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Books > Medicine > Pre-clinical medicine: basic sciences > Human reproduction, growth & development > Human growth & development > Maturation & ageing

Comparative Biology of Aging (Hardcover, 2010 Ed.): Norman S. Wolf Comparative Biology of Aging (Hardcover, 2010 Ed.)
Norman S. Wolf
R5,700 Discovery Miles 57 000 Ships in 10 - 15 working days

The processes of aging and death remain one of the most fascinating, and mysterious, areas of biological research. Huge anomalies between species raise questions the answers to which could have fundamental implications for the field of medical science. As scientists unlock the secrets of the exceptionally long-lived little brown bat (up to 34 years), or the common budgerigar, for example, which despite having a metabolic rate 1.5 times that of a laboratory mouse, can live for up to 20 years, it has become more important than ever to be able to make a comparative analysis of the various species used in research.

Dealing with every one of the mammalian species that are employed in laboratory research, this is the first book on the subject of aging that provides detailed comparative data for age-related changes in its subjects. It does so at the level of the whole animal, its organs, organelles and molecules. The comparative data, supplied in 15 chapters by leading experts, provides information on fields as disparate as telomere function and loss, the importance of the Sirtuins and Tor, the influence of hormones on lifespans, the relationship between body size and lifespan, the effects of restricted calorific intake, age-related changes in cell replication, and DNA damage and repair. Chapters are devoted to cardiac aging, comparative skeletal muscle aging, the aging of the nervous and immune systems, the comparative biology of lyosomal function and how it is affected by age, and many other key areas of research.

This much-needed text will provide scientists working in a wide spectrum of fields with key data to aid them in their studies.

Handbook of Cognitive Aging - Causes, Processes & Effects (Hardcover, New): Quentin Gariepy, Raphael Menard Handbook of Cognitive Aging - Causes, Processes & Effects (Hardcover, New)
Quentin Gariepy, Raphael Menard
R5,969 Discovery Miles 59 690 Ships in 12 - 17 working days

Ageing is the accumulation of changes in an organism or object over time. Ageing in humans refers to a multidimensional process of physical, psychological, and social change. Some dimensions of ageing grow and expand over time, while others decline. Reaction time, for example, may slow with age, while knowledge of world events and wisdom may expand. Research shows that even late in life potential exists for physical, mental, and social growth and development. Ageing is an important part of all human societies reflecting the biological changes that occur, but also reflecting cultural and societal conventions. More people are reaching older age today than ever before and the incidence of dementia is thus expected to rise. It is important to investigate the possible prevention of dementia and cognitive decline. This new book gathers the latest research from around the globe in this field of study and related topics such as cardiovascular disease and cognitive function, physical exercise and cognitive function in the elderly, the dementia diagnosis, the role of MRI in Alzheimer's disease, oestrogen decline effects on the mental health of ageing women and the relationship between dementia and depression.

Epigenetics of Aging (Hardcover, 2010 ed.): Trygve O Tollefsbol Epigenetics of Aging (Hardcover, 2010 ed.)
Trygve O Tollefsbol
R4,485 Discovery Miles 44 850 Ships in 10 - 15 working days

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research.

The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins.

Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

New Directions in Aging Research - Health & Cognition (Hardcover): Ruby R. Brougham New Directions in Aging Research - Health & Cognition (Hardcover)
Ruby R. Brougham
R3,614 R2,296 Discovery Miles 22 960 Save R1,318 (36%) Ships in 12 - 17 working days

One of the greatest challenges of the 21st century is global ageing. A primary objective of this book is to review research that is at the forefront in providing information regarding the decline, maintenance, and improvements in health and cognition that are associated with age. Another objective is to provide information regarding pioneering methods to ameliorate age-related declines. It brings together scholars with a wide variety of expertise who present innovative ideas about lifestyle and brain health, quality of life issues, memory interventions, methodology for pain assessment, health communication, decision-making, future time perspective, and retirement goals. The reader will finish this book with a greater understanding of the problems and potential solutions for addressing the important problems of an ageing population. This timely book will make an important contribution to the current aging literature by offering new ideas to stimulate further research and application in understanding health, cognition, and ageing. This book is appropriate for advanced undergraduate students, graduate students, and professionals who study or work in the fields of psychology, gerontology, social work, human development and health fields such as nursing, physical therapy, and occupational therapy.

