If there is one aspect of current cancer research that represents a major ch- lenge in both novice and experienced researchers, it is the rapid advance in our understanding of the disease. Researchers can be required to switch from analysis of gene expression to kinetics of protein activation, from genetic studies to the analysis of protein funtion. Cancers are highly complex disease systems and researchers aiming to understand the functioning of cancer systems require access to a wide range of laboratory techiques from a broad range of research disciplines. Increasingly, however, published methods are incomplete or refer back to a series of previous publications each containing only a small part of the complete pro- col. The aim of Ovarian Cancer: Methods and Protocols is to provide for ovarian cancer researchers in the first instance, a laboratory handbook that will facilitate research into cancer systems by providing a series of expert protocols, with proven efficacy, across a broad range of technical expertise. Thus, there are sections on tumor genetics and cellular signal transduction, as well as sections on apoptosis and RNA analysis. The value of Ovarian Cancer: Methods and Protocols to the ovarian cancer researcher will, I trust, be considerably enhanced by (1) the provision of a series of overviews relating to the biology, diagnosis, and treatment of this important neoplasm, and (2) the provision of a series of technical overviews introducing each part that provides an expert review of the applications and pitfalls of the various techniques included.

Regional Analgesia in Obstetrics provides an account of the developments in the provision of regional analgesia and anaesthesia in obstetrics over the last decade. The book covers the attitudes to obstetric analgesia in different countries; the indications for regional analgesia in labour; the effects of regional analgesia on outcome; and operative delivery.

This text provides a quick reference to all the important facts in the clinical sciences for candidates aiming at a postgraduate qualification in obstetrics and gynaecology, including those candiadtes studying for the MRCOG Part II examination. The text has been revised and updated, but the concise style and comprehensive coverage of all the essential aspects of the subject are retained. Written by a highly expert team of authors, this text will be an invaluable reference for students and will also be of value to clinicians as a brief guide. This volume serves as a companion to the highly successful "Basic Sciences for Obstetrics and Gynaecology" by Chard and Lilford, which is now in its Fifth Edition.

This book is based on the experience of an European Network on Congenital Toxoplasmosis which associates more than 50 European specialized Centers from 17 diferent European Countries. Some American colleagues among the best specialists in the world also collaborate to this book which gives the most recent data on congenital toxoplasmosis in epidemiology, biology, clinical symptoms, diagnostic, treatment and prevention.

List of Contributors xviii An Aging Humankind: New Realities E. Dicgalusy Does Menopause Increase the Risk of Coronary Heart Disease? M.V. Huisrnan Chronic Low-Grade Metabolic Acidosis in Normal Adult Humans: Pathophysiology and Consequences L. Frassetto, R.C. Morris, Jr., K. Todd, and A. Sebastian The Menopause, Sex Hormones, and Rheumatic Disease G. Hall Novel Mechanisms of Estrogen Action J.-A. Gustafsson The Action of Ovarian Steroid Hormones on Tissues and Organs M.J. Legato Nongenomic Mechanisms of Sex Hormones J.H.H. Thijssen Action of Specific Estrogens on Vascular Cells C.S. Wingrove and J.C. Stevenson Direct Actions of Estrogen on Vascular Cells Ameliorates Response to hjury D. W. Losordo ix Newer Progestogens G. Samsioe IV. 11. Cardiovascular Disease: Risk Factors Related to Thrombosis G. de Gaetano, M.B. Donati, and L. Iacoviello Estrogen Effect upon Coronary Vasculature G.M.C. Rosano, F. Leonardo, and G. Panina Estrogen and Endothelial Function A. Virdis, L. Ghiadoni, I. Sudano, S. Pinto, S. Taddei, and A. Salvetti Action of Specific Estrogens on the Coronary Artery: Effects on Lipoproteins, Coagulation, and Fibrinolysis J.M. Sullivan Coronary Heart Disease in Women: Status 1998 N. K. Wenger Introduction to Osteoporosis C. Christiansen Genetics of Osteoporosis L. Masi, L. Gennari, A. Falchetti, and M.L. Brandi The Clinical Management of Osteoporosis S.E. Papapou los VI.

