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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics

Progress in Heritable Soft Connective Tissue Diseases (Paperback, Softcover reprint of the original 1st ed. 2014): Jaroslava... Progress in Heritable Soft Connective Tissue Diseases (Paperback, Softcover reprint of the original 1st ed. 2014)
Jaroslava Halper
R5,476 Discovery Miles 54 760 Ships in 10 - 15 working days

This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

Regulatory Non-Coding RNAs - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2015): Gordon G... Regulatory Non-Coding RNAs - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2015)
Gordon G Carmichael
R3,740 Discovery Miles 37 400 Ships in 10 - 15 working days

Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.

Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease (Paperback, Softcover reprint of the original... Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease (Paperback, Softcover reprint of the original 1st ed. 2015)
Hoa Huu Phuc Nguyen, M. Angela Cenci
R4,021 Discovery Miles 40 210 Ships in 10 - 15 working days

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Dissecting Regulatory Interactions of RNA and Protein - Combining Computation and High-throughput Experiments in Systems... Dissecting Regulatory Interactions of RNA and Protein - Combining Computation and High-throughput Experiments in Systems Biology (Paperback, Softcover reprint of the original 1st ed. 2014)
Marvin Jens
R3,161 Discovery Miles 31 610 Ships in 10 - 15 working days

The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.

Molecular Mechanisms Underpinning the Development of Obesity (Paperback, Softcover reprint of the original 1st ed. 2014):... Molecular Mechanisms Underpinning the Development of Obesity (Paperback, Softcover reprint of the original 1st ed. 2014)
Clevio Nobrega, Raquel Rodriguez-Lopez
R3,420 Discovery Miles 34 200 Ships in 10 - 15 working days

Obesity is a multi-factorial disease, in which an excess of accumulated body fat can reach levels capable of affecting health. It results from an interplay between environmental factors, eating behavior, genes, epigenetics, and neuronal stimuli. The main aim of this book is to provide a state-of-the-art revision about the molecular mechanisms underpinning the development of obesity, reviewing the current knowledge in areas like monogenic and polygenic obesity forms, but also providing an updated view of the emerging knowledge about epigenetics, nutrigenomics, and neuronal aspects that also contribute to obesity.

Techniques and Methodological Approaches in Breast Cancer Research (Paperback, Softcover reprint of the original 1st ed. 2014):... Techniques and Methodological Approaches in Breast Cancer Research (Paperback, Softcover reprint of the original 1st ed. 2014)
Jose Russo, Irma H Russo
R5,180 Discovery Miles 51 800 Ships in 10 - 15 working days

This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.

Genes and the Motivation to Use Substances (Paperback, Softcover reprint of the original 1st ed. 2014): Scott F. Stoltenberg Genes and the Motivation to Use Substances (Paperback, Softcover reprint of the original 1st ed. 2014)
Scott F. Stoltenberg
R3,266 Discovery Miles 32 660 Ships in 10 - 15 working days

Human beings have been using intoxicating substances for millennia. But while most people have used psychoactive substances without becoming dependent on them, a significant minority develop substance use disorders. The question remains: why does addiction occur in some and not others? The 61st installment of the Nebraska Symposium on Motivation, Genes and the Motivation to Use Substances probes the complex role of genetics in substance use and abuse across diverse methodologies, research organisms, levels of analysis and disciplines. Its combined lifespan/motivation approach to individual differences sheds necessary light on genetic vs. environmental factors in vulnerability, addiction risk, the relationship between behavioral disinhibition and substance use and the motivation to quit. While alcohol use/abuse is the focus of much of the book, its chapters provide scientific and clinical insights into substance abuse in general as well as implications for treatment. And an intriguing conclusion discusses the need to bridge the gap between genetics and neuroscience and the best scientific conditions in which this integration may thrive. Included in the coverage: * Rodent models of genetic contributions to the motivation to use alcohol. * The adolescent origins of substance abuse disorders * The developmental matrix of addictive behavior * The genetics of cannabis involvement * The DNA methylation signature of smoking * Genomics of impulsivity: integrating genetics and neuroscience. Reflecting the current state of knowledge in a field with groundbreaking potential, Genes and the Motivation to Use Substances is a fascinating resource for psychologists, psychiatrists, geneticists, neuroscientists, social workers, policymakers and researchers in addiction.