Life-Span Extension - Single-Cell Organisms to Man (Hardcover, 2009 ed.): Christian Sell, Antonello Lorenzini, Holly M.... Life-Span Extension - Single-Cell Organisms to Man (Hardcover, 2009 ed.)
Christian Sell, Antonello Lorenzini, Holly M. Brown-Borg
R4,393 Discovery Miles 43 930 Ships in 10 - 15 working days

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.

Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.

Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

New Topics in Aging (Hardcover): Pauline T. Seplina New Topics in Aging (Hardcover)
Pauline T. Seplina
R1,973 R1,738 Discovery Miles 17 380 Save R235 (12%) Ships in 12 - 17 working days

Ageing or aging is the accumulation of changes in an organism or object over time. Ageing in humans refers to a multidimensional process of physical, psychological, and social change. Some dimensions of ageing grow and expand over time, while others decline. Reaction time, for example, may slow with age, while knowledge of world events and wisdom may expand. Research shows that even late in life potential exists for physical, mental, and social growth and development. Ageing is an important part of all human societies reflecting the biological changes that occur, but also reflecting cultural and societal conventions. This book examines several important issues in the field.

Protein Oxidation and Aging (Hardcover): T. Grune Protein Oxidation and Aging (Hardcover)
T. Grune
R4,021 Discovery Miles 40 210 Ships in 12 - 17 working days

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging.

"Protein Oxidation and Aging" begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation processCellular mechanisms for managing oxidized proteinsRole of protein oxidation in agingInfluence of genetic and environmental factors on protein oxidationMeasuring protein oxidation in the aging processProtein oxidation in age-related diseases

References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

Human Chromosomes & Aging (Paperback, New): Teimuraz Lezhava Human Chromosomes & Aging (Paperback, New)
Teimuraz Lezhava
R1,385 R1,093 Discovery Miles 10 930 Save R292 (21%) Ships in 12 - 17 working days

This book presents a comprehensive review of the morphology and function of chromosomes in elderly people. The wide range of topics includes cyclical chromosome properties, mutations, repair, progressive chromosome heterochromatinization with increasing age, roles of nucleolar organiser regions, sister chromatid exchanges, homologue relationships, heterochromatin regions and other chromosomal features in very old age. This ground-breaking book focuses on heterochromatinisation as a key determinant of the genetic apparatus function during senescence and an area to seek life-prolonging interventions. The book illustrates and updates progress in the field of cytogenetics of ageing. The book contains 16 tables and 25 figures.

Closing Chapters of Long Lives - Results from the 10-Year Swilsoo Study on the Oldest Old (Hardcover): Edith Guilley, Christian... Closing Chapters of Long Lives - Results from the 10-Year Swilsoo Study on the Oldest Old (Hardcover)
Edith Guilley, Christian J. Lalive d'Epinay
R2,424 R1,946 Discovery Miles 19 460 Save R478 (20%) Ships in 12 - 17 working days

