Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The sigma receptor was originally thought to be a subset of the opioid receptor family, and it is less than 10 years since it was recognized that this receptor represents unique binding sites in mammalian brain and peripheral organs, distinct from any other known neurotransmitter receptor. Since the sigma receptors exhibit high affinity for members of diverse classes of psychotropic drugs, and have been postulated to be involved in various central nervous disorders, neuroscientists have demonstrated a great deal of interest in the elucidation of these receptor sites and their biological relevance. Relatively little is known about the precise role of sigma receptors in normal brain function and in CNS disorders, despite an overwhelming research effort. This research has resulted in many controversies, some of which have been reconciled while others have not. This volume aims to update the reader on the current situation, and deals with the potential functional significance of these receptors in the brain and peripheral organs and, where appropriate, makes reference to the clinical potential of these sites.

Serves as a comprehensive review to the substantial impact of gene amplification in molecular biology, genetic engineering and medical science. The book covers the mechanism of gene amplification, organization and structure of amplified genes.

Modeling of Oxygen Transport to Skeletal Muscle: Blood Flow Distribution, Shunt, and Diffusion.- The Haldane Effect of Rabbit Blood Under Different Acid-Base Conditions.- Interaction of Blood Flow, Diffusive Transport and Cell Metabolism in Isovolemic Anemia.- The Role of Wall Shear Stress in Microvascular Network Adaptation.- Changes in Tissue Histology Associated with Adaptation and Acclimation to Hypoxia.- Transcutaneous Measurements of Skin O2 Supply and Blood Gases.- Relating Measuring Signals from PO2 Electrodes to Tissue PO2: A Theoretical Study.- A New Catheter for Quasi-Continuous Measurement of Arterial Partial Oxygen Pressure.- Continuous Intra-Arterial PO2 Monitoring During Thoracic Surgery.- Construction, Calibration and Evaluation of PO2 Electrodes for Chronical Implantation in the Rabbit Brain Cortex.- Photothrombosis in Rabbit Brain Cortex: Follow Up by Continuous pO2 Measurement.- Intravitreal and Intraretinal Oxygen Tension in the Rat Eye.- Brain Oxygenation State: Preparation of Isolated Perfused Rat Brain and Near-Infrared Spectrophotometry.- The Simultaneous Measurement of the Redox State of Cytochrome Oxidase in Heart and Brain of Rat In Vivo by NIR.- Picosecond Time of Flight Measurement of Living Tissue: Time Resolved Beer-Lambert Law.- Cerebral Oxygenation State in Chemically-Induced Seizures in the Rat: Study by Near Infrared Spectrophotometry.- Experimentally Measured Optical Pathlengths for the Adult Head, Calf and Forearm and the Head of the Newborn Infant as a Function of Inter Optode Spacing.- Near-Infrared Imaging in vivo (I): Image Restoration Technique Applicable to the NIR Projection Images.- Muscle Oxygenation by Fast Near Infrared Spectrophotometry (NIRS) in Ischemic Forearm.- Near-Infrared Imaging in vivo (II): 2-Dimensional Visualization of Tissue Oxygenation State.- Monitoring of the Oxygen Pressure in the Blood of Live Animals Using the Oxygen Dependent Quenching of Phosphorescence.- Nuclear Magnetic Resonance Spectroscopy and the Study of Tissue Oxygen Metabolism: A Review.- On-Line Oxygen Uptake Measurement (VO2): A Computer Feed-Back Controlled Rebreathing Circuit for Long Term Oxygen Uptake Registration.- Oxygen Delivery (DEL O2) Dependent and Independent Oxygen Consumption (VO2).- Microtopographic Analysis of Oxidative Stress in Organ Microcirculatory Units.- Cytochrome P-450 Under Conditions of Oxidative Stress: Role of Antioxidant Recycling in the Protection Mechanisms.- Ischemia-Reperfusion Injury and Free Radical Involvement in Gastric Mucosal Disorders.- Influence of Anti-Inflammatory Drugs and Free Radical Scavengers on Intestinal Ischemia Induced Oxidative Tissue Damage.- Influence of Free Radical Scavengers on Myeloperoxidase Activity and Lipid Peroxidation in Acute Skin Grafts.- Morphometric Methods for the Evaluation of Capillary Grouping Patterns in Rat Heart.- Estimation of the Oxygen Gradient Across Phospholipid Bilayers of Mitochondria from Reperfused Rabbit Hearts after Ischemia.- The Oxygen Dependence of Mitochondrial Oxidative Phosphorylation and Its Role in Regulation of Coronary Blood Flow.- Oxygen Penetration in and Release from Lung Surfactant.- Improvement of Pulmonary Gas Exchange After Surfactant Replacement in Rats With Pneumocystis Carinii Pneumonia.- Attenuation of Hypoxic Pulmonary Vasoconstriction in Acute Oleic Acid Lung Injury: Significance of Vasodilator Prostanoids.- 99mTc-DTPA Clearance: A Sensitive Method for Early Detection of An Impending Disturbance in Gas Exchange.- Acute Respiratory Failure During Pneumonia Induced by Sendai Virus.- Estimation of Respiratory Mechanics in Dogs with Acute Lung Injury.- Effect of Hyperventilation on Oxygenation of the Brain Cortex of Neonates.- Hypoxia and the "Reaction Theory" of Central Respiratory Chemosensitivity.- Oxygenation of Mammary Tumors: From Isotransplanted Rodent Tumors to Primary Malignancies in Patients.- Measurements of Tumor Blood Flow Using Intraperitoneal Deuterium and 2H-NMR Spectroscopy....

