Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

In Male Mid-Life Crisis, Justin K. Lim investigates this phase of human life through the perspectives of analytical psychology and through existential theology. Research suggests 80 percent of men suffer from this crisis, and that it is not limited to any culture or period of history. He applies his findings to pastoral/spiritual interventions, seeking deeper and broader psychological and theological insights.

It can slowly drain the life force from your body over time. Or kill swiftly without warning. But you will never find it on a medical chart or see it listed on a death certificate. It's called stress. It exacts a tremendous toll on our lives. It saps our strength, robs our youth and makes us old before our time. We encounter it day in and day out, yet do little, if anything about it. It's no wonder. In today's 'pressure cooker society', the average lunch hour lasts about 11 minutes. Dinner is often consumed in less than 6 minutes (usually seated in front of the television). The average workday can last 10 hours or more. We seem to be living in a society where there's virtually no time for quality time. Strictly speaking, stress itself is not among the direct causes of ageing, yet it plays an extremely important role in the ageing process. It is a powerful force that serves as a catalyst in every known mechanism that causes us to age. Readers might be surprised to find out that this book has as much to do with ageing, life extension and specific measures we can take to postpone the inevitable as it does with stress. The fact is that stress and ageing are inextricably bound together.

Providing a comprehensive overview of issues of ageing from a global perspective this ambitious text introduces the reader to a wide range of issues and policies on ageing. Topics examined include: theoretical perspectives on ageing in society; demographic trends; roles played by older people as political actors; migration; health; pensions; family and institutional care; and elder abuse.

This will be an essential text for students of social gerontology, as well as an invaluable resource for students of nursing, social work, social policy and development studies.

This book gives an overview of the potential and the practical details that need to be resolved in order to make human germline engineering possible. It presents the ethical and social concerns, and implications of our fast-approaching capability to alter our own germline and take an active role in the future evolution of our own species. It provides explanations of how we have arrived at the capability to clone higher animals, and discusses the implications for human therapies and for our own future when these techniques are applied to the human germline.

When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission.
In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes--gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection--resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. Thus the book presents a holistic view of human genetics.
In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism--the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in theiroccurrence. Hence, there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise.

A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.

This volume is one of the first to concentrate on positive growth and development in a clinical arena, rather than loss and pathology. In contrast to the general theories and cross-sectional studies of existing adult developmental research, much of this volume looks at the whole-life level of development of adults through case studies. The book unites three compatible approaches to the study of adult development. The first considers the development of whole life. The second approach examines behavior during certain periods in adults' lives by combining clinical and developmental stage perspectives. The third approach examines periods of life following the work of Erikson, Levinson, and Vaillant. The editors of this volume believe that these three approaches form, in their synergy, a comprehensive and multifaceted approach to uniquely difficult problems of late adolescence and early adulthood. It is the unification of these three approches that makes this book unique in its field.

This volume is one of the first to concentrate on positive growth and development in a clinical arena, rather than loss and pathology. In contrast to the general theories and cross-sectional studies of existing adult developmental research, much of this volume looks at the whole-life level of development of adults through case studies. The book unites three compatible approaches to the study of adult development. The first considers the development of whole life. The second approach examines behavior during certain periods in adults' lives by combining clinical and developmental stage perspectives. The third approach examines periods of life following the work of Erikson, Levinson, and Vaillant. The editors of this volume believe that these three approaches form, in their synergy, a comprehensive and multifaceted approach to uniquely difficult problems of late adolescence and early adulthood. It is the unification of these three approches that makes this book unique in its field.

The University of Florida has an ambitious goal: to harness the power of its faculty, staff, students, and alumni to solve some of society's most pressing problems and to become a resource for the state of Florida, the nation, and the world. In the upcoming decades, an unprecedented demographic shift will take place; the eighty-five and over population is projected to climb far higher than any other age group. To keep the current elderly population healthy and help prevent future generations from experiencing poor health outcomes, researchers are studying crucial connections between skeletal muscles and whole-body health. The University of Florida is at the forefront of this research, utilizing its nationally recognized excellence in the fields of muscle biology and exercise physiology to discover unique ways to preserve muscle health in the aging and those with diseases. Find out how the proteins within muscle can be manipulated to reduce recovery times for individuals who are bedridden. Learn how older, elite athletes have resisted the inevitable degeneration that comes with aging, and how intermittent fasting may help you live longer and healthier. Step inside the lab where a researcher is uncovering the origins of cancer cachexia a wasting syndrome responsible for 20 percent of cancer deaths worldwide to improve the lives of patients. The loss of skeletal muscle through disease, disuse, or aging is associated with a host of poor health outcomes, but promising new avenues of research are being studied every day at the University of Florida to make for a healthier tomorrow.

