Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

This book focuses on broadly defined areas of chemical information science- with special emphasis on chemical informatics- and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jurgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.

The subject of geomathematics focuses on the interpretation and classification of data from geoscientific and satellite sources, reducing information to a comprehensible form and allowing the testing of concepts. Sphere oriented mathematics plays an important part in this study and this book provides the necessary foundation for graduate students and researchers interested in any of the diverse topics of constructive approximation in this area. This book bridges the existing gap between monographs on special functions of mathematical physics and constructive approximation in Euclidean spaces. The primary objective is to provide readers with an understanding of aspects of approximation by spherical harmonics, such as spherical splines and wavelets, as well as indicating future directions of research. Scalar, vectorial, and tensorial methods are each considered in turn. The concentration on spherical splines and wavelets allows a double simplification; not only is the number of independent variables reduced resulting in a lower dimensional problem, but also radial basis function techniques become applicable. When applied to geomathematics this leads to new structures and methods by which sophisticated measurements and observations can be handled more efficiently, thus reducing time and costs.

These worksheets provide extra practice exercises for every section of the text with ample space for students to show their work on the practice exercises and Math Coach problems. Additionally, the workbook is correlated to the new Guided Learning Videos and the Math Coach Videos so that students can follow along, take notes, and practice as they go.

Assuming no previous study in logic, this informal yet rigorous text covers the material of a standard undergraduate first course in mathematical logic, using natural deduction and leading up to the completeness theorem for first-order logic. At each stage of the text, the reader is given an intuition based on standard mathematical practice, which is subsequently developed with clean formal mathematics. Alongside the practical examples, readers learn what can and can't be calculated; for example the correctness of a derivation proving a given sequent can be tested mechanically, but there is no general mechanical test for the existence of a derivation proving the given sequent. The undecidability results are proved rigorously in an optional final chapter, assuming Matiyasevich's theorem characterising the computably enumerable relations. Rigorous proofs of the adequacy and completeness proofs of the relevant logics are provided, with careful attention to the languages involved. Optional sections discuss the classification of mathematical structures by first-order theories; the required theory of cardinality is developed from scratch. Throughout the book there are notes on historical aspects of the material, and connections with linguistics and computer science, and the discussion of syntax and semantics is influenced by modern linguistic approaches. Two basic themes in recent cognitive science studies of actual human reasoning are also introduced. Including extensive exercises and selected solutions, this text is ideal for students in logic, mathematics, philosophy, and computer science.

The chapters in this monograph are contributions from the Advances in Quantum Monte Carlo symposium held at Pacifichem 2010, International Chemical Congress of Pacific Basin Societies. The symposium was dedicated to celebrate the career of James B. Anderson, a notable researcher in the field. Quantum Monte Carlo provides an ab initio solution to the Schroedinger equation by performing a random walk through configuration space in imaginary time. Benchmark calculations suggest that its most commonly-used variant, "fixed-node" diffusion Monte Carlo, estimates energies with an accuracy comparable to that of high-level coupled-cluster calculations. These two methods, each having advantages and disadvantages, are complementary "gold-standards" of quantum chemistry. There are challenges facing researchers in the field, several of which are addressed in the chapters in this monograph. These include improving the accuracy and precision of quantum Monte Carlo calculations; understanding the exchange nodes and utilizing the simulated electron distribution; extending the method to large and/or experimentally-challenging systems; and developing hybrid molecular mechanics/dynamics and Monte Carlo algorithms.

A principal feature of this book is the substantial care and attention devoted to explaining the basic ideas of the subject. Whenever a new theoretical concept is introduced it is carefully explained by reference to practical examples drawn mainly from the physical sciences. Subjects covered include: spectral analysis which is closely intertwined with the "time domain" approach, elementary notions of Hilbert Space Theory, basic probability theory, and practical analysis of time series data. The inclusion of material on "kalman filtering," state-space filtering," "non-linear models" and continuous time" models completes the impressive list of unique and detailed features which will give this book a prominent position among related literature. The first section -- Volume 1 -- deals with single (univariate) series, while the second -- Volume 2 -- treats the analysis of several (multivariate) series and the problems of prediction, forecasting and control.

This volume is a systematic treatment of the additive number theory of polynomials over a finite field, an area possessing deep and fascinating parallels with classical number theory. In providing asymptomatic proofs of both the Polynomial Three Primes Problem (an analog of Vinogradov's theorem) and the Polynomial Waring Problem, the book develops the various tools necessary to apply an adelic "circle method" to a wide variety of additive problems in both the polynomial and classical settings. A key to the methods employed here is that the generalized Riemann hypothesis is valid in this polynomial setting. The authors presuppose a familiarity with algebra and number theory as might be gained from the first two years of graduate course, but otherwise the book is self-contained. Starting with analysis on local fields, the main technical results are all proved in detail so that there are extensive discussions of the theory of characters in a non-Archimidean field, adele class groups, the global singular series and Radon-Nikodyn derivatives, L-functions of Dirichlet type, and K-ideles.

