This book highlights recent advances in the field of districting, territory design, and zone design. Districting problems deal essentially with tactical decisions, and involve mainly dividing a set of geographic units into clusters or territories subject to some planning requirements. This book presents models, theory, algorithms (exact or heuristic), and applications that would bring research on districting systems up-to-date and define the state-of-the-art. Although papers have addressed real-world problems that require districting or territory division decisions, this is the first comprehensive book that directly addresses these problems. The chapters capture the diverse nature of districting applications, as the book is divided into three different areas of research. Part I covers recent up-to-date surveys on important areas of districting such as police districting, health care districting, and districting algorithms based on computational geometry. Part II focuses on recent advances on theory, modeling, and algorithms including mathematical programming and heuristic approaches, and finally, Part III contains successful applications in real-world districting cases.

The aim of the book is to present side-by-side representative and cutting-edge samples of work in mathematical psychology and the analytic philosophy with prominent use of mathematical formalisms.

See also GEOMETRIC MECHANICS - Part II: Rotating, Translating and Rolling (2nd Edition) This textbook introduces the tools and language of modern geometric mechanics to advanced undergraduates and beginning graduate students in mathematics, physics and engineering. It treats the fundamental problems of dynamical systems from the viewpoint of Lie group symmetry in variational principles. The only prerequisites are linear algebra, calculus and some familiarity with Hamilton's principle and canonical Poisson brackets in classical mechanics at the beginning undergraduate level.The ideas and concepts of geometric mechanics are explained in the context of explicit examples. Through these examples, the student develops skills in performing computational manipulations, starting from Fermat's principle, working through the theory of differential forms on manifolds and transferring these ideas to the applications of reduction by symmetry to reveal Lie-Poisson Hamiltonian formulations and momentum maps in physical applications.The many Exercises and Worked Answers in the text enable the student to grasp the essential aspects of the subject. In addition, the modern language and application of differential forms is explained in the context of geometric mechanics, so that the importance of Lie derivatives and their flows is clear. All theorems are stated and proved explicitly.The organisation of the first edition has been preserved in the second edition. However, the substance of the text has been rewritten throughout to improve the flow and to enrich the development of the material. In particular, the role of Noether's theorem about the implications of Lie group symmetries for conservation laws of dynamical systems has been emphasised throughout, with many applications.

See also GEOMETRIC MECHANICS - Part II: Rotating, Translating and Rolling (2nd Edition) This textbook introduces the tools and language of modern geometric mechanics to advanced undergraduates and beginning graduate students in mathematics, physics and engineering. It treats the fundamental problems of dynamical systems from the viewpoint of Lie group symmetry in variational principles. The only prerequisites are linear algebra, calculus and some familiarity with Hamilton's principle and canonical Poisson brackets in classical mechanics at the beginning undergraduate level.The ideas and concepts of geometric mechanics are explained in the context of explicit examples. Through these examples, the student develops skills in performing computational manipulations, starting from Fermat's principle, working through the theory of differential forms on manifolds and transferring these ideas to the applications of reduction by symmetry to reveal Lie-Poisson Hamiltonian formulations and momentum maps in physical applications.The many Exercises and Worked Answers in the text enable the student to grasp the essential aspects of the subject. In addition, the modern language and application of differential forms is explained in the context of geometric mechanics, so that the importance of Lie derivatives and their flows is clear. All theorems are stated and proved explicitly.The organisation of the first edition has been preserved in the second edition. However, the substance of the text has been rewritten throughout to improve the flow and to enrich the development of the material. In particular, the role of Noether's theorem about the implications of Lie group symmetries for conservation laws of dynamical systems has been emphasised throughout, with many applications.

