In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable. But what if everything you think you know about ageing is wrong? What if ageing is a disease? And that disease is curable. In LIFESPAN, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death. But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more. Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

'Some people improve mentally with age - here's how you can be one of them.' Mail on Sunday 'More than a game-changer, this book's a no-brainer for anyone who wants to optimise their brain.' Piers Morgan With a new chapter on Covid and the Brain, this is the definitive guide to keeping your brain healthy for a long and lucid life, by one of the world's leading scientists in the field of brain health and ageing. The brain is our most vital and complex organ. It controls and coordinates our actions, thoughts and interactions with the world around us. It is the source of personality, of our sense of self, and it shapes every aspect of our human experience. Yet most of us know precious little about how our brains actually work, or what we can do to optimise their performance. Whilst cognitive decline is the biggest long-term health worry for many of us, practical knowledge of how to look after our brain is thin on the ground. In this ground-breaking new book, leading expert Professor James Goodwin explains how simple strategies concerning exercise, diet, social life and sleep can transform your brain health paradigm, and shows how you can keep your brain youthful and stay sharp across your life. Combining the latest scientific research with insightful storytelling and practical advice, Supercharge Your Brain reveals everything you need to know about how your brain functions, and what you can do to keep it in peak condition.

This authoritative reference work contains more than 300 entries covering all aspects of the multi-disciplinary field of adult development and aging Brings together concise, accurate summaries of classic topics as well as the most recent thinking and research in new areas Covers a broad range of issues, from biological and physiological changes in the body to changes in cognition, personality, and social roles to applied areas such as psychotherapy, long-term care, and end-of-life issues Includes contributions from major researchers in the academic and clinical realms 3 Volumes www.encyclopediaadulthoodandaging.com

The age-friendly community movement is a global phenomenon, currently growing with the support of the WHO and multiple international and national organizations in the field of aging. Drawing on an extensive collection of international case studies, this volume provides an introduction to the movement. The contributors - both researchers and practitioners - touch on a number of current tensions and issues in the movement and offer a wide-ranging set of recommendations for advancing age-friendly community development. The book concludes with a call for a radical transformation of a medical and lifestyle model of aging into a relational model of health and social/individual wellbeing.

*** 'Are you aging fabulously? Here's how.' Anna Murphy, The Times 'A lovely book celebrating female beauty over 40.' Top Sante 'You become what you see. What you see determines what you believe - and the most powerful way of inspiring people is with images. My goal with AndBloom is to motivate women to embrace life without fear. To provide examples of women between the age of 40 and, currently, 100, so that any woman can open this book and see themselves recognized.' Denise Boomkens launched the AndBloom project on Instagram in 2018, to create a 'happy place for women over 40' - a community where women can be themselves and where aging is celebrated instead of feared. In this, her first book, she shares her own experiences of aging and brings together portraits and interviews with more than 100 extraordinary 'ordinary' women to create both a gloriously illustrated celebration of female beauty over 40 and an empowering handbook to aging happily.

Predicting water runoff in ungauged water catchment areas is vital to practical applications such as the design of drainage infrastructure and flooding defences, runoff forecasting, and for catchment management tasks such as water allocation and climate impact analysis. This full colour book offers an impressive synthesis of decades of international research, forming a holistic approach to catchment hydrology and providing a one-stop resource for hydrologists in both developed and developing countries. Topics include data for runoff regionalisation, the prediction of runoff hydrographs, flow duration curves, flow paths and residence times, annual and seasonal runoff, and floods. Illustrated with many case studies and including a final chapter on recommendations for researchers and practitioners, this book is written by expert authors involved in the prestigious IAHS PUB initiative. It is a key resource for academic researchers and professionals in the fields of hydrology, hydrogeology, ecology, geography, soil science, and environmental and civil engineering.

From the author of the New York Times bestseller The Plant Paradox comes a groundbreaking plan for living a long, healthy, happy life. From the moment we are born, our cells begin to age. But aging does not have to mean decline. World-renowned surgeon Dr. Steven Gundry has been treating mature patients for most of his career. He knows that everyone thinks they want to live forever, until they hit middle age and witness the suffering of their parents and even their peers. So how do we solve the paradox of wanting to live to a ripe old age-but enjoy the benefits of youth? This groundbreaking book holds the answer. Working with thousands of patients, Dr. Gundry has discovered that the "diseases of aging" we most fear are not simply a function of age; rather, they are a byproduct of the way we have lived over the decades. In The Longevity Paradox, he maps out a new approach to aging well-one that is based on supporting the health of the "oldest" parts of us: the microorganisms that live within our bodies. Our gut bugs-the bacteria that make up the microbiome-largely determine our health over the years. From diseases like cancer and Alzheimer's to common ailments like arthritis to our weight and the appearance of our skin, these bugs are in the driver's seat, controlling our quality of life as we age. The good news is, it's never too late to support these microbes and give them what they need to help them-and you-thrive. In The Longevity Paradox, Dr. Gundry outlines a nutrition and lifestyle plan to support gut health and live well for decades to come. A progressive take on the new science of aging, The Longevity Paradox offers an action plan to prevent and reverse disease as well as simple hacks to help anyone look and feel younger and more vital.

