Serves as a comprehensive review to the substantial impact of gene amplification in molecular biology, genetic engineering and medical science. The book covers the mechanism of gene amplification, organization and structure of amplified genes.

Not since the early 1970s has there been an attempt to describe and illustrate the anatomy of the developing mouse embryo. More than ever such material is needed by biologists as they begin to unravel the molecular mechanisms underlying development and differentiation. After more than ten years of painstaking work, Matt Kaufman has completed The Atlas of Mouse Development--the definitive account of mouse embryology and development.
For all those researching or studying mammalian development, The Atlas of Mouse Development will be the standard reference work for many years to come.
Key Features
* Provides a comprehensive sequential account of the development of the mouse from pre-implantation to term
* Contains clear and concise descriptions of the anatomical features relevant to each stage of development
* Large format for easy use
* Contains explanatory notes and legends, and more than 180 meticulously labeled plates, 1,300 photographs of individual histological sections, and 200 electron micrographs, illustrating:
* Intermittent serial histological sections through embryos throughout embryogenesis and organogenesis
* Differentiation of specific organs and organ systems, including the spinal cord, eyes, gonads, kidneys, lungs and skeletal system
* External appearance of intact embryos throughout development

The polar bear, king of the Arctic, is one of the world's most recognizable animals. Images of the majestic beasts roaming across the ice cap, plunging into frigid waters, and playing with furry cubs have come to symbolize the beauty and grandeur of the Arctic. Andrew E. Derocher and Wayne Lynch have spent decades following the bears, and this book offers the most comprehensive and readable review of their biology, ecology, behavior, and conservation.

With gripping photographs by Lynch, a preeminent wildlife photographer, and the personal stories of Derocher, this book is as stunning to look at as it is fascinating to read. It weaves together their remarkable experiences with the latest research to tell the amazing story of these Arctic predators, tracing the animals back to their evolutionary roots and looking ahead to the future of polar bears on a warming planet Earth.

Through informative and engaging language, Derocher carefully explains the sea ice ecosystem that is essential to the survival of polar bears. He addresses the threat of global warming to the Arctic--home to polar bears for tens of thousands of years--and describes in impressive detail their feeding habits, distribution, den ecology, and reproduction. Lynch's vivid photographs capture all this and more as they chronicle the wide range of polar bear behavior, from family rituals to ferocious predatory practices.

Captivating, accurate, and inspiring, "Polar Bears" belongs in the hands of all who love the wild.