Simulation-Based Engineering and Science (SBE&S) cuts across disciplines, showing tremendous promise in areas from storm prediction and climate modeling to understanding the brain and the behavior of numerous other complex systems.In this groundbreaking volume, nine distinguished leaders assess the latest research trends, as a result of 52 site visits in Europe and Asia and hundreds of hours of expert interviews, and discuss the implications of their findings for the US government.The authors conclude that while the US remains the quantitative leader in SBE&S research and development, it is very much in danger of losing that edge to Europe and Asia.Commissioned by the National Science Foundation, this multifaceted study will capture the attention of Fortune 500 companies and policymakers.Distinguished contributors: Sharon C Goltzer, University of Michigan, Ann Arbor, USA Sangtae Kim, Morgridge Institute for Research, USA Peter T Cummings, Vanderbilt University, USA and Oak Ridge National Laboratory, USA Abhijit Deshmukh, Texas A&M University, USA Martin Head-Gordon, University of California, Berkeley, USA George Em Karniadakis, Brown University, USA Linda Petzold, University of California, Santa Barbara, USA Celeste Sagui, North Carolina State University, USA Masanobu Shinozuka, University of California, Irvine, USA

From the spontaneous rapid firing of cortical neurons to the spatial diffusion of disease epidemics, biological systems exhibit rich dynamic behaviour over a vast range of time and space scales. Unifying many of these diverse phenomena, Dynamics of Biological Systems provides the computational and mathematical platform from which to understand the underlying processes of the phenomena. Through an extensive tour of various biological systems, the text introduces computational methods for simulating spatial diffusion processes in excitable media, such as the human heart, as well as mathematical tools for dealing with systems of nonlinear ordinary and partial differential equations, such as neuronal activation and disease diffusion. The mathematical models and computer simulations offer insight into the dynamics of temporal and spatial biological systems, including cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behaviour, the interaction of autonomous agents, and hierarchical and structured network topologies. Tools from complex systems and complex networks are also presented for dealing with real phenomenological systems. With exercises and projects in each chapter, this classroom-tested text shows students how to apply a variety of mathematical and computational techniques to model and analyze the temporal and spatial phenomena of biological systems. MATLAB (R) implementations of algorithms and case studies are available on the author's website.

A ubiquitous tool in mathematical biology and chemical engineering, the chemostat often produces instabilities that pose safety hazards and adversely affect the optimization of bioreactive systems. Singularity theory and bifurcation diagrams together offer a useful framework for addressing these issues. Based on the authors' extensive work in this field, Dynamics of the Chemostat: A Bifurcation Theory Approach explores the use of bifurcation theory to analyze the static and dynamic behavior of the chemostat.

Introduction
The authors first survey the major work that has been carried out on the stability of continuous bioreactors. They next present the modeling approaches used for bioreactive systems, the different kinetic expressions for growth rates, and tools, such as multiplicity, bifurcation, and singularity theory, for analyzing nonlinear systems.

Application
The text moves on to the static and dynamic behavior of the basic unstructured model of the chemostat for constant and variable yield coefficients as well as in the presence of wall attachment. It then covers the dynamics of interacting species, including pure and simple microbial competition, biodegradation of mixed substrates, dynamics of plasmid-bearing and plasmid-free recombinant cultures, and dynamics of predator-prey interactions. The authors also examine dynamics of the chemostat with product formation for various growth models, provide examples of bifurcation theory for studying the operability and dynamics of continuous bioreactor models, and apply elementary concepts of bifurcation theory to analyze the dynamics of a periodically forced bioreactor.

Using singularity theory and bifurcation techniques, this book presents a cohesive mathematical framework for analyzing and modeling the macro- and microscopic interactions occurring in chemostats. The text includes models that describe the intracellular and operating elements of the bioreactive system. It also explains the mathematical theory behind the models.

This book is a collection of articles, some introductory, some extended surveys, and some containing previously unpublished research, on a range of topics linking infinite permutation group theory and model theory. Topics covered include: oligomorphic permutation groups and omega-categorical structures; totally categorical structures and covers; automorphism groups of recursively saturated structures; Jordan groups; Hrushovski's constructions of pseudoplanes; permutation groups of finite Morley rank; applications of permutation group theory to models of set theory without the axiom of choice. There are introductory chapters by the editors on general model theory and permutation theory, recursively saturated structures, and on groups of finite Morley rank. The book is almost self-contained, and should be useful to both a beginning postgraduate student meeting the subject for the first time, and to an active researcher from either of the two main fields looking for an overview of the subject.

This volume contains the selected contributed papers of the BIOMAT 2010 International Symposium which has been organized as a joint conference with the 2010 Annual Meeting of the Society for Mathematical Biology (http: //www.smb.org) by invitation of the Director Board of this Society. The works presented at Tutorial and Plenary Sessions by expert keynote speakers have been also been included.

