The Sunday Times Top Ten Bestseller TV and radio presenter Kate Garraway has a lot on her mind. She's turned 50, and suddenly seems to have MANY questions about EVERYTHING. Should she get plastic surgery? Will the menopause ruin her life? What's the secret to making love last? Can anyone really deal with the idea of death? And why, oh why, did nobody tell her how important big knickers would be?! As she tries to find what's useful amongst the deluge of advice we are bombarded with, Kate discovers a lesson on why women in their midlife and beyond should be loved and celebrated, especially by themselves...

'Some people improve mentally with age - here's how you can be one of them.' Mail on Sunday 'More than a game-changer, this book's a no-brainer for anyone who wants to optimise their brain.' Piers Morgan With a new chapter on Covid and the Brain, this is the definitive guide to keeping your brain healthy for a long and lucid life, by one of the world's leading scientists in the field of brain health and ageing. The brain is our most vital and complex organ. It controls and coordinates our actions, thoughts and interactions with the world around us. It is the source of personality, of our sense of self, and it shapes every aspect of our human experience. Yet most of us know precious little about how our brains actually work, or what we can do to optimise their performance. Whilst cognitive decline is the biggest long-term health worry for many of us, practical knowledge of how to look after our brain is thin on the ground. In this ground-breaking new book, leading expert Professor James Goodwin explains how simple strategies concerning exercise, diet, social life and sleep can transform your brain health paradigm, and shows how you can keep your brain youthful and stay sharp across your life. Combining the latest scientific research with insightful storytelling and practical advice, Supercharge Your Brain reveals everything you need to know about how your brain functions, and what you can do to keep it in peak condition.

In Slavic studies, aging and old age have thus far been only marginal concerns. This volume brings together the scattered research that has been done up to now on aging as represented and narrated in Slavic literatures. The essays investigate Bosnian/Croatian/Serbian, Polish, Russian, Slovak, Slovene and Ukrainian representations of age/aging in various literary genres and epochs and analyze age as a powerful marker of difference and as constitutive of social relations and personal identity.

Research results indicate that older adults have a higher rate of fatality and injury in motor vehicle crashes than any other age group except for teenagers. With the ageing of the American population, concern arises regarding potential increases in rates of crash involvement and injury. This book examines the association of the impairing effects of multiple medication use, drug/drug interactions and drug/disease interactions on motor vehicle crashes in individuals age fifty years and greater.

Take control of your hormones and feel happier and healthier, with this practical guide to re-balancing your body and getting your life back on track ____________ Hormones play a crucial role in our health and well-being, yet few of us understand the toll they take on our bodies when we don't achieve a balance. Whether you're riding the roller coasters of puberty, pregnancy or the menopause, we're all a slave to our hormones at some point in our lives, and they can leave you feeling tired, low and irritable. In It Must Be My Hormones, leading specialists in women's health Dr Marion Gluck and nutritionist Vicki Edgson, show you the role that each of our major hormones plays, how a deficiency can affect our well-being, and what we can do to restore the balance. In this book you'll discover: * How to keep the weight off with thyroid boosting mega-foods * Vitamins which work wonders for your skin * How herbs and spices can give you a caffeine-free energy kick * Which aromatherapy herbs are actually beneficial * Ways to improve cognitive function through mineral supplements From boosting fertility to easing symptoms of PMS, this practical, easy-to-implement guidance will restore mental and physical well-being. Filled with inspiring personal stories, nutritional suggestions and advice on bio-identical hormone therapy, this book will help you regain control of your hormones and your life.

A delicious way to hack your DNA and prevent early aging While some enjoy extremely active and healthy lives as they age, others spend years of their life burdened by heart disease, dementia, and other age-related diseases. Until recently, this was often chalked up to luck or "good genes." But fascinating new research suggests that telomeres, the protective caps on your chromosomes, are actually directly linked to aging. Telomeres, when protected, can lead to a longer, happier life. Fortunately, one of the key components to protecting your telomeres is a balanced diet. The Telomere Diet and Cookbook is the first book to offer an easy-to-read, targeted overview of telomeres and nutrition. Including detailed meal plans and shopping lists, this book offers a simple step-by-step starter program and over 75 delicious recipes.

