basic principles of pertinent cryobiology, and contains major sections on the different therapies available, written by international specialists combining experience from both academic centers and commercial industries.

Now in a completely revised and expanded fourth edition, including two new chapters, this user-friendly textbook offers a succinct overview of both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities. Included here are updated chapters on major reproductive endocrinology and infertility issues, such as polycystic ovary syndrome (PCOS), pubertal disorders, amenorrhea, menopause, management of endometriosis and fibroids (including interventional radiology), laboratory and clinical aspects of assisted reproductive technologies (ART), imaging modalities such as ultrasonography and sonohysterography, hysteroscopic and laparoscopic techniques, an expansion of female infertility and fertility, preimplantation diagnosis and screening, osteoporosis, and contraception and sterilization. Chapters new to this edition discuss third-party reproduction and uterine transplantation. In addition, chapters opens with a list of bulleted key points and end with multiple choice review questions, and most include vibrant clinical case material to illustrate important concepts. Residents, fellows, and new clinicians in obstetrics and gynecology interested in reproductive endocrinology and infertility will find this fourth edition of Clinical Reproductive Medicine and Surgery: A Practical Guide a valuable and focused reference.

The late 20th century has witnessed dramatic technological developments in biomedical science and the delivery of health care, and these developments have brought with them important social changes. All too often ethical analysis has lagged behind these changes. The purpose of this series is to provide lively, up-to-date, and authoritative studies for the increasingly large and diverse readership concerned with issues in biomedical ethics - not just healthcare trainees and professionals, but also social scientists, philosophers, lawyers, social workers, and legislators. This volume brings together work by an international group of contributors from various fields and perspectives, on ethical, social, and legal issues raised by recent advances in reproductive technology. These advances have put us in a position to choose what kinds of children and parents there should be; the aim of the essays is to illuminate how we should deal with these possibilities for choice. Topics discussed include gender and race selection, genetic engineering, fertility treatment, ovarian tissue transfer, and post-menopausal pregnancy. The central focus of the volume is the interface between reproductive c

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

This text will provide doctors both in training and in practice with useful advice on managing women and men who are having trouble conceiving and couples with infertility and related disorders. Its combination of scientific information and practical advice for tackling problematic cases make this an accessible handy reference in outpatient clinics or in revision for professional exams, as well as a fully referenced information resource. Contents: Glossary of terms * Problems with puberty and its onset * Understanding infertility * Investigations in infertility * Influencing the sperm count * Helping women to ovulate * Damage to the uterus, the fallopian tubes and the ovaries * What to do if nothing wrong can be found and how to answer when a couple asks 'what can we do to improve our fertility?' *Assisted conception * Preserving fertility * Global perspectives on reproductive medicine * Reproductive biology in one other great ape (the gorilla) * Research questions still unanswered - And further reading

This volume comprehensively focuses on polycystic ovary, metabolic syndrome and obesity and their impact on women's health, reproduction and quality of life from adolescence to old age. PCOS is analyzed form the early origins - highlighting the importance of diagnosis, management and treatment starting from the high-risk period of adolescence - throughout infertility PCOS-related issues, pregnancy and menopause transition. All aspects of this syndrome are covered also in relation with endocrine and metabolic features that affects women's health. This book is a very useful tool for gynecologists, endocrinologists, obstetricians, reproductive medicine and general practitioners and is an important resource for all physicians involved in women's health.

This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.

God of Sperm tells the remarkable story of Dr. Cappy Miles Rothman, the son of notorious gangster Norman "Roughhouse" Rothman, who went on to become a trailblazer in the field of reproductive medicine. Rothman started the California Cryobank, one of the world's largest repositories of reproductive genetic material and cord-blood stem cells. Among other achievements, Rothman also pioneered the use of microsurgery in urological procedures, postmortem sperm retrieval techniques, and was one of the first practitioners of andrology, a specialty dealing with male reproductive biology and medicine. How Cappy Rothman went from Mafia scion and man-about-town during the postwar Miami Beach--Havana era of gangster chic to one of the most consequential figures in modern medicine is an epic, only-in-America tale that is also a fine reminder of the broad horizons and wild possibilities life in the U.S. can offer.