Modeling of Oxygen Transport to Skeletal Muscle: Blood Flow Distribution, Shunt, and Diffusion.- The Haldane Effect of Rabbit Blood Under Different Acid-Base Conditions.- Interaction of Blood Flow, Diffusive Transport and Cell Metabolism in Isovolemic Anemia.- The Role of Wall Shear Stress in Microvascular Network Adaptation.- Changes in Tissue Histology Associated with Adaptation and Acclimation to Hypoxia.- Transcutaneous Measurements of Skin O2 Supply and Blood Gases.- Relating Measuring Signals from PO2 Electrodes to Tissue PO2: A Theoretical Study.- A New Catheter for Quasi-Continuous Measurement of Arterial Partial Oxygen Pressure.- Continuous Intra-Arterial PO2 Monitoring During Thoracic Surgery.- Construction, Calibration and Evaluation of PO2 Electrodes for Chronical Implantation in the Rabbit Brain Cortex.- Photothrombosis in Rabbit Brain Cortex: Follow Up by Continuous pO2 Measurement.- Intravitreal and Intraretinal Oxygen Tension in the Rat Eye.- Brain Oxygenation State: Preparation of Isolated Perfused Rat Brain and Near-Infrared Spectrophotometry.- The Simultaneous Measurement of the Redox State of Cytochrome Oxidase in Heart and Brain of Rat In Vivo by NIR.- Picosecond Time of Flight Measurement of Living Tissue: Time Resolved Beer-Lambert Law.- Cerebral Oxygenation State in Chemically-Induced Seizures in the Rat: Study by Near Infrared Spectrophotometry.- Experimentally Measured Optical Pathlengths for the Adult Head, Calf and Forearm and the Head of the Newborn Infant as a Function of Inter Optode Spacing.- Near-Infrared Imaging in vivo (I): Image Restoration Technique Applicable to the NIR Projection Images.- Muscle Oxygenation by Fast Near Infrared Spectrophotometry (NIRS) in Ischemic Forearm.- Near-Infrared Imaging in vivo (II): 2-Dimensional Visualization of Tissue Oxygenation State.- Monitoring of the Oxygen Pressure in the Blood of Live Animals Using the Oxygen Dependent Quenching of Phosphorescence.- Nuclear Magnetic Resonance Spectroscopy and the Study of Tissue Oxygen Metabolism: A Review.- On-Line Oxygen Uptake Measurement (VO2): A Computer Feed-Back Controlled Rebreathing Circuit for Long Term Oxygen Uptake Registration.- Oxygen Delivery (DEL O2) Dependent and Independent Oxygen Consumption (VO2).- Microtopographic Analysis of Oxidative Stress in Organ Microcirculatory Units.- Cytochrome P-450 Under Conditions of Oxidative Stress: Role of Antioxidant Recycling in the Protection Mechanisms.- Ischemia-Reperfusion Injury and Free Radical Involvement in Gastric Mucosal Disorders.- Influence of Anti-Inflammatory Drugs and Free Radical Scavengers on Intestinal Ischemia Induced Oxidative Tissue Damage.- Influence of Free Radical Scavengers on Myeloperoxidase Activity and Lipid Peroxidation in Acute Skin Grafts.- Morphometric Methods for the Evaluation of Capillary Grouping Patterns in Rat Heart.- Estimation of the Oxygen Gradient Across Phospholipid Bilayers of Mitochondria from Reperfused Rabbit Hearts after Ischemia.- The Oxygen Dependence of Mitochondrial Oxidative Phosphorylation and Its Role in Regulation of Coronary Blood Flow.- Oxygen Penetration in and Release from Lung Surfactant.- Improvement of Pulmonary Gas Exchange After Surfactant Replacement in Rats With Pneumocystis Carinii Pneumonia.- Attenuation of Hypoxic Pulmonary Vasoconstriction in Acute Oleic Acid Lung Injury: Significance of Vasodilator Prostanoids.- 99mTc-DTPA Clearance: A Sensitive Method for Early Detection of An Impending Disturbance in Gas Exchange.- Acute Respiratory Failure During Pneumonia Induced by Sendai Virus.- Estimation of Respiratory Mechanics in Dogs with Acute Lung Injury.- Effect of Hyperventilation on Oxygenation of the Brain Cortex of Neonates.- Hypoxia and the "Reaction Theory" of Central Respiratory Chemosensitivity.- Oxygenation of Mammary Tumors: From Isotransplanted Rodent Tumors to Primary Malignancies in Patients.- Measurements of Tumor Blood Flow Using Intraperitoneal Deuterium and 2H-NMR Spectroscopy....

This laboratory guidebook provides step-by-step procedures that will aid in the dissection and collection of major organs and tissues of the most common species of small animals used in biomedical research. Through extensive use of photographs and illustrations, the dissector is guided through a complete necropsy of each species for the purpose of collecting the organs and tissues routinely examined by pathologists. The techniques described will enable the technician to perform necropsies on almost any mammal in a precise and logical sequence, and to properly collect tissue in order to avoid diagnostic errors. Morphological differences among the various species are discussed.

From two of the world’s leading authorities on dogs, an imaginative journey into a future of dogs without people What would happen to dogs if humans simply disappeared? Would dogs be able to survive on their own without us? A Dog’s World imagines a posthuman future for dogs, revealing how dogs would survive—and possibly even thrive—and explaining how this new and revolutionary perspective can guide how we interact with dogs now. Drawing on biology, ecology, and the latest findings on the lives and behavior of dogs and their wild relatives, Jessica Pierce and Marc Bekoff—two of today’s most innovative thinkers about dogs—explore who dogs might become without direct human intervention into breeding, arranged playdates at the dog park, regular feedings, and veterinary care. Pierce and Bekoff show how dogs are quick learners who are highly adaptable and opportunistic, and they offer compelling evidence that dogs already do survive on their own—and could do so in a world without us. Challenging the notion that dogs would be helpless without their human counterparts, A Dog’s World enables us to understand these independent and remarkably intelligent animals on their own terms.

