This is the first book to cover all aspects of Lagomorph biology. Lagomorphs are a mammalian order which includes rabbits, hares and pikas. They are distributed throughout the world and are of both scientific and public interest as they are classified between endangered and pest species. In addition, some have a high economic value as important game species. In the last few decades, a huge amount of information has been made available to the scientific community that has resulted in remarkable advances on all aspects of Lagomorph biology.

More than 25 years ago, the first major review of primate communication appeared (Altmann, 1967). Since then, information on the communicative abilities of primates increased rapidly, resulting, 15 years later, in the appearance of the first volume in which signaling systems were analyzed in a broader variety of primate groups within an evolutionary perspective (Snowdon, Brown and Petersen, 1982). Seven years later, the first volume dedicated solely to primate vocal communication appeared (Todt, Goedeking and Symmes, 1988) and another four years later a volume followed in which nonverbal vocal communication in non-human primates and human infants was compared (Papousek, Jurgens and Papousek, 1992). None of these volumes, however, provided information about current technical advances in the field of bioacoustics, especially in digital sound analyzing systems, which offer primatologists, anthropologists and linguists nowadays a variety of rapid methods for analyzing human speech and non-human primate vocalizations in a quantitative and comparative way. Choosing the right method is difficult if a synopsis of these tools is lacking. Furthermore, information was particularly lacking on the natural signaling systems of two important primate groups, the prosimians and the apes. Likewise, new and unexpected insights into the ontogeny and evolution of vocal communication were gained during the past few years by the use of highly sophisticated sound analysis and statistical techniques.

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than 50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain."

The ovary is a suitable organ for studying the processes of cell death. Cell death was first described in the rabbit ovary (Graaffian follicles), the phenomenon being called 'chromatolysis'. To date, it is recognized that various forms of cell death (programmed cell death, apoptosis and autophagy) are essential components of ovarian development and function. Programmed cell death is responsable for the ovarian endowment of primordial follicles around birth; in the prepuberal and adult period, apoptosis is a basic mechanism by which oocytes are eliminated by cancer therapies and environmental toxicants; in the ovarian cycle, follicular atresia and luteal regression involve follicular cell apoptosis. Finally, abnormalities in cell death processes may lead to ovarian disease such as cancer and chemoresistance. In this book, after an introductory description of various forms of cell death and of the ovary development and function in mammals, the processes of cell death in ovarian somatic cells and oocytes are described at cytological, physiological and molecular levels and analyzed in the embryonic, prepuberal and adult ovary. A complex array of molecular pathways triggered by extrinsic and intrinsic signals able tor induce or suppress cell death in the same cell, according to cell type and ovary developmental stage, emerges. Physiological interactions with the axis hypothalamus-hypophysis as well as ovarian internal functional signal are also critically reviewed to explain the abortive development of follicles before the beginning of the ovarian cycle. The book conveys information useful to the updating of biologists and physicians who are interested to the ovary biology and functions. Hopefully it should provide also clues for stimulating novel experiments in the study of cell death in the mammalian ovary still at an early stage.

In the 1960s, it was believed that no more than about 4,000 orang-utans remained in the wild. Consequently, IUCN - The World Conservation Union - declared the ape an endangered species, demanding its world-wide protection. Nevertheless, the orang-utan today faces extinction because it is dependent on a rain-forest habitat that is rapidly being demolished due to human greed, and a growing human population. Rijksen was among the first to make a detailed study of the ape in the wild, emerging as an authority on orang-utan conservation. In the late 1980s he became so alarmed by local rumours of the rapid decline of wild orang-utans that he initiated the study leading to this book. Meijaard conducted the ambitious, island-spanning surveys in Borneo and Sumatra to reveal the ape's whereabouts. This is the story of their findings. It is the first comprehensive study of the ape's distribution and status based on a wealth of first-hand field data, and a frank, disturbing account of a mixture of good intentions, ignorance and greed, spelling doom for our Asian relative. Nevertheless, the authors emphasise that the orang-utan can survive. A realistic plan to save the ape, and with it thousands of unique wild animals and plants, does exist. It is the authors' hope that Our Vanishing Relative, so urgent and eloquent in its description of the deadly net of problems descending over our helpless relative, will awaken attention and empathy in order to safeguard the future of the orang-utan.

