This book describes the development of two kinds of continuous-flow transformation using heterogeneous catalysts, and explains how they can be applied in the multistep synthesis of active pharmaceutical ingredients. It demonstrates and proves that fine chemicals can be synthesized under continuous-flow conditions using heterogeneous catalysis alone. Importantly, the book also proposes a general concept and strategy for achieving multistep flow synthesis and developing heterogeneous catalysts, and shows that commercially available anion exchange resin can be used as a water-tolerant strong base catalyst for various types of continuous-flow aldol-type reaction. Reviewing the state of the art in heterogeneous catalysis in flow chemistry - a "hot topic" and rapidly developing area of organic synthesis - the book will provide readers with a deeper understanding of fine chemical flow synthesis and its future prospects.

Synthesis of Carbon-Phosphorus Bonds, Second Edition is a working guide for the laboratory, incorporating classical approaches with the recent developments of carbon-phosphorus (C-P) bond formation. These advances include the preparation of phosphoranes -- specifically in the use of transient oxophosphoranes as intermediates in organophosphorus compound synthesis - along with the new approaches towards the preparation of compounds with aromatic and vinylic C-P bonds.

Synthesis of Carbon-Phosphorus Bonds, Second Edition serves as a useful tool in the laboratory. It offers detailed surveys of IUPAC nomenclature recommendations, common notation systems, and various experimental examples. These features help to make this text an effective source of critical and annotated references, as well as a a working guide for organic and phosphorus chemists specifically, or for any chemists working with C-P bonds.

Heteroligand molecular systems with extremely varied properties are widespread in inorganic, coordination, and organometallic chemistry, areas which are developing rapidly and have a wide range of practical applications. There is currently a great deal of interest in such systems, and this book aims to summarize and analyze the wealth of data concerning the structure, isomerism, and isomerization of heteroligand systems which has been accumulated over recent years.

The first two chapters provide an introduction to quantum chemistry and the applications of perturbation theory to chemical problems. This theoretical basis is then used in the remaining chapters, where perturbation theory methods are used to describe a wide range of problems related to the mutual influences of ligands and relative isomer stabilities in typical heteroligand molecules and complexes of nontransition and transition metals.

The book is aimed at advanced students, teachers, and researchers dealing with molecular structure and coordination, inorganic, and organometallic chemistry.