Beavers are represented by two extant species, the Eurasian beaver (Castor fiber) and the North American beaver (Castor canadensis); each has played a significant role in human history and dominated wetland ecology in the northern hemisphere. Their behaviour and ecology both fascinate and perhaps even infuriate, but seemingly never fail to amaze. Both species have followed similar histories from relentless persecution to the verge of extinction (largely through hunting), followed by their subsequent recovery and active restoration which is viewed by many as a major conservation success story. Beavers have now been reintroduced throughout Europe and North America, demonstrating that their role as a keystone engineer is now widely recognised with proven abilities to increase the complexity and biodiversity of freshwater ecosystems. What animals other than humans can simultaneously act as engineers, forest workers, carpenters, masons, creators of habitats, and nature managers? Over the last 20 years, there has been a huge increase in the number of scientific papers published on these remarkable creatures, and an authoritative synthesis is now timely. This accessible text goes beyond their natural history to describe the impacts on humans, conflict mitigation, animal husbandry, management, and conservation. Beavers: Ecology, Behaviour, Conservation, and Management is an accessible reference for a broad audience of professional academics (especially carnivore and mammalian biologists), researchers and graduate students, governmental and non-governmental wildlife bodies, and amateur natural historians intrigued by these wild animals and the extraordinary processes of nature they exemplify.

With its iconic appearance and historic popular appeal, the giraffe is the world's tallest living terrestrial animal and the largest ruminant. Recent years have seen much-needed new research undertaken to improve our understanding of this unique animal. Drawing together the latest research into one resource, this is a detailed exploration of current knowledge on the biology, behaviour and conservation needs of the giraffe. Dagg highlights striking new data, covering topics such as species classification, the role of infrasound in communication, biological responses to external temperature changes and motherly behaviour and grief. The book discusses research into behaviour alongside practical information on captive giraffe, including diet, stereotypical behaviour, ailments and parasites, covering both problems and potential solutions associated with zoo giraffe. With giraffe becoming endangered species in Africa, the book ultimately focuses on efforts to halt population decline and the outlook for conservation measures.

The book provides up-to-date summaries on the main systems of blood group antigens and MHC molecules. The human systems are used to explain the necessary background knowledge and the systems in nonhuman primates are then described and compared. The emphasis is on the molecular nature of the gene products, the evolutionary relationships among the various systems, and the presumed mechanims by which the systems have evolved. All articles are written in such a way that they can serve as an introduction to the field for nonexperts and at the same time as a handbook for experts. Numerous tables, diagrams, and figures provide overviews of structure, distribution in different species, lists of known forms, and evolutionary relationships. Extensive reference lists guide the reader through the literature on each topic.

Illustrated with 200 outstanding photographs, Dangerous Animals presents an in-depth look at the natural world's most deadly creatures, from poisonous spiders and sea snakes to aggressive lions and man-eating sharks. The selection spans a broad spectrum of wildlife, from large carnivores such as the grizzly bear and great white shark to smaller but equally deadly predators such as the black widow spider and puff adder. Each world habitat is covered, with examples carefully drawn from every region of the planet - from the majestic lion of the African plains and the polar bear of the arctic wastes, to the Komodo dragon of South-east Asia, whose saliva carries poisonous bacteria that can kill a person in hours. Featuring around 100 species, each photographic entry is supported with a fascinating caption, explaining how the animal manages to be so deadly. Beautifully presented, this accessible book is a wonderful introduction to some of the planet's fiercest - or just most poisonous - creatures.