Book & CD. One of the most striking demographic changes over the last century in Western countries has been the rapid growth, both absolute and relative, of the oldest-old population, to such an extent that living beyond the age of 80 years constitutes a new stage of life. But what is life like after 80? Rather than scrutinizing the pathologies of very old age, this book enquires into the normal aging of the oldest old, their health trajectories, their socio-demographic inequalities; it analyses their daily life, including their social relationships, social support, and activities, and observes how the oldest old adapt to the multiple stresses and challenges of very old age. The book reports major results obtained from Swilsoo, a long-term longitudinal study based on two cohorts of octogenarians. The two cohorts were assessed on an approximately yearly basis, the first for 9 waves from 1994 to 2004, with 340 participants at inception, and the second for 5 waves from 19v9 to 2004, initially with 377 participants. The book demonstrates that many common stereotypes concerning the oldest old are false. For examples, their main shared characteristic is not sickness, but frailty, which affects them in different ways. A long life does not necessarily culminate in dependence. Dependence is a risk -- especially among persons of lower socio-economic status -- but not an ineluctable outcome. It also helps to bring out the importance of social and psychological resources in the lives of the oldest old. Although multiple stresses such as negative health-related changes or self-reported bereavements of a loved one often occur in the life of the elderly and affect their health and well-being, the very old can take advantage of various resources or adjustment mechanisms to help preserve their well-being and robustness. The book shows for instance that the preservation by the elderly of a positive and active role within the family is a boon to their health and that the continuation of leisure activities or the effective use of psychological resources counters the negative effects of frailty on well-being.

When Puberty is Precocious - Scientific and Clinical Aspects (Hardcover, 2007 ed.): Ora H. Pescovitz, Emily C. Walvoord When Puberty is Precocious - Scientific and Clinical Aspects (Hardcover, 2007 ed.)
Ora H. Pescovitz, Emily C. Walvoord
R5,752 Discovery Miles 57 520 Ships in 10 - 15 working days

This book focuses on precocious puberty, providing a unique continuum of expertise looking at puberty from anthropologic, epidemiologic, clinical, and molecular perspectives. The volume addresses broad pubertal changes in the general population while at the same time providing in depth information about specific disorders of puberty and the latest management changes. In particular, the book is intended for endocrinologists and internists.

Biological Aging - Methods and Protocols (Hardcover, 2007 ed.): Trygve O Tollefsbol Biological Aging - Methods and Protocols (Hardcover, 2007 ed.)
Trygve O Tollefsbol
R5,212 Discovery Miles 52 120 Ships in 10 - 15 working days

The goal of Biological Aging: Methods and Protocols is to present some of the most promising and important tools that are currently used in biological aging research. These tools include established protocols such as aging cell culture as well as many more contemporary approaches such as nuclear transfer, microarray and proteomics technologies and the use of ribozymes in aging research. Collectively, these powerful tools combined with the many other techniques that are presented are rapidly advancing the exciting and expanding field of biological aging.

New Research on Cell Aging (Hardcover, Illustrated Ed): Reginald B. Garvey New Research on Cell Aging (Hardcover, Illustrated Ed)
Reginald B. Garvey
R5,138 R4,539 Discovery Miles 45 390 Save R599 (12%) Ships in 12 - 17 working days

This book presents research on cell growth and the ageing process. Emphasis is given to implications for cancer therapy, abnormal mitosis and aberrant nuclear morphology, neoplastic transformations, negative charges on various malignant cell types.

The Many Faces of Health, Competence and Well-Being in Old Age - Integrating Epidemiological, Psychological and Social... The Many Faces of Health, Competence and Well-Being in Old Age - Integrating Epidemiological, Psychological and Social Perspectives (Hardcover, 2006 ed.)
Hans-Werner Wahl, Herrmann Brenner, Heidrun Mollenkopf, Dietrich Rothenbacher, Christoph Rott
R4,414 Discovery Miles 44 140 Ships in 10 - 15 working days

Hans-Werner Wahl, Hermann Brenner, Heidrun Mollenkopf, Dietrich Rothenbacher and Christoph Rott Ageing research has been identi?ed as a prototypical ?eld of inquiry deserving the full exploitation of single discipline approaches and interdisciplinary synergies amongst these single perspectives. Although this is a generally accepted insight, there still is a strong need to provide models of how this global and most fundamental challenge can be dealt with. It seems in any case necessary to narrow down the wide scope of ageing research issues to sets of key constructs most promising in terms of interdisciplinary cross-fertilisation. Againstthis,themajoraimofthebookistoprovideacomprehensive treatment of one well-selected set of key issues of recent ageing research, i. e. health, competence and well-being. In addition, the book's ambition is to identify priorities for future ageing research and to further new avenues for interdisciplinary approaches and social policy applications. The substance of the book is based on an international conference which took place on June 18 and 19, 2004 in Heidelberg, Germany. Framed within the array of health, competence and well-being perspectives in ageing research, the idea of the conf- ence was to provide an integrated presentation of ?ndings generated in the German Centre for Research on Ageing at the University of Heidelberg (Deutsches Zentrum f. ur Alternsforschung, DZFA). The centre's three departments, i. e.

