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Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Aging of the Genome - The dual role of DNA in life and death (Paperback)
Loot Price: R2,351
Discovery Miles 23 510
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Aging of the Genome - The dual role of DNA in life and death (Paperback)
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Aging has long since been ascribed to the gradual accumulation of
DNA mutations in the genome of somatic cells. However, it is only
recently that the necessary sophisticated technology has been
developed to begin testing this theory and its consequences. Vijg
critically reviews the concept of genomic instability as a possible
universal cause of aging in the context of a new, holistic
understanding of genome functioning in complex organisms resulting
from recent advances in functional genomics and systems biology. It
provides an up-to-date synthesis of current research, as well as a
look ahead to the design of strategies to retard or reverse the
deleterious effects of aging. This is particularly important in a
time when we are urgently trying to unravel the genetic component
of aging-related diseases. Moreover, there is a growing public
recognition of the imperative of understanding more about the
underlying biology of aging, driven by continuing demographic
change.
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