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Books > Science & Mathematics > Mathematics > Applied mathematics > Mathematical modelling

Geostatistical Reservoir Modeling (Hardcover, 2nd Revised edition): Michael J. Pyrcz, Clayton V. Deutsch Geostatistical Reservoir Modeling (Hardcover, 2nd Revised edition)
Michael J. Pyrcz, Clayton V. Deutsch
R3,651 Discovery Miles 36 510 Ships in 10 - 15 working days

Published in 2002, the first edition of Geostatistical Reservoir Modeling brought the practice of petroleum geostatistics into a coherent framework, focusing on tools, techniques, examples, and guidance. It emphasized the interaction between geophysicists, geologists, and engineers, and was received well by professionals, academics, and both graduate and undergraduate students. In this revised second edition, Deutsch collaborates with co-author Michael Pyrcz to provide a full update on the latest tools, methods, practice, and research in the field of petroleum Geostatistics. Key geostatistical concepts such as integration of production data, scale-up, and cosimulation receive greater attention, and new topics like model checking, multiple point simulation, and production data integration are included in detail. Geostatistical methods are extensively illustrated through enhanced schematics, work flows and examples. A greater number of examples also are included, such as the integration of a single geostatistical study developed from data analysis and cleaning to post-processing, ranking and flow simulation. New methods, which have developed in the field since the publication of the first edition, are discussed, such as models for integration of diverse data sources, surface-based, advanced object-based, event-based and multiple point-based simulation, and spatial boot-strap.

Discrete and Continuous Simulation - Theory and Practice (Hardcover): Susmita Bandyopadhyay, Ranjan Bhattacharya Discrete and Continuous Simulation - Theory and Practice (Hardcover)
Susmita Bandyopadhyay, Ranjan Bhattacharya
R6,339 Discovery Miles 63 390 Ships in 10 - 15 working days

When it comes to discovering glitches inherent in complex systems-be it a railway or banking, chemical production, medical, manufacturing, or inventory control system-developing a simulation of a system can identify problems with less time, effort, and disruption than it would take to employ the original. Advantageous to both academic and industrial practitioners, Discrete and Continuous Simulation: Theory and Practice offers a detailed view of simulation that is useful in several fields of study. This text concentrates on the simulation of complex systems, covering the basics in detail and exploring the diverse aspects, including continuous event simulation and optimization with simulation. It explores the connections between discrete and continuous simulation, and applies a specific focus to simulation in the supply chain and manufacturing field. It discusses the Monte Carlo simulation, which is the basic and traditional form of simulation. It addresses future trends and technologies for simulation, with particular emphasis given to .NET technologies and cloud computing, and proposes various simulation optimization algorithms from existing literature. Includes chapters on input modeling and hybrid simulation Introduces general probability theory Contains a chapter on Microsoft (R) Excel (TM) and MATLAB (R)/Simulink (R) Discusses various probability distributions required for simulation Describes essential random number generators Discrete and Continuous Simulation: Theory and Practice defines the simulation of complex systems. This text benefits academic researchers in industrial/manufacturing/systems engineering, computer sciences, operations research, and researchers in transportation, operations management, healthcare systems, and human-machine systems.

Introduction to Numerical Geodynamic Modelling (Hardcover): Taras Gerya Introduction to Numerical Geodynamic Modelling (Hardcover)
Taras Gerya
R2,175 Discovery Miles 21 750 Ships in 10 - 15 working days

Numerical modelling of geodynamic processes was predominantly the domain of high-level mathematicians experienced in numerical and computational techniques. Now, for the first time, students and new researchers in the Earth Sciences can learn the basic theory and applications from a single, accessible reference text. Assuming only minimal prerequisite mathematical training (simple linear algebra and derivatives) the author provides a solid grounding in basic mathematical theory and techniques, including continuum mechanics and partial differential equations, before introducing key numerical and modelling methods. 8 well-documented, state-of-the-art visco-elasto-plastic, 2-D models are then presented, which allow robust modelling of key dynamic processes such as subduction, lithospheric extension, collision, slab break-off, intrusion emplacement, mantle convection and planetary core formation. Incorporating 47 practical exercises and 67 MATLAB examples (for which codes are available online at www.cambridge.org/gerya), this textbook provides a user-friendly introduction for graduate courses or self-study, encouraging readers to experiment with geodynamic models.

