This new edition of an acclaimed text reviews the evidence for best practice in Maternal-Fetal Medicine, to present the reader with the right information, with appropriate use of proven interventions and avoidance of ineffectual or harmful ones. The information is presented in the right format by summarizing evidence succinctly and clearly in tables and algorithms. The aim is to inform the clinician, to reduce errors and "to make it easy to do it right." The volume can be purchased separately or together with the companion volume on Obstetric Evidence Based Guidelines (set ISBN 9780367567033). The Series in Maternal-Fetal Medicine is published in conjunction with the Journal of Maternal-Fetal and Neonatal Medicine. From reviews of previous editions: An excellent resource with quick and easy protocols... this book has a permanent spot on my shelf. -Doody's Review Service

"Studies on Men s Health and Fertility "provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view.

"Studies on Men s Health and Fertility "is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, "Studies on Men s Health and Fertility "will be seen as a clear and important milestone. "

In the last 15 years, fertility treatment has become mainstream medical practice. With this evolution has come a change in focus from effectiveness ('success rates') to safety, patient acceptability and ethical questions. It is recognized that effectiveness also depends crucially on safety and good risk management. The purpose of this book is to address this wider change in focus. Reducing Risk in Fertility Treatment examines risk in assisted conception, covering a wide range of topics and areas. 'Risk' refers to situations in which an outcome of value to people is uncertain. Specifically for the purpose of this book, 'Risk' means situations where patients or professionals or society as a whole is at risk of an adverse outcome in relation to fertility treatment. It therefore encompasses clinical complications, risks inherent in laboratory practice, reputational and business risks to clinics and ethical risks to society as a whole. It will be an essential resource for all clinic staff to consult in reducing the risk associated with their work. It will provide practical resources such as 'how to' guides, but also a theoretical discussion of uncertainty where this exists. The book is primarily directed to practitioners in the area of fertility treatment, namely clinicians, embryologists, nurses, counsellors and administrators. However, it is likely also to be relevant to policy-makers, commissioners of health services, researchers in this field and biomedical ethicists.

There are several possible solutions to the different problems presented with female patients who have been unable to conceive. This completely revised edition provides guidance on the technical aspects of diagnosis and explanations of treatment using a how to, when and why approach, incorporating new expanded sections on endometriosis and polycystic ovary syndrome. Illustrated throughout with tables and graphs as a source for easy reference for guidance and counselling in clinical decision making, it will be essential reading for all those working in the clinical practice setting within infertility, providing all the necessary information required for developing sound clinical judgement in the diagnosis and surgical management of structural abnormalities of the reproductive tract.

Erectile dysfunction is a common problem that may result from a number of medical conditions. With increasing public awareness, men with ED are seeking medical help. This pocketbook will assist the physician in treating and managing ED effectively with either drugs or devices.

Reproductive biologists, evolutionary biologists, demographers and social scientists all have a common interest in the business of human reproduction. Their perspectives, however, are very different and have traditionally prevented them from having much to do with each other. The conference on which this book is based brought together contributors from each of these disciplines in an attempt to explore the common ground that they share and so generate a better understanding of the factors that influence human fertility.

Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility provides cutting-edge information and solutions to help support the worldwide rise of fertility challenges. It addresses common, yet not commonly known, root-causes of oxidative stress that are at the heart of reproductive issues (and all chronic health issues). These solutions can help enhance the outcomes of Assisted Reproductive Technologies (ART) or support women to avoid them altogether. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility will show you how to improve cell health (including egg and sperm), lower inflammation, balance nervous system functioning, and optimize genetic expression, allowing the body to return to its naturally fertile state. It details information on numerous root causes of health-derailing inflammation and oxidative stress, while the appendices discuss the genetic and biochemical pathways related to these topics. Each chapter also provides easy "Action Steps" that can be implemented immediately. Chapter topics include iron dysregulation; oxalates; mold/mycotoxins; phase 2 liver detoxification pathways; fat utilization; introductory information on genetics, epigenetics, and nutrigenomics; everything one needs to know about histamine intolerance; and how these factors adversely affect metabolic and reproductive functions. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility is the handbook for people wanting to achieve and sustain a healthy pregnancy. It highlights lesser-known causes of fertility challenges the reader can learn how to investigate. This book also serves as a reference guide for practitioners, providing them with additional tools to add to their repertoires when other protocols have not been effective. It may also provide clarity as to why other protocols did not work, and will enable the practitioner to custom-tailor protocols for each patient.

Documenting the latest statistical data on current problems related to reproductive health issues in Central and Eastern Europe, this book explores the reasons for these problems and recommends action based on the scientific evidence for improving reproductive health.

The main issues covered in the book are: declining standards of reproductive health care; rising trends in the incidence of sexually transmitted diseases; low rates of use of modern contraceptives; high rates of induced abortion; high prevalence of infertility; and the needs of adolescents with regard to reproductive health.