This laboratory guidebook provides step-by-step procedures that will aid in the dissection and collection of major organs and tissues of the most common species of small animals used in biomedical research. Through extensive use of photographs and illustrations, the dissector is guided through a complete necropsy of each species for the purpose of collecting the organs and tissues routinely examined by pathologists. The techniques described will enable the technician to perform necropsies on almost any mammal in a precise and logical sequence, and to properly collect tissue in order to avoid diagnostic errors. Morphological differences among the various species are discussed.

Of all Africa's wildlife, none has captured the imagination more than those species that have come over the years to be known as the big five. Whether the biggest, the most beautiful, the fiercest or most formidable, these animals are the ones that have the power to remind us of our insignificance in the face of the true kings of the savannas. This is a truly magnificent record of Africa's Big Five.

The book provides up-to-date summaries on the main systems of blood group antigens and MHC molecules. The human systems are used to explain the necessary background knowledge and the systems in nonhuman primates are then described and compared. The emphasis is on the molecular nature of the gene products, the evolutionary relationships among the various systems, and the presumed mechanims by which the systems have evolved. All articles are written in such a way that they can serve as an introduction to the field for nonexperts and at the same time as a handbook for experts. Numerous tables, diagrams, and figures provide overviews of structure, distribution in different species, lists of known forms, and evolutionary relationships. Extensive reference lists guide the reader through the literature on each topic.

Beavers are represented by two extant species, the Eurasian beaver (Castor fiber) and the North American beaver (Castor canadensis); each has played a significant role in human history and dominated wetland ecology in the northern hemisphere. Their behaviour and ecology both fascinate and perhaps even infuriate, but seemingly never fail to amaze. Both species have followed similar histories from relentless persecution to the verge of extinction (largely through hunting), followed by their subsequent recovery and active restoration which is viewed by many as a major conservation success story. Beavers have now been reintroduced throughout Europe and North America, demonstrating that their role as a keystone engineer is now widely recognised with proven abilities to increase the complexity and biodiversity of freshwater ecosystems. What animals other than humans can simultaneously act as engineers, forest workers, carpenters, masons, creators of habitats, and nature managers? Over the last 20 years, there has been a huge increase in the number of scientific papers published on these remarkable creatures, and an authoritative synthesis is now timely. This accessible text goes beyond their natural history to describe the impacts on humans, conflict mitigation, animal husbandry, management, and conservation. Beavers: Ecology, Behaviour, Conservation, and Management is an accessible reference for a broad audience of professional academics (especially carnivore and mammalian biologists), researchers and graduate students, governmental and non-governmental wildlife bodies, and amateur natural historians intrigued by these wild animals and the extraordinary processes of nature they exemplify.