Challenges in Fluid Dynamics - A New Approach (Hardcover, 1st ed. 2017): R. Kh Zeytounian Challenges in Fluid Dynamics - A New Approach (Hardcover, 1st ed. 2017)
R. Kh Zeytounian
R3,803 Discovery Miles 38 030 Ships in 18 - 22 working days

This monograph presents a synopsis of fluid dynamics based on the personal scientific experience of the author who has contributed immensely to the field. The interested reader will also benefit from the general historical context in which the material is presented in the book. The book covers a wide range of relevant topics of the field, and the main tool being rational asymptotic modelling (RAM) approach. The target audience primarily comprises experts in the field of fluid dynamics, but the book may also be beneficial for graduate students.

Computational Models for CO2 Geo-sequestration & Compressed Air Energy Storage (Hardcover): Rafid Al-Khoury, Jochen Bundschuh Computational Models for CO2 Geo-sequestration & Compressed Air Energy Storage (Hardcover)
Rafid Al-Khoury, Jochen Bundschuh
R7,936 Discovery Miles 79 360 Ships in 10 - 15 working days

A comprehensive mathematical and computational modeling of CO2 Geosequestration and Compressed Air Energy Storage

Energy and environment are two interrelated issues of great concern to modern civilization. As the world population will soon reach eight billion, the demand for energy will dramatically increase, intensifying the use of fossil fuels. Utilization of fossil fuels is by far the largest anthropogenic source of CO2 emission into the earth s atmosphere. This unavoidable reality necessitates efforts to mitigate CO2 from indefi nitely being emitted in the atmosphere. CO2 geo-sequestration is currently considered to be a vital technology for this purpose. Meanwhile, and as fossil fuels will sooner or later be depleted, utilization of renewable energy resources is inevitable. Nowadays, wind and solar energy, being clean and sustainable, are gaining momentum. However, their availability is intermittent. This intermittent nature of solar and wind energy necessitates storing the produced energy at off-peak times for later use. Compressed air energy storage in subterranean caverns, aquifers and coal seams is currently considered to be a plausible technology for this purpose. CO2 geo-sequestration and compressed air energy storage are thus vital technologies for current and future energy strategy development. These technologies can be made safe and cost-effective by utilizing computational tools capable of simulating the involved multiphysical phenomena and processes. Computational modeling of such systems is challenging and resource-consuming. Meeting such a challenge constitutes the focal point of this book.

This book addresses comprehensive theoretical and computational modeling aspects of CO2 geosequestration and compressed air energy storage. The book consists of 16 chapters authored by prominent researchers in these two fi elds. The authors of the book endeavoured to present years of innovative work, making it available for a wide range of readers, including geoscientists, poromechanists, applied mathematicians, computational geoscientists, geologists and reservoir engineers."

Introduction to Continuous Optimization (Hardcover, 1st ed. 2021): Roman A. Polyak Introduction to Continuous Optimization (Hardcover, 1st ed. 2021)
Roman A. Polyak
R3,701 Discovery Miles 37 010 Ships in 10 - 15 working days

This self-contained monograph presents the reader with an authoritative view of Continuous Optimization, an area of mathematical optimization that has experienced major developments during the past 40 years. The book contains results which have not yet been covered in a systematic way as well as a summary of results on NR theory and methods developed over the last several decades. The readership is aimed to graduate students in applied mathematics, computer science, economics, as well as researchers working in optimization and those applying optimization methods for solving real life problems. Sufficient exercises throughout provide graduate students and instructors with practical utility in a two-semester course in Continuous Optimization. The topical coverage includes interior point methods, self-concordance theory and related complexity issues, first and second order methods with accelerated convergence, nonlinear rescaling (NR) theory and exterior point methods, just to mention a few. The book contains a unified approach to both interior and exterior point methods with emphasis of the crucial duality role. One of the main achievements of the book shows what makes the exterior point methods numerically attractive and why. The book is composed in five parts. The first part contains the basics of calculus, convex analysis, elements of unconstrained optimization, as well as classical results of linear and convex optimization. The second part contains the basics of self-concordance theory and interior point methods, including complexity results for LP, QP, and QP with quadratic constraint, semidefinite and conic programming. In the third part, the NR and Lagrangian transformation theories are considered and exterior point methods are described. Three important problems in finding equilibrium are considered in the fourth part. In the fifth and final part of the book, several important applications arising in economics, structural optimization, medicine, statistical learning theory, and more, are detailed. Numerical results, obtained by solving a number of real life and test problems, are also provided.