The Ninth Decade is a path-breaking and timely book on aging: the first to focus explicitly and at length on eighty-somethings, the fastest-growing demographic in the industrialized world. Covering eight years in lively six-month installments, Klaus tells a vivid story not only of his own ninth decade and survival routines, but also of his loving companion, Jackie, who is strikingly different from him in her physical well-being, practical outlook, sociable temperament, and vigorous workouts. Cameos of their octogenarian friends and relatives near and far add to a wide-ranging and revelatory portrayal of advanced aging, as do bios of notable octogenarians. The multi-year scope of his chronicle reveals the numerous physical and mental problems that arise during octogenarian life and how eighty-year-olds have dealt with those challenges. The Ninth Decade is a unique, first-hand source of information for anyone in their sixties, seventies, or eighties, as well as for persons devoted to care of the aged. Though the challenges of octogenarian life often require specialized care, The Ninth Decade also shows the pleasures of it to be so special as to have inspired Lillian Hellman's paradoxical description of "longer life" as "the happy problem of our time."

Recent research findings on the impact of nutrition on telomere length is unlocking the potential to combat premature aging at the cellular level. We have learned that while aging is a natural cellular process, premature aging is not and it can be positively impacted by an Evidence-Based Proactive Nutrition to Slow Cellular Aging diet plan. This book examines key elements of the biology of cell aging and focuses on enhancing mitochondrial function and preventing abnormal cell turnover thus preserving telomere length. It details the cellular damage caused by free radicals and ROS, explains the salutary effects of antioxidants, and the body's need for adequate nitrates and other nutrient substrates from which the body derives nitric oxide (NO) to support cardiovascular health. This book is the first to feature a simple do-it-yourself test of the effects of the diet on the availability of NO for - heart health. The book guides the reader through the rationale for a modified Mediterranean style diet that supplies the body with an adequate daily intake of essential nutrients, simple high antioxidants, and other functional foods. It includes simple, easy to prepare appealing recipes promoting a seamless transition to a healthy, age-defying lifestyle.

Written by established and emerging leaders in a broad array of disciplines, this two-volume set provides undergraduate and graduate students, scholars, professionals, and policymakers with an overview of the field of aging that examines the social landscape as well as key changes, challenges, and solutions. The people who make up the rapidly growing population of Americans over age 65 are changing, and as a result, our nation will change. This shift presents new issues, controversies, and challenges that affect health, wellness, welfare, retirement, politics, and economics. This two-volume work examines where we are and where we are headed, paying careful attention to the differential impacts of gender, race, class, marital status, and other social variables. It considers key changes in demographics, old-age policies, families, work, and death and dying. Volume one covers an array of demographic issues, policies, and politics, highlighting how factors such as gender and race shape families, income, retirement, immigrants, and veterans across the life course. The second volume covers education, religion, volunteering, exercise, nutrition, and health care policies across the life course. Topics addressed include the old-age welfare state, the extension of retirement age, home care, care work, nursing home care, end of life planning, and euthanasia. Provides an up-to-date, multidisciplinary, and forward-thinking look at the key areas and issues in gerontology Highlights links between topics and relevant demographic, social, economic, and health trends with implications for immediate and long-range work in aging Includes contributions from experts in the fields of sociology, psychology, medicine, education, politics, and government Identifies the key changes, challenges, and solutions in each subfield Includes an appendix containing lists of descriptions and contact information for aging organizations as well as an annotated list of documentaries about aging

Although books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

When confronted with a neurological or psychiatric disorder in an elderly individual, a clinician or researcher is likely to ask how the processes of ageing have influenced the aetiology and presentation of the disorder, and will impact on its efficient management. There are many urban myths about ageing, and some of these apply to the brain. The reviews included in this book are an attempt to flush out some of these myths, and arm the clinician and general researcher with the empirical facts that can be mustered to substantiate claims about ageing. There are many salient questions: is cognitive change to be expected in an elderly individual? Is this change progressive, relentless and unselective, or is it focal and constrained? Would every person who lived long enough develop Alzheimer s disease? Do our neurones die as we get old? What happens to the size of the brain and its metabolic activity? How do our hormones change with age? Can anti-oxidants slow or even stop the process of ageing? Are genes important in the ageing brain or is it all in the environment? How much of what we are is due to what we eat? The contributors to this book, each an expert in their field, have addressed some of these questions in a language simple enough for a general reader to understand.