This guide provides descriptions of when the bat species resident in Britain and Ireland use natural and human-made rock habitats, how they use them, and the environments each species occupies therein. For the first time it brings together findings from historical scientific investigations, useful photographic accounts and open-access biological records, along with a rich seam of new data – all in a practical and user-friendly structure. The book encompasses: ~ Descriptions of the features that a climber, caver or professional ecologist might encounter on and in rock habitats where bats roost. ~ Recording criteria for both the physical and environmental attributes of different features and situations. ~ Identification of suitability thresholds against which the recorded information can be compared to assess the likelihood that a specific feature might be exploited by a particular bat species. ~ Suggestions for how to avoid mistakes and difficulties when performing a survey. The intention is that using this book will help generate standardised biological records which can feed into the fully accessible online database at www.batrockhabitatkey.co.uk. These data will be analysed to search for patterns that can increase the confidence in the suitability thresholds and help build roost features that deliver the environment each species really needs. As well as offering many new insights, this book allows the reader to participate in cutting-edge research.

This engaging personal account of one of America's most contested wildlife conservation campaigns has as its central character the black-footed ferret. Once feared extinct, and still one of North America's rarest mammals, the black-footed ferret exemplifies the ecological, social, and political challenges of conservation in the West, including the risks involved with intensive captive breeding and reintroduction to natural habitat.
David Jachowski draws on more than a decade of experience working to save the ferret. His unique perspective and informative anecdotes reveal the scientific and human aspects of conservation as well as the immense dedication required to protect a species on the edge of extinction.
By telling one story of conservation biology in practice--its routine work, triumphs, challenges, and inevitable conflicts--this book gives readers a greater understanding of the conservation ethic that emerged on the Great Plains as part of one of the most remarkable recovery efforts in the history of the Endangered Species Act.

The population of the Persian leopard (Panthera pardus saxicolor) has drastically declined; this Asian leopard subspecies has disappeared from some parts of its former range. Containing large areas of potential habitats with leopard presence across almost all of its provinces, Iran is known to be the last stronghold for the Persian leopard in the region. This book comprehensively covers research, management and conservation practices of the Persian leopard, including: * The first phase of the Persian Leopard National Action Plan in Iran together with an innovative leopard insurance program and a contingent valuation practice with respect to the wildlife trafficking law enforcement in Iran * Research on a hypothesis about the risk of a major fragmentation and splitting the leopard distribution range in Iran into a northern and a southern parts * An innovative and empirically fitted species- and region-specific approach for assessing the cumulative effect of land use and land cover changes on the leopard persistence * Distribution modeling of leopard potential habitats on a regional basis, accompanied by ground validation techniques * An evaluation to three threshold rules to define the habitat suitability indices * Persian leopard habitats and relative corridors in the trans-boundary areas of the East Azarbaijan province of the northwest of Iran in the Caucasus Ecoregion. The innovative research and conservation approaches presented in this book will be of great interest to those studying the leopard and other large carnivore species. The innovative models presented in this book about cumulative effect of the land use and land cover changes will be beneficial to land use managers, planners and decision makers in selecting wildlife friendly solutions for development programs. The strategic and action planning model as well as the leopard compensation program as an insurance scheme are developed specifically for the local condition and leopard status in Iran.

Following the success of earlier ‘Quick Guide’ books, this slim little volume tackles one of the few groups of mammals that can fly. Divided into large fruit bats and smaller insecteating bats, this ultimate quick identification guide covers Africa’s 12 bat families. An informative introduction touches on evolution, flight, echolocation and reproduction, demystifying an animal that is all too often misunderstood. The text describes the facial characteristics and wing shapes common to each family and points out features that can help to distinguish between them. But it is the photographs and annotated line drawings that are most useful for identification. They include bats in flight and roosting sites, and close-ups of facial structures and wings that highlight key diagnostic attributes. An added extra is a photographic section showing the skulls of a variety bats.

This is a valuable guide for anyone with an interest in wildlife and its less common members.

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model's husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats-from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.

Laboratory animals, including ferrets, play an important role in biomedical research and advances. The humane care and management of these animals remains an ongoing concern. Published in color to provide greater clarity to the techniques and concepts discussed, The Laboratory Ferret presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. The book presents a greater understanding of the use of the ferret in research, such as in studies on influenza. It is a valuable, handy reference for experienced individuals and for those without extensive training in working with ferrets.