Longevity and Frailty (Hardcover, 2005 ed.): J. R. Carey, Jean-Marie Robine, J.P. Michel Longevity and Frailty (Hardcover, 2005 ed.)
J. R. Carey, Jean-Marie Robine, J.P. Michel
R5,622 Discovery Miles 56 220 Ships in 10 - 15 working days

Understanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship.

Resilient Widowers - Older Men Adjusting to a New Life (Paperback): Alinde J. Moore, Dorothy C. Stratton Resilient Widowers - Older Men Adjusting to a New Life (Paperback)
Alinde J. Moore, Dorothy C. Stratton
R558 R491 Discovery Miles 4 910 Save R67 (12%) Ships in 10 - 15 working days

Based on an intensive qualitative study of a diverse group of 51 older widowers, this unique book sets widowhood within the context of life experience and identifies characteristics and patterns of behaviour that contribute to widowers' success, or lack of it, in adjusting satisfactorily to their circumstances. The authors shed light on widowers' specific needs and on the services needed to help widowers develop greater self-reliance. Among the topics discussed are models of resilience, marriage and illness of the spouse, caregiving and communication, death of the wife, grief and adjustment, living alone and remarriage, life values carried forward, adult children and other social support, and cohorts and the future. The authors conclude with a consideration of trends that may influence the next generation's experience of widowhood. This excellent volume offers expert guidance on the needs and care of the nearly invisible population of older widowers.

Handbook of Adult Development (Hardcover, 2003 ed.): Jack Demick, Carrie Andreoletti Handbook of Adult Development (Hardcover, 2003 ed.)
Jack Demick, Carrie Andreoletti
R8,922 Discovery Miles 89 220 Ships in 10 - 15 working days

This volume is an outgrowth ofcontemporary research on development over the adult lifespan, which by now has burgeoned and developed both nationally and internationally. However, for us, the impetus to be involved in this area was spawned and nurtured by our initial association with the Society for Research in Adult Development (SRAD) with its origins some 15 years ago by Michael Commonsand his associates inCambridge, Massachusetts. Throughthegood will and support of this society, we also became, and are still, heavily involved with the Journal of Adult Development and the Kluwer-Plenum Monograph Series on Adult Development and Aging, ofwhich this volume is a companion. Many ofthe contributions in the volume are from SRAD members, who con sistently adhere to a focus on positive adult development. Their chapters have been complemented by pieces from other researchers, who have adopted more mainstream approaches to adult development and/oraging. Regardless ofthe par ticular approach and/or focus of the chapter, all the work reported herein sup ports the relatively recent idea that development is not restricted to children and adolescents but continues throughout the adult lifespan in ways that we never envisionedsome 20 years ago. Thus, the volume represents state-of-the-arttheory, research, and practice on adult development, which has the potential to occupy us all for some time to come."

Trace Elements and Minerals in Health and Longevity (Hardcover, 1st ed. 2018): Marco Malavolta, Eugenio Mocchegiani Trace Elements and Minerals in Health and Longevity (Hardcover, 1st ed. 2018)
Marco Malavolta, Eugenio Mocchegiani
R4,700 Discovery Miles 47 000 Ships in 10 - 15 working days

This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Aging Methods and Protocols (Hardcover, 2000 ed.): Yvonne A. Barnett, Christopher R Barnett Aging Methods and Protocols (Hardcover, 2000 ed.)
Yvonne A. Barnett, Christopher R Barnett
R3,140 Discovery Miles 31 400 Ships in 10 - 15 working days