Obstetrics can be a particularly daunting prospect for those starting out. This book is designed for those SHOs, trainee obstetricians, trainee GPs, and medical students doing their obstetrics rotations, who find that they need a small, practical guide to dealing with the many and varied problems they will face. The chapters are arranged chronologically, starting with early pregnancy. Following chapters chart the course of the pregnancy and labour right the way through to the post-natal visit. Throughout the book, Dr Neuberg stresses the importance of the Confidential Enquiries into Maternal Deaths and emphasizes the intensive nature of much of the specialty, the potential for sudden problems, and the constant need for vigilance. The text is supplemented by many simple line drawings to aid clarification and numerous check lists to reinforce important points. A final section has been written specifically to help candidates for the DRCOG. Obstetrics is the ideal book for everybody coming to the field. Its chronological structure means that finding information is quick and easy, the check-lists aid recall, and the text focuses on those aspects of the specialty that the physician on the ward needs in everyday practice. It is not an `exam-crammer' but a well-written and concise guidebook to obstetrics and as such it will find a place in the library of every health worker who works with pregnant women.

There are many haematological complications associated with obstetrics, pregnancy and gynaecology, and unfortunately, they often lead to significant morbidity or mortality for both mother and child. As the first comprehensive reference on all aspects of haematological complications of obstetrics, pregnancy and gynaecology this book will be a valuable resource to haematologists, obstetricians, gynaecologists, reproductive medicine specialists, internists, anaesthesiologists and others. The chapters are written by acknowledged experts in the field, and for each condition covered the etiology, pathophysiology, clinical and laboratory diagnosis and management are discussed where appropriate.

These proceedings of the 2018 XIII International Symposium on Spermatology focus on comparative biology, and encourages discussion and the exchange of ideas. The aim of this Symposium was to provide a unique opportunity and bring together scientists from a wide spectrum of research fields - human, domestic animals and other mammals, vertebrates, insects, and plants. The underlying focus is on the function of the spermatozoon - a common feature for sexual reproduction, but extremely varied. By exploring the variability, a better understanding of male reproductive functions can develop. These proceedings address the mechanisms of physiology and pathophysiology, rather than diagnosis and treatment. The symposium featured keynote lectures by invited speakers, followed by presentations on specific aspects of the general topic of the session. Experimental studies are given priority over clinical studies of patient populations. The proceedings comprise both keynote speakers' texts and selected free communications. Posters were considered for publication in the proceedings, and the volume includes exhibited materials on the work of prominent spermatologists, highlighting their important past achievements in the field.

This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer. Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.

The ideal of equality constitutes a criterion for assessing current practice through attention to differences among individuals and groups. Inequality occurs when irrelevant differences are invoked in order to secure power or advantages over others. This book examines health care issues from an egalitarian perspective, focusing particularly on those that affect the lives of women and children. These are some of the most hotly debated, controversial, yet genuinely humanitarian issues of our time. They include gender stereotypes in medicine and in adolescent socialization, fertility curtailment and enhancement, coercive treatment during pregnancy, fetal tissue transplantation, decisions regarding newborns, decision-making by minors, the feminization of poverty and its impact on women's and children's health, and the meaning and role of "family" in health care decisions. The book describes a case-based or "feminine" model of reasoning as appropriate to the health care setting, but also as a possible rationale for exploitation of women. Different versions of feminism are clearly explained and specifically related to care-based reasoning. To overcome the pitfalls of paternalism and excessive stress on patient autonomy, a concept of "parentalism" is defended. An egalitarian perspective, the author claims, involves use of one's power to empower others. Because of the timeliness of the topics discussed, and the depth of detail, this book will be necessary reading for all bioethicists, health-care analysts and policy-makers, and women's studies researchers.

Cambridge Pocket Clinician Neonatology covers a wide variety of topics related to neonatal medicine, as well as clinical questions on maternal and neonatal conditions, symptoms, and procedures that will challenge providers in both the outpatient and inpatient settings. The topics are organized under headings on different diagnoses, evaluation, treatment, complications, and prognosis so that the user will find the desired information quickly and easily. More than 200 diseases and conditions are discussed in detail. Editors Richard A. Polin, M.D. John M. Lorenz, M.D. An electrionic version of this book can be purchased at http: //www.

Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in aetiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal. This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.

This book covers current controversies in women's health care. It takes a broad interdisciplinary approach to the subject. With topics ranging from the controversies in breast and cervical cancer screening, through osteoporosis and the menopause, to the relationships of older women with their doctors, it provides a well-rounded view of health care for older women. Each chapter has been written by an authority in that field and includes issues of current debate. The book is suitable both for students new to the area and for specialists wishing to read about the work of others in related fields, as well as being a useful source of information for general practitioners about the provision of women's health care from a primary care perspective.