Qualitative Mathematics for the Social Sciences - Mathematical Models for Research on Cultural Dynamics (Paperback): Jaan... Qualitative Mathematics for the Social Sciences - Mathematical Models for Research on Cultural Dynamics (Paperback)
Jaan Valsiner; Edited by Lee Rudolph
R1,699 Discovery Miles 16 990 Ships in 10 - 15 working days

In this book Lee Rudolph brings together international contributors who combine psychological and mathematical perspectives to analyse how qualitative mathematics can be used to create models of social and psychological processes. Bridging the gap between the fields with an imaginative and stimulating collection of contributed chapters, the volume updates the current research on the subject, which until now has been rather limited, focussing largely on the use of statistics.

Qualitative Mathematics for the Social Sciences contains a variety of useful illustrative figures, introducing readers from the social sciences to the rich contribution that modern mathematics has made to our knowledge of logic, structures, and dynamic systems. A beguiling array of conceptual systems, topological models and fractals are discussed which transcend the application of statistics, and bring a fresh perspective to the study of social representations.

The wide selection of qualitative mathematical methodologies discussed in this volume will be hugely valuable to higher-level undergraduate and postgraduate students of psychology, sociology and mathematics. It will also be useful for researchers, academics and professionals from the social sciences who want a firmer grasp on the use of qualitative mathematics.

Modeling and Inverse Problems in the Presence of Uncertainty (Hardcover): H.T. Banks, Shuhua Hu, W. Clayton Thompson Modeling and Inverse Problems in the Presence of Uncertainty (Hardcover)
H.T. Banks, Shuhua Hu, W. Clayton Thompson
R5,776 Discovery Miles 57 760 Ships in 10 - 15 working days

Modeling and Inverse Problems in the Presence of Uncertainty collects recent research-including the authors' own substantial projects-on uncertainty propagation and quantification. It covers two sources of uncertainty: where uncertainty is present primarily due to measurement errors and where uncertainty is present due to the modeling formulation itself. After a useful review of relevant probability and statistical concepts, the book summarizes mathematical and statistical aspects of inverse problem methodology, including ordinary, weighted, and generalized least-squares formulations. It then discusses asymptotic theories, bootstrapping, and issues related to the evaluation of correctness of assumed form of statistical models. The authors go on to present methods for evaluating and comparing the validity of appropriateness of a collection of models for describing a given data set, including statistically based model selection and comparison techniques. They also explore recent results on the estimation of probability distributions when they are embedded in complex mathematical models and only aggregate (not individual) data are available. In addition, they briefly discuss the optimal design of experiments in support of inverse problems for given models. The book concludes with a focus on uncertainty in model formulation itself, covering the general relationship of differential equations driven by white noise and the ones driven by colored noise in terms of their resulting probability density functions. It also deals with questions related to the appropriateness of discrete versus continuum models in transitions from small to large numbers of individuals. With many examples throughout addressing problems in physics, biology, and other areas, this book is intended for applied mathematicians interested in deterministic and/or stochastic models and their interactions. It is also s

Interior Point Algorithms - Theory and Analysis (Hardcover, New): Y. Ye Interior Point Algorithms - Theory and Analysis (Hardcover, New)
Y. Ye
R5,278 Discovery Miles 52 780 Ships in 18 - 22 working days

The first comprehensive review of the theory and practice of one of today's most powerful optimization techniques.

The explosive growth of research into and development of interior point algorithms over the past two decades has significantly improved the complexity of linear programming and yielded some of today's most sophisticated computing techniques. This book offers a comprehensive and thorough treatment of the theory, analysis, and implementation of this powerful computational tool.