Mylene's light-hearted advice is all about navigating the world with confidence.' Daily Mail In this witty and uplifting book Parisian blogger Mylene Desclaux speaks tenderly and honestly about turning 50 and what it means for herself and for the other women in her entourage. Mylene assures us that we are still 'young women' in our fifties - but with more opportunities. 'By the time we're fifty, we've generally done all the important things - career, family. Now we can re-centre and discover a new energy within ourselves. It's our time to blossom - to reprogramme gently. To revitalise. We realise that we are the mistresses of our own lives . . . The desire to do battle disappears. We feel calm. And we know we're going to have time to make the most of it.' With acerbic French humour she distils the essence of getting the most out of your middle age and gives advice on everything from: * Relationships * Sex * Fashion * Dating * Skincare * Friendships * Kids * Beauty In WHY FRENCH WOMEN FEEL YOUNG AT 50 you will learn how to take pleasure from the simple things in life and how to make the most of your fifties, the Parisian way.

Hypertension and osteoporosis are two major age-related diseases. They are clinically silent disorders with high morbidity and mortality and the link between them has been reported recently with inconclusive evidence. This book presents and discusses research in this field which will improve our understanding of the relationship between high blood pressure and bone loss. It will begin by examining the clinical and experimental evidence of the involvement of the Renin-Angiotensin System (RAS), playing a central role in blood pressure control, in bone metabolism. This book concludes by summarising the association between hypertension and osteoporosis in a comprehensive literature review.

As life expectancy continues to increase, so does the need to understand the factors that increase health and vitality. "Physiology of Exercise and Healthy Aging" applies the science of exercise physiology to an analysis of the aging process and identifies the positive effects that regular exercise and physical activity have not only on longevity but also on delaying specific diseases, decreasing morbidity, and increasing quality of life. It presents theories on aging, the aging process, the structural and functional changes that characterize advancing age, exercise programming concerns for the aged, drug use and abuse by seniors, and the benefits of exercise and physical activity.

This text offers a more expansive discussion of the particulars of exercise physiology of aging persons than is found in other texts on the subject. With "Physiology of Exercise and Healthy Aging," readers will gain a thorough understanding of the role of physical activity on the aging process, the principles of exercise and assessment considerations for elderly adults, and training for special needs of older adults. Information is presented in the context of three groups found in the aging and health spectrum: average aging individuals, frail elderly, and master athletes. This information is organized within a three-part structure:

-Part I explores age-related changes in the major physiological systems. The effects of physical activity on these systems, as well as necessary adaptations for those with impaired abilities in each system, are also discussed.

-Part II deals with the interactive roles of nutrition; age-related diseases, such as diabetes and osteoporosis; and physical activity.

-Part III presents the physiologic adaptability that may be expected with training and physical activity of older adults. It also addresses the practical issues that must be considered when working with this population, including training for aerobic, anerobic, and muscular fitness; exercise adherence and safety measures; and potential substance abuse of commonly used medications.In addition to the presentation of foundational concepts of physiology as they relate to the process of aging, chapters of" Physiology of Exercise and Healthy Aging" contain exercise regimens related to the chapter topic, other forms of physical activity that have proven beneficial to the aging population, and contraindicated exercises. Physiological responses to acute and chronic exercise perturbations are examined, including studies of cardiorespiratory fitness, muscle metabolism and strength, neurophysiology and the senses, and the effects of exercise on older adults with the diseases of aging, including type 2 diabetes, osteoporosis, arthritis, and cardiovascular disease. Chapter-opening quotes provide the insights of selected thinkers, scientists, and fitness professionals on the topic discussed.

Practitioners who work with older adults will find programming recommendations in each chapter to help translate the science into practice. An appendix offers easy access to forms and assessments, including a Three-Day Nutritional Assessment form and a Client History form. The language used throughout the text embraces the science of exercise physiology but also welcomes practitioners to apply the information presented.

For student readers, "Physiology of Exercise and Healthy Aging" incorporates these helpful features to assist learning and retention:

-Chapter-opening outlines offer quick reference to topics.

-Chapter-ending Questions to Consider provide tools for self-study and reflection.

-Numerous tables and figures reinforce chapter concepts and add visual or statistical information related to the process of aging, fall prevention, international demographics, and theories of aging.

-References provide additional opportunities for reading and research with selected books, articles, and Web sites.