The population of the Persian leopard (Panthera pardus saxicolor) has drastically declined; this Asian leopard subspecies has disappeared from some parts of its former range. Containing large areas of potential habitats with leopard presence across almost all of its provinces, Iran is known to be the last stronghold for the Persian leopard in the region. This book comprehensively covers research, management and conservation practices of the Persian leopard, including: * The first phase of the Persian Leopard National Action Plan in Iran together with an innovative leopard insurance program and a contingent valuation practice with respect to the wildlife trafficking law enforcement in Iran * Research on a hypothesis about the risk of a major fragmentation and splitting the leopard distribution range in Iran into a northern and a southern parts * An innovative and empirically fitted species- and region-specific approach for assessing the cumulative effect of land use and land cover changes on the leopard persistence * Distribution modeling of leopard potential habitats on a regional basis, accompanied by ground validation techniques * An evaluation to three threshold rules to define the habitat suitability indices * Persian leopard habitats and relative corridors in the trans-boundary areas of the East Azarbaijan province of the northwest of Iran in the Caucasus Ecoregion. The innovative research and conservation approaches presented in this book will be of great interest to those studying the leopard and other large carnivore species. The innovative models presented in this book about cumulative effect of the land use and land cover changes will be beneficial to land use managers, planners and decision makers in selecting wildlife friendly solutions for development programs. The strategic and action planning model as well as the leopard compensation program as an insurance scheme are developed specifically for the local condition and leopard status in Iran.

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model's husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats-from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.

Laboratory animals, including ferrets, play an important role in biomedical research and advances. The humane care and management of these animals remains an ongoing concern. Published in color to provide greater clarity to the techniques and concepts discussed, The Laboratory Ferret presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. The book presents a greater understanding of the use of the ferret in research, such as in studies on influenza. It is a valuable, handy reference for experienced individuals and for those without extensive training in working with ferrets.

This comprehensive handbook covers all the rodents occurring in Southern, Central, East and West Africa, south of the Sahara. Detailed treatments of 79 genera and 420 species are provided for the following families: Anomaluridae (anomalures), Bathyergidae (mole-rats), Gliridae (dormice), Hystricidae (porcupines), Muridae (rats and mice), Nesomyidae (nesomyids), Pedetidae (springhares), Sciuridae (squirrels) and Thryonomyidae (canerats). The work comprises short reviews of the systematics of African rodents and African biogeography, identification matrices and keys,79 detailed genus accounts, 420 species accounts and an extensive bibliography. Genus and species accounts include diagnostic descriptions, systematics and taxonomy, biogeographical environment, fossil species, photographs of skull and mandible, illustrations of molar dentition, photographs of live animals, distribution maps and tables of standard museum measurements. This is an essential handbook for all zoologists.

Theoretical Models of O2 Transport: Local Plasma Convection Can Be Important for Oxygen Release in Tissue Capillaries; C. Bos, et al. Abstracts. Methods and Instrumentation: Phosphorescence Quenching, Magnetic Resonance Techniques, Near Infrared Spectroscopy, Other Abstracts. Systemic Oxygen Transport: Is Red Cell Flow Heterogeneity a Critical Variable in the Regulation and Limitation of Oxygen Transport to Tissue? B.R. Duling Abstracts.Heart: Effects of Energy Demand in Ischemic and in Hypoxemic Isolated Rat Hearts; M. Samaja Abstracts. Lung: Respiratory Gas Exchange and Inert Gas Retention during Partial Liquid Ventilation; E.A. Mates Abstracts. Brain: Effect of Mild Hypothermia on Active and Basal Cerebral Oxygen Metabolism and Blood Flow; E.M. Nemoto, et al. Skeletal Muscle: Oxygen Supply to Exercising Muscle, Roles of Diffusion Limitation and Heterogeneity of Blood Flow; J. Piiper Abstracts. Kidney and Gut: Filtration, Reabsorption and Oxygen in the Kidney;R.C. Blantz Abstracts. Tumor: Abstracts. 110 additional articles. Index.

Contents:
1. Introduction-metabolism 2. Enzyme-catalysed Reactions 3. Overview of Signal Transduction 4. Glycolysis 5. Citric Acid Cycle 6. Fatty Acid Oxidation 7. Amino Acid Metabolism 8. Glycogen 9. Gluconcogenesis 10. Synthesis of Triglycerides 11. Cholesterol 12. Metabolic Interrelationships of Tissue.