This book contains state-of-the-art articles on special research topics on mathematical biology, biological physics and mathematical modelling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and sufficiently advanced to enhance future scientific research.

This monograph has the ambitious aim of developing a mathematical theory of complex biological systems with special attention to the phenomena of ageing, degeneration and repair of biological tissues under individual self-repair actions that may have good potential in medical therapy. The approach to mathematically modeling biological systems needs to tackle the additional difficulties generated by the peculiarities of living matter. These include the lack of invariance principles, abilities to express strategies for individual fitness, heterogeneous behaviors, competition up to proliferative and/or destructive actions, mutations, learning ability, evolution and many others. Applied mathematicians in the field of living systems, especially biological systems, will appreciate the special class of integro-differential equations offered here for modeling at the molecular, cellular and tissue scales. A unique perspective is also presented with a number of case studies in biological modeling.

This book Algebraic Modeling Systems - Modeling and Solving Real World Optimization Problems - deals with the aspects of modeling and solving real-world optimization problems in a unique combination. It treats systematically the major algebraic modeling languages (AMLs) and modeling systems (AMLs) used to solve mathematical optimization problems. AMLs helped significantly to increase the usage of mathematical optimization in industry. Therefore it is logical consequence that the GOR (Gesellschaft fur Operations Research) Working Group Mathematical Optimization in Real Life had a second meeting devoted to AMLs, which, after 7 years, followed the original 71st Meeting of the GOR (Gesellschaft fur Operations Research) Working Group Mathematical Optimization in Real Life which was held under the title Modeling Languages in Mathematical Optimization during April 23-25, 2003 in the German Physics Society Conference Building in Bad Honnef, Germany. While the first meeting resulted in the book Modeling Languages in Mathematical Optimization, this book is an offspring of the 86th Meeting of the GOR working group which was again held in Bad Honnef under the title Modeling Languages in Mathematical Optimization.

This book introduces the method of lower and upper solutions for ordinary differential equations. This method is known to be both easy and powerful to solve second order boundary value problems. Besides an extensive introduction to the method, the first half of the book describes some recent and more involved results on this subject. These concern the combined use of the method with degree theory, with variational methods and positive operators. The second half of the book concerns applications. This part exemplifies the method and provides the reader with a fairly large introduction to the problematic of boundary value problems. Although the book concerns mainly ordinary differential equations, some attention is given to other settings such as partial differential equations or functional differential equations. A detailed history of the problem is described in the introduction.
- Presents the fundamental features of the method
- Construction of lower and upper solutions in problems
- Working applications and illustrated theorems by examples
- Description of the history of the method and Bibliographical notes

Mathematics for the Environment shows how to employ simple mathematical tools, such as arithmetic, to uncover fundamental conflicts between the logic of human civilization and the logic of Nature. These tools can then be used to understand and effectively deal with economic, environmental, and social issues. With elementary mathematics, the book seeks answers to a host of real-life questions, including: * How safe is our food and will it be affordable in the future? * What are the simple lessons to be learned from the economic meltdown of 2008-2009? * Is global climate change happening? * Were some humans really doing serious mathematical thinking 50,000 years ago? * What does the second law of thermodynamics have to do with economics? * How can identity theft be prevented? * What does a mathematical proof prove? A truly interdisciplinary, concrete study of mathematics, this classroom-tested text discusses the importance of certain mathematical principles and concepts, such as fuzzy logic, feedback, deductive systems, fractions, and logarithms, in various areas other than pure mathematics. It teaches students how to make informed choices using fundamental mathematical tools, encouraging them to find solutions to critical real-world problems.

Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to commercialization. It presents the theories and methods needed to carry out computer simulations efficiently, covers both descriptive and pseudocode algorithms that provide the basis for implementation of the simulation methods, and illustrates real-world problems through case studies. The text first emphasizes the importance of analogy and simulation using examples from a variety of areas, before introducing general sampling methods and the different stages of drug development. It then focuses on simulation approaches based on game theory and the Markov decision process, simulations in classical and adaptive trials, and various challenges in clinical trial management and execution. The author goes on to cover prescription drug marketing strategies and brand planning, molecular design and simulation, computational systems biology and biological pathway simulation with Petri nets, and physiologically based pharmacokinetic modeling and pharmacodynamic models. The final chapter explores Monte Carlo computing techniques for statistical inference. This book offers a systematic treatment of computer simulation in drug development. It not only deals with the principles and methods of Monte Carlo simulation, but also the applications in drug development, such as statistical trial monitoring, prescription drug marketing, and molecular docking.