Interior Point Algorithms provides detailed coverage of all basic and advanced aspects of the subject. Beginning with an overview of fundamental mathematical procedures, Professor Yinyu Ye moves swiftly on to in-depth explorations of numerous computational problems and the algorithms that have been developed to solve them. An indispensable text/reference for students and researchers in applied mathematics, computer science, operations research, management science, and engineering, Interior Point Algorithms:

  • Derives various complexity results for linear and convex programming
  • Emphasizes interior point geometry and potential theory
  • Covers state-of-the-art results for extension, implementation, and other cutting-edge computational techniques
  • Explores the hottest new research topics, including nonlinear programming and nonconvex optimization.
Analysis of Complex Diseases - A Mathematical Perspective (Hardcover, New): Phd Guanyu Wang Analysis of Complex Diseases - A Mathematical Perspective (Hardcover, New)
Phd Guanyu Wang
R5,476 Discovery Miles 54 760 Ships in 10 - 15 working days

A complex disease involves many etiological and risk factors operating at multiple levels-molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize treatments. The understanding of biological data derived from studying diseases can be enhanced by theories and mathematical models, which clarify the big picture and help to reveal the overarching mechanisms that govern complex biological phenomena. Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, Analysis of Complex Diseases: A Mathematical Perspective presents a holistic approach for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. Using mathematics to identify patterns of deviation from normality, or the healthy state-spanning multiple levels from molecules to the organism-the author identifies a range of dynamical behaviors that correspond to either cellular physiology or pathology. He uses the information from multiple levels in order to develop a unified theory, which includes the discovery that certain diseases may stem from well-evolved, useful mechanisms activated in the wrong context. This book is divided into three parts. Part I focuses on the organismal level to describe normal physiology and how the body as a whole meets its functional requirements. Part II addresses the subcellular, molecular level to elucidate the organizing principles of cellular biomolecules to meet the demands of the organism. Part III examines complex diseases by combining information from the organismal level and the molecular level, offering a paradigm that can be extended to the study of other categories of diseases.

Splines And Compartment Models: An Introduction (Hardcover): Karl-ernst Erich Biebler, Michael Wodny Splines And Compartment Models: An Introduction (Hardcover)
Karl-ernst Erich Biebler, Michael Wodny
R3,015 Discovery Miles 30 150 Ships in 18 - 22 working days

This book presents methods of mathematical modeling from two points of view. Splines provide a general approach while compartment models serve as examples for context related to modeling. The preconditions and characteristics of the developed mathematical models as well as the conditions surrounding data collection and model fit are taken into account. The substantial statements of this book are mathematically proven. The results are ready for application with examples and related program codes given.In this book, splines are algebraically developed such that the reader or user can easily understand and vary the numerical construction of the different kinds of spline functions. The classical compartment models of the pharmacokinetics are systematically analyzed and connected with lifetime distributions. As such, parameter estimation and model fit can be treated statistically with a varied minimum chi-square method. This method is applicable for single kinetics and also allows the calculation of average kinetics.

Introduction to Complex Variables and Applications (Paperback): Mark J. Ablowitz, Athanassios S. Fokas Introduction to Complex Variables and Applications (Paperback)
Mark J. Ablowitz, Athanassios S. Fokas
R1,478 R1,395 Discovery Miles 13 950 Save R83 (6%) Ships in 10 - 15 working days

The study of complex variables is beautiful from a purely mathematical point of view, and very useful for solving a wide array of problems arising in applications. This introduction to complex variables, suitable as a text for a one-semester course, has been written for undergraduate students in applied mathematics, science, and engineering. Based on the authors' extensive teaching experience, it covers topics of keen interest to these students, including ordinary differential equations, as well as Fourier and Laplace transform methods for solving partial differential equations arising in physical applications. Many worked examples, applications, and exercises are included. With this foundation, students can progress beyond the standard course and explore a range of additional topics, including generalized Cauchy theorem, Painleve equations, computational methods, and conformal mapping with circular arcs. Advanced topics are labeled with an asterisk and can be included in the syllabus or form the basis for challenging student projects.