This is a practical guide to the optimal clinical management of preterm labour, using the best available evidence. Preterm labour remains a challenge today, even with the latest developments summarised here. The editors and authors (mostly practising clinicians) are all actively involved in research into the mechanisms, aetiology, treatment and associated outcomes of preterm labour. The chapters are based on common clinical scenarios and each provides a comprehensive literature review followed by evidence-based recommendations on appropriate management. A summary of the pathophysiology of parturition is provided, and the obstetric scenarios cover management of threatened preterm labour, management of preterm premature ruptured membranes and management of preterm labour with specific complications (such as intrauterine growth restriction). Other chapters include the epidemiology, the prediction and the prevention of preterm labour. Anaesthetic and paediatric issues are explored in depth, and there are chapters on legal and organisational issues around preterm labour.

This book brings together the most up-to-date information about the physiology of progestogens. Addressing the bidirectional communication between hormones, fertility, tumors, and autoimmunity, it provides the basic science and clinical perspectives of progestogens which have not been previously available in one volume. In addition to estrogens, androgens, mineralocorticoids and glucocorticoids, progestogens are a major class of steroid hormone. While present in certain phases of estrous and menstrual cycles, progestogens are named for their function in maintaining pregnancy. This book is essentially practical in orientation, addressing the specific issues that confront the practitioner, and provides information to Obstetricians, Gynecologists, Reproductive endocrinologists, as well as Gynecological Oncologists and Rheumatologists. Contributions are from an international team of experts in the field, now completely updated in this new edition with new developments in primary dysmenorrhea and contraception.

This volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life. It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.

In addition to covering clinical topics and surgical procedures, this essential textbook provides detailed commentary on the contemporary social, psychological and economic issues that affect women's health. Acknowledged authorities in respective research fields have contributed specific sections to address the topics of women's mental health, genetics, prescribing for women, health promotion, hormones throughout the life cycle, psychological and behavioral issues.

This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technicians in the field of andrology as well as practitioners and clinicians in andrology, urology, pathology, IVF and other ART programs

This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.

This unique source of reference provides a comprehensive guide to the adverse side-effects of many commonly prescribed drugs on fertility and sexual health. More than 150 drugs are listed in this compilation, and the evidence linking them with infertility and sexual dysfunction is carefully reviewed. The volume is designed to provide a rapid source of reference to alert doctors and pharmacists to these hazardous side-effects. The volume also includes an introductory account of the reproductive process and a review of the mechanisms by which these drugs can interfere or inhibit reproduction. Another important theme of the volume is the effect of social and recreational drugs and environmental agents on reproductive health.

Essential Reproduction provides an accessible account of the fundamentals of reproduction within the context of cutting-edge knowledge and examples of its application. The eighth edition of this internationally best-selling title provides a multidisciplinary approach integrating anatomy, physiology, genetics, behaviour, biochemistry, molecular biology and clinical science, to give thorough coverage of the study of mammalian reproduction. Key features: Contains discussion of the latest on conceptual, informational and applied aspects of reproduction New pedagogical features such as clinical case studies at the end of each chapter Better use of boxed material to improve separation of narrative text from ancillary information Highlighted key words for ease of reference relate to summary of key points Introduction now split into two sections Expanded content in Fetal challenges, and Society and reproduction Substantial rearrangement and updating in Making sperm, Controlling fertility, and Restoring fertility

Welcomed as liberation and dismissed as exploitation, egg freezing (oocyte cryopreservation) has rapidly become one of the most widely-discussed and influential new reproductive technologies of this century. In Freezing Fertility, Lucy van de Wiel takes us inside the world of fertility preservation—with its egg freezing parties, contested age limits, proactive anticipations and equity investments—and shows how the popularization of egg freezing has profound consequences for the way in which female fertility and reproductive aging are understood, commercialized and politicized. Beyond an individual reproductive choice for people who may want to have children later in life, Freezing Fertility explores how the rise of egg freezing also reveals broader cultural, political and economic negotiations about reproductive politics, gender inequities, age normativities and the financialization of healthcare. Van de Wiel investigates these issues by analyzing a wide range of sources—varying from sparkly online platforms to heart-breaking court cases and intimate autobiographical accounts—that are emblematic of each stage of the egg freezing procedure. By following the egg’s journey, Freezing Fertility examines how contemporary egg freezing practices both reflect broader social, regulatory and economic power asymmetries and repoliticize fertility and aging in ways that affect the public at large. In doing so, the book explores how the possibility of egg freezing shifts our relation to the beginning and end of life.