Aging is an almost universal process within biological systems, one which leads to a decline in functional capacity, disease onset, and eventually death. There has been much interest in recent years to elucidate the molecular mec- nisms that underlie the aging process. Many theories have been proposed since the last century that aim to explain the causes of aging. There is no one theory that completely satisfies the phenotype of aging, but genetics and environm- tal factors play an important role in the etiology of age-related pathologies and the aging process. However, there is still much to be learned about the aging process which has been termed one of the last great frontiers in biology. De- graphic changes worldwide are leading to increased average life expectancies within our populations. These changes in population characteristics will impact upon the economies of the supporting society, with increasing healthcare and infrastructural costs arising from the prevalence of age-related pathologies and other physical disabilities associated with advancing years. Many researchers worldwide are working in the attempt to identify key cellular processes through which it might one day be possible to slow down the aging process and thus increase the health span of humans. Numerous research projects-from the cellular through to tissue, organ, and whole organism studies-are currently underway to investigate the mul- factorial aging process.

Aging and Human Longevity (Paperback, 1996 ed.): Marie-Francoise Schulz-Aellen Aging and Human Longevity (Paperback, 1996 ed.)
Marie-Francoise Schulz-Aellen
R1,539 Discovery Miles 15 390 Ships in 10 - 15 working days

The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Women's Health in Menopause - Behaviour, Cancer, Cardiovascular Disease, Hormone Replacement Therapy (Hardcover,... Women's Health in Menopause - Behaviour, Cancer, Cardiovascular Disease, Hormone Replacement Therapy (Hardcover, illustrated edition)
P.G. Crosignani, Rodolfo Paoletti, P.M. Sarrel, Nanette Kass Wenger, M. Meschia, …
R2,651 Discovery Miles 26 510 Ships in 10 - 15 working days

Few topics in women's medicine today are as fraught with confusion and controversy as the question of appropriate treatment for menopausal symptoms and the prevention of negative long term health outcomes common to post-menopausal women. Cardiovascular disease (CVD), osteoporosis, and cancer - the most common causes of death, disability and impaired quality of life for women - can potentially be prevented or forestalled by dietary, behavioural and drug interventions. A better understanding of the natural history of the menopause is critical to providing better care. If women and their physicians have a better understanding of predictors of risk, they could make more informed decisions about interventions related to menopausal symptoms, CVD, osteoporosis and gynaecologic and breast cancer. Few other recently introduced medical interventions have as great a potential of affecting morbidity and mortality as does hormone replacement therapy (HRT). HRT has produced effect on health risk: some are reduced, some are raised, and some uncertain, and these data are interpreted differently by various scientific, medical and consumer groups.

It Must Be My Hormones - A Practical Guide to Re-balancing your Body and Getting your Life Back on Track (Paperback): Marion... It Must Be My Hormones - A Practical Guide to Re-balancing your Body and Getting your Life Back on Track (Paperback)
Marion Gluck, Vicki Edgson 2
R512 R415 Discovery Miles 4 150 Save R97 (19%) Ships in 9 - 15 working days

Take control of your hormones and feel happier and healthier, with this practical guide to re-balancing your body and getting your life back on track ____________ Hormones play a crucial role in our health and well-being, yet few of us understand the toll they take on our bodies when we don't achieve a balance. Whether you're riding the roller coasters of puberty, pregnancy or the menopause, we're all a slave to our hormones at some point in our lives, and they can leave you feeling tired, low and irritable. In It Must Be My Hormones, leading specialists in women's health Dr Marion Gluck and nutritionist Vicki Edgson, show you the role that each of our major hormones plays, how a deficiency can affect our well-being, and what we can do to restore the balance. In this book you'll discover: * How to keep the weight off with thyroid boosting mega-foods * Vitamins which work wonders for your skin * How herbs and spices can give you a caffeine-free energy kick * Which aromatherapy herbs are actually beneficial * Ways to improve cognitive function through mineral supplements From boosting fertility to easing symptoms of PMS, this practical, easy-to-implement guidance will restore mental and physical well-being. Filled with inspiring personal stories, nutritional suggestions and advice on bio-identical hormone therapy, this book will help you regain control of your hormones and your life.

