This is the first book to cover all aspects of Lagomorph biology. Lagomorphs are a mammalian order which includes rabbits, hares and pikas. They are distributed throughout the world and are of both scientific and public interest as they are classified between endangered and pest species. In addition, some have a high economic value as important game species. In the last few decades, a huge amount of information has been made available to the scientific community that has resulted in remarkable advances on all aspects of Lagomorph biology.

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than 50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain."

The ovary is a suitable organ for studying the processes of cell death. Cell death was first described in the rabbit ovary (Graaffian follicles), the phenomenon being called 'chromatolysis'. To date, it is recognized that various forms of cell death (programmed cell death, apoptosis and autophagy) are essential components of ovarian development and function. Programmed cell death is responsable for the ovarian endowment of primordial follicles around birth; in the prepuberal and adult period, apoptosis is a basic mechanism by which oocytes are eliminated by cancer therapies and environmental toxicants; in the ovarian cycle, follicular atresia and luteal regression involve follicular cell apoptosis. Finally, abnormalities in cell death processes may lead to ovarian disease such as cancer and chemoresistance. In this book, after an introductory description of various forms of cell death and of the ovary development and function in mammals, the processes of cell death in ovarian somatic cells and oocytes are described at cytological, physiological and molecular levels and analyzed in the embryonic, prepuberal and adult ovary. A complex array of molecular pathways triggered by extrinsic and intrinsic signals able tor induce or suppress cell death in the same cell, according to cell type and ovary developmental stage, emerges. Physiological interactions with the axis hypothalamus-hypophysis as well as ovarian internal functional signal are also critically reviewed to explain the abortive development of follicles before the beginning of the ovarian cycle. The book conveys information useful to the updating of biologists and physicians who are interested to the ovary biology and functions. Hopefully it should provide also clues for stimulating novel experiments in the study of cell death in the mammalian ovary still at an early stage.

The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides. The first took place in 1968 in New York [Ann. New York Acad. Sci. (1969), 765,508-819] and the second was held in 1977 in East Lansing, Michigan [eyclitols and Phosphoinositides, Wells, W. W. and Eisenberg, F. , eds. , (1978) Academic press, New York, pp. 1-607. ] In the interim since the previous conference, not only has the pace of research in the field accelerated markedly, but the physiological importance of phosphoinositide metabolism has become apparent to an increasing number of investigators from diverse fields in the life sciences. Thus it seemed to us timely for both recent and established workers in this area, as well as others whose interests impinged on it, to meet in order to disseminate new information, to review, and perhaps arrive at, a consensus of our current understanding of the role of inositol and phosphoinositides, and to establish new directions for research for the next few years. The expansion of the field since the last meeting made it mandatory to restrict the scope of the topics covered at the conference, primarily to aspects dealing with mammalian systems. We sincerely regretted the exclusion of recent research on cyclitols and phosphoinositides in microbes and plants and hope that these areas will be included in future conferences.

First published in 1981, Dynamics of Large Mammal Populations was written by experts from four continents and six countries. It is a collection of papers on the population dynamics of large mammals and was the first synthesis of work in the field. The book helped provide identity and coherence to an emerging field. It has become a much-sought-after book. The theoretical and empirical studies presented demonstrate the ways in which numbers of animals in large mammal populations change over time in response to a variety of factors. The studies cover a wide variety of species - including both terrestrial and marine mammals - and compare the population dynamics of various groups such as herbivores, carnivores, ungulates, cetaceans and pinnipeds. Included are species involved in controversial population management problems. Also covered are advances in managing the populations of large mammals, and advances in the theoretical basis of large mammal population dynamics. Numerous examples detail the interaction of mammals with their ecosystems. Population biologists, wildlife biologists and managers, government researchers, environmentalists and marine mammal scientists can use the information made available here as a basis for comparative research and practical applications. "The book contains an excellent mix of theoretical chapters, general overviews, and studies of specific animal speces, ranging from seals and whales to lions and elephants, taking deer, wolves, and grizzly bears along the way... But to the specialist it will be indispensable, forming as it does the only authoritative volume that deals with the population dynamics of this important group of animals." ORYX Fauna & Flora Preservation Society, July, 1983. "One immediately realizes, by skimming the citations of the different chapters, that the researchers, working on such animals as whales, bears, seals, lions, and elephants had not been talking to one another, and that this book represents something of a first in this regard." Mathematical Biosciences, 1983. "The book will be of particular interest and value to wildlife biologists faced with problems of managing wildlife resources and to people who use the resources." The Quarterly Review of Biology, 1982. "This is an excellent book. One doesn't have to be a population biologist to understand the material. Best of all, the authors are refreshingly frank about areas of ignorance in population biology and the failure of even the best simulaion models to fit the real world... To sum up, there is food for thought in this volume for every zoologist with an interest in population biology and especially for those who study large mammals." BioScience 1982. "In bringing a wealth of research effort to a wider readership, this book cannot fail to stimulate" Biometrics, 1982.