This book introduces readers to the principles of laser interaction with biological cells and tissues with varying degrees of organization. In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field. It discusses a range of mathematical modeling topics, including optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers; heating blood vessels using laser irradiation on the outer surface of the skin; and thermo-chemical denaturation of biological structures based on the example of human skin. In this second edition, a new electrodynamic model of the interaction of laser radiation with blood cells is presented for the structure of cells and the in vitro prediction of optical properties. The approach developed makes it possible to determine changes in cell size as well as modifications in their internal structures, such as transformation and polymorphism nucleus scattering, which is of interest for cytological studies. The new model is subsequently used to calculate the size distribution function of irregular-shape particles with a variety of forms and structures, which allows a cytological analysis of the observed deviations from normal cells.

This book covers a wide range of topics within mathematical modelling and the optimization of economic, demographic, technological and environmental phenomena. Each chapter is written by experts in their field and represents new advances in modelling theory and practice. These essays are exemplary of the fruitful interaction between theory and practice when exploring global and local changes.

The unifying theme of the book is the use of mathematical models and optimization methods to describe age-structured populations in economy, demography, technological change, and the environment. Emphasis is placed on deterministic dynamic models that take age or size structures, delay effects, and non-standard decision variables into account. In addition, the contributions deal with the age structure of assets, resources, and populations under study. Interdisciplinary modelling has enormous potential for discovering new insights in global and regional development.

Optimal Control of Age-structured Populations in Economy, Demography, and the Environment is a rich and excellent source of information on state-of-the-art modelling expertise and references. The book provides the necessary mathematical background for readers from different areas, such as applied sciences, management sciences and operations research, which helps guide the development of practical models. As well as this the book also surveys the current practice in applied modelling and looks at new research areas for a general mathematical audience. This book will be of interest primarily to researchers, postgraduate students, as well as a wider scientific community, including those focussing on the subjects of applied mathematics, environmental sciences, economics, demography, management, and operations research.

Complex Analysis with Applications to Flows and Fields presents the theory of functions of a complex variable, from the complex plane to the calculus of residues to power series to conformal mapping. The book explores numerous physical and engineering applications concerning potential flows, the gravity field, electro- and magnetostatics, steady heat conduction, and other problems. It provides the mathematical results to sufficiently justify the solution of these problems, eliminating the need to consult external references. The book is conveniently divided into four parts. In each part, the mathematical theory appears in odd-numbered chapters while the physical and engineering applications can be found in even-numbered chapters. Each chapter begins with an introduction or summary and concludes with related topics. The last chapter in each section offers a collection of many detailed examples. This self-contained book gives the necessary mathematical background and physical principles to build models for technological and scientific purposes. It shows how to formulate problems, justify the solutions, and interpret the results.

This is the first book to comprehensively discuss and synthesize the emerging field of dynamic modeling, i.e. the analysis and application of population models that have changing vital rates. Incorporating the latest research, it includes thorough discussions of population growth and momentum under gradual fertility declines, the impact of changes in the timing of events on fertility measures, and the complex relationship between period and cohort measures. Recently developed models for the analysis of changing mortality are examined, generalizations of Lotka's fixed rate stable population model are developed and applied. The book is well organized and is accessible to those with only a minimal knowledge of calculus. It begins with a review of fixed rate population models, from the basic life table to multistate stable populations. The process of convergence to stability is described, and the regularities underlying change in the size and composition of any population are explored.

This book contains a selection of revised and extended research articles written by prominent researchers participating in the 27th World Congress on Engineering and Computer Science (WCECS 2019) which was held in San Francisco, USA, on October 22-24, 2019. Topics covered include engineering mathematics, electrical engineering, communications systems, computer science, chemical engineering, systems engineering, manufacturing engineering, and industrial applications. With contributions carefully chosen to represent the most cutting-edge research presented during the conference, the book contains some of the state-of-the-art in engineering technologies and the physical sciences and their applications and serves as a useful reference for researchers and graduate students working in these fields.