Advances In Wave Turbulence (Hardcover): Victor Shrira, Sergei Nazarenko Advances In Wave Turbulence (Hardcover)
Victor Shrira, Sergei Nazarenko
R2,897 Discovery Miles 28 970 Ships in 18 - 22 working days

Wave or weak turbulence is a branch of science concerned with the evolution of random wave fields of all kinds and on all scales, from waves in galaxies to capillary waves on water surface, from waves in nonlinear optics to quantum fluids. In spite of the enormous diversity of wave fields in nature, there is a common conceptual and mathematical core which allows to describe the processes of random wave interactions within the same conceptual paradigm, and in the same language. The development of this core and its links with the applications is the essence of wave turbulence science (WT) which is an established integral part of nonlinear science. The book comprising seven reviews aims at discussing new challenges in WT and perspectives of its development. A special emphasis is made upon the links between the theory and experiment. Each of the reviews is devoted to a particular field of application (there is no overlap), or a novel approach or idea. The reviews cover a variety of applications of WT, including water waves, optical fibers, WT experiments on a metal plate and observations of astrophysical WT.

Thermal Protection Modeling of Hypersonic Flying Apparatus (Hardcover, 1st ed. 2018): A S Yakimov Thermal Protection Modeling of Hypersonic Flying Apparatus (Hardcover, 1st ed. 2018)
A S Yakimov
R3,785 Discovery Miles 37 850 Ships in 18 - 22 working days

This book is devoted to studies of unsteady heat and mass exchange processes taking into account thermochemical destruction of thermal protective materials, research of transpiration cooling systems, thermal protection of composite materials exposed to low-energy disturbances, as well as the numerical solution of heat and mass transfer of the exchange. It proposes several mathematical models of passive and active thermal protection systems with regard to factors such as surface ablation, surface roughness, phase transition of a liquid in porous materials, rotation of the body around its longitudinal axis, and exposure to low-energy disturbances. The author studies the possibilities to control thermochemical destruction and heat mass exchange processes in transpiration cooling systems exposed to low-energy disturbances. The numerical analysis of the heat and mass exchange process in carbon plastics under repeated impulse action is also presented. The numerical solutions of problems are compared with the known experimental data. The book is intended for specialists in the field of thermal protection and heat mass exchange, as well as graduate and undergraduates in physics and mathematics.

Mesoscale Meteorological Modeling, Volume 98 (Hardcover, 3rd edition): Roger A. Pielke, Sr. Mesoscale Meteorological Modeling, Volume 98 (Hardcover, 3rd edition)
Roger A. Pielke, Sr.
R2,645 Discovery Miles 26 450 Ships in 10 - 15 working days

The 3rd edition of "Mesoscale Meteorological Modeling" is a fully revised resource for researchers and practitioners in the growing field of meteorological modeling at the mesoscale. Pielke has enhanced the new edition by quantifying model capability (uncertainty) by a detailed evaluation of the assumptions of parameterization and error propagation. Mesoscale models are applied in a wide variety of studies, including weather prediction, regional and local climate assessments, and air pollution investigations.
Broad expansion of the concepts of parameterization and parameterization methodology Addition of new modeling approaches, including modeling summaries and summaries of data setsAll-new section on dynamic downscaling

Lozi Mappings - Theory and Applications (Hardcover): Zeraoulia Elhadj Lozi Mappings - Theory and Applications (Hardcover)
Zeraoulia Elhadj
R3,512 Discovery Miles 35 120 Ships in 10 - 15 working days

This book is a comprehensive collection of known results about the Lozi map, a piecewise-affine version of the Henon map. Henon map is one of the most studied examples in dynamical systems and it attracts a lot of attention from researchers, however it is difficult to analyze analytically. Simpler structure of the Lozi map makes it more suitable for such analysis. The book is not only a good introduction to the Lozi map and its generalizations, it also summarizes of important concepts in dynamical systems theory such as hyperbolicity, SRB measures, attractor types, and more.