This book fills the gap in the available literature on modelling farm animal systems. This monograph has a broad and comprehensive coverage of ruminant systems and features the application of models in animal biology. It will be of great value to animal scientists, agricultural scientists, modellers and animal physiologists.

Amino acid transport is a part of each of two larger subjects, amino acid metabolism and the biomembrane transport of various . small molecules and ions. Nevertheless in this volume we treat amino acid transport as more than a fragment of either of these two larger subjects. A more comprehensive approach is justified when we remember two historic and ongoing aspects of the title subject. First, amino acid transport had its beginning and acquired a distinct momentum (even if somewhat interrupted from 1913 until about 1945) as amino acid metabolism with the central and pioneer work of Van Slyke and Meyer in 1913. The reviews in this volume will show that it steadily becomes a larger aspect of amino acid metabolism, broadly perceived. These chapters will show for how many organelles, cells, tissues, organs and organ systems, the transmembrane compartmentations and flows of amino acids play very large parts in their fundamental biological relations. The authors here are tending collectively to evaluate an understanding of amino acid flows across biomernbranes, and the regulation of these flows, as necessary to an ultimate understanding of the full range of development and metabolism. Such an understanding goes far beyond the purely substrate-destabilizing contributions by enzymes, which have often been arbitrarily limited to that conceptual entity, "the cell," and which for so long a splendid time had most of biochemical research attention.

A comprehensive guide to the calls of the 44 species of bat currently known to occur in Europe. Following on from the popular British Bat Calls by Jon Russ, this new book draws on the expertise of more than forty specialist authors to substantially update all sections, further expanding the volume to include sound analysis and species identification of all European bats. Aimed at volunteers and professional alike, topics include the basics of sound, echolocation in bats, an introduction to acoustic communication, equipment used and call analysis. For each species, detailed information is given on distribution, emergence, flight and foraging behaviour, habitat, echolocation calls - including parameters of common measurements - and social calls. Calls are described for both heterodyne and time expansion/full spectrum systems. A simple but complete echolocation guide to all species is provided for beginners, allowing them to analyse call sequences and arrive at the most likely species or group. The book also includes access to a downloadable library of over 450 calls presented as sonograms in the species sections.

Environmental conditions change considerably in the course of 24 h with respect to abiotic factors and intra- and interspecific interactions. These changes result in limited time windows of opportunity for animal activities and, hence, the question of when to do what is subject to fitness maximisation. This volume gives a current overview of theoretical considerations and empirical findings of activity patterns in small mammals, a group in which the energetic and ecological constraints are particularly severe and the diversity of activity patterns is particularly high. Following a comparative ecological approach, for the first time activity timing is consequently treated in terms of behavioural and evolutionary ecology, providing the conceptual framework for chronoecology as a new subdiscipline within behavioural ecology. An extensive Appendix gives an introduction to methods of activity modelling and to tools for statistical pattern analysis.