Anticancer Genes (Paperback, Softcover reprint of the original 1st ed. 2014): Stefan Grimm Anticancer Genes (Paperback, Softcover reprint of the original 1st ed. 2014)
Stefan Grimm
R3,679 Discovery Miles 36 790 Ships in 10 - 15 working days

This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genesâ€, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

Fungal RNA Biology (Paperback, Softcover reprint of the original 1st ed. 2014): Ane Sesma, Tobias von der Haar Fungal RNA Biology (Paperback, Softcover reprint of the original 1st ed. 2014)
Ane Sesma, Tobias von der Haar
R5,486 Discovery Miles 54 860 Ships in 10 - 15 working days

This book presents an overview of the RNA networks controlling gene expression in fungi highlighting the remaining questions and future challenges in this area.It covers several aspects of the RNA-mediated mechanisms that regulate gene expression in model yeasts and filamentous fungi, organisms of great importance for industry, medicine and agriculture. It is estimated that there are more than one million fungal species on the Earth. Despite their diversity (saprophytic, parasitic and mutualistic), fungi share common features distinctive from plants and animals and have been grouped taxonomically as an independent eukaryotic kingdom. In this book, 15 chapters written by experts in their fields cover the RNA-dependent processes that take place in a fungal cell ranging from formation of coding and non-coding RNAs to mRNA translation, ribosomal RNA biogenesis, gene silencing, RNA editing and epigenetic regulation.

RNA and DNA Diagnostics (Paperback, Softcover reprint of the original 1st ed. 2015): Volker A. Erdmann, Stefan Jurga, Jan... RNA and DNA Diagnostics (Paperback, Softcover reprint of the original 1st ed. 2015)
Volker A. Erdmann, Stefan Jurga, Jan Barciszewski
R3,868 Discovery Miles 38 680 Ships in 10 - 15 working days

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.â€

Histone Recognition (Paperback, Softcover reprint of the original 1st ed. 2015): Ming-Ming Zhou Histone Recognition (Paperback, Softcover reprint of the original 1st ed. 2015)
Ming-Ming Zhou
R3,667 Discovery Miles 36 670 Ships in 10 - 15 working days

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Advances in Nutrition and Cancer (Paperback, Softcover reprint of the original 1st ed. 2014): Vincenzo Zappia, Salvatore... Advances in Nutrition and Cancer (Paperback, Softcover reprint of the original 1st ed. 2014)
Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione
R5,933 Discovery Miles 59 330 Ships in 10 - 15 working days

This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed “nutrition and cancer†from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the “omicsâ€) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

Nucleic Acid Nanotechnology (Paperback, Softcover reprint of the original 1st ed. 2014): Jørgen Kjems, Elena Ferapontova, Kurt... Nucleic Acid Nanotechnology (Paperback, Softcover reprint of the original 1st ed. 2014)
Jørgen Kjems, Elena Ferapontova, Kurt V. Gothelf
R5,322 Discovery Miles 53 220 Ships in 10 - 15 working days

This volume on nucleic acid nanotechnology offers authoritative, up-to-date and comprehensive coverage of nanotechnological studies and applications of nucleic acids. It provides reviews of various aspects of nucleic acid nanotechnology, each written by an internationally leading expert in the field, and presents state-of-the-art and recent advances in nucleic acid synthetic modifications, nanoscale design, manipulation and current and future applications in bioengineering, medicine, electronics, genetic analysis, chemistry, molecular biology, surface and material sciences. It examines how nucleic acid research is merging with nanotechnology, allowing the nanoscale properties of nucleic acid to be exploited in performing challenging nanotechnological tasks, from nanorobotics and nanosensing to nucleic acid computing. This book will above all benefit anyone who is interested in nanotechnological concepts of nucleic acid design and applications, and offers a valuable resource for teaching these concepts. It is essential reading for a broad audience of scientists both in academia and industry who wish to expand their expertise on the potential of nucleic acid functions and applications.

