Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.

God of Sperm tells the remarkable story of Dr. Cappy Miles Rothman, the son of notorious gangster Norman "Roughhouse" Rothman, who went on to become a trailblazer in the field of reproductive medicine. Rothman started the California Cryobank, one of the world's largest repositories of reproductive genetic material and cord-blood stem cells. Among other achievements, Rothman also pioneered the use of microsurgery in urological procedures, postmortem sperm retrieval techniques, and was one of the first practitioners of andrology, a specialty dealing with male reproductive biology and medicine. How Cappy Rothman went from Mafia scion and man-about-town during the postwar Miami Beach--Havana era of gangster chic to one of the most consequential figures in modern medicine is an epic, only-in-America tale that is also a fine reminder of the broad horizons and wild possibilities life in the U.S. can offer.

Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critical role of nutrients on human placental development and its' in utero programming effects on the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, hypertension, and obesity in later life. The book begins with discussions of the central process of placentation and its regulation on size and growth of the fetus. It also covers the effects of key macronutrients on placental growth, metabolism, transport, and secretory function. The text details important vitamins and few micronutrients and their roles in the feto-placental growth and development. It includes information on the influence of maternal lifestyle and environmental factors on regulation of the growth, metabolism and gene expression in the feto-placental unit. A review of the genes linked to the process of placentation rounds out the coverage. An examination of a broad range of evidence in the areas of placental growth, function, and its impact on feto-placental outcome, the book presents new knowledge on nutrition and its relevance with early human development. This includes not only the effects of maternal nutrients on possible neonatal growth and development but also their regulation by maternal lifestyle associated factors. A fine blending of epidemiology, clinical nutrition, perinatal and neonatal medicine, and biochemistry and molecular biology areas of research activities, the book helps you to understand the impact of maternal nutrition on placentation and its relevance with pregnancy outcome and fetal programming of adult health and disease.

"Framed around the MRCOG Part 1 syllabus, this revision guide brings together the fundamentals of the basic sciences required to pass the exam. Highly visual in order to best aid revision technique, the book focuses not only on preparing for the exam, but retaining facts beyond it. As well as a revision aid, the book acts as a refresher for facts and figures ensuring that they are readily available.Information is concise and presented through visually memorable tools, such as boxes and flow diagrams. References to Basic Science in Obstetrics and Gynaecology, which explains the principles and workings of basic sciences, are made throughout to aid revision"--Provided by publisher.

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

Mary Warnock steers a clear path through the web of complex issues underlying the use of new reproductive technologies. She begins by analysing what it means to claim something as a 'right', and goes on to discuss the cases of different groups of people. She also examines the ethical problems faced by particular types of assisted reproduction, including artificial insemination, in-vitro fertilization, and surrogacy, and argues that in the future human cloning may well be a viable and acceptable form of treatment for some types of infertility.

Millions of Americans rely on the likes of birth control, IVF, and genetic testing to make plans as intimate and farreaching as any over a lifetime. This is no less than the medicine of miracles. It fills empty cradles, frees families from terrible disease, and empowers them to fashion their lives on their own terms. But accidents happen. Pharmacists mix up pills. Lab techs misread tests. Obstetricians tell women their healthy fetuses would be stillborn. Political and economic forces conspire against regulation. And judges throw up their hands when professionals foist parenthood on people who didn't want it, or childlessness on those who did. Failed abortions, switched donors, and lost embryos may be first-world problems. But these aren't innocent lapses or harmless errors. They're wrongs in need of rights. This book lifts the curtain on reproductive negligence, gives voice to the lives it upends, and vindicates the interests that advances in medicine and technology bring to full expression. It charts the legal universe of errors that: (1) deprive pregnancy or parenthood of people who set out to pursue them; (2) impose pregnancy or parenthood on those who tried to avoid these roles; or (3) confound efforts to have a child with or without certain genetic traits. This novel architecture forces citizens and courts to rethink the reproductive controversies of our time, and equips us to meet the new challenges-from womb transplants to gene editing-that lie just over the horizon.

