This book reviews research on presently known theories and
mechanisms responsible for the rate of ageing and maximum longevity
of different animals including birds, mammals and humans (to
explain "how" do we age and the velocity of the ageing process). In
addition, this book deals with the historical evolutionary
explanations of ageing and longevity ("why" do we age). The
mechanisms discussed include mitochondria and oxygen free radicals,
the presence of macromolecules constitutively highly resistant to
deleterious modification in the tissues of long-lived animals,
insulin/IGF-1 like signalling, telomere shortening, dietary
restrictions, and other proposed molecular mechanisms.
General
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