Multivariate Analysis deals with observations on more than one variable where there is some inherent interdependence between the variables. With several texts already available in this area, one may very well enquire of the authors as to the need for yet another book. Most of the available books fall into two categories, either theoretical or data analytic. The present book not only combines the two approaches but it also has been guided by the need to give suitable matter for the beginner as well as illustrating some deeper aspects of the subject for the research worker. Practical examples are kept to the forefront and, wherever feasible, each technique is motivated by such an example.

The UK's most trusted A level Mathematics resources With over 900,000 copies sold (plus 1.3 million copies sold of the previous edition), Pearson's own resources for Pearson Edexcel are the market-leading and most trusted for AS and A level Mathematics. This book can be used alongside the Year 1 book to cover all the content needed for the compulsory Edexcel A level Core Pure Mathematics exams Enhanced focus on problem-solving and modelling, as well as supporting the large data set and calculators Packed with worked examples with guidance, lots of exam-style questions, practice papers, and plenty of mixed and review exercises Full worked solutions to every question available free and online for quick and easy access. Plus free additional online content with GeoGebra interactives and Casio calculator tutorials Practice books also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions Includes access to an online digital edition (valid for 3 years once activated) Pearson Edexcel A level Further Mathematics Core Pure Mathematics Book 2 Textbook + e-book matches the Pearson Edexcel exam structure and is fully integrated with Pearson Edexcel's interactive scheme of work. All of the books in this series focus on problem-solving and modelling, as well as supporting the large data set and calculators. They are packed with worked examples with guidance, lots of exam-style questions, practice papers, and plenty of mixed and review exercises. There are full worked solutions to every question available free and online for quick and easy access. You will also have access to lots of free additional online content with GeoGebra interactives and Casio calculator tutorials. There are separate Pure and Applied textbooks for AS and A level Maths, and a textbook per option for AS and A level Further Maths. Practice books are also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions. Pearson's revision resources are the smart choice for those revising for Pearson Edexcel AS and A level Mathematics - there is a Revision Workbook for exam practice and a Revision Guide for classroom and independent study. Practice Papers Plus+ books contain additional full length practice papers, so you can practice answering questions by writing straight into the book and perfect your responses with targeted hints, guidance and support for every question, including fully worked solutions.

Written by one of the subject's foremost experts, this is the first book on division space integration theory. It is intended to present a unified account of many classes of integrals including the Lebesgue-Bochner, Denjoy-Perron gauge, Denjoy-Hincin, Cesaro-Perron, and Marcinkiewicz-Zygmund integrals. Professor Henstock develops here the general axiomatic theory of Riemann-type integration from first principles in such a way that familiar classes of integrals (such as Lebesgue and Wiener integrals) are subsumed into the general theory in a systematic fashion. In particular, the theory seeks to place Feynman integration on a secure analytical footing. By adopting an axiomatic approach, proofs are, in general, simpler and more transparent than have previously appeared. The author also shows how one proof can prove corresponding results for a wide variety of integrals. As a result, this book will be the central reference work in this subject for many years to come.

This volume is a collection of papers presented at the 2007 colloquium on new perspectives on games and interaction at the Royal Dutch Academy of Sciences in Amsterdam. The purpose of the colloquium was to clarify the uses of the concepts of game theory, and to identify promising new directions. This important collection testifies to the growing importance of game theory as a tool to capture the concepts of strategy, interaction, argumentation, communication, cooperation and competition. Also, it provides evidence for the richness of game theory and for its impressive and growing application.

This volume is a collects papers originally presented at the 7th Conference on Logic and the Foundations of Game and Decision Theory (LOFT), held at the University of Liverpool in July 2006. LOFT is a key venue for presenting research at the intersection of logic, economics, and computer science, and this collection gives a lively and wide-ranging view of an exciting and rapidly growing area.