The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides. The first took place in 1968 in New York [Ann. New York Acad. Sci. (1969), 765,508-819] and the second was held in 1977 in East Lansing, Michigan [eyclitols and Phosphoinositides, Wells, W. W. and Eisenberg, F. , eds. , (1978) Academic press, New York, pp. 1-607. ] In the interim since the previous conference, not only has the pace of research in the field accelerated markedly, but the physiological importance of phosphoinositide metabolism has become apparent to an increasing number of investigators from diverse fields in the life sciences. Thus it seemed to us timely for both recent and established workers in this area, as well as others whose interests impinged on it, to meet in order to disseminate new information, to review, and perhaps arrive at, a consensus of our current understanding of the role of inositol and phosphoinositides, and to establish new directions for research for the next few years. The expansion of the field since the last meeting made it mandatory to restrict the scope of the topics covered at the conference, primarily to aspects dealing with mammalian systems. We sincerely regretted the exclusion of recent research on cyclitols and phosphoinositides in microbes and plants and hope that these areas will be included in future conferences.

First published in 1981, Dynamics of Large Mammal Populations was written by experts from four continents and six countries. It is a collection of papers on the population dynamics of large mammals and was the first synthesis of work in the field. The book helped provide identity and coherence to an emerging field. It has become a much-sought-after book. The theoretical and empirical studies presented demonstrate the ways in which numbers of animals in large mammal populations change over time in response to a variety of factors. The studies cover a wide variety of species - including both terrestrial and marine mammals - and compare the population dynamics of various groups such as herbivores, carnivores, ungulates, cetaceans and pinnipeds. Included are species involved in controversial population management problems. Also covered are advances in managing the populations of large mammals, and advances in the theoretical basis of large mammal population dynamics. Numerous examples detail the interaction of mammals with their ecosystems. Population biologists, wildlife biologists and managers, government researchers, environmentalists and marine mammal scientists can use the information made available here as a basis for comparative research and practical applications. "The book contains an excellent mix of theoretical chapters, general overviews, and studies of specific animal speces, ranging from seals and whales to lions and elephants, taking deer, wolves, and grizzly bears along the way... But to the specialist it will be indispensable, forming as it does the only authoritative volume that deals with the population dynamics of this important group of animals." ORYX Fauna & Flora Preservation Society, July, 1983. "One immediately realizes, by skimming the citations of the different chapters, that the researchers, working on such animals as whales, bears, seals, lions, and elephants had not been talking to one another, and that this book represents something of a first in this regard." Mathematical Biosciences, 1983. "The book will be of particular interest and value to wildlife biologists faced with problems of managing wildlife resources and to people who use the resources." The Quarterly Review of Biology, 1982. "This is an excellent book. One doesn't have to be a population biologist to understand the material. Best of all, the authors are refreshingly frank about areas of ignorance in population biology and the failure of even the best simulaion models to fit the real world... To sum up, there is food for thought in this volume for every zoologist with an interest in population biology and especially for those who study large mammals." BioScience 1982. "In bringing a wealth of research effort to a wider readership, this book cannot fail to stimulate" Biometrics, 1982.

This book fills the gap in the available literature on modelling farm animal systems. This monograph has a broad and comprehensive coverage of ruminant systems and features the application of models in animal biology. It will be of great value to animal scientists, agricultural scientists, modellers and animal physiologists.

Research in whale origins is now in an explosive phase, with a cascade of discoveries adding to our understanding of the evolutionary pattern and a suite of new techniques being applied to address new questions. The objective of this volume is to provide a snapshot of this explosion. The volume paints the scene with a broad brush. Taken together the chapters clearly indicate that cetacean origins is a field that is dynamic, multidisciplinary, and that the end of the explosive phase is not in sight.