Describing novel mathematical concepts for recommendation engines, Realtime Data Mining: Self-Learning Techniques for Recommendation Engines features a sound mathematical framework unifying approaches based on control and learning theories, tensor factorization, and hierarchical methods. Furthermore, it presents promising results of numerous experiments on real-world data. The area of realtime data mining is currently developing at an exceptionally dynamic pace, and realtime data mining systems are the counterpart of today's "classic" data mining systems. Whereas the latter learn from historical data and then use it to deduce necessary actions, realtime analytics systems learn and act continuously and autonomously. In the vanguard of these new analytics systems are recommendation engines. They are principally found on the Internet, where all information is available in realtime and an immediate feedback is guaranteed. This monograph appeals to computer scientists and specialists in machine learning, especially from the area of recommender systems, because it conveys a new way of realtime thinking by considering recommendation tasks as control-theoretic problems. Realtime Data Mining: Self-Learning Techniques for Recommendation Engines will also interest application-oriented mathematicians because it consistently combines some of the most promising mathematical areas, namely control theory, multilevel approximation, and tensor factorization.

This handbook provides a comprehensive overview of Partial Least Squares (PLS) methods with specific reference to their use in marketing and with a discussion of the directions of current research and perspectives. It covers the broad area of PLS methods, from regression to structural equation modeling applications, software and interpretation of results. The handbook serves both as an introduction for those without prior knowledge of PLS and as a comprehensive reference for researchers and practitioners interested in the most recent advances in PLS methodology.

Approaches to the recovery of three-dimensional information on a biological object, which are often formulated or implemented initially in an intuitive way, are concisely described here based on physical models of the object and the image-formation process. Both three-dimensional electron microscopy and X-ray tomography can be captured in the same mathematical framework, leading to closely-related computational approaches, but the methodologies differ in detail and hence pose different challenges. The editors of this volume, Gabor T. Herman and Joachim Frank, are experts in the respective methodologies and present research at the forefront of biological imaging and structural biology. Computational Methods for Three-Dimensional Microscopy Reconstruction will serve as a useful resource for scholars interested in the development of computational methods for structural biology and cell biology, particularly in the area of 3D imaging and modeling.

The human brain is made up of 85 billion neurons, which are connected by over 100 trillion synapses. For more than a century, a diverse array of researchers searched for a language that could be used to capture the essence of what these neurons do and how they communicate. The language they were looking for was mathematics, and we would not be able to understand the brain as we do today without it. In Models of the Mind, author and computational neuroscientist Grace Lindsay explains how mathematical models have allowed scientists to understand and describe many of the brain's processes. She introduces readers to the most important concepts in modern neuroscience, and highlights the tensions that arise when the abstract world of mathematical modelling collides with the messy details of biology. Each chapter of Models of the Mind focuses on mathematical tools that have been applied in a particular area of neuroscience, progressing from the simplest building block of the brain - the individual neuron - through to circuits of interacting neurons, whole brain areas and even the behaviours that brains command. Grace examines the history of the field, starting with experiments done on frog legs in the late eighteenth century and building to the large models of artificial neural networks that form the basis of modern artificial intelligence. Throughout, she reveals the value of using the elegant language of mathematics to describe the machinery of neuroscience.

Examines dynamic models, and how time is fundamental to the structure of the model and data as well as the understanding of how a process unfolds Discusses mathematical modeling with soft computing and the implementations of uncertain mathematical models Examines how uncertain dynamic systems models include uncertain state, uncertain state space and uncertain state's transition functions Assists readers to become familiar with many soft numerical methods to simulate the solution function's behavior

This volume provides recent developments and a state-of-the-art review in various areas of mathematical modeling, computation and optimization. It contains theory, computation as well as the applications of several mathematical models to problems in statistics, games, optimization and economics for decision making. It focuses on exciting areas like models for wireless networks, models of Nash networks, dynamic models of advertising, application of reliability models in economics, support vector machines, optimization, complementarity modeling and games.