The capybara is the neotropical mammal with the highest potential for production and domestication. Amongst the favorable characteristics for domestication we can list its high prolificacy, rapid growth rate, a herbivorous diet, social behavior and relative tameness. The genus (with only two species) is found from the Panama Canal to the north of Argentina on the east of the Andes. Chile is the only country in South America where the capybara is not found. The species is eaten all over its range, especially by poor, rural and traditional communities engaged in subsistence hunting. On the other hand, in large urban settlements wildlife is consumed by city dwellers as a delicacy. The sustainable management of capybara in the wild has been adopted by some South American countries, while others have encouraged capybara rearing in captivity.

A COLLECTION OF ESSAYS PLACING THE HUMAN - WOLF RELATIONSHIP IN HISTORICAL PERSPECTIVE International in range and chronological in organisation, this volume aims to grasp the maincurrents of thought about interactions with the wolf in modern history. It focuses on perceptions, interactions and dependencies, and includes cultural and social analyses as well as biological aspects. Wolves have been feared and admired, hunted and cared for. At the same historical moment, different cultural and social groups have upheld widely diverging ideas about the wolf. Fundamental dichotomies in modern history, between nature and culture, wilderness and civilisation and danger and security, have been portrayed in terms of wolf - human relationships. The wolf has been part of aesthetic, economic, political, psychological and cultural reasoning albeit it is nowadays mainly addressed as an object of wildlife management. There has been a major shift in perception from dangerous predator to endangered species, but the big bad fairytale wolf remains a cultural icon.

This is the companion volume to Daniel Klionsky s "Autophagy: Lower Eukaryotes, " which features the basic methods in autophagy covering yeasts and alternative fungi (aspergillus, podospora, magnaporthe). Klionsky is one of the leading authorities in the field. He is the editor-in-chief of "Autophagy." The November 2007 issue of "Nature Reviews" highlighted his article, Autophagy: From phenomenology to molecular understanding in less than a decade. He is currently editing guidelines for the field, with 230 contributing authors, that will publish in "Autophagy."
Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal house cleaning in the cell is called autophagy - literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 (autophagy-related gene 1) in yeast. (To date, 30 additional yeast genes have been identified.) These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth."

Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminaeof Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN).
The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements.
The major topics addressed are:
- development of the spinal cord
- the gross anatomy of the spinal cord and its meninges
- spinal nerves, nerve roots, and dorsal root ganglia
- the vertebral column, vertebral joints, and vertebral muscles
- blood supply of the spinal cord
- cytoarchitecture and chemoarchitecture of the spinal gray matter
- musculotopic anatomy of motoneuron groups
- tracts connecting the brain and spinal cord
- spinospinal pathways
- sympathetic and parasympathetic elements in the spinal cord
- neuronal groups and pathways that control micturition
- the anatomy of spinal cord injury in experimental animals
The atlas of the rat and mouse spinal cord has the following features:
- Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse.
- Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level.
- Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN).
- All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply.

From the Preface
The major change in the format of the fifth edition is the presentation of the book in two volumes, necessitated by the rapidly increasing knowledge of metabolism, interactions, and requirements of trace elements ... The guiding principle was to present the minimum of results that would serve as a logical foundation for the description of the present state of knowledge.
Recent results of research were accommodated by devoting new chapters to the subjects "Methodology of Trace Element Research" and "Quality Assurance for Trace Element Analysis" and by expanding the discussion of lithium and aluminum in separate, new chapters. The first two subjects are of outstanding importance as determinants of future progress. The concern for the quality of analytical data motivated the authors of the individual chapters to review critically and, where necessary, revise analytical data presented in the previous editions. The rapid progress of trace analytical methodology since the mid-1970s has changed what had been accepted as normal for the concentrations of many trace elements in tissues and foods. The new data reflect the present state of the art in trace element analysis, but they may be subject to future revision.

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

Felines of the World: Discoveries in Taxonomic Classification and History provides the most recent taxonomic, paleontological, phylogenetic and DNA advances of wild felid and domestic cat species following guidelines dictated by the IUCN SSC Cat Specialist Group. It highlights the importance of felines and their role as predators in maintaining the ecological biome balance in which they have evolved. The book delves into the anatomical, evolutionary and zoogeographic features of fossil and current felid species. Each species is described in detail, detailing its classification, habitat and biological habits. This book also presents the most updated threat and conservation status of each species. This book is an ideal resource for zoologists and paleontologists, primarily those interested in the evolution and features of extinct and extant felines.

Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer's, Parkinson's, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.

More is known about the behavior, anatomy, and molecular biology of the laboratory rat than any other animal species. Although its natural history and psychological functions have been described previously in books, this is the first comprehensive description of its behavior. Both seasoned and beginning investigators will be amazed at the range and complexity of the species as described in the 43 chapters of this volume. The behavioral descriptions are closely tied to the laboratory methods from which they were derived, thus allowing investigators to correlate the behavior and methods and exploit them in their own research. This book is aimed at investigators in neuroscience who may not be familiar with rat behavior, but who wish to incorporate behavioral studies into their own research. Nevertheless, seasoned investigators will also find the book to be a handy reference for behavioral paradigms with which they may not be familiar. It is expected that as the genetic and molecular understanding of the rat develops, there will be an increasing need for knowledge about rat behavior. This book will serve as an indispensable resource for neuroscientists, psychologists, pharmacologists, geneticists, molecular biologists, zoologists, and their students and trainees.

Provides a comprehensive systematic review of the African proboscidean fossil record Includes a summary of taxonomy, geochronology, biogeography and morphology Documents major faunal events including those associated with hominin origins Synthesizes new data from genomic, isotopic and microware analyses Emphasizes the role of elephants in ecosystems and the importance of conservation

Cheetahs: Biology and Conservation reports on the science and conservation of the cheetah. This volume demonstrates the interdisciplinary nature of research and conservation efforts to study and protect the cheetah. The book begins with chapters on the evolution, genetics, physiology, ecology and behavior of the species, as well as distribution reports from range countries. These introductory chapters lead into discussions of the challenges facing cheetah survival, including habitat loss, declining prey base, human-wildlife conflict, illegal trade, and newly-emerging threats, notably climate change. This book also focuses on conservation strategies and solutions, including environmental education and alternative livelihoods. Chapters on the role of captive cheetahs to conservation and the long-term research of the species are included, as are a brief discussion of the methods and analyses used to study the cheetah. The book concludes with the conservation status and future outlook of the species. Cheetahs: Biology and Conservation is a valuable resource for the regional and global communities of cheetah conservationists, researchers, and academics. Although cheetah focussed the book provides information relevant to the study of broader topics such as wildlife conservation, captive breeding, habitat management, conservation biology and animal behaviour. Cover photograph by Angela Scott

With the substantial advances in the miniaturization of electronic components, wildlife biologists now routinely monitor the movements of free-ranging animals with radio-tracking devices. This book explicates the many analytical techniques and computer programs available to extract biological information from the radio tracking data.
Key Features:
* Presentation of software programs for solving specific problems
* Design of radio-tracking studies
* Mechanics of data collection
* Estimation of position by triangulation
* Graphic presentation of animal migration, dispersal, fidelity, and association
* Home range estimation, habitat utilization, and estimation of survival rates and population size

From the Preface
The major change in the format of the fifth edition is the presentation of the book in two volumes, necessitated by the rapidly increasing knowledge of metabolism, interactions, and requirements of trace elements. The guiding principle was to present the minimum of results that would serve as a logical foundation for the description of the present state of knowledge.

This book brings together scientific evidence and experience relevant to the practical conservation of bats. The authors worked with an international group of bat experts and conservationists to develop a global list of interventions that could benefit bats. For each intervention, the book summarises studies captured by the Conservation Evidence project, where that intervention has been tested and its effects on bats quantified. The result is a thorough guide to what is known, or not known, about the effectiveness of bat conservation actions throughout the world. Bat Conservation is the fifth in a series of Synopses that will cover different species groups and habitats, gradually building into a comprehensive summary of evidence on the effects of conservation interventions for all biodiversity throughout the world. By making evidence accessible in this way, we hope to enable a change in the practice of conservation, so it can become more evidence-based. We also aim to highlight where there are gaps in knowledge. Evidence from all around the world is included. If there appears to be a bias towards evidence from northern European or North American temperate environments, this reflects a current bias in the published research that is available to us. Conservation interventions are grouped primarily according to the relevant direct threats, as defined in the International Union for the Conservation of Nature (IUCN)'s Unified Classification of Direct Threats (www.iucnredlist.org/technical-documents/classification-schemes).