Disorders of menstruation are a major cause of morbidity in women. The treatment of such conditions presents an enormous clinical challenge, especially since some of the treatments used can themselves result in further menstrual and hormonal complications. Clinical Disorders of the Endometriumand Menstrual Cycle provides the first in-depth review of current knowledge of the pathophysiology, investigation, and treatment of menstruation disorders. The emphasis of the book is on the practical management of these common clinical conditions. Included are chapters outlining menstruation from a cultural and historical perspective, as well as from the woman's point of view. While being an important work for gynacologist and family practitioners, the book will also be of great interest to women's health groups.

This volume surveys the state of knowledge and research on the determinants of human reproduction. It adopts an inter-disciplinary approach and integrates information from demographic, epidemiological and biological studies of fertility. The chapters provide a comprehensive overview of reproductive processes, including puberty and menopause, conception and fetal loss, and the effects of sexually transmitted diseases and lactation. The volume also considers the effects on fertility of nutrition and stress, environmental and occupational hazards, and social behaviour, and includes clinical papers on fertility following contraceptive use and treatment of infertility. Findings from original research on the determinants of human reproduction are also presented.

Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.

With contributions from: Eric Blyth, Ken Daniels, Julia Feast, Robert Lee, Nina Martin, Alexina McWhinnie, Derek Morgan, Clare Murray, Sharon Pettle, Claire Potter, Jim Richards and Francoise Shenfield

The separation of procreation from conception has broadened notions of parenthood and created novel dilemmas. A woman may carry a foetus derived from gametes neither or only one of which came from her or her partner; or she may carry a foetus created using in vitro fertilisation (IVF) with the purpose of handing it to two other parents one, neither or both of whom may be genetically related to the prospective child. Parents may consist of single-sex couples, only one of them genetically related to the child; the prospective mother may be past her menopause; and genetic parenthood after death is now achievable. In a world increasingly reliant on medical science, how can the argument that equates traditional with natural and novel with unnatural/unethical be justified? Should there be legislation, which is notoriously slow to change, in a field driven by dazzling new possibilities at ever faster rate; particularly when restrictions differ from country to country, so that those who can afford it travel elsewhere for their treatment of choice? Whose rights are paramount - the adults hoping to build a family or the prospective child(ren)s future well being? On what basis can apparently competing rights be regulated or adjudicated and how and to what extent can these be enforced in practice?

In the 1960s thousands of poor women of color on the (post)colonial French island of Reunion had their pregnancies forcefully terminated by white doctors; the doctors operated under the pretext of performing benign surgeries, for which they sought government compensation. When the scandal broke in 1970, the doctors claimed to have been encouraged to perform these abortions by French politicians who sought to curtail reproduction on the island, even though abortion was illegal in France. In The Wombs of Women-first published in French and appearing here in English for the first time-Francoise Verges traces the long history of colonial state intervention in black women's wombs during the slave trade and postslavery imperialism as well as in current birth control politics. She examines the women's liberation movement in France in the 1960s and 1970s, showing that by choosing to ignore the history of the racialization of women's wombs, French feminists inevitably ended up defending the rights of white women at the expense of women of color. Ultimately, Verges demonstrates how the forced abortions on Reunion were manifestations of the legacies of the racialized violence of slavery and colonialism.

