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Diseases of the Cardiac Pump (Hardcover, 2015 ed.)
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Diseases of the Cardiac Pump (Hardcover, 2015 ed.)
Series: Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, 7
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Together, the volumes in this series present all of the data needed
at various length scales for a multidisciplinary approach to
modeling and simulation of flows in the cardiovascular and
ventilatory systems, especially multiscale modeling and coupled
simulations. The cardiovascular and respiratory systems are tightly
coupled, as their primary function is to supply oxygen to and
remove carbon dioxide from the body's cells. Because physiological
conduits have deformable and reactive walls, macroscopic flow
behavior and prediction must be coupled to nano- and microscopic
events in a corrector scheme of regulated mechanism. Therefore,
investigation of flows of blood and air in anatomical conduits
requires an understanding of the biology, chemistry, and physics of
these systems together with the mathematical tools to describe
their functioning in quantitative terms. The present volume focuses
on macroscopic aspects of the cardiovascular and respiratory
systems in pathological conditions, i.e., diseases of the cardiac
pump, blood vessels, and airways, as well as their treatments. Only
diseases that have a mechanical origin or are associated with
mechanical disorders are covered. Local flow disturbances can
trigger pathophysiological processes or, conversely, result from
diseases of conduit walls or their environment. The ability to
model these phenomena is essential to the development and
manufacturing of medical devices, which incorporate a stage of
numerical tests in addition to experimental procedures.
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