Leading researchers and experienced clinicians join forces not only to illuminate today's understanding of the endocrinology of menopause, but also to provide a sound basis for its successful management. These seasoned experts review in detail the cardiovascular, bone, brain, and genitourinary changes that accompany menopause and spell out the risks, benefits, and alternatives of conventional hormone replacement therapy. Selective estrogen receptor modulators (SERMs), androgen replacement, calcium supplementation, and the role of phytoestrogens are also fully reviewed. Menopause: Endocrinology and Management offers practicing physicians a comprehensive understanding of the menopause process, as well as an evidence-based approach to optimizing treatment strategies for the challenging medical problems accompanying this important period in women's lives.

Master the effective evaluation, analysis and management of placental-fetal growth restriction (PFGR), developing strategies to reduce the risk of perinatal mortality and morbidity in patients worldwide. Extensively researched by international experts, this manual provides practitioners with a detailed, hands-on approach to the practical 'pearls' for direct patient management. This authoritative volume advises on matters such as the correct evaluation and management of high-risk patients in danger of PFGR through to delivery. Extensive and wide-ranging, this book is an invaluable companion to the developing research interest and clinical applications in PFGR, including developmental outcomes in early childhood. Featuring a critical evaluation of a variety of abnormal conditions, such as fetal hypoxia and extreme prematurity, which are clearly displayed through extensive illustrations, this essential toolkit ensures that practitioners at all levels can effectively limit adverse outcome and reach the correct diagnosis.

A. Wayne Meikle and a distinguished panel of expert clinicians bring to bear their extensive knowledge and experience in managing adults and children undergoing hormone replacement therapy for the pituitary, parathyroid, thyroid, pancreas, adrenal glands, and gonads. Emphasizing proper patient management, the book provides to specialists and general practitioners alike time-tested, cutting-edge guidelines on the use, monitoring, and dosage of hormone therapeutics in the treatment of disorders of endocrine function, while giving an exhaustive analysis of each therapy. Comprehensive and eminently practical, Hormone Replacement Therapy captures the most recent advances in hormone replacement therapeutics and is certain to serve endocrinologists, gynecologists, pediatricians, urologists, internists, and family practitioners as today's standard reference for managing and monitoring their patients.

Although the histological typing of ovarian tumours is the focus of this volume, other aspects of investigation of a specimen of ovarian tumour are also important. Some of these aspects are mentioned in the text or illustrated. They include tumour grading, which is impor- tantprognostically and therapeutically for certain types ofovarian tu- mour, quantification ofcomponents in mixed tumours and evaluation of the stroma of certain tumours that are associated with endocrine function. Grading methodologies have varied from one tumour type to another and from one group of investigators to another for the same type of tumour. Because a standard internationally recognized grading methodology has not been established, no specific guidance is presented in this volume. Nevertheless, grading by any generally acceptable method should be incorporated in the diagnosis whenever appropriate. The clinical and pathological classification of the extent of tu- mour growth (staging) should be taken into account for the purposes of treatment and prognosis. The TNlV1/FIGO system is therefore in- cluded (p. 45). Histological Classification of Ovarian Tumours 1 Surface Epithelial-Stromal Tumours 1. 1 Serous tumours 1. 1. 1 Benign 1 1. 1. 1. 1 Cystadenoma 8441/0 Papillary cystadenoma 8460/0 1. 1. 1. 2 Surface papilloma ...8461/0 1. 1. 1. 3 Adenofibroma; cystadenofibroma ...9014/0 1. 1. 2 Of borderline malignancy (of low malignant potential) 2 1. 1. 2. 1 Cystic tumour 8442/1 Papillary cystic tumour ...846211 Surface papillary tumour...8463/1 1. 1. 2. 2 1. 1. 2. 3 Adenofibroma; cystadenofibroma 9014/1 1. 1.

With the advent of Assisted Reproductive Technologies, our understanding of the reproductive system in both men and women has progressed in an exponential manner. Along with this increase in knowledge has emerged new and advanced laboratories performing unique techniques aimed at diagnosing and treating infertility problems. And as these laboratories expand, the need for properly trained technicians has also emerged. But while many ART labs are staffed with biologists well trained in reproductive research techniques, they lack the necessary skills to effectively manage these labs. The Handbook of the Assisted Reproduction Laboratory addresses many of the management issues and basic background information on reproductive biology and medicine needed by the technicians staffing and directing these ART labs. Internationally recognized experts in the field discuss various topics in this handbook, which: oReviews male and female reproductive systems and processes oDiscusses the clinical diagnosis and management of male and female infertility oProvides new information on the state-of-the-art techniques of egg and embryo culture, micromanipulation, and biopsy oPresents various aspects of quality control, quality assurance, and clinical laboratory management With its in-depth analysis of management issues, as well as basic background information on reproductive biology and medicine, the Handbook of the Assisted Reproduction Laboratory serves as an ideal guide for current investigation and as a stimulus for future developments in the field.