Jahrlich werden in Deutschland ca. 1.000 kunstliche Befruchtungen durchgefuhrt (sog. heterologe kunstliche Befruchtung). Insbesondere der Samenspender, aber auch alle anderen beteiligten Personen gehen dabei ein rechtliches Risiko ein - haufig ohne es zu wissen. Die Autorin entwickelt Moglichkeiten der zivilrechtlichen Haftungsfreistellung des Samenspenders und stellt ihre Alternative vor: die "rechtsfolgenlose Vaterschaftsfeststellungsklage." "

Helping the Stork The sourcebook for all the information parents-to-be need to know about the choices and challenges of donor insemination Each year donor insemination (DI) offers a pathway to parenthood for the hundreds of thousands who turn to family-building alternatives. Although DI is considered as often as adoption, couples facing male infertility, as well as single women and lesbian couples, have had few places to turn for information about this method, which has been shrouded in secrecy. In Helping the Stork, parents-to-be, as well as friends and family, doctors, and counselors, can explore the choices and challenges raised by this alternative to overcoming childlessness. This comprehensive handbook moves through each step of the process: reaching a solid decision about whether donor insemination is the best choice for a family's future; handling the difficult issue of privacy; selecting a donor and getting started; and learning to thrive as a family meeting DI's added challenges. Full of wisdom from medical and mental health experts, Helping the Stork is also enriched with stories from many families who share their insights and experiences. This book is a reassuring, supportive, and helpful guide that no one considering or going through the process of donor insemination should be without. Visit us online at http: //www.mcp.com/mgr

Cosa si prova a non poter avere un figlio? Quanto e difficile comunicare alla coppia una diagnosi di sterilita? Come affrontare il 70% dei fallimenti delle tecniche di PMA? Come una legge puo' incidere sul futuro di un embrione? Il testo, nato dalla fusione multidisciplinare medica, psicologica e sociologica, vuole riflettere su queste domande e accompagnare il lettore in una nuova forma mentis sulle criticita nella fecondazione assistita. La trama scientifica si accompagna a un linguaggio diretto dove hanno un posto rilevante le emozioni, cosi' centrali in campi quali la ginecologia, la riproduzione e la psicologia dell'infertilita, che vanno al cuore del bisogno psico-sessuale piu forte e arcaico: quello riproduttivo. Al centro del volume e la relazione medico-paziente che, nel campo dell'infertilita, e caratterizzata dall'attivazione di forti echi emotivi da parte di entrambi. Il volume, a tale riguardo, propone il protocollo SAHARAI che comprende due metodi inediti (il questionario e il nurse-ring) capaci di intervenire, rispettivamente, nella fase diagnostica e in quella terapeutica della fecondazione. I metodi e le riflessioni proposti sono volti alla riduzione dei disagi psicologici delle coppie e al riequilibrio del rapporto medico-paziente. Dal testo emerge forte una nuova idea di formazione per gli operatori dei centri di fecondazione assistita e un percorso di qualificazione per le nuove figure professionali (gli psicologi addetti alla PMA) in accordo con le nuove direttive della legge."

Reproductive technology is typically discussed in the future tense. Yet doctors have always treated involuntary childlessness. This book looks at the recent history of infertility and the different ways medicine has treated it. It traces the reluctance to allow infertility a past to a new tension that has emerged between utopian and anti-utopian fears about the growth rate and composition of population.

"The Stork and the Syringe" argues that although doctors' approach to infertility is formed in response to the exigencies of the political economy of medical practice, it also accommodates a persistent gender bias: the tendency to regard women's bodies as inviting intervention and men's as demanding caution. This bias is manifest in relation to gametes (eggs and sperm), sex hormones, in the form of medical investigations and treatment, and the frequency and enthusiasm with which the latter are carried out. Departures from this theme are rare and controversial, as the history of artificial insemination using donor semen demonstrates.

This book is a major contribution to the history and sociology of reproduction, fertility, population and medicine.

Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today's generation of stem cell researchers, including the field's potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.