-Appendixes contain information on specific Web sites and numerous tests and forms that may be photocopied for use with clients or patients or for course projects."Physiology of Exercise and Healthy Aging "contains a thorough discussion of the unique effects of aging on the human body and illustrates the power of exercise as a preventive tool to reduce or offset the deleterious effects of aging in order to increase the quality of life enjoyed by our aging population. With this text, both students and professionals will grasp the advantages of appropriate physical activity for the elderly and how to safely administer exercise programs that contribute to the increased health and quality of life for older adults.

Late aging associated changes in alcohol sensitivity, neurobehavioral function, and neuroinflammation, Volume 148, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

Women and Positive Aging: An International Perspective presents the noted research in the fields of psychology, gerontology, and gender studies, reflecting the increasingly popular and pervasive positive aging issues of women in today's society from different cohorts, backgrounds, and life situations. Each section describes a bridge between the theoretical aspects and practical applications of the theory that is consistent with the scientist-practitioner training model in psychology, including case studies and associated intervention strategies with older women in each chapter. In addition to incorporating current research on aging women's issues, each section provides the reader with background about the topic to give context and perspective.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Providing a comprehensive overview of issues of ageing from a global perspective this ambitious text introduces the reader to a wide range of issues and policies on ageing. Topics examined include: theoretical perspectives on ageing in society; demographic trends; roles played by older people as political actors; migration; health; pensions; family and institutional care; and elder abuse.

This will be an essential text for students of social gerontology, as well as an invaluable resource for students of nursing, social work, social policy and development studies.

With the accelerating discovery of human genes, public health professionals are increasingly confronted with a large body of scientific information that will guide public health action. Because the broad mission of public health is to fulfill society's interest in assuring conditions in which people can be healthy, the integration of new genetic information in public health research, policy and program development is unavoidable. Public health leadership is urgently needed to use genetic information to improve health and prevent disease, and to address ethical, legal and social issues resulting from inappropriate use of such information. In the not too-distant future, disease prevention and health promotion programs will routinely consider whether or not to use genetic information to help target behavioral, medical or environmental intervention activities in order to maximize benefit and minimize costs and harm to individuals. In anticipation of the expected growth at the interface of genetics and public health, this book delineates a framework for the integration of advances in human genetics into public health practice. It provides a comprehensive review of public health genetics, including chapters on important general issues such as newborn and other genetic screening, the delivery of genetic services, and the ethical, legal and social implications of the use of genetics within public health. It also reviews relevant clinical topics, the historical background, cross-cultural aspects, and communication issues. Contributors come from a wide range of fields including epidemiology, biostatistics, health policy and management, health services research, behavioral and social sciences, ethics, law, health economics, and laboratory sciences.

When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission.
In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes--gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection--resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. Thus the book presents a holistic view of human genetics.
In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism--the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in theiroccurrence. Hence, there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise.

The University of Florida has an ambitious goal: to harness the power of its faculty, staff, students, and alumni to solve some of society's most pressing problems and to become a resource for the state of Florida, the nation, and the world. In the upcoming decades, an unprecedented demographic shift will take place; the eighty-five and over population is projected to climb far higher than any other age group. To keep the current elderly population healthy and help prevent future generations from experiencing poor health outcomes, researchers are studying crucial connections between skeletal muscles and whole-body health. The University of Florida is at the forefront of this research, utilizing its nationally recognized excellence in the fields of muscle biology and exercise physiology to discover unique ways to preserve muscle health in the aging and those with diseases. Find out how the proteins within muscle can be manipulated to reduce recovery times for individuals who are bedridden. Learn how older, elite athletes have resisted the inevitable degeneration that comes with aging, and how intermittent fasting may help you live longer and healthier. Step inside the lab where a researcher is uncovering the origins of cancer cachexia a wasting syndrome responsible for 20 percent of cancer deaths worldwide to improve the lives of patients. The loss of skeletal muscle through disease, disuse, or aging is associated with a host of poor health outcomes, but promising new avenues of research are being studied every day at the University of Florida to make for a healthier tomorrow.