The order Rodentia is the most abundant and successful group of mammals, and it has been a focal point of attention for compar ative and evolutionary biologists for many years. In addition, rodents are the most commonly used experimental mammals for bio medical research, and they have played a central role in investi gations of the genetic and molecular mechanisms of speciation in mammals. During recent decades, a tremendous amount of new data from various aspects of the biology of living and fossil rodents has been accumulated by specialists from different disciplines, ranging from molecular biology to paleontology. Paradoxically, our understanding of the possible evolutionary relationships among different rodent families, as well as the possible affinities of rodents with other eutherian mammals, has not kept pace with this information "explosion. " This abundance of new biological data has not been incorporated into a broad synthesis of rodent phylo geny, in part because of the difficulty for any single student of rodent evolution to evaluate the phylogenetic significance of new findings from such diverse disciplines as paleontology, embryology, comparative anatomy, molecular biology, and cytogenetics. The origin and subsequent radiation of the order Rodentia were based primarily on the acquisition of a key character complex: specializations of the incisors, cheek teeth, and associated mus culoskeletal features of the jaws and skull for gnawing and chewing."

Originally published in 2004, the Kingdon Pocket Guide to African Mammals quickly became the field guide of choice to take on African safaris. Its compact format makes it ideal for use in the field, while its coverage is the most comprehensive currently possible in this format. Adapted from the Kingdon Field Guide to African Mammals, the greatly condensed text focuses on essential information such as identification and distribution, while the author's superb illustrations have been rearranged into an easy-to-use plate format and placed opposite the text. Complex and more obscure groups like the bats and certain rodent families are summarised by genera. Over 500 maps plot the distribution of all larger species, and for smaller mammals the maps show distribution by genus. This is a completely revised second edition of this popular guide. The information and taxonomy have been updated to follow the newly published second edition of the Kingdon Field Guide to African Mammals (2015), and this new edition of the pocket guide contains several new species and illustrations. The maps have been completely replaced and there are now 200 more maps than in the original edition.

This revised edition of Bats of Southern and Central Africa builds on the solid foundation of the first edition and supplements the original account of bat species then known to be found in Southern and Central Africa with an additional eight newly described species, bringing the total to 124. The chapters on evolution, biogeography, ecology and echolocation have been updated, citing dozens of recently published papers. The book covers the latest systematic and taxonomic studies, ensuring that the names and relationships of bats in this new edition reflect current scientific knowledge. The species accounts provide descriptions, measurements and diagnostic characters as well as detailed information about the distribution, habitat, roosting habits, foraging ecology and reproduction of each species. The updated species distribution maps are based on 6 100 recorded localities. A special feature of the 2010 publication was the mode of identification of families, genera and species by way of character matrices rather than the more generally used dichotomous keys. Since then these matrices have been tested in the field and, where necessary, slightly altered for this edition. New photographs fill in gaps and updated sonograms aid with bat identification in acoustic surveys. The bibliography, which now contains more than 700 entries, will be an invaluable aid to students and scientists wishing to consult original research.

This book describes the major steps by which the mammalian ear transforms sound into nerve impulses. The author leads us along the pathway followed by an acoustic signal--collected by the outer ear, augmented by the middle ear, then delivered to the inner ear where the minuscule vibrations of the sound waves are transformed into nerve impulses. At each stage, the basic mechanisms are described qualitatively in terms of current theories and illustrated with experimental data. Where appropriate, related mechanisms in the ears of other vertebrates are considered. It is shown that the mammalian ear does an exquisite job of translating sound signals into a very robust nerve-pulse code. The book concludes with descriptions of some common ear impairments and a brief survey of the treatments available for them. The text is integrated with animations of mechanical and neural phenomena available through the Internet.

The Springer Handbook oj Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modern auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focuses on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. Each volume in the series consists of five to eight substantial chapters on a particular topic. In some cases, the topics will be ones of traditional interest for which there is a solid body of data and theory, such as auditory neuroanatomy (Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series will deal with topics which have begun to mature more recently, such as development, plasticity, and computational models of neural processing."