Can one undertake a round-the-world trip with conservation uppermost in the mind? This is exactly what Nils Bouillard sought to do in 2019, adapting a popular concept in birding known as the 'big year' and focusing instead on bats. This had never been done before and so became the ideal platform to spotlight countless conservation projects across the globe. In this engaging and inspiring account we follow Nils on his adventures – along the way discovering the extraordinary diversity of bat appearances and behaviour, and learning how we might help to protect these fascinating creatures. During his itinerary covering just shy of 30 countries, Nils was lucky enough to encounter no fewer than 400 bat species. But beyond the impressive list, Big Bat Year is a passionate tale about the people who are protecting bats all over the world, the amazing life of these animals and the unique and doughty journey it required to set a world record. Going off the beaten path isn’t difficult when it comes to bat watching, offering the chance for genuine exploration and even discovery – as evidenced by the important discovery of a species new to science while visiting Southeast Asia. This book will appeal to any nature enthusiast, regardless of whether you enjoy chasing new species.

This book is the first to explore the diversity of management objectives and the different approaches to wildlife management of large ungulates in a wide range of different European countries. Specialist authors from each country present an analysis of the species present, numerical status and distribution of different ungulates which occur in their particular country and consider issues which must be addressed by management (whether management for conservation, for control of damaging impacts or for exploitation). Management systems are described (and both legislative and administrative structures) together with an evaluation of how effective current management practices may be in addressing problems identified - or the extent to which they may contribute to those problems. The book is aimed primarily at those who may be actively involved in research into improving methods of wildlife management; practising wildlife managers and game-keepers; policy makers in local regional or national administrations, responsible for formulating policies.

Veterinary practitioners are faced regularly by diseases and disorders in a large and ever increasing range of small mammalian patients. The Editors have gathered together contributions from 29 experts, who cover all aspects of medicine and surgery in small mammals including rabbits, guinea pigs, rodents, hedgehogs, ferrets, primates, squirrels, foxes, potbellied pigs, raccoons and many more.

The randomised self-assessment format is used to enable the reader to think through each case step by step. Each of the 225 questions and illustrations - colour photos, imaging, charts and tables is followed by a thorough explanation to provide diagnosis and a suggested treatment plan.

For sales to North American, please visit http: //store.blackwell-professional.com/0813820928.html

Mammalian skull structure is notably diverse; however at a basic level the jaw mechanism is remarkably similar, if not essentially the same, in the majority of mammals. Using simple models that are compared with real animals at every step, this book examines the basic structural features of the mammalian jaw mechanism from a mechanical point of view. It explores how the mechanical constraints placed on the jaw have contributed to the evolution of an efficient basic structure, used by many mammals, which precludes mechanical difficulties and uses a minimum amount of bone tissue. Throughout the book the emphasis is on conceptual understanding, with explanations linked together to form a complete story that can be applied to both fossil and extant mammals. Summarising over forty years of research from one of the leading pioneers in 3D jaw mechanics, this is a must-have for anyone interested in mammalian jaw morphology.

Written by an award-winning writer and the leader of the Yellowstone Wolf Project, this definitive book recounts the years since the wolves' return to Yellowstone.

A comprehensive, richly illustrated introduction to the behavior and qualities of the cat Of all the domesticated species, cats have enjoyed the most complex relationship with people-one that still leads to arguments about whether you can truly call the cat asleep by your fire "tame." The Cat is a comprehensive, richly illustrated exploration of the natural and cultural history of this much-loved pet. Chapters on Evolution & Development, Anatomy & Biology, Society & Behavior, and Cats & Humans take different angles on matters feline, offering rich information and insights about kitten development, the hierarchy of cats, how cats think, communication between cats and people, historic and extinct breeds, the challenges facing cats today and how we can help, and much, much more. The book also features a visually stunning photographic directory of more than forty popular breeds, with essential information about each. Filled with surprising facts, The Cat will enchant anyone with an interest in, or a love for, these animals. Provides a comprehensive, richly illustrated introduction to the natural and cultural history of the cat Offers an in-depth discussion of behavior, including social organization, communication, courtship, and learning Covers anatomy and physiology, including mobility, predation skills, and the genetics of coat colors Features clear and accessible text plus infographics, diagrams, and some 250 stunning color photographs Includes a beautiful photographic directory to more than forty breeds