Research documents that rural elders are poorer, live in less adequate housing, and have far fewer health and service options available to them than their urban counterparts, yet there is a critical lack of current and detailed information on the problems facing rural elders and on the professional practices that serve this population. This text fills this gap by introducing readers to rural areas and their residents and discussing the issues, programs, and policies designed to meet their needs. Through a multidisciplinary lens, it examines and defines specific competencies required for successful work with older adults and their families in these communities.

The text presents a research-driven, competency-based approach for the health and human service professionals who work with older rural residents. It discusses both the problems facing older adults and their families and evidence-based solutions regarding policy and best practices. Key issues examined include health and wellness, transportation, housing, long-term care, income, employment, and retirement, along with the needs of special populations (ethnic minorities, immigrants, and the LGBT population). Case examples reinforce an interdisciplinary model that addresses practice with rural elders that encompasses professional competencies, values and ethics, and the roles of a spectrum of health and human service professionals. The text also examines current policies affecting health and social services to rural elders and recommendations for policy change to build an effective health and human service workforce in rural communities. Links to Podcast interviews with scholars and respected professionals working in the field and "Spotlight" excerpts from the text reinforce information. In addition, the text provides discussion questions, PowerPoint slides, a test question bank, and suggested activities and exercises.

Key Features: Fills a vacuum regarding information on health and social services for rural elders Provides current and comprehensive knowledge about issues besetting this population and programs and policies designed to meet their needs Examines and defines specific competencies required for effective health and social services Based on a research-driven, competency-based, interdisciplinary approach to policy and best practice Includes links to Podcast interviews with scholars and respected professionals in the field

The processes that control senescence have been the subject of more then a century of serious biological research. Two institutions closely involved in this programme, the Society for the Study of Human Biology and the British Society for Research in Ageing, held a joint symposium in 1984 to consider human ageing and longevity from an interdisciplinary point of view. The resulting book has four main sections: the evolution and genetics of ageing, biological age assessment, demographic and social aspects, and the nutritional and physiological aspects of ageing and longevity. The fundamental nature of the subject will generate interest across a wide range of biological and medical disciplines.

No one wants to think about getting older. It's true. At any age, when things are moving along normally day to day and everyone seems fit and well, there seems no reason to think about future problems that your friends and relatives might (and probably will) come across as they age. In fact, it might even seem a little morbid to think such thoughts, or possibly even tempting fate? Yet there will come a time when you must raise these issues and, ideally, this should be before any problems arise. The Essential Family Guide to Caring for Older People is the ultimate source of information and help for families with care responsibilities. Deborah Stone draws on her extensive experience working in elder care to offer practical advice on every aspect of the field indepth. Topics range from how to get help immediately, legal information, care funding options, a guide to useful technology and advice on the main physical and mental health issues that affect older people. Plus guidance is given on dealing with social services and ensuring you choose the right care for your situations. Crucially, the book also offers help on how to cope as a carer with practical advice on juggling family, work and your caring responsibilities while looking after yourself.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Combining anthropological, gerontological and biocultural evidence, this study explores how humans came to grow old as slowly as they do, and what impacts this has had on their health and lives. It is only comparatively recent that humans have developed late-life survival, but much of the research on senescence is based on isolated cells, worms, and fruit flies, which may be only of peripheral relevance to human aging.

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging.

"Protein Oxidation and Aging" begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation processCellular mechanisms for managing oxidized proteinsRole of protein oxidation in agingInfluence of genetic and environmental factors on protein oxidationMeasuring protein oxidation in the aging processProtein oxidation in age-related diseases

References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

This book describes mechanisms of skin damage generation and examines the potential impact of free radicals, reactive oxygen species (ROS) and oxidative damage on the skin ageing process. It also evaluates methods to decrease skin oxidative stress, oxidative damage, and skin ageing. The identification of free radical reactions as promoters of the skin ageing process implies that interventions aimed at limiting or inhibiting free radical reactions should be able to reduce the rate of formation of ageing-related changes with a consequent reduction of the ageing rate. This book highlights how ageing of the skin happens, as well as what are the causes and the best ways to prevent and treat it.

When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission.
In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes--gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection--resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and their products. Thus the book presents a holistic view of human genetics.
In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism--the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in theiroccurrence. Hence, there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise.

A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.

This book presents a comprehensive review of the morphology and function of chromosomes in elderly people. The wide range of topics includes cyclical chromosome properties, mutations, repair, progressive chromosome heterochromatinization with increasing age, roles of nucleolar organiser regions, sister chromatid exchanges, homologue relationships, heterochromatin regions and other chromosomal features in very old age. This ground-breaking book focuses on heterochromatinisation as a key determinant of the genetic apparatus function during senescence and an area to seek life-prolonging interventions. The book illustrates and updates progress in the field of cytogenetics of ageing. The book contains 16 tables and 25 figures.