Amino acid transport is a part of each of two larger subjects, amino acid metabolism and the biomembrane transport of various . small molecules and ions. Nevertheless in this volume we treat amino acid transport as more than a fragment of either of these two larger subjects. A more comprehensive approach is justified when we remember two historic and ongoing aspects of the title subject. First, amino acid transport had its beginning and acquired a distinct momentum (even if somewhat interrupted from 1913 until about 1945) as amino acid metabolism with the central and pioneer work of Van Slyke and Meyer in 1913. The reviews in this volume will show that it steadily becomes a larger aspect of amino acid metabolism, broadly perceived. These chapters will show for how many organelles, cells, tissues, organs and organ systems, the transmembrane compartmentations and flows of amino acids play very large parts in their fundamental biological relations. The authors here are tending collectively to evaluate an understanding of amino acid flows across biomernbranes, and the regulation of these flows, as necessary to an ultimate understanding of the full range of development and metabolism. Such an understanding goes far beyond the purely substrate-destabilizing contributions by enzymes, which have often been arbitrarily limited to that conceptual entity, "the cell," and which for so long a splendid time had most of biochemical research attention.

It has been twelve years since a work relating to the long-tailed African monkeys known as the guenons has been published and fifteen years have passed since the last major scientific symposium was held that was solely dedicated to current research on members of this monkey group living in the wild. Since that time, new guenon species and subspecies have been discovered, previously unstudied guenon species have become the subject of long-term research projects, and knowledge of the more well-known guenon species has greatly increased. This volume presents novel information and keen insight on research previously studied and newly discovered. A wide range of topics related to guenon biology is presented, including evolution, taxonomy, biogeography, reproductive physiology, social and positional behavior, ecology, and conservation. Composed of 26 chapters compiled by 47 authors, many of whom are young investigators in their field, The Guenons: Diversity and Adaptation in African Monkeys provides a valuable resource for researchers and scientists in the fields of anthropology, primatology, zoology, and conservation biology.

"Planet Without Apes" demands that we consider whether we can live with the consequences of wiping our closest relatives off the face of the Earth. Leading primatologist Craig Stanford warns that extinction of the great apes chimpanzees, bonobos, gorillas, and orangutans threatens to become a reality within just a few human generations. We are on the verge of losing the last links to our evolutionary past, and to all the biological knowledge about ourselves that would die along with them. The crisis we face is tantamount to standing aside while our last extended family members vanish from the planet.

Stanford sees great apes as not only intelligent but also possessed of a culture: both toolmakers and social beings capable of passing cultural knowledge down through generations. Compelled by his field research to take up the cause of conservation, he is unequivocal about where responsibility for extinction of these species lies. Our extermination campaign against the great apes has been as brutal as the genocide we have long practiced on one another. Stanford shows how complicity is shared by people far removed from apes shrinking habitats. We learn about extinction s complex links with cell phones, European meat eaters, and ecotourism, along with the effects of Ebola virus, poverty, and political instability.

Even the most environmentally concerned observers are unaware of many specific threats faced by great apes. Stanford fills us in, and then tells us how we can redirect the course of an otherwise bleak future."

This book challenges the assumption that morphological data are inherently unsuitable for phylogeny reconstruction, argues that both molecular and morphological phylogenies should play a major role in systematics, and provides the most comprehensive review of the comparative anatomy, homologies and evolution of the head, neck, pectoral and upper limb muscles of primates. Chapters 1 and 2 provide an introduction to the main aims and methodology of the book. Chapters 3 and 4 and Appendices I and II present the data obtained from dissections of the head, neck, pectoral and upper limb muscles of representative members of all the major primate groups including modern humans, and compare these data with the information available in the literature. Appendices I and II provide detailed textual (attachments, innervation, function, variations and synonyms) and visual (high quality photographs) information about each muscle for the primate taxa included in the cladistic study of Chapter 3, thus providing the first comprehensive and up to date overview of the comparative anatomy of the head, neck, pectoral and upper limb muscles of primates. The most parsimonious tree obtained from the cladistic analysis of 166 head, neck, pectoral and upper limb muscle characters in 18 primate genera, and in representatives of the Scandentia, Dermoptera and Rodentia, is fully congruent with the evolutionary molecular tree of Primates, thus supporting the idea that muscle characters are particularly useful to infer phylogenies. The combined anatomical materials provided in this book point out that modern humans have fewer head, neck, pectoral and upper limb muscles than most other living primates, but are consistent with the proposal that facial and vocal communication and specialized thumb movements have probably played an important role in recent human evolution. This book will be of interest to primatologists, comparative anatomists, functional morphologists, zoologists, physical anthropologists, and systematicians, as well as to medical students, physicians and researchers interested in understanding the origin, evolution, homology and variations of the muscles of modern humans. Contains 132 color plates.