The cerebral neocortex, a structure unique to the mammalian brain and prerequisite for higher cognitive functions, has since decades attracted the curiosity of neurobiologists and developmental biologists alike. This volume gives a comprehensive and up-to-date overview of early cortical development. It provides concise information on the birth, specification, migration and terminal differentiation of neocortical cells. Both the cellular and molecular events leading to the establishment of a functional neocortex are presented in considerable detail, and possible implications for neurodegenerative diseases are discussed.

It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.

Illustrated throughout with 200 outstanding colour photographs, Endangered Animals presents an in-depth look at around 100 species of animal from around the world, all of which are currently endangered or threatened according to the annual list drawn up by the World Conservation Union (IUCN). The selection spans a broad spectrum of wildlife, from large, charismatic mammals such as the Bengal tiger to lesser-known species such as New Zealand's kakapo, the world's only flightless parrot, which was once presumed to be extinct. Each continent is covered, with examples carefully drawn from every habitat - from the mysterious aye-aye of Madagascar's shrinking rainforest, to the shy spectacled bear of the high Andes. Arranged geographically, each photographic entry is supported by a fascinating caption, which explains the animal's current plight and whether it is critically endangered or classified as vulnerable. From the Ethiopian wolf to the Bengal tiger to monk seal and dugong, Endangered Animals is a fascinating introduction to some of the most threatened species on the planet.

Jonathan Kingdon, one of the world's foremost authorities on African mammals, has both written and illustrated this landmark field guide. The unique combination of his extensive field experience and artistic talent has produced a stunning work that sets new standards. The concise text provides full information on identification, distribution, ecology, relationships and conservation status, with introductory profiles that summarise the characteristics of each mammal group. All known species of African land mammal are covered, with coverage of several of the more complex groups of small mammals simplified by reference to genera. Classification has been fully updated and this new edition includes many newly recognised species. With over 780 colour illustrations, numerous line drawings and more than 520 maps, this book will be an essential companion to anyone visiting Africa or with an interest in the mammals of the continent. Competition note: There are regional mammal books covering southern Africa, for example, but none that covers the whole continent in a portable format. The smaller-format and more concise Kingdon Pocket Guide to African Mammals may be more appealing to a more general safari market, but is much less comprehensive and more out of date.

Mammalian skin, skeletal muscles and connective tissue contain a wide variety of miniature sensory receptors which respond to mechanical stimuli. The monograph describes different types of these mechanoreceptors, such as mucles spindles, tendon organs, Pacinian corpuscles, tactile digital corpuscles etc., and outlines the role of sensory nerve terminals in their development and maintenance.

This guide provides descriptions of when the bat species resident in Britain and Ireland use natural and human-made rock habitats, how they use them, and the environments each species occupies therein. For the first time it brings together findings from historical scientific investigations, useful photographic accounts and open-access biological records, along with a rich seam of new data – all in a practical and user-friendly structure. The book encompasses: ~ Descriptions of the features that a climber, caver or professional ecologist might encounter on and in rock habitats where bats roost. ~ Recording criteria for both the physical and environmental attributes of different features and situations. ~ Identification of suitability thresholds against which the recorded information can be compared to assess the likelihood that a specific feature might be exploited by a particular bat species. ~ Suggestions for how to avoid mistakes and difficulties when performing a survey. The intention is that using this book will help generate standardised biological records which can feed into the fully accessible online database at www.batrockhabitatkey.co.uk. These data will be analysed to search for patterns that can increase the confidence in the suitability thresholds and help build roost features that deliver the environment each species really needs. As well as offering many new insights, this book allows the reader to participate in cutting-edge research.

Sasol First Field Guide to Mammals of Southern Africa provides fascinating insight into the wild animals of the region.

Through full-colour photographs and distribution maps, and easy-to-read text, the beginner and budding naturalist will be able to identify the more common mammal species found in southern Africa, discover where they live, and learn about their unique feeding and breeding habits.