Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Biomechanics of the Female Pelvic Floor, Second Edition, is the first book to specifically focus on this key part of women's health, combining engineering and clinical expertise. This edited collection will help readers understand the risk factors for pelvic floor dysfunction, the mechanisms of childbirth related injury, and how to design intrapartum preventative strategies, optimal repair techniques, and prostheses. The authors have combined their expertise to create a thorough, comprehensive view of female pelvic floor biomechanics in order to help different disciplines discuss, research, and drive solutions to pressing problems. The book includes a common language for the design, conduct, and reporting of research studies in female PFD, and will be of interest to biomechanical and prosthetic tissue engineers and clinicians interested in female pelvic floor dysfunction, including urologists, urogynecologists, maternal fetal medicine specialists, and physical therapists.

Nano- and Microfabrication for Industrial and Biomedical Applications, Second Edition, focuses on the industrial perspective on micro- and nanofabrication methods, including large-scale manufacturing, the transfer of concepts from lab to factory, process tolerance, yield, robustness, and cost. The book gives a history of miniaturization and micro- and nanofabrication, and surveys industrial fields of application, illustrating fabrication processes of relevant micro and nano devices. In this second edition, a new focus area is nanoengineering as an important driver for the rise of novel applications by integrating bio-nanofabrication into microsystems. In addition, new material covers lithographic mould fabrication for soft-lithography, nanolithography techniques, corner lithography, advances in nanosensing, and the developing field of advanced functional materials. Luttge also explores the view that micro- and nanofabrication will be the key driver for a "tech-revolution" in biology and medical research that includes a new case study that covers the developing organ-on-chip concept.

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

Nanobiomaterials in Soft Tissue Engineering brings together recent developments and the latest approaches in the field of soft tissue engineering at the nanoscale, offering a new perspective on the evolution of current and future applications. Leading researchers from around the world present the latest research and share new insights. This book covers the major conventional and unconventional fabrication methods of typical three-dimensional scaffolds used in regenerative medicine. Surface modification and spatial properties are included in an up-to-date overview, with the latest in vivo applications of engineered 3D scaffolds discussed. The book also considers the impact, advantages and future scope of the various methods. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.

Nanobiomaterials in Hard Tissue Engineering covers the latest developments in the field of hard tissue engineering at the nanoscale. Leading researchers from around the world discuss the latest research and offer new insights. This book presents data about the fabrication and characterization of nanobiomaterials involved in hard tissue reconstruction, describing recent progress and the advantages of both conventional and computer-aided methods. Recent applications of different classes of nanobiomaterials are discussed, with in vitro and in vivo applications also explained in detail. Special attention is paid to the applications of nanobiomaterials in bone regeneration and in the development of functional coatings for tailored implants to improve osseointegration. Finally, the book considers future challenges and perspectives. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.

Surface Chemistry of Nanobiomaterials brings together the most recent findings regarding the surface modification of currently used nanomaterials, which is a field that has become increasingly important during the last decade. This book enables the results of current research to reach those who wish to use this knowledge in an applied setting. Leading researchers from around the world present various types of nanobiomaterials, such as quantum dots (QDs), carbon nanotubes, silver nanoparticles, copper oxide, zinc oxide, magnesium oxide, magnetite, hydroxyapatite and graphene, and discuss their related functionalization strategies. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.

Materials for the Direct Restoration of Teeth focuses on the important role teeth play in our lives and how biomaterials scientists are ensuring that new dental materials are functional and esthetic. As research in the field is shifting away from traditional materials like metal, and towards more advanced materials, such as resins and ceramics, this book on the subject of modern materials for the direct repair of teeth provides readers with a comprehensive reference. The most pertinent modern dental materials and their properties and applications for the direct restoration of teeth are presented, along with case examples and guidance notes making this book an essential companion for materials scientists and clinicians.

Boron Nitride Nanotubes in Nanomedicine compiles, for the first time in a single volume, all the information needed by researchers interested in this promising type of smart nanoparticles and their applications in biomedicine. Boron nitride nanotubes (BNNTs) represent an innovative and extremely intriguing class of nanomaterials. After introducing BNNTs and explaining their preparation and evaluation, the book shows how the physical, chemical, piezoelectric and biocompatibility properties of these nanotubes give rise to their potential uses in biomedicine. Evidence is offered (from both in vitro and in vivo investigations) for how BNNTs can be useful in biomedical and nanomedicine applications such as therapeutic applications, tissue regeneration, nanovectors for drug delivery, and intracellular nanotransducers.

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.

In an effort to create a more educated workforce in the United States, many community colleges are implementing the use of advisory groups to assist under-prepared students. These efforts will ultimately support a stronger and more resilient global workforce. The Role of Advisory Committees in Biomedical Education and Workforce Development: Emerging Research and Opportunities is a pivotal reference source for the latest research findings on the development of advisory committees in biomedical education, workforce development, and the guiding principles that result in successful research and opportunities. Featuring extensive coverage on relevant areas such as workforce education programs, collaborative decision-making, and skillset training, this publication is an ideal resource for academics, researchers, graduate-level students, committee development officers, business professionals, administrators, and workforce education specialists.

In this issue of Clinics in Podiatric Medicine and Surgery, guest editor Dr. Michael Theodoulou brings his considerable expertise to the topic of Update on Fibro-Cartilaginous Disease. Disease of fibrocartilage in the foot can have severe negative impact on patients' quality of life. In this issue, top experts in the field explore strategies for managing this disease (both operative and non-operative) as well as imaging strategies, complications, and other repair techniques. Contains 16 relevant, practice-oriented topics including types of fibrocartilage; hHistophysiology of fibrocartilage; gross anatomy: plantar plate; normal and diseased imaging: US/MRI; failed healing; and more. Provides in-depth clinical reviews on fibro-cartilaginous disease, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.