Environmental conditions change considerably in the course of 24 h with respect to abiotic factors and intra- and interspecific interactions. These changes result in limited time windows of opportunity for animal activities and, hence, the question of when to do what is subject to fitness maximisation. This volume gives a current overview of theoretical considerations and empirical findings of activity patterns in small mammals, a group in which the energetic and ecological constraints are particularly severe and the diversity of activity patterns is particularly high. Following a comparative ecological approach, for the first time activity timing is consequently treated in terms of behavioural and evolutionary ecology, providing the conceptual framework for chronoecology as a new subdiscipline within behavioural ecology. An extensive Appendix gives an introduction to methods of activity modelling and to tools for statistical pattern analysis.

The order Rodentia is the most abundant and successful group of mammals, and it has been a focal point of attention for compar ative and evolutionary biologists for many years. In addition, rodents are the most commonly used experimental mammals for bio medical research, and they have played a central role in investi gations of the genetic and molecular mechanisms of speciation in mammals. During recent decades, a tremendous amount of new data from various aspects of the biology of living and fossil rodents has been accumulated by specialists from different disciplines, ranging from molecular biology to paleontology. Paradoxically, our understanding of the possible evolutionary relationships among different rodent families, as well as the possible affinities of rodents with other eutherian mammals, has not kept pace with this information "explosion. " This abundance of new biological data has not been incorporated into a broad synthesis of rodent phylo geny, in part because of the difficulty for any single student of rodent evolution to evaluate the phylogenetic significance of new findings from such diverse disciplines as paleontology, embryology, comparative anatomy, molecular biology, and cytogenetics. The origin and subsequent radiation of the order Rodentia were based primarily on the acquisition of a key character complex: specializations of the incisors, cheek teeth, and associated mus culoskeletal features of the jaws and skull for gnawing and chewing."

In very general terms, "scaling" can be defined as the structural and func tional consequences of differences in size (or scale) among organisms of more or less similar design. Interest in certain aspects of body size and scaling in primate biology (e. g., relative brain size) dates to the turn of the century, and scientific debate and dialogue on numerous aspects of this general subject have continued to be a primary concern of primatologists, physical an thropologists, and other vertebrate biologists up to the present. Indeed, the intensity and scope of such research on primates have grown enormously in the past decade or so. Information continues to accumulate rapidly from many different sources, and the task of synthesizing the available data and theories on any given topic is becoming increasingly formidable. In addition to the formal exchange of new ideas and information among scientific experts in specific areas of scaling research, two of the major goals of this volume are an assessment of our progress toward understanding various size-related phe nomena in primates and the identification of future prospects for continuing advances in this realm. Although the subject matter and specific details of the issues considered in the 20 chapters that follow are very diversified, all topics share the same fundamental and unifying biological theme: body size variation in primates and its implications for behavior and ecology, anatomy and physiology, and evolution."

This book is a collection of original research papers given at a symposium entitled "Sensory Systems and Behavior of Aquatic Mammals", hosted by the USSR Academy of Sciences. The meeting was held in Moscow from 16 to 25 October, 1991 and involved nearly 100 scientists from around the world. The major headings of the book correspond to the session topics at the symposium. This meeting was not the first dedicated to problems of sensory systems in aquatic mammals. Experts in this field met several times previously to discuss important problems of sensory functions in echolocating animals. symposia on biosonar systems were held in Frascati, Italy in 1966, then in Jersey, France in 1978, and in Helsingor, Denmark in 1986. Papers presented at these meetings were pUblished in books that advanced significantly the understanding of sensory systems (Busnel and Fish, 1980; Nachtigall and Moore, 1988). Initially, echolocating bats were the main subjects of consideration. However, studies on echolocating aquatic mammals, whales and dolphins, increased from one meeting to the next. Indeed, aquatic mammals are of exceptional interest for studying the adaptation of sensory functions for echolocation in specific aquatic environments. As a natural consequence of these developments, the 1989 symposium in Rome was devoted specifically to the sensory systems of cetaceans (Thomas and Kastelein, 1990). This symposium was held within the Fifth International Theriological Congress and was attended by many scientists.