'It is very hard to produce a timely book about a subject that changes as quickly as technologically assisted reproduction, but John Harris and Soren Holm have managed to do exactly that. The fourteen essays in this small volume provide an extremely useful and highly readable overview of the key moral, legal, and social themes raised by new ways of making babies. . . . The book is unique in that it offers perspectives on all these topics from a variety of disciplines and professions as well as from a broad range of national and cultural perspectives.' Arthur Caplan, British Medical Journal

Die moderne Reproduktionsmedizin wird oftmals als letzte Chance von Partnern ausgewahlt, um ihren starken, bisher unerfullten Wunsch nach einem eigenen Kind einzuloesen - ungeachtet dessen, dass sie oeffentlich sehr kontrovers diskutiert werden und haufig auf grosse Ablehnung stossen. Die Teilnahme an einer Reproduktionsbehandlung ist kostenintensiv: Zusatzlich zu den finanziellen Kosten der medizinischen Behandlung kommen noch weitere subjektive Kosten hinzu, so z.B. ein erheblicher Zeitaufwand wahrend der Fertilisierungstherapien oder aber auch das Ertragen koerperlicher und psychischer Belastungen. Die vorliegende Arbeit erforscht die Einstellung der Betroffenen zur Reproduktionsmedizin und was sie mit einem Kind verbinden. Daruber hinaus wird erforscht, wie die ungewollt kinderlosen Partner die koerperlichen, psychischen und finanziellen Belastungen erleben und bewerten.

Nowhere has the impact of ultrasonography been more dramatic than in reproductive medicine, particularly in the diagnosis of female and male infertility, the management of assisted reproductive procedures and the monitoring of early pregnancy. This authoritative textbook encompasses the complete role of ultrasonography in the evaluation of infertility and assisted reproduction. Covering every indication for ultrasonography in assisted reproductive technology, this will prove an invaluable resource in the evaluation of the infertile patient and optimization of the outcome of treatment. The interpretation of images to improve fertility and reproductive success is emphasized throughout. Ultrasonography in Reproductive Medicine and Infertility is essential reading for clinicians working both in IVF clinics and in office practice. It will be particularly useful to gynecologists, infertility specialists, ultrasonographers and radiologists working in reproductive endocrinology and infertility, assisted reproductive technology, ultrasonography and radiology.

Die medizinische Behandlung der ungewollten Kinderlosigkeit wird hierzulande nach wie vor mit einer Mischung aus Interesse am medizinisch-technischen Fortschritt und Sorge uber die mogli- cherweise nicht mehr kalkulierbaren Risiken dieses Fortschrittes betrachtet. Die Reaktionen reichen dabei von der implizi ten Gleichsetzung konkreter Formen der Reproduktionsmedizin mit den fiktiven Verhaltnissen in der 'Schonen Neuen welt'1, bis hin zu Einschatzungen, wonach sich die Reproduktionsmedizin in naher Zukunft als ein unverzichtbares Instrument bei der Bekampfung eines langandauernden Bevolkerungsruckganges in der BRD erweisen 2 werde. Auch wenn sich in den letzten 5-10 Jahren das Interesse der Offentlichkeit verstarkt den verschiedenen Formen der medizini- 3 schen Behandlung ungewollter Kinderlosigkeit zugewandt hat, so scheint mit diesem verstarkten Interesse kein Anstieg der Anzahl Der Vergleich des heutigen Potentials der Reproduk- tionsmedizin mit den Schilderungen der industriellen Erzeugung von Menschen in A. Huxleys Roman "Schone Neue Welt" gehort zu den Standardbildern in weiten Teilen der Literatur uber die medizinische Behandlung der ungewollten Kinderlosigkeit. So z.B. auch bei: Hirsch, G. und Eberbach W. (1987): Auf dem Weg zum kunstlichen Leben - Retortenkinder, Leihmutter, pro- grammierte Gene Basel, Boston, Stuttgart. S.31ff. 2 So ein Reproduktionsmediziner in der Fernsehsendung 'Explosiv' (RTL 22.5.'91). 3 Man denke z. B. nur an die Kontroversen im Zuge der Erarbeitung des Embryonenschutzgesetzes, an die Richt- linien zur Durchfuhrung der In-vitro-Fertilisation der Bundesarztekammer, an die Initiativen auf dem 56.