Optimal Control of Age-structured Populations in Economy, Demography, and the Environment (Paperback): Raouf Boucekkine, Natali... Optimal Control of Age-structured Populations in Economy, Demography, and the Environment (Paperback)
Raouf Boucekkine, Natali Hritonenko, Yuri Yatsenko
R1,506 Discovery Miles 15 060 Ships in 10 - 15 working days

This book covers a wide range of topics within mathematical modelling and the optimization of economic, demographic, technological and environmental phenomena. Each chapter is written by experts in their field and represents new advances in modelling theory and practice. These essays are exemplary of the fruitful interaction between theory and practice when exploring global and local changes. The unifying theme of the book is the use of mathematical models and optimization methods to describe age-structured populations in economy, demography, technological change, and the environment. Emphasis is placed on deterministic dynamic models that take age or size structures, delay effects, and non-standard decision variables into account. In addition, the contributions deal with the age structure of assets, resources, and populations under study. Interdisciplinary modelling has enormous potential for discovering new insights in global and regional development. Optimal Control of Age-structured Populations in Economy, Demography, and the Environment is a rich and excellent source of information on state-of-the-art modelling expertise and references. The book provides the necessary mathematical background for readers from different areas, such as applied sciences, management sciences and operations research, which helps guide the development of practical models. As well as this the book also surveys the current practice in applied modelling and looks at new research areas for a general mathematical audience. This book will be of interest primarily to researchers, postgraduate students, as well as a wider scientific community, including those focussing on the subjects of applied mathematics, environmental sciences, economics, demography, management, and operations research.

Mathematical Modelling of Gas-Phase Complex Reaction Systems: Pyrolysis and Combustion, Volume 45 (Hardcover): Tiziano... Mathematical Modelling of Gas-Phase Complex Reaction Systems: Pyrolysis and Combustion, Volume 45 (Hardcover)
Tiziano Faravelli, Flavio Manenti, Eliseo Ranzi
R5,042 Discovery Miles 50 420 Ships in 10 - 15 working days

Mathematical Modelling of Gas-Phase Complex Reaction Systems: Pyrolysis and Combustion, Volume 45, gives an overview of the different steps involved in the development and application of detailed kinetic mechanisms, mainly relating to pyrolysis and combustion processes. The book is divided into two parts that cover the chemistry and kinetic models and then the numerical and statistical methods. It offers a comprehensive coverage of the theory and tools needed, along with the steps necessary for practical and industrial applications.

Artificial Intelligence and Mathematical Methods in Pavement and Geomechanical Systems - Proceedings of the international... Artificial Intelligence and Mathematical Methods in Pavement and Geomechanical Systems - Proceedings of the international symposium, Miami, Florida, USA, 5-6 November 1998 (Hardcover)
Nii O.Attoh- Okine
R1,640 Discovery Miles 16 400 Ships in 9 - 17 working days

The book covers a wide range of Artificial Intelligence (AI) and Mathematical Methods issues, research and applications in the area of pavement, geomechanical and few examples on geo-environmental systems: Application of Artificial Neural Networks; Data mining applications; Stochastic Finite Element; Fuzzy Set Theory; Artificial Immune Systems; Probabilistic Reasoning; System Identification Techniques; Image Processing. This collection of papers provides researchers and engineers with a current comprehensive look at available and emerging AI and Mathematical Methods within pavement and geomechanical systems.

Methods of Statistical Model Estimation (Hardcover, New): Joseph Hilbe, Andrew Robinson Methods of Statistical Model Estimation (Hardcover, New)
Joseph Hilbe, Andrew Robinson
R2,808 Discovery Miles 28 080 Ships in 10 - 15 working days

Methods of Statistical Model Estimation examines the most important and popular methods used to estimate parameters for statistical models and provide informative model summary statistics. Designed for R users, the book is also ideal for anyone wanting to better understand the algorithms used for statistical model fitting.

The text presents algorithms for the estimation of a variety of regression procedures using maximum likelihood estimation, iteratively reweighted least squares regression, the EM algorithm, and MCMC sampling. Fully developed, working R code is constructed for each method. The book starts with OLS regression and generalized linear models, building to two-parameter maximum likelihood models for both pooled and panel models. It then covers a random effects model estimated using the EM algorithm and concludes with a Bayesian Poisson model using Metropolis-Hastings sampling.

The book's coverage is innovative in several ways. First, the authors use executable computer code to present and connect the theoretical content. Therefore, code is written for clarity of exposition rather than stability or speed of execution. Second, the book focuses on the performance of statistical estimation and downplays algebraic niceties. In both senses, this book is written for people who wish to fit statistical models and understand them.

See Professor Hilbe discuss the book.

Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response... Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response (Hardcover, New)
Rodrick Wallace, Deborah Wallace
R2,673 Discovery Miles 26 730 Ships in 18 - 22 working days

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from $200 million in 1950 to $1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of "magic bullets", we must now apply "magic strategies" that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies.