This book describes the major steps by which the mammalian ear transforms sound into nerve impulses. The author leads us along the pathway followed by an acoustic signal--collected by the outer ear, augmented by the middle ear, then delivered to the inner ear where the minuscule vibrations of the sound waves are transformed into nerve impulses. At each stage, the basic mechanisms are described qualitatively in terms of current theories and illustrated with experimental data. Where appropriate, related mechanisms in the ears of other vertebrates are considered. It is shown that the mammalian ear does an exquisite job of translating sound signals into a very robust nerve-pulse code. The book concludes with descriptions of some common ear impairments and a brief survey of the treatments available for them. The text is integrated with animations of mechanical and neural phenomena available through the Internet.

The Springer Handbook oj Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modern auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focuses on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. Each volume in the series consists of five to eight substantial chapters on a particular topic. In some cases, the topics will be ones of traditional interest for which there is a solid body of data and theory, such as auditory neuroanatomy (Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series will deal with topics which have begun to mature more recently, such as development, plasticity, and computational models of neural processing."

The cerebral neocortex, a structure unique to the mammalian brain and prerequisite for higher cognitive functions, has since decades attracted the curiosity of neurobiologists and developmental biologists alike. This volume gives a comprehensive and up-to-date overview of early cortical development. It provides concise information on the birth, specification, migration and terminal differentiation of neocortical cells. Both the cellular and molecular events leading to the establishment of a functional neocortex are presented in considerable detail, and possible implications for neurodegenerative diseases are discussed.

It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.

'Brilliant, eye-opening, and absolutely inspiring - and a riveting read.' Cass Sunstein, author of How Change Happens and co-author of Nudge What is the secret to humanity's evolutionary success? Could it be our strength, our intellect... or something much nicer? From the authors of New York Times bestseller The Genius of Dogs comes a powerful new idea about how 'friendliness' is the key factor in the flourishing of our species. Hare and Woods present an elegant new theory called self-domestication, looking at examples of co-operation and empathy and what this can tell us about the evolutionary success of Homo sapiens...

‘Steve Brusatte, the author of The Rise and Fall of the Dinosaurs, brings mammals out from the shadow of their more showy predecessors in a beautifully written book that . . . makes the case for them as creatures who are just as engaging as dinosaurs.’ – The Sunday Times, ‘Best Books For Summer’ 'In this terrific new book, Steve Brusatte . . . brings well-known extinct species, the sabre-toothed tigers and the woolly mammoths, thrillingly back to life' – The Times The passing of the age of the dinosaurs allowed mammals to become ascendant. But mammals have a much deeper history. They – or, more precisely, we – originated around the same time as the dinosaurs, over 200 million years ago; mammal roots lie even further back, some 325 million years. Over these immense stretches of geological time, mammals developed their trademark features: hair, keen senses of smell and hearing, big brains and sharp intelligence, fast growth and warm-blooded metabolism, a distinctive line-up of teeth (canines, incisors, premolars, molars), mammary glands that mothers use to nourish their babies with milk, qualities that have underlain their success story. Out of this long and rich evolutionary history came the mammals of today, including our own species and our closest cousins. But today’s 6,000 mammal species - the egg-laying monotremes including the platypus, marsupials such as kangaroos and koalas that raise their tiny babies in pouches, and placentals like us, who give birth to well-developed young – are simply the few survivors of a once verdant family tree, which has been pruned both by time and mass extinctions. In The Rise and Reign of the Mammals, palaeontologist Steve Brusatte weaves together the history and evolution of our mammal forebears with stories of the scientists whose fieldwork and discoveries underlie our knowledge, both of iconic mammals like the mammoths and sabre-toothed tigers of which we have all heard, and of fascinating species that few of us are aware of. For what we see today is but a very limited range of the mammals that have existed; in this fascinating and ground-breaking book, Steve Brusatte tells their – and our – story.