DNA Cloning and Assembly Methods (Paperback, Softcover reprint of the original 1st ed. 2014): Svein Valla, Rahmi Lale DNA Cloning and Assembly Methods (Paperback, Softcover reprint of the original 1st ed. 2014)
Svein Valla, Rahmi Lale
R3,180 Discovery Miles 31 800 Ships in 10 - 15 working days

In DNA Cloning and Assembly Methods, expert researchers in the field detail many of the methods which are now commonly used for DNA cloning and make cloning procedures faster, more reliable and also suitable for high-throughput handling. These include methods and protocols that are based on several mechanisms including type II and IIS restriction enzymes, single stranded annealing, sequence overlap, and recombination. With additional chapters on software programs that are suitable for primer design, a feature crucial for the functionality of the described methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, DNA Cloning and Assembly Methods seeks to provide scientist with a valuable and useful resource for wet lab researchers within life sciences.

Therapeutic Applications of Ribozymes and Riboswitches - Methods and Protocols (Paperback, Softcover reprint of the original... Therapeutic Applications of Ribozymes and Riboswitches - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2014)
Daniel Lafontaine, Audrey Dube
R4,106 Discovery Miles 41 060 Ships in 10 - 15 working days

In Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target. These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool. We are convinced that these methods will help researchers from various domains of life sciences, including clinicians, biochemists and virologists. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols seeks to aid scientists in the further development of new therapeutic applications implicating RNA molecules or directly targeting harmful RNA.

Plant Epigenetics and Epigenomics - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2014): Charles... Plant Epigenetics and Epigenomics - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2014)
Charles Spillane, Peter C. McKeown
R3,974 Discovery Miles 39 740 Ships in 10 - 15 working days

Many fundamental discoveries concerning epigenetics and the elucidation of mechanisms of epigenetic regulation have developed from studies performed in plants. In Plant Epigenetics and Epigenomics: Methods and Protocols, leading scientists in the epigenetics field describe comprehensive techniques that have been developed to understand the plant epigenetic landscape. These include recently developed methods and techniques for analysis of epigenetically regulated traits, such as flowering time, transposon activation, genomic imprinting and genome dosage effects. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoidance of known pitfalls. Authoritative and practical, Plant Epigenetics and Epigenomics: Methods and Protocols seek to aid scientists in the further study of plant epigenetic phenomena using advanced contemporary methods.

Electroporation Protocols - Preclinical and Clinical Gene Medicine (Paperback, Softcover reprint of the original 2nd ed. 2014):... Electroporation Protocols - Preclinical and Clinical Gene Medicine (Paperback, Softcover reprint of the original 2nd ed. 2014)
Shulin Li, Jeffry Cutrera, Richard Heller, Justin Teissie
R3,672 Discovery Miles 36 720 Ships in 10 - 15 working days

Electroporation gene therapy, or gene electrotransfer, has evolved greatly over the last few decades as a result of the remarkable progress in genetic sequencing, gene array analysis, gene cloning, gene expression detection, DNA manufacture and discovery and synthesis of siRNA. Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition provides in-depth knowledge on the delivery of naked DNA and small-interfering RNA (siRNA) to the targeted cells, tissues, and animals for prevention and treatment of disease. It builds on the success of the first edition and on the progress made in siRNA delivery and DNA vaccines for large animals as well as discovery of electroporation applications for the fragile tissues and for internal organs. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Electroporation Protocols: Preclinical and Clinical Gene Medicine, Second Edition aims to provide not only comprehensive coverage of the basic theory and practical application of electroporation siRNA therapy, gene therapy, and vaccine, but also elaborates on the most current views from the experts in this field, serving as an invaluable resource for investigators both in and outside of this field.

Gene Network Inference - Verification of Methods for Systems Genetics Data (Paperback, Softcover reprint of the original 1st... Gene Network Inference - Verification of Methods for Systems Genetics Data (Paperback, Softcover reprint of the original 1st ed. 2013)
Alberto Fuente
R4,709 Discovery Miles 47 090 Ships in 10 - 15 working days

This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.

The Neurobiology and Genetics of Nicotine and Tobacco (Paperback, Softcover reprint of the original 1st ed. 2015): David J. K.... The Neurobiology and Genetics of Nicotine and Tobacco (Paperback, Softcover reprint of the original 1st ed. 2015)
David J. K. Balfour, Marcus R. Munafò
R3,514 Discovery Miles 35 140 Ships in 10 - 15 working days

The primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the book The Neuropharmacology of Nicotine Dependence focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans.  These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic.