This book brings together scientific evidence and experience relevant to the practical conservation of bats. The authors worked with an international group of bat experts and conservationists to develop a global list of interventions that could benefit bats. For each intervention, the book summarises studies captured by the Conservation Evidence project, where that intervention has been tested and its effects on bats quantified. The result is a thorough guide to what is known, or not known, about the effectiveness of bat conservation actions throughout the world. Bat Conservation is the fifth in a series of Synopses that will cover different species groups and habitats, gradually building into a comprehensive summary of evidence on the effects of conservation interventions for all biodiversity throughout the world. By making evidence accessible in this way, we hope to enable a change in the practice of conservation, so it can become more evidence-based. We also aim to highlight where there are gaps in knowledge. Evidence from all around the world is included. If there appears to be a bias towards evidence from northern European or North American temperate environments, this reflects a current bias in the published research that is available to us. Conservation interventions are grouped primarily according to the relevant direct threats, as defined in the International Union for the Conservation of Nature (IUCN)'s Unified Classification of Direct Threats (www.iucnredlist.org/technical-documents/classification-schemes).

Mammals range in body size from the gigantic blue whale to the tiny Etruscan shrew. Elephants and man may live for nearly one hundred years, while most shrews die before they are three months old. During the past decade, mammalogists and evolutionary biologists have begun to unravel the numerous factors that shape the enormous diversity of mammal life histories. In this volume, leading scientists provide a variety of perspectives on the newest theories in this active field of study. The principle uniting all studies of life history evolution is adaptation by natural selection. The first chapters in the book discuss this topic, offering evolutionary interpretations of geographic variation in mammal life histories, explaining how natural selection operates in fluctuating environments, introducing evolutionary predictions of demographic mathematics, and integrating life histories with behavioral ecology. The next chapters offer functional interpretations of the importance of body size in the life history. Next, several essays explain how developments in quantitative genetics have enabled us to distinguish between genetic and environmental components of variation within and between species. With this as a basis, the chapters that follow draw from principles of natural selection, allometry, and genetics to interpret differences among species of mammals. The book concludes with speculations on various areas where research seems most urgent for the development of a comprehensive understanding of mammal life history evolution. According to the authors, the field is rich with questions, and opportunities abound for both theoretical and empirical research.

"The Biology and Identification of the Coccidia (Apicomplexa) of Rabbits of the World" is a taxonomic summation of a damaging intestinal parasite found in rabbits and transmissible to other species, including humans. This book conceptually and historically summarizes the world's literature on the parasite and also provides a quick guide to isolation procedures, identification, strategies for management, and available chemotherapy. It is a vital source of knowledge about coccidia s real and potential transmission to humans, which can lead to dangerous health problems, like severe dehydration, vomiting, lethargy and even death.

Coccidiosis is an intestinal disease that affects several different animal species, including canines and humans, and is one of the most prevalent protozoal infections in North America. The causative agent is a protozoan that has the ability to multiply rapidly and cause major damage in the intestinal wall, rupturing the cells of the intestinal lining. The final stage, the oocyst, is extremely resistant to environmental stress and is difficult to completely remove from the environment. Oocysts are frequent contaminants of feed and water and when the sporulated oocysts are ingested by other animals, they start the life cycle over in the new host. With the demand for rabbits in scientific research and for rabbit meat for human consumption increasingly globally each year, rabbits are of epidemiologic significance for laboratory workers, university researchers, veterinarians, pet owners, and breeders.
Evaluates the scientific and scholarly merit of each of the publications written about coccidian from every rabbit species, providing a complete historical renditionA treatise for the identification of coccidia and their treatment as neededWritten in a style that can be understood by most educated lay persons and laboratory workersWritten by the first ranked author team among the world-class parasitologists who study coccidiaCombined in one single source, this book follows the gold standards in coccidian biology and identificationBrings all that information together in one volume and solves the problems faced by researchers, veterinarians, students and others in trying to find and navigate through this scattered literature"