The biological and social sciences often generalize causal conclusions from one context or location to others that may differ in some relevant respects, as is illustrated by inferences from animal models to humans or from a pilot study to a broader population. Inferences like these are known as extrapolations. The question of how and when extrapolation can be legitimate is a fundamental issue for the biological and social sciences that has not received the attention it deserves. In Across the Boundaries, Steel argues that previous accounts of extrapolation are inadequate and proposes a better approach that is able to answer methodological critiques of extrapolation from animal models to humans.
Across the Boundaries develops the thought that knowledge of mechanisms linking cause to effect can serve as a basis for extrapolation. Despite its intuitive appeal, this idea faces several obstacles. Extrapolation is worthwhile only when there are stringent practical or ethical limitations on what can be learned about the target (say, human) population by studying it directly. Meanwhile, the mechanisms approach rests on the idea that extrapolation is justified when mechanisms are the same or similar enough. Yet since mechanisms may differ significantly between model and target, it needs to be explained how the suitability of the model could be established given only very limited information about the target. Moreover, since model and target are rarely alike in all relevant respects, an adequate account of extrapolation must also explain how extrapolation can be legitimate even when some causally relevant differences are present.
Steel explains how his proposal can answer thesechallenges, illustrates his account with a detailed biological case study, and explores its implications for such traditional philosophy of science topics ceteris paribus laws and reductionism. Finally, he considers whether mechanisms-based extrapolation can work in social science.

The UK's most trusted A level Mathematics resources With over 900,000 copies sold (plus 1.3 million copies sold of the previous edition), Pearson's own resources for Pearson Edexcel are the market-leading and most trusted for AS and A level Mathematics. Our A level Mathematics Statistics and Mechanics Year 1 Practice Book helps you get exam-ready with confidence and practice at the right pace. Coverage: the practice workbooks cover all Pure, Statistics and Mechanics topics Quantity: the most A level question practice available, with over 2,000 extra questions per book Practice at the right pace: start with the essentials, build your skills with various practice questions to make connections between topics, then apply this to exam-style questions at the end of each chapter Get exam-ready with confidence: differentiated questions including 'Bronze, Silver, Gold' in each chapter, and a mixed problem-solving section for each book, will guide and help you to develop the skills you need for your exams Designed to be used flexibly, the practice books are fully mapped to the scheme of work and textbooks so you can use them seamlessly in and out of the classroom and all year round. Use them lesson by lesson, topic by topic, for homework, revision and more - the choice is yours Great value practice materials that are cheaper than photocopying, saves more time than independently sourcing questions and answers, and are all in one place Pearson Edexcel AS and A level Mathematics Statistics and Mechanics Year 1/AS Practice Book matches the Pearson Edexcel exam structure and is fully integrated with Pearson Edexcel's interactive scheme of work. Practice books are also available offering the most comprehensive and flexible AS/A level Maths practice with over 2000 extra questions. Pearson's revision resources are the smart choice for those revising for Pearson Edexcel AS and A level Mathematics - there is a Revision Workbook for exam practice and a Revision Guide for classroom and independent study. Practice Papers Plus+ books contain additional full length practice papers, so you can practice answering questions by writing straight into the book and perfect your responses with targeted hints, guidance and support for every question, including fully worked solutions.

This textbook offers an accessible, modern introduction at undergraduate level to an area known variously as general topology, point-set topology or analytic topology with a particular focus on helping students to build theory for themselves. It is the result of several years of the authors' combined university teaching experience stimulated by sustained interest in advanced mathematical thinking and learning, alongside established research careers in analytic topology. Point-set topology is a discipline that needs relatively little background knowledge, but sufficient determination to grasp ideas precisely and to argue with straight and careful logic. Research and long experience in undergraduate mathematics education suggests that an optimal way to learn such a subject is to teach it to yourself, pro-actively, by guided reading of brief skeleton notes and by doing your own spadework to fill in the details and to flesh out the examples. This text will facilitate such an approach for those learners who opt to do it this way and for those instructors who would like to encourage this so-called 'Moore approach', even for a modest segment of the teaching term or for part of the class. In reality, most students simply do not have the combination of time, background and motivation needed to implement such a plan fully. The accessibility, flexibility and completeness of this text enable it to be used equally effectively for more conventional instructor-led courses. Critically, it furnishes a rich variety of exercises and examples, many of which have specimen solutions, through which to gain in confidence and competence.

• Contains 12 examples that are completely new and have been used by student groups.
• The chapter on difference equations is new to this edition.
• Presents modeling methodology in detail and includes the essential skills for producing a successful model.
• Provides coverage of 'discrete' models where the outcome is needed at discrete time intervals, such as hourly, daily, and yearly.
• Investigates models in which the variables are continuous functions of time, such as often occurs in physics and engineering problems.
• Covers problems that include a random feature that demand some statistical analysis.
• Presents a collection of more demanding examples, some of which are fully developed while others are left for students to process.
• Offers a chapter on communication skills, enabling students to explain the ideas behind the model to other people.

This book is a unique introduction to graph theory, written by one of its founding fathers. It is not intended as a comprehensive treatise, but rather as an account of those parts of the theory that have been of special interest to the author. Professor Tutte details his experiences in the area, and provides a fascinating insight into the processes leading to his proofs.