Recent research findings on the impact of nutrition on telomere length is unlocking the potential to combat premature aging at the cellular level. We have learned that while aging is a natural cellular process, premature aging is not and it can be positively impacted by an Evidence-Based Proactive Nutrition to Slow Cellular Aging diet plan. This book examines key elements of the biology of cell aging and focuses on enhancing mitochondrial function and preventing abnormal cell turnover thus preserving telomere length. It details the cellular damage caused by free radicals and ROS, explains the salutary effects of antioxidants, and the body's need for adequate nitrates and other nutrient substrates from which the body derives nitric oxide (NO) to support cardiovascular health. This book is the first to feature a simple do-it-yourself test of the effects of the diet on the availability of NO for - heart health. The book guides the reader through the rationale for a modified Mediterranean style diet that supplies the body with an adequate daily intake of essential nutrients, simple high antioxidants, and other functional foods. It includes simple, easy to prepare appealing recipes promoting a seamless transition to a healthy, age-defying lifestyle.

Although books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.

When confronted with a neurological or psychiatric disorder in an elderly individual, a clinician or researcher is likely to ask how the processes of ageing have influenced the aetiology and presentation of the disorder, and will impact on its efficient management. There are many urban myths about ageing, and some of these apply to the brain. The reviews included in this book are an attempt to flush out some of these myths, and arm the clinician and general researcher with the empirical facts that can be mustered to substantiate claims about ageing. There are many salient questions: is cognitive change to be expected in an elderly individual? Is this change progressive, relentless and unselective, or is it focal and constrained? Would every person who lived long enough develop Alzheimer s disease? Do our neurones die as we get old? What happens to the size of the brain and its metabolic activity? How do our hormones change with age? Can anti-oxidants slow or even stop the process of ageing? Are genes important in the ageing brain or is it all in the environment? How much of what we are is due to what we eat? The contributors to this book, each an expert in their field, have addressed some of these questions in a language simple enough for a general reader to understand.

The book also deals with some of the most prominent brain disorders of old age - Alzheimer's disease, Parkinson's disease, vascular dementia, and depression. The focus is on the impact of ageing on these disorders. The discussions lay out a broad map for the clinician dealing with neuropsychiatric disorders, and the future researcher of brain ageing. In a field in which the developments are too numerous for any one individual to keep pace with, this book presents up-to-date summaries that can be a useful starting point. The field of brain ageing abounds in tabloid science. This book counters this by providing a strong empirical grounding and considered synthesis of the research."

Is Menstruation Obsolete? argues that regular monthly bleeding is not the "natural" state of women, and that it actually places them at risk of several medical conditions of varying severity. The authors maintain that while menstruation may be culturally significant, it is not medically meaningful. Moreover, they propose that suppressing menstruation has remarkable health advantages. Because of cultural changes, shorter durations of breast feeding, and birth control, the reproductive patterns of modern women no longer resemble that of their Stone age ancestors. Women have moved from the age of incessant reproduction to the age of incessant menstruation. Consequently, they often suffer from clinical disorders related to menstruation: anemia, endometriosis, and PMS, just to name a few. The authors encourage readers to recognize what has gone previously unnoticed that this monthly discomfort is simply not obligatory. They present compelling evidence that the suppression of menstruation is a viable option for women today, and that it can be easily attained through the use of birth control pills. In fact, they reveal that contraceptive manufacturers, knowing that many women equate menstruation with femininity and that without monthly bleeding would fear that they were pregnant, engineered pill dosage regimens to ensure the continuation of their cycles. Indeed, throughout history societies have assigned menstruation powerful meaning, and Is Menstruation Obsolete? presents a fascinating history of how menstruation inspired doctors to try therapeutic bleeding for a variety of ailments, and how this therapy remained dominant in Western medicine until the early 20th century. Is Menstruation Obsolete? offers women a fresh view of menstruation, providing them with the information they need to make progressive choices about their health. This is a message whose time has come.

The past century has witnessed a revolution. Less than a hundred years ago, the average Western life expectancy was 40; now it is 80. And there is no end in sight: the first person who will reach 135 has already been born. It's the most radical change in our society since industrialisation, and naturally it raises many questions. What do longer life spans mean for the way we organise our societies? How can people best prepare themselves for living considerably longer? Does it help to eat less, or to take hormones, vitamins, or minerals? And what can we learn from old people who remain full of vitality, despite illness and infirmity? Growing Older without Feeling Old is the definitive book on a key issue for the 21st century, written by one of the world's leading experts in geriatric medicine. Combining medical, biological, economic, and sociological insights, Rudi Westendorp explores the causes of the ageing revolution and explains how we can greet it with confidence and enjoy leading longer, healthier, and more productive lives than ever before.