This comprehensive handbook covers all the rodents occurring in Southern, Central, East and West Africa, south of the Sahara. Detailed treatments of 79 genera and 420 species are provided for the following families: Anomaluridae (anomalures), Bathyergidae (mole-rats), Gliridae (dormice), Hystricidae (porcupines), Muridae (rats and mice), Nesomyidae (nesomyids), Pedetidae (springhares), Sciuridae (squirrels) and Thryonomyidae (canerats). The work comprises short reviews of the systematics of African rodents and African biogeography, identification matrices and keys,79 detailed genus accounts, 420 species accounts and an extensive bibliography. Genus and species accounts include diagnostic descriptions, systematics and taxonomy, biogeographical environment, fossil species, photographs of skull and mandible, illustrations of molar dentition, photographs of live animals, distribution maps and tables of standard museum measurements. This is an essential handbook for all zoologists.

Theoretical Models of O2 Transport: Local Plasma Convection Can Be Important for Oxygen Release in Tissue Capillaries; C. Bos, et al. Abstracts. Methods and Instrumentation: Phosphorescence Quenching, Magnetic Resonance Techniques, Near Infrared Spectroscopy, Other Abstracts. Systemic Oxygen Transport: Is Red Cell Flow Heterogeneity a Critical Variable in the Regulation and Limitation of Oxygen Transport to Tissue? B.R. Duling Abstracts.Heart: Effects of Energy Demand in Ischemic and in Hypoxemic Isolated Rat Hearts; M. Samaja Abstracts. Lung: Respiratory Gas Exchange and Inert Gas Retention during Partial Liquid Ventilation; E.A. Mates Abstracts. Brain: Effect of Mild Hypothermia on Active and Basal Cerebral Oxygen Metabolism and Blood Flow; E.M. Nemoto, et al. Skeletal Muscle: Oxygen Supply to Exercising Muscle, Roles of Diffusion Limitation and Heterogeneity of Blood Flow; J. Piiper Abstracts. Kidney and Gut: Filtration, Reabsorption and Oxygen in the Kidney;R.C. Blantz Abstracts. Tumor: Abstracts. 110 additional articles. Index.

From two of the world’s leading authorities on dogs, an imaginative journey into a future of dogs without people What would happen to dogs if humans simply disappeared? Would dogs be able to survive on their own without us? A Dog’s World imagines a posthuman future for dogs, revealing how dogs would survive—and possibly even thrive—and explaining how this new and revolutionary perspective can guide how we interact with dogs now. Drawing on biology, ecology, and the latest findings on the lives and behavior of dogs and their wild relatives, Jessica Pierce and Marc Bekoff—two of today’s most innovative thinkers about dogs—explore who dogs might become without direct human intervention into breeding, arranged playdates at the dog park, regular feedings, and veterinary care. Pierce and Bekoff show how dogs are quick learners who are highly adaptable and opportunistic, and they offer compelling evidence that dogs already do survive on their own—and could do so in a world without us. Challenging the notion that dogs would be helpless without their human counterparts, A Dog’s World enables us to understand these independent and remarkably intelligent animals on their own terms.

Contents:
1. Introduction-metabolism 2. Enzyme-catalysed Reactions 3. Overview of Signal Transduction 4. Glycolysis 5. Citric Acid Cycle 6. Fatty Acid Oxidation 7. Amino Acid Metabolism 8. Glycogen 9. Gluconcogenesis 10. Synthesis of Triglycerides 11. Cholesterol 12. Metabolic Interrelationships of Tissue.

This book is the first to explore the diversity of management objectives and the different approaches to wildlife management of large ungulates in a wide range of different European countries. Specialist authors from each country present an analysis of the species present, numerical status and distribution of different ungulates which occur in their particular country and consider issues which must be addressed by management (whether management for conservation, for control of damaging impacts or for exploitation). Management systems are described (and both legislative and administrative structures) together with an evaluation of how effective current management practices may be in addressing problems identified - or the extent to which they may contribute to those problems. The book is aimed primarily at those who may be actively involved in research into improving methods of wildlife management; practising wildlife managers and game-keepers; policy makers in local regional or national administrations, responsible for formulating policies.

Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. Systematic Approach to Evaluation of Mouse Mutations includes information on medical photography, grafting procedures, how to map the genes and evaluate the special biological characteristics of the mice.