Human papillomavirus (HPV) is a major cause of cervical cancer. Human Papillomavirus Infections in Dermatovenereology pulls together the diverse disciplines of clinical, molecular biological, socio epidemiological, and immunological research to bridge the gap between the clinical aspects and basic biology of HPV. This volume provides a much-needed overview of the scientific and clinical data of HPV and HPV-associated diseases, exploring opinions on current therapies and diagnostic methods. It critically reviews the most frequently used molecular biologic methods, evaluating their potential in HPV detection. Specialists in dermatology, genitourinary medicine, gynecology, urology, as well as pathologists, microbiologists, epidemiologists, and virologists will appreciate this timely examination of the ubiquitous pathogen, HPV.

Doctors increasingly recognize that sexual unhappiness has serious effects on the health of individuals and families. Sexual function depends on our bodies and our minds and sexual problems may present with physical symptoms. Using case histories the book describes the practice of psychosexual medicine and explores the skills used by doctors therapists and counsellors. A systematic and comprehensive examination of this field for the first time this book places psychosexual medicine in context with other therapies. For those working at all levels throughout primary care including doctors and nurses in general practice and in family planning clinics therapists and counsellors and for specialists in the fields of genito-urinary medicine gynaecology andrology and urology Blocks and Freedoms in Sexual Life is an essential reference and a tool for increasing the scope and effectiveness of their work.

The Cassell Hospital Monograph Series, No. 1. The first in a series of monographs, intended to present accessible teaching material concerned with the practice of residential care.

With technological advances in reproduction no longer confined to the laboratory or involving only the isolated individual, women and men are increasingly resorting to a variety of technologies unheard of a few decades ago to assist them in becoming parents. The public at large, and feminists as a group, are confused and divided over how to view these technologies and over what positions to take on the moral and legal dilemmas. The Other Machine provides a rigorous analysis of contemporary feminist debates.

The numbers of women undergoing Assisted Reproduction Technology (ART) treatments have risen steadily, yet they remain largely outside the scope of equality and employment law protection while undergoing treatment. Assisted Reproduction, Discrimination, and the Law examines this gap in UK law, with reference to EU law as appropriate, and argues that new conceptions of equality are necessary. Drawing from the literature on multidimensional and intersectional discrimination, it is argued that an intersectionality approach offers a more useful analytical framework to extend protection to those engaged in ART treatments. Drawing from Schiek's intersectional nodes model, the book critically examines two alternative interpretations of existing protected characteristics, namely infertility as a disability, with reference to the social model of disability and the UN Convention on the Rights of Persons with Disabilities 2006, and redefining the boundaries of pregnancy and/or sex discrimination, with reference to attempts to extend associative discrimination to pregnancy. Comparisons are drawn with the US, where infertility has been recognised as a disability under the American's with Disabilities Act 1990 and as a pregnancy-related condition under the Pregnancy Discrimination Act 1978. A specific right to paid time off work to undergo treatment is also proposed, drawing comparisons with the US Family and Medical Leave Act 1993 and the existing UK work-family rights framework. It is argued that the reinterpretations of equality law and the rights proposed here are not only conceptually possible, but could practically be achieved with minor, but significant, amendments to existing legislation.

In 2015, a study of surrogacy and other reproductive technologies was conducted among women who served as surrogate mothers in Chennai, Tamil Nadu, India. There are some social taboos are associated with the concept of surrogacy, and it is not a mainstream procedure in India. To know the ground reality, thirty-three surrogates were interviewed to explore their concerns. The primary objective of this book is to explore the causes and consequences of being a surrogate, the motivation and negotiation factors, and the social, economic, and gender issues encountered during and after procreation. This book further explored the perception of various stakeholders on new draft bill was introduced to ban commercial surrogacy in order to safeguard the women from exploitation. This book argues that if the government regularizes and legalizes commercial surrogacy, it may create a win-win situation for both sides - surrogates and the commissioning couples - to avoid exploitation

'Amy's book is everything I should have learned at school. It is a reminder to empower ourselves, in a world that still sadly lacks so much knowledge around women's health, by getting to know our own bodies more intimately - with the help of technology built by women' Emma Gannon 'Moody is a fascinating and friendly guide for you to understand you better.' Melissa Hemsley 'Knowledge is power and this book equips you with the power to unlock potential and happiness.' Poppy Jamie, author of Happy Not Perfect There is a secret inside you which, once you understand it fully, has the capacity to unlock untold potential. Once you learn the science of your hormones, you will be able to harness it forever. Hormones were something Amy Thomson, founder and CEO of leading women's health app and tech service Moody, never paid attention to, until one day her periods stopped and what had been an inconvenience each month became a barometer for her body's health and mental happiness. When she discovered that her hormonal burnout was driven by stress, she quit her job and focused on trying to understand how her body worked, to establish why and how she had pushed herself too far. In this guide, Amy shares the research and science behind how our hormones work for twenty-first-century survival, how understanding them can help you build better and healthier routines, and why the systems and cycles inside us are an invisible but powerful force. With insights from nutritionists, gynaecologists, endocrinologists, personal trainers and others, Moody provides a holistic and practical blueprint for understanding your hormones and optimising your life around them. Praise for Moody 'As a woman, medical doctor and scientist I found Moody hugely illuminating' Dr Tara Swart