'Steve Brusatte, the author of The Rise and Fall of the Dinosaurs, brings mammals out from the shadow of their more showy predecessors in a beautifully written book that . . . makes the case for them as creatures who are just as engaging as dinosaurs.' - The Sunday Times, 'Best Books For Summer' 'In this terrific new book, Steve Brusatte . . . brings well-known extinct species, the sabre-toothed tigers and the woolly mammoths, thrillingly back to life' - The Times The passing of the age of the dinosaurs allowed mammals to become ascendant. But mammals have a much deeper history. They - or, more precisely, we - originated around the same time as the dinosaurs, over 200 million years ago; mammal roots lie even further back, some 325 million years. Over these immense stretches of geological time, mammals developed their trademark features: hair, keen senses of smell and hearing, big brains and sharp intelligence, fast growth and warm-blooded metabolism, a distinctive line-up of teeth (canines, incisors, premolars, molars), mammary glands that mothers use to nourish their babies with milk, qualities that have underlain their success story. Out of this long and rich evolutionary history came the mammals of today, including our own species and our closest cousins. But today's 6,000 mammal species - the egg-laying monotremes including the platypus, marsupials such as kangaroos and koalas that raise their tiny babies in pouches, and placentals like us, who give birth to well-developed young - are simply the few survivors of a once verdant family tree, which has been pruned both by time and mass extinctions. In The Rise and Reign of the Mammals, palaeontologist Steve Brusatte weaves together the history and evolution of our mammal forebears with stories of the scientists whose fieldwork and discoveries underlie our knowledge, both of iconic mammals like the mammoths and sabre-toothed tigers of which we have all heard, and of fascinating species that few of us are aware of. For what we see today is but a very limited range of the mammals that have existed; in this fascinating and ground-breaking book, Steve Brusatte tells their - and our - story.

This volume comprehensively covers new technologies and methodologies that have appeared for the study of mouse development.

This volume is the first of a 2 part update of volume 225, "Guide to Techniques in Mouse Development," edited by P.M. Wassarman and M.L. DePamphilis and published in 1993.

Comprehensively covers new techniques for the cryopreservation of gametes and embryos, production of transgenic and null (knockout) animals (use of ES cells), generation of conditional/inducible mutant animals, use of gene-trap mutagenesis, analysis of allele-specific expression, use of new reporter constructs, humanizing of transgenic animals, transcript profiling of mouse development, imaging of mouse development, and rederivation of animals and use of mouse genomics.

Guide to Techniques in Mouse Development, Part B, is an authoritative guide to different methods used in enzymology, focusing on investigating mouse development using technological advances. The text provides information regarding the principles of the methods in mouse development, and it offers readers reliable experimental protocols and recipes described comprehensively by leaders in the field of enzymology. The text is divided into three sections and organized into 25 chapters. Below are several concepts covered by the text: Lentivirus transgenesis o Germline modification using mouse stem cells Electroporation Applications of transposons in mouse genetics Functional genomics using transposon systems The use of DNA transposons in detecting cancer genes in mice Recombination, conditional mutagenesis and induction of tamoxifen Genetic fate mapping using recombinases Genetic screens mouse ES cells Gene trap mutagenesis Mouse mutagenesis Self- renewal and pluripotency Transgenic RNAi applications Gene knockdowns Tetracycline-controlled transcription Gene expression profiling of mouse embryos The book is a comprehensive guide for students and professionals in genetics, cytology and molecular biology, who will find this book invaluable for their learning and practice.

* Comprehensive and an easily accessible reference volume for developing, running, and analyzing biomedical research using the rat as model system Grown exponentially by the genomic revolution, the use of the rat as a model of choice for physiological studies continues in popularity and at a much greater depth of understanding. In Rat Genomics: Methods and Protocols, world-wide experts provide both practical information for researchers involved in genomic research in the rat along with a more contextual discussion about the usefulness of the rat in physiological or translational research in different organs and systems. The volume extensively covers topics including genome sequencing, quantitative trait loci mapping, and the identification of single nucleotide polymorphisms as well as the development of transgenic technologies such as nuclear cloning, lentiviral-mediated transgenesis, gene knock-down using RNA interference, gene knock-out by mutagenesis, and zinc finger nucleases plus exciting advances in the obtention of rat embryonic cell lines. As a volume in the highly successful Methods in Molecular BiologyT series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Comprehensive and up-to-date, Rat Genomics: Methods and Protocols thoroughly covers the current techniques used in labs around the world and overviews the applications of the data obtained, making it certain to be useful to the scientific community as a key source of references and methods.

Cilia--the tiny hairlike structures on the surface of cells--have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.