Functional Analysis of DNA and Chromatin (Paperback, Softcover reprint of the original 1st ed. 2014): Juan C. Stockert, Jesus... Functional Analysis of DNA and Chromatin (Paperback, Softcover reprint of the original 1st ed. 2014)
Juan C. Stockert, Jesus Espada, Alfonso Blazquez-Castro
R4,220 Discovery Miles 42 200 Ships in 10 - 15 working days

In Functional Analysis of DNA and Chromatin, expert researchers in the field provide an overview of standard and more recent methods for the functional analysis of the genetic material. These include methods on DNA-dye binding modes, chromatin staining, nuclear dispersion assays, DNA labeling in vivo, sister chromatid exchanges, FISH, DNA and chromatin imaging by fluorescence, electron and atomic force microscopy, detection of apoptotic DNA, cytosine methylation and hydroxy-methylation, DNA thermophoresis, improved methods for histone analysis, chromatin immunoprecipitation, and analysis of rDNA genes and chromatin-associated RNA. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Functional Analysis of DNA and Chromatin seeks to aid scientists in the further study of cellular and molecular biology of the nucleus.

Primary Aldosteronism - Molecular Genetics, Endocrinology, and Translational Medicine (Paperback, Softcover reprint of the... Primary Aldosteronism - Molecular Genetics, Endocrinology, and Translational Medicine (Paperback, Softcover reprint of the original 1st ed. 2014)
Per Hellman
R4,351 Discovery Miles 43 510 Ships in 10 - 15 working days

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene - KCNJ5 - in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

G-Quadruplex DNA - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2010): Peter Baumann G-Quadruplex DNA - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2010)
Peter Baumann
R3,166 Discovery Miles 31 660 Ships in 10 - 15 working days

Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.

Carbohydrate Microarrays - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2012): Yann Chevolot Carbohydrate Microarrays - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2012)
Yann Chevolot
R3,491 Discovery Miles 34 910 Ships in 10 - 15 working days

Carbohydrate microarrays emerged as a key technology for the deciphering of the glycospace by providing a multiplex technology where tens to hundreds of carbohydrates/protein interactions can be probed in parallel. Carbohydrate Microarrays: Methods and Protocols aims to give the reader the theoretical and experimental clues necessary for the fabrication and implementation of carbohydrate microarrays. This requires three essential steps: 1) to obtain the carbohydrate probes (monosacharides, oligosacchrides, polysacchairdes, glycoconjugates or glycoclusters), 2) to immobilize these probes, and 3) to implement the protocols for biological/biochemical interaction with the desired target. This volume gives an overview of carbohydrate microarray and carbohydrate chemistry and illustrates different detection techniques and their applications. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Carbohydrate Microarrays: Methods and Protocols compiles a catalogue of protocols on carbohydrate microarrays to span the needs of researchers around the globe.

Epigenetics Protocols (Paperback, Softcover reprint of the original 2nd ed. 2011): Trygve O Tollefsbol Epigenetics Protocols (Paperback, Softcover reprint of the original 2nd ed. 2011)
Trygve O Tollefsbol
R3,147 Discovery Miles 31 470 Ships in 10 - 15 working days

The field of epigenetics has played a major role at the forefront not only of molecular biology, but also of medical genetics and clinical medicine. Few disciplines have experienced growth comparable to that which we have witnessed for epigenetics in the past decade. The goal of Epigenetics Protocols, Second Edition is to highlight select techniques that have been mainstays in the field as well as to cover methods that are especially relevant to extant discoveries in epigenetics. This volume focuses on the two broad areas of epigenetics: DNA methylation and chromatin modifications, and also covers the complex topic of computational methods for epigenetic analyses which is essential to a complete understanding of the vast body of information that is being derived with the use of these newly-developed tools. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Epigenetics Protocols, Second Edition serves as an ideal guide to advanced students, basic scientists and clinical researchers as well as clinicians and biotechnology investigators who wish to continue exploring this exciting and progressive research field.

Gene Therapy for Neurological Disorders - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2016):... Gene Therapy for Neurological Disorders - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2016)
Fredric P. Manfredsson
R4,920 Discovery Miles 49 200 Ships in 10 - 15 working days

This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.

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