Non-Local Cell Adhesion Models - Symmetries and Bifurcations in 1-D (Hardcover, 1st ed. 2021): Andreas Buttenschoen, Thomas... Non-Local Cell Adhesion Models - Symmetries and Bifurcations in 1-D (Hardcover, 1st ed. 2021)
Andreas Buttenschoen, Thomas Hillen
R3,106 Discovery Miles 31 060 Ships in 18 - 22 working days

This monograph considers the mathematical modeling of cellular adhesion, a key interaction force in cell biology. While deeply grounded in the biological application of cell adhesion and tissue formation, this monograph focuses on the mathematical analysis of non-local adhesion models. The novel aspect is the non-local term (an integral operator), which accounts for forces generated by long ranged cell interactions. The analysis of non-local models has started only recently, and it has become a vibrant area of applied mathematics. This monograph contributes a systematic analysis of steady states and their bifurcation structure, combining global bifurcation results pioneered by Rabinowitz, equivariant bifurcation theory, and the symmetries of the non-local term. These methods allow readers to analyze and understand cell adhesion on a deep level.

Geometry Of Crystallographic Groups (Hardcover): Andrzej Szczepanski Geometry Of Crystallographic Groups (Hardcover)
Andrzej Szczepanski
R2,164 Discovery Miles 21 640 Ships in 18 - 22 working days

Crystallographic groups are groups which act in a nice way and via isometries on some n-dimensional Euclidean space. They got their name, because in three dimensions they occur as the symmetry groups of a crystal (which we imagine to extend to infinity in all directions). The book is divided into two parts. In the first part, the basic theory of crystallographic groups is developed from the very beginning, while in the second part, more advanced and more recent topics are discussed. So the first part of the book should be usable as a textbook, while the second part is more interesting to researchers in the field. There are short introductions to the theme before every chapter. At the end of this book is a list of conjectures and open problems. Moreover there are three appendices. The last one gives an example of the torsion free crystallographic group with a trivial center and a trivial outer automorphism group.This volume omits topics about generalization of crystallographic groups to nilpotent or solvable world and classical crystallography. We want to emphasize that most theorems and facts presented in the second part are from the last two decades. This is after the book of L Charlap "Bieberbach groups and flat manifolds" was published.

Network Games, Control, and Optimization - Proceedings of NETGCOOP 2018, New York, NY (Hardcover, 1st ed. 2019): Jean Walrand,... Network Games, Control, and Optimization - Proceedings of NETGCOOP 2018, New York, NY (Hardcover, 1st ed. 2019)
Jean Walrand, Quanyan Zhu, Yezekael Hayel, Tania Jimenez
R2,682 Discovery Miles 26 820 Ships in 18 - 22 working days

This contributed volume offers a collection of papers presented at the 2018 Network Games, Control, and Optimization conference (NETGCOOP), held at the New York University Tandon School of Engineering in New York City, November 14-16, 2018. These papers highlight the increasing importance of network control and optimization in many networking application domains, such as mobile and fixed access networks, computer networks, social networks, transportation networks, and, more recently, electricity grids and biological networks. Covering a wide variety of both theoretical and applied topics in the areas listed above, the authors explore several conceptual and algorithmic tools that are needed for efficient and robust control operation, performance optimization, and better understanding the relationships between entities that may be acting cooperatively or selfishly in uncertain and possibly adversarial environments. As such, this volume will be of interest to applied mathematicians, computer scientists, engineers, and researchers in other related fields.

New Directions in Mathematical Finance (Hardcover): P. Wilmott New Directions in Mathematical Finance (Hardcover)
P. Wilmott
R2,945 Discovery Miles 29 450 Ships in 10 - 15 working days

New ideas in quantitative finance are always welcome, especially so in recent years as new techniques have steadily gained in popularity and old techniques have become more sophisticated.

This book features new contributions from many highly regarded individuals, collected together by Paul Wilmott and Henrik Rasmussen. Subjects featured include new techniques for:

  • Risk Management
  • Equity Modelling
  • Interest Rate Modelling
This book is a worthy addition to the canon of literature on quantitative finance.

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