Holistic pregnancy and childbirth.

Your month-by-month guide to the latest therapies, techniques, and natural approaches.

For the most rewarding path to a comfortable pregnancy, a shorter labor, and the joyful delivery of a healthy baby, turn to this wise and warm compendium of proven holistic advice.

Approved by an advisory board of leaders in obstetrics and holistic medicine, this comprehensive book helps you make the birthing experience the most fulfilling and beautiful of your life. Let the journey begin. Monitor your physical changes and your baby’s. Decide where you want to have your baby. Choose a holistic caregiver and prepare a birth plan. Design your optimum diet and personal exercise program. Discover today’s holistic techniques for bonding, postpartum recovery, breast-feeding, and much more, including:

• Acupuncture and acupressure • aromatherapy • Ayurvedic medicine
• Bach flower remedies • breathing techniques • botanical medicine
• Chiropractic • diet and nutrition • exercise • homeopathy
• Hydrotherapy • hypnosis • intimacy exercises • massage
• Meditation • osteopathy • qigong • traditional Chinese medicine
• Vitamin and mineral therapies • yoga

Since Roe v. Wade, there has been increasing public interest in fetuses, in part as a result of effective antiabortion propaganda and in part as a result of developments in medicine and technology. While feminists have begun to take note of the proliferation of fetal images in various media, such as medical journals, magazines, and motion pictures, few have openly addressed the problems that the emergence of the fetal subject poses for feminism.

Fetal Subjects, Feminist Positions foregrounds feminism's effort to focus on the importance of women's reproductive agency, and at the same time acknowledges the increasing significance of fetal subjects in public discourse and private experience. Essays address the public fascination with the fetal subject and its implications for abortion discourse and feminist commitment to reproductive rights in the United States. Contributors include scholars from fields as diverse as anthropology, communications, political science, sociology, and philosophy.

This timely volume provides scholars and reproductive rights activists a forum for dialogue about fetuses without conceding to a moral or political agenda that would sanctify them at women's expense.

Breast Care: A Clinical Guidebook for Women's Primary Health Care Providers presents the expertise and protocols of the renowned Breast Diagnostic Center at USC School of Medicine's Department of Obstetrics and Gynecology. A user-friendly reference for the primary care physician, this book details the management of both benign and malignant breast diseases. Topics include: * the clinical examination and instruction for self-exam * mammography for both screening and diagnosis, management of the abnormal mammogram * lactation and breast feeding * diagnosis and treatment of lumps, cysts, fibroadenomas * fine-needle aspiration and ultrasound guided tissue core needle biopsy * evaluation and management of mastalgia * menstrual and hormonal therapy effects on the breast * the cosmetically treated breast * guidelines for follow-up and surveillance An important section on consultation and referrals reviews the roles of the radiologist, oncologist, and surgeon and provides the primary care physician with the information necessary to counsel the patient on the myriad aspects of multidisciplinary treatment planning. The text includes more than 100 illustrations and algorithms -- with 16 in color -- as well as "Practice Guides" which organize the key practice points, signs, and symptoms. This is a must-have handbook for all providers of health care to women.

As many as one in ten women experience amenorrhea--the absence of menstrual function in women who have not yet reached menopause--in varying degrees of severity, at some point in their lives. This book offers women guidance and information about a subject that is often difficult to discuss.

As many as one in ten women experience amenorrhea--the absence of menstrual function in women who have not yet reached menopause--in varying degrees of severity, at some point in their lives. This book offers women guidance and information about a subject that is often difficult to discuss.