The book also deals with some of the most prominent brain disorders of old age - Alzheimer's disease, Parkinson's disease, vascular dementia, and depression. The focus is on the impact of ageing on these disorders. The discussions lay out a broad map for the clinician dealing with neuropsychiatric disorders, and the future researcher of brain ageing. In a field in which the developments are too numerous for any one individual to keep pace with, this book presents up-to-date summaries that can be a useful starting point. The field of brain ageing abounds in tabloid science. This book counters this by providing a strong empirical grounding and considered synthesis of the research."

In this new edition of the acclaimed "Dementia: Presentations, Differential Diagnosis, and Nosology, " V. Olga B. Emery, Ph.D., and Thomas E. Oxman, M.D., bring together a distinguished group of medical authorities--including many who have done seminal research in this field--to discuss the spectrum of dementing disorders and explain their overlap, presentations, and differential diagnosis. The chapters present original data as well as material from the authors' clinical experiences. Current classification systems are evaluated and modified to better account for common presentations of dementia.

Thoroughly revised, updated, and expanded, the second edition includes new material on neuroimaging, genetics, the role of inflammation in Alzheimer disease, retrophylogenesis in Alzheimer memory, and on AIDS dementia. In addition, each chapter includes a new section entitled describing clinical applications.

With the accelerating discovery of human genes, public health professionals are increasingly confronted with a large body of scientific information that will guide public health action. Because the broad mission of public health is to fulfill society's interest in assuring conditions in which people can be healthy, the integration of new genetic information in public health research, policy and program development is unavoidable. Public health leadership is urgently needed to use genetic information to improve health and prevent disease, and to address ethical, legal and social issues resulting from inappropriate use of such information. In the not too-distant future, disease prevention and health promotion programs will routinely consider whether or not to use genetic information to help target behavioral, medical or environmental intervention activities in order to maximize benefit and minimize costs and harm to individuals. In anticipation of the expected growth at the interface of genetics and public health, this book delineates a framework for the integration of advances in human genetics into public health practice. It provides a comprehensive review of public health genetics, including chapters on important general issues such as newborn and other genetic screening, the delivery of genetic services, and the ethical, legal and social implications of the use of genetics within public health. It also reviews relevant clinical topics, the historical background, cross-cultural aspects, and communication issues. Contributors come from a wide range of fields including epidemiology, biostatistics, health policy and management, health services research, behavioral and social sciences, ethics, law, health economics, and laboratory sciences.

Is Menstruation Obsolete? argues that regular monthly bleeding is not the "natural" state of women, and that it actually places them at risk of several medical conditions of varying severity. The authors maintain that while menstruation may be culturally significant, it is not medically meaningful. Moreover, they propose that suppressing menstruation has remarkable health advantages. Because of cultural changes, shorter durations of breast feeding, and birth control, the reproductive patterns of modern women no longer resemble that of their Stone age ancestors. Women have moved from the age of incessant reproduction to the age of incessant menstruation. Consequently, they often suffer from clinical disorders related to menstruation: anemia, endometriosis, and PMS, just to name a few. The authors encourage readers to recognize what has gone previously unnoticed that this monthly discomfort is simply not obligatory. They present compelling evidence that the suppression of menstruation is a viable option for women today, and that it can be easily attained through the use of birth control pills. In fact, they reveal that contraceptive manufacturers, knowing that many women equate menstruation with femininity and that without monthly bleeding would fear that they were pregnant, engineered pill dosage regimens to ensure the continuation of their cycles. Indeed, throughout history societies have assigned menstruation powerful meaning, and Is Menstruation Obsolete? presents a fascinating history of how menstruation inspired doctors to try therapeutic bleeding for a variety of ailments, and how this therapy remained dominant in Western medicine until the early 20th century. Is Menstruation Obsolete? offers women a fresh view of menstruation, providing them with the information they need to make progressive choices about their health. This is a message whose time has come.