'Steve Brusatte, the author of The Rise and Fall of the Dinosaurs, brings mammals out from the shadow of their more showy predecessors in a beautifully written book that . . . makes the case for them as creatures who are just as engaging as dinosaurs.' - The Sunday Times, 'Best Books For Summer' 'In this terrific new book, Steve Brusatte . . . brings well-known extinct species, the sabre-toothed tigers and the woolly mammoths, thrillingly back to life' - The Times The passing of the age of the dinosaurs allowed mammals to become ascendant. But mammals have a much deeper history. They - or, more precisely, we - originated around the same time as the dinosaurs, over 200 million years ago; mammal roots lie even further back, some 325 million years. Over these immense stretches of geological time, mammals developed their trademark features: hair, keen senses of smell and hearing, big brains and sharp intelligence, fast growth and warm-blooded metabolism, a distinctive line-up of teeth (canines, incisors, premolars, molars), mammary glands that mothers use to nourish their babies with milk, qualities that have underlain their success story. Out of this long and rich evolutionary history came the mammals of today, including our own species and our closest cousins. But today's 6,000 mammal species - the egg-laying monotremes including the platypus, marsupials such as kangaroos and koalas that raise their tiny babies in pouches, and placentals like us, who give birth to well-developed young - are simply the few survivors of a once verdant family tree, which has been pruned both by time and mass extinctions. In The Rise and Reign of the Mammals, palaeontologist Steve Brusatte weaves together the history and evolution of our mammal forebears with stories of the scientists whose fieldwork and discoveries underlie our knowledge, both of iconic mammals like the mammoths and sabre-toothed tigers of which we have all heard, and of fascinating species that few of us are aware of. For what we see today is but a very limited range of the mammals that have existed; in this fascinating and ground-breaking book, Steve Brusatte tells their - and our - story.

Veterinary practitioners are faced regularly by diseases and disorders in a large and ever increasing range of small mammalian patients. The Editors have gathered together contributions from 29 experts, who cover all aspects of medicine and surgery in small mammals including rabbits, guinea pigs, rodents, hedgehogs, ferrets, primates, squirrels, foxes, potbellied pigs, raccoons and many more.

The randomised self-assessment format is used to enable the reader to think through each case step by step. Each of the 225 questions and illustrations - colour photos, imaging, charts and tables is followed by a thorough explanation to provide diagnosis and a suggested treatment plan.

For sales to North American, please visit http: //store.blackwell-professional.com/0813820928.html

After drawing its first breath, every newborn mammal turns his or her complete attention to obtaining milk. This primal act was once thought to stem from a basic fact: milk provides the initial source of calories and nutrients for all mammalian young. But it turns out that milk is a much more complicated biochemical cocktail and provides benefits beyond nutrition. In this fascinating book, biologists Michael L. Power and Jay Schulkin reveal this liquid's evolutionary history and show how its ingredients have changed over many millions of years to become a potent elixir. Power and Schulkin walk readers through the early origins of the mammary gland and describe the incredible diversification of milk among the various mammalian lineages. After revealing the roots of lactation, the authors describe the substances that naturally occur in milk and discuss their biological functions. They reveal that mothers pass along numerous biochemical signals to their babies through milk. The authors explain how milk boosts an infant's immune system, affects an infant's metabolism and physiology, and helps inoculate and feed the baby's gut microbiome. Throughout the book, the authors weave in stories from studies of other species, explaining how comparative research sheds light on human lactation. The authors then turn their attention to the fascinating topic of cross-species milk consumption-something only practiced by certain humans who evolved an ability to retain lactase synthesis into adulthood. The first book to discuss milk from a comparative and evolutionary perspective, Power and Schulkin's masterpiece reveals the rich biological story of the common thread that connects all mammals.

Can one undertake a round-the-world trip with conservation uppermost in the mind? This is exactly what Nils Bouillard sought to do in 2019, adapting a popular concept in birding known as the 'big year' and focusing instead on bats. This had never been done before and so became the ideal platform to spotlight countless conservation projects across the globe. In this engaging and inspiring account we follow Nils on his adventures – along the way discovering the extraordinary diversity of bat appearances and behaviour, and learning how we might help to protect these fascinating creatures. During his itinerary covering just shy of 30 countries, Nils was lucky enough to encounter no fewer than 400 bat species. But beyond the impressive list, Big Bat Year is a passionate tale about the people who are protecting bats all over the world, the amazing life of these animals and the unique and doughty journey it required to set a world record. Going off the beaten path isn’t difficult when it comes to bat watching, offering the chance for genuine exploration and even discovery – as evidenced by the important discovery of a species new to science while visiting Southeast Asia. This book will appeal to any nature enthusiast, regardless of whether you enjoy chasing new species.