Providing a comprehensive review of the interactions between exercise and human reproduction, this unique text focuses on both the positive and negative consequences of sport and physical activity on male and female fertility and infertility and the biological mechanisms and processes behind them. Beginning with a review of the structure and function of the male and female reproductive systems as well as fertilization and gestation, the discussion then turns to the physiology and endocrinology of sport and exercise, which is further elaborated in subsequent chapters on the impact of physical activity, hormonal changes, pathologies, and consequences of drug use for active men and women. Additional chapters address related topics, such as the impact of sport on young athletes and developing reproductive potential, physical activity and pregnancy, the use of oral contraceptives in athletes, oxidative stress, and the impact of nutritional deficiencies on athletes' fertility, with a final chapter providing recommendations and therapeutic guidelines for exercise-related reproductive disorders. Covering everything from the fundamental principles of sports physiology and human reproductive potential to the interaction between physical exercise and the endocrinology of the reproductive system, Exercise and Human Reproduction is an authoritative resource for helping clinicians understand how the reproductive system adapts to activity and exercise and offers strategies to avoid potential harm to human reproduction.

Reproductive health care professionals in fields such as Obstetrics and Gynecology, Family Medicine, and Pediatrics face difficult ethical issues because they work at the crossroads of patient decision-making, scientific advancement, political controversy, legal regulation, and profound moral considerations. The dilemmas these professionals face expose big-picture bioethics questions of interest to everyone. Yet for clinicians striving to deliver excellent patient care, the ethical questions that make daily practice challenging can be just as nuanced. This volume presents a carefully curated compilation of essays written by leading experts in the fields of medicine, ethics, and law, who address key issues at the forefront of reproductive ethics. It is organized into three main sections: I. Contraception and Abortion Ethics - Preventing Pregnancy and Birth, II. Assisted Reproduction Ethics - Initiating Pregnancy, and III. Obstetric Ethics - Managing Pregnancy and Delivery. Each section begins with a short introduction by the editors providing an overview of the area and contextualizing the essays that follow. This volume's primary aim is to be useful to practicing clinicians, students, and trainees by providing short and practical essays covering urgent topics-from race, religion and abortion, to legal liability, violations of confidentiality and maternal choices that risk future children's health. This collection provides clinicians at all levels of training with frameworks they need to approach the intimate and high-stakes encounters central to their profession.

The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.

God of Sperm tells the remarkable story of Dr. Cappy Miles Rothman, the son of notorious gangster Norman "Roughhouse" Rothman, who went on to become a trailblazer in the field of reproductive medicine. Rothman started the California Cryobank, one of the world's largest repositories of reproductive genetic material and cord-blood stem cells. Among other achievements, Rothman also pioneered the use of microsurgery in urological procedures, postmortem sperm retrieval techniques, and was one of the first practitioners of andrology, a specialty dealing with male reproductive biology and medicine. How Cappy Rothman went from Mafia scion and man-about-town during the postwar Miami Beach--Havana era of gangster chic to one of the most consequential figures in modern medicine is an epic, only-in-America tale that is also a fine reminder of the broad horizons and wild possibilities life in the U.S. can offer.

A wide-ranging history of assisted reproductive technologies and their ethical implications. Finalist of the PROSE Award for Best Book in History of Science, Medicine and Technology by the Association of American Publishers Since the 1978 birth of the first IVF baby, Louise Brown, in England, more than eight million children have been born with the help of assisted reproductive technologies. From the start, they have stirred controversy and raised profound questions: Should there be limits to the lengths to which people can go to make their idea of family a reality? Who should pay for treatment? How can we ensure the ethical use of these technologies? And what can be done to address the racial and economic disparities in access to care that enable some to have children while others go without? In The Pursuit of Parenthood, historian Margaret Marsh and gynecologist Wanda Ronner seek to answer these challenging questions. Bringing their unique expertise in gender history and women's health to the subject, Marsh and Ronner examine the unprecedented means-liberating for some and deeply unsettling for others-by which families can now be created. Beginning with the early efforts to create embryos outside a woman's body and ending with such new developments as mitochondrial replacement techniques and uterus transplants, the authors assess the impact of contemporary reproductive technology in the United States. In this volume, we meet the scientists and physicians who have developed these technologies and the women and men who have used them. Along the way, the book dispels a number of fertility myths, offers policy recommendations that are intended to bring clarity and judgment to this complicated medical history, and reveals why the United States is still known as the "Wild West" of reproductive medicine.