In June 1998 the Fourth International Workshop on Digital Mammography was held in Nijmegen, The Netherlands, where it was hosted by the department of Radiology of the University Hospital Nijmegen. This series of meetings was initiated at the 1993 SPIE Biomedical Image Processing Conference in San Jose, USA, where a number of sessions were entirely devoted to mammographic image analysis. At very successful subsequent workshops held in York, UK (1994) and Chicago, USA (1996), the scope of the conference was broadened, establishing a platform for presentation and discussion of new developments in digital mammog raphy. Topics that are addressed at these meetings are computer-aided diagnosis, image processing, detector development, system design, observer performance and clinical evaluation. The goal is to bring researchers from universities, breast cancer experts, and engineers together, to exchange information and present new scientific developments in this rapidly evolving field. This book contains all the scientific papers and posters presented at the work shop in Nijmegen. Contributions came from as many as 20 different countries and 190 participants attended the meeting. At a technical exhibit companies demon strated new products and work in progress. Abstracts of all papers were reviewed by members of the scientific committee. Many of the accepted papers had excellent quality, but due to limited space not all of them could be included as full papers in these proceedings. Papers that were rated high by the reviewers are included as long or short papers, others appear as extended abstracts in the last chapter."

Gynaecological textbooks are divided into sections according to pathological diagnoses, not according to symptoms or symptom complexes. Students of gynaecology, because they initially acquire information from textbooks are conditioned by the organisation of these texts to think of gynaecology in terms of pathological entities rather than symptom complexes. Gynaecological patients, however, do not present complaining of endometriosis or endometrial malignancy or hypophyseal-ovarian dysfunction; rather, they present with symptoms such as 'pain low down in the tummy', 'bleeding from the front passage', or 'irregular periods'. This book attempts to help students of gynaecology (including everyone from students learning the subject for the first time, through family doctors, to doctors of all grades) to approach their patients as people as distinct from pathological entities, to listen to them, and to communicate with them. In order to help achieve this, the text is divided according to symptoms or related groups of symptoms. Within each division, pertinent questions are listed in the words that might be used in addressing a patient, followed by a key explaining the significance of the questions and a brief discussion of the problems under consideration. It is hoped that this apPfQach will facilitate the taking and interpretation of case histories, thus aiding differential diagnosis and clinical management, and will initiate the process of self-teaching. The book tries to emphasise that, especially in gynaecology, the same symptom (e. g. , heavy periods) may have a very different significance in different patients in terms of diagnosis and management.

With advances in ultrasound, birth defects are increasingly detected during pregnancy and may be amenable to surgical correction before delivery, to improve outcomes. This essential book discusses the different birth defects that can be treated during pregnancy and the important anesthetic considerations for the mother and fetus undergoing these procedures. Experts in the fields of anesthesiology, maternal fetal medicine, surgery, and pediatrics have come together to develop the content of this book. Enhanced throughout with full color images and illustrations, the book covers important topics such as spina bifida, twin-twin transfusion syndrome, sacrococcygeal teratoma, and lung masses, as well as fetal cardiac intervention, intrauterine transfusion, ex utero intrapartum treatment, and multidisciplinary approaches to fetal surgery. An invaluable guide for pediatric and obstetric anesthesiologists, anesthesiology, obstetrics, and surgical trainees, nurse anesthetists, and maternal-fetal medicine specialists.

This book clarifies and explains perineal anatomy and the pathophysiology of anal incontinence as well as applied pharmacology. It also institutes the new recommended classification of perineal tears, and describes anal sphincter repair techniques. The emphasis is on correct post-operative management, management of pregnancy following previous anal sphincter injury, and prevention of anal sphincter tears. The book will interest students, colorectal surgeons, physiotherapists, midwives, continence advisors, labour wards and lawyers.

A comprehensive, cutting-edge review of the complex interactions between maternal and fetal-placental tissues that control the establishment and maintenance of pregnancy, the proper development of the fetus, the birth process, and the behavioral aspects of bonding between mother and newborn. Expert researchers review the endocrine and physiological events that culminate in the delivery of offspring, and provide a solid base of comparative information on the menstrual cycle of primates, including humans. They also discuss the sources and functions of both steroid and protein hormones from the placenta and the details of their effects on uterine function, placental development, fetal growth and well-being, and maternal responses to pregnancy. This book will become the standard reference source not only for reproductive scientists, but also for those clinicians who want better to understand the complex factors that affect pregnancy-and their pregnant patients.