By many accounts, in the next two decades a greater number of Americans will be over sixty than any other period in history. Aging in America examines the great challenges America will face in caring for aging baby boomers. The collection begins with statistical data on the major health issues for boomers, the demographics of the population, and the availability of health care in the future. How to negotiate rising medical costs and a growing population of seniors is one of the greatest challenges, the topic of the following chapter. The challenges and opportunities for families who care for aging parents is certain to be a developing issue in the future. The two following chapters examine progressive opportunities presented by an aging population. First, in the way perspectives on the senior years have evolved in the recent decade; second, on innovations in medicine that must respond to health care in the future. The final chapter compares America's response to an aging population with that of other counties in the world. Each book in The Reference Shelf series offers extensive, unbiased exploration of a topic of importance in modern society, in a compilation of notable articles from respected publications, abstracts of 20 to 30 additional articles, and a bibliography of other sources.

Research documents that rural elders are poorer, live in less adequate housing, and have far fewer health and service options available to them than their urban counterparts, yet there is a critical lack of current and detailed information on the problems facing rural elders and on the professional practices that serve this population. This text fills this gap by introducing readers to rural areas and their residents and discussing the issues, programs, and policies designed to meet their needs. Through a multidisciplinary lens, it examines and defines specific competencies required for successful work with older adults and their families in these communities.

The text presents a research-driven, competency-based approach for the health and human service professionals who work with older rural residents. It discusses both the problems facing older adults and their families and evidence-based solutions regarding policy and best practices. Key issues examined include health and wellness, transportation, housing, long-term care, income, employment, and retirement, along with the needs of special populations (ethnic minorities, immigrants, and the LGBT population). Case examples reinforce an interdisciplinary model that addresses practice with rural elders that encompasses professional competencies, values and ethics, and the roles of a spectrum of health and human service professionals. The text also examines current policies affecting health and social services to rural elders and recommendations for policy change to build an effective health and human service workforce in rural communities. Links to Podcast interviews with scholars and respected professionals working in the field and "Spotlight" excerpts from the text reinforce information. In addition, the text provides discussion questions, PowerPoint slides, a test question bank, and suggested activities and exercises.

Key Features: Fills a vacuum regarding information on health and social services for rural elders Provides current and comprehensive knowledge about issues besetting this population and programs and policies designed to meet their needs Examines and defines specific competencies required for effective health and social services Based on a research-driven, competency-based, interdisciplinary approach to policy and best practice Includes links to Podcast interviews with scholars and respected professionals in the field

The study of ageing is a fundamental issue for social science. Age is seen much less as a "natural" developmental phase of life and more as a socio-cultural construct. This opens opportunities to new ways to see ageing as a social process and factor in power relations, and for examining in theory and in empirical research, the intersections of age with class, race, gender and sexuality. In four volumes this MW examines: Volume 1: Origins, Theories and Practical Concerns (Classic approaches and contemporary thinkers); Volume 2: Forms and Practice (ageing in pre-industrial societies; ageing historically; aging and identity); Volume 3: Key Dimensions (ageing and life course; ageing and work/leisure; ageing and gender; ageing and health; ageing and sexuality; ageing and family; ageing and culture/ethnicity) and Volume 4: Key Debates (theory versus practice; ageing bodies; critical gerontology

The past century has witnessed a revolution. Less than a hundred years ago, the average Western life expectancy was 40; now it is 80. And there is no end in sight: the first person who will reach 135 has already been born. It's the most radical change in our society since industrialisation, and naturally it raises many questions. What do longer life spans mean for the way we organise our societies? How can people best prepare themselves for living considerably longer? Does it help to eat less, or to take hormones, vitamins, or minerals? And what can we learn from old people who remain full of vitality, despite illness and infirmity? Growing Older without Feeling Old is the definitive book on a key issue for the 21st century, written by one of the world's leading experts in geriatric medicine. Combining medical, biological, economic, and sociological insights, Rudi Westendorp explores the causes of the ageing revolution and explains how we can greet it with confidence and enjoy leading longer, healthier, and more productive lives than ever before.

Finch and Kirkwood are two of the leaders of biological gerontology. This book establishes the role of chance variations in affecting the process of ageing in individuals. All the relevant animal and human data are collected and analysed, to establish the relative roles of genes and chance in the ageing process. This is a new theoretical approach to understanding ageing, which will be of widespread interest to gerontologists and developmental and cellular biologists. There are obvious applications of this perspective to the role of chance in various disease processes, so that interest from the medical and public health communities should be strong.