Healthy Ageing and Aged Care takes an inter-disciplinary approach to supporting older people within the community and in care. It represents current Australian policies and practices and takes a holistic view of the older person, and emphasises the positive aspects of the ageing process, maintaining that people age in healthy ways and continue to be an integral part of their families and communities. This is one of the rewarding aspects of working with older people-assessing accurately and collaboratively putting in place strategies that can maintain the person's quality of life. The goal is for students to be able to develop those skills by engaging with the material in this book.

New science updates the "blue zones" secrets to healthy longevity with a flexible, holistic approach that incorporates epigenetics, nutrition, and mental health. Through his documentary film series, The Human Longevity Project, Jason Prall traveled to select regions around the world known for their long-lived, healthy populations. He sought to understand not only the longevity secrets of these societies but also the scientific basis underpinning their health wisdom. Through his travels, he came to the realization that while the pursuit of longevity is sexy, it's insufficient and hollow-what most of us really want is an extended life filled with vibrant health, meaning, and purpose. We want to thrive as we age. This book combines his own personal experiences with the knowledge and wisdom gained from interviewing more than 100 health experts and dozens of amazing elders from around the world. You'll discover that when experiential wisdom is supported by the latest scientific research, a more integrated picture emerges of how you can most effectively increase your happiness, health, and longevity. Life is a mysterious process with a natural development, order, and cycle. It is lent to us for a brief moment before the physical body is left behind. If we wish to thrive in the modern world, we must create a mental, emotional, physical, and energetic environment that is congruent with this natural lifecycle. The reality that humanity has created, filled with next-generation technologies and increasing comforts, presents both unique opportunities and novel challenges. We have the option to choose a more harmonious path that establishes greater coherence within ourselves, one another, and the environment. This is the amazing opportunity that lies before us. When we live from alignment, all life benefits.

Ever wondered what's really going on in your body as you age? Can you really eat to beat cancer or prevent heart disease? These questions and more are answered in Eat Better, Live Longer, helping you make achievable, sensible, science-based changes to your diet from day one. Discover the secrets of long life from centenarians around the world, and explore the 10 simple but meaningful adaptations you can make both to what you eat and to how you eat to follow in their footsteps. A four-week eating plan, with over 110 nutrient-packed recipes, helps you learn to make smarter choices about foods that can reduce your risk of certain diseases and lessen the effects of others. Use this new-found knowledge together with details on how each part of your body changes as you age and which nutrients you need to support support all-round health, helping you live a longer, happier life. Future-proof your life with this science-based superfood approach to discovering what is really happening to your body as you are aging.

This new book will enable family practitioners, obstetricians and pediatricians to answer the concerns of the families in their care. It is the first book to make information on this important topic so easily accessible to clinicians. The book is firmly rooted in clinical practice and based on many years of experience, much of it involving the development and implementation of new techniques for examining the fetus in utero. The techniques now available are assessed and better ways to identify pregnancies which are eligible to their application are proposed. The authors describe both the sampling and laboratory techniques available. Other sections cover both predictable and unpredictable pregnancy risks from genetic diseases to abnormal ultrasound, including the possibilities for laboratory evaluation, and the risks and limitations. Throughout the book, the special status of the fetus as a patient is emphasized and the concerns and questions of families are considered, making this the first fully comprehensive and authoritative volume on fetal medicine.

Despite the undeniable physical, psychological, and social effects of aging, most older persons cope quite well and find considerable satisfaction in their later years. Part of the explanation for this finding is based on what Robert C. Atchley calls "continuity"--the ability of older persons to maintain a strong sense of purpose and self in the face of the changes associated with aging. Continuity can help individuals evolve psychologically and socially in the presence of life events such as retirement, widowhood, and physical disability.

Atchley begins with a thorough explanation of continuity theory, identifying important methodological considerations in its evaluation and use. He then looks at evidence for continuity over time in the ways individuals interpret their experiences and make decisions regarding their living arrangements and lifestyles. He examines continuity as a personal goal that most people use to guide their development as individuals. Atchley finds that many aging adults add transcendence as a personal goal in later adulthood. In a concluding chapter, he revisits the basic elements of continuity theory, summarizing the evidence that supports it.

Drawing on data from a twenty-year longitudinal study that began with more than 1,200 individuals, "Continuity and Adaptation in Aging" explains one of the primary underlying forces that promotes effective adaptation to the aging process. This book will be of interest to researchers and students in gerontology and adult development.

A delicious way to hack your DNA and prevent early aging While some enjoy extremely active and healthy lives as they age, others spend years of their life burdened by heart disease, dementia, and other age-related diseases. Until recently, this was often chalked up to luck or "good genes." But fascinating new research suggests that telomeres, the protective caps on your chromosomes, are actually directly linked to aging. Telomeres, when protected, can lead to a longer, happier life. Fortunately, one of the key components to protecting your telomeres is a balanced diet. The Telomere Diet and Cookbook is the first book to offer an easy-to-read, targeted overview of telomeres and nutrition. Including detailed meal plans and shopping lists, this book offers a simple step-by-step starter program and over 75 delicious recipes.

This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.