You Can Feel Good Again A great book, loaded with practical information from an author I love and respect. If Pam Smith said it, I believe it. She's the best!--DR. KEVIN LEMAN, Author of The Birth Order Book and Sex Begins in the KitchenIn When Your Hormones Go Haywire Pam Smith draws on breakthrough research to provide you with proven step-by-step solutions that will help you regain hormonal balance as you choose how to navigate the challenges of midlife. It includes:* Help in deciding how to respond to the latest research on hormone replacement therapy. * Natural solutions for: ? Fatigue ? Weight Gain ? Anxiety ? Hot Flashes ? Irritability ? Low Libido ? Fuzzy Thinking ? Memory Loss ? Insomnia ? Depression ? Headaches ? Achy Joints * A 12 Week Action Plan to achieve hormone balance and nourish yourself, body and soul. * Recipes to help you increase daily energy and feel healthy again. Pam Smith knows that midlife transition can sometimes be tough. In When Your Hormones Go Haywire she helps you discover how it can also be an opportunity for personal growth and renewal, a time in which you emerge as a stronger, healthier woman in every respect.

Given the rapid increase in the worldwide incidence of gestational diabetes, the need for defining the risks and effects associated with raised glucose concentrations in pregnancy is great. Recent large studies are helping to define the risks, as well as identify the benefits of reducing glucose intolerance. Written by an esteemed list of international authors, Gestational Diabetes: Origins, Complications, and Treatment presents timely reviews relating to some of the most important aspects of gestational diabetes, specifically its causes, consequences, and treatments. Divided into five sections, the book begins with a section on metabolism in pregnancy and gestational diabetes, dealing with maternal and foetal glucose metabolism and the controversial area of what actually constitutes gestational diabetes. The next section examines risk factors and causes of gestational diabetes, including the obvious but often overlooked factors-being female and pregnant. The text also outlines environmental and genetic risk factors. The third section deals with the potential complications of gestational diabetes for both mother and offspring, considering short-term and long-term effects. The largest section in the book addresses treatments in an effort to improve the outcome for the mother and the baby. Chapters describe the nutritional approach, considered the cornerstone of treating gestational diabetes, as well as evidence for the role of exercise in its treatment and a useful strategy for treating gestational diabetes pharmacologically. The final section discusses future prospects in screening, diagnosis, prevention, pathophysiology, and treatment of gestational diabetes.

This text provides health care professionals dealing with obstretics and gynaecology with the essentials for meeting the nutritional needs of the patient group. It includes information related to changes in nutritional requirements with pregnancy and lactation, how to assess weight gain, suggestions to meet increased needs for specific nutrients important to the growth of a healthy child, and vitamin/mineral supplementation during preganacy and lactation. Practical suggestions are also given concerning breast feeding and for getting back into shape after delivery.

Chronic Pelvic Pain: Evaluation and Management presents a clinically oriented, multi-disciplinary approach to the diagnosis, treatment, and management of chronic pelvic pain in women -- one of the most common problems encountered in the practice setting. The editors present this challenging and often vexing subject in a practical, user-friendly, highly illustrated text, including chapters on: physiology of pain; pain associated with endometriosis; pain associated with fibroids; surgical management; the role of office based surgery; the role of the psychiatrist in pain management; pelvic pain of urinary origin; pelvic pain of gastrointestinal origin. Designed to be incorporated into the every day practice, this book is a must for all clinicians in obstetrics-gynecology as well as for any physician involved in the health care of women.

How did a magnificent rescue operation become such a common way of giving birth? And how safe is it really? Why do some countries have 10 per cent of caesarian births, and some more than 50 per cent? Why have risky procedures, such as forceps deliveries, not been eliminated by the C-section? What is the birthing pool test? What are the very first microbes met by a caesarean-born baby? Is it easy to breastfeed after a caesarean? Why are different approaches taken to scheduled C-sections, C-sections during labour, and emergency C-sections? What do mother and baby miss out on by not sharing a vaginal birth? What do we know about the long-term consequences of being born by caesarean? What do we know about the long-term consequences of giving birth by caesarean? What is the future of the 'a la carte'C-section? What is the future of a civilisation born by caesarean? Having been involved in half a century of the history of the caesarean, Dr Michel Odent is uniquely and authoritatively equipped to deal with these vital and urgent questions.