Environmental Pollutants-Induced Oxidative Stress - A Role for Antioxidants in Health Promotion & Aging Prevention (Hardcover):... Environmental Pollutants-Induced Oxidative Stress - A Role for Antioxidants in Health Promotion & Aging Prevention (Hardcover)
Borut Poljsak, Uros Glavan
R6,360 R5,552 Discovery Miles 55 520 Save R808 (13%) Ships in 12 - 17 working days

The book offers a comprehensive review of current research regarding the influences of environmental factors involved in human health and ageing. Many environmental compounds promote excessive oxidative stress, which is the primary cause of accelerated ageing and which also contributes to the development of human diseases. The basic concepts of ageing theories are discussed, as is the promotion of oxidative stress which has been identified as one of the most important mechanisms responsible for the toxic effects of the majority of environmental pollutants. Antioxidants play an important role in the defence against pollutant-induced toxicity.

Cognitive Aging - Progress in Understanding and Opportunities for Action (Hardcover): Institute of Medicine, Board on Health... Cognitive Aging - Progress in Understanding and Opportunities for Action (Hardcover)
Institute of Medicine, Board on Health Sciences Policy, Committee on the Public Health Dimensions of Cognitive Aging; Edited by Catharyn T Liverman, Kristine Yaffe, …
R1,666 Discovery Miles 16 660 Ships in 12 - 17 working days

For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors. Table of Contents Front Matter Summary 1 Introduction 2 Characterizing and Assessing Cognitive Aging 3 Population-Based Information About Cognitive Aging 4A Risk and Protective Factors and Interventions: Lifestyle and Physical Environment 4B Risk and Protective Factors and Interventions: Health and Medical Factors 4C Risk and Protective Factors and Interventions: General Cognitive Aging Interventions and Next Steps 5 Health Care Response to Cognitive Aging 6 Community Action: Health, Financial Management, Driving, Technology, and Consumer Decisions 7 Public Education and Key Messages 8 Opportunities for Action Appendix A: Meeting Agendas Appendix B: U.S. Surveys and Studies That Include One or More Items to Measure Cognition Appendix C: Committee Biographies

Skin Aging, Free Radicals & Antioxidants (Hardcover): Borut Poljsak Skin Aging, Free Radicals & Antioxidants (Hardcover)
Borut Poljsak
R5,909 R5,457 Discovery Miles 54 570 Save R452 (8%) Ships in 12 - 17 working days

This book describes mechanisms of skin damage generation and examines the potential impact of free radicals, reactive oxygen species (ROS) and oxidative damage on the skin ageing process. It also evaluates methods to decrease skin oxidative stress, oxidative damage, and skin ageing. The identification of free radical reactions as promoters of the skin ageing process implies that interventions aimed at limiting or inhibiting free radical reactions should be able to reduce the rate of formation of ageing-related changes with a consequent reduction of the ageing rate. This book highlights how ageing of the skin happens, as well as what are the causes and the best ways to prevent and treat it.

Acute Geriatric Care (Hardcover): Jochanan E. Naschitz, Yitshal N Berner Acute Geriatric Care (Hardcover)
Jochanan E. Naschitz, Yitshal N Berner
R8,144 R7,090 Discovery Miles 70 900 Save R1,054 (13%) Ships in 12 - 17 working days

During the last decades as the population has become older, the demand for acute hospital care for elderly people has increased and gerontologically adjusted services have become the norm for the highest standard of care. Compared with younger adults, elderly patients have more severe illnesses, including worsened functional impairment and more frequent and longer hospitalisations. Additionally, diagnosis is often challenging because clinical presentations of common disorders may often be atypical in the elderly. When prescribing medications, physicians have to take into account the pharmacokinetic and pharmacodynamic changes observed with ageing. This book fills the gap in the literature available on acute geriatric care.

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