Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets. There are sections discussing helminths; including metabolic, neuromuscular, microtubular and tegumental targets. The design of more selective and less toxic drugs is emphasized throughout.

Frontiers in Molecular Biology is a series of books designed to report on rapidly evolving, key areas of research in molecular biology. Individual chapters are written by leading researchers who are specialists in their fields. Each book is carefully organized to provide an integrated analysis of current progress in the area covered. Parasitic protozoa cause major infectious diseases of humans and domestic animals. In recent years, new techniques in molecular biology have allowed tremendous advances in our understanding of these parasites. Molecular Biology of Parasitic Protozoa covers this fast-moving field at an advanced level for which there is no other up-to-date book. Topics covered include trypanosomatid and Toxoplasma genetics, structure and replication of kinetoplast DNA, regulation of gene expression in trypanosomes, trans-splicing, RNA editing, the three genomes of Plasmodium, mechanisms of drug resistance, biogenesis of glycosomes and hydrogenosomes, glycosylphosphatidylinositols and the surface architecture of parasitic protozoa. Molecular Biology of Parasitic Protozoa is a unique compendium of current research findings in this important area. It contains over 900 references and provides a comprehensive review of the field as well as valuable insights and predictions of future progress by leading researchers.

Neurocysticercosis, a preventable parasitic infection of the central nervous system caused by tapeworm, is a serious, potentially fatal disease that can cause neurologic syndromes such as epileptic seizures. Chapter One of this monograph describes the existing treatment options for neurocysticercosis, along with possible therapeutic alternatives under different drug development phases. Chapter Two explains the difficulties associated with correctly diagnosing neurocysticercosis, resulting from its varied clinical presentation, and mentions current guidelines of diagnostic criteria for neurocysticercosis. Chapter Three describes the various merits and demerits of techniques for detecting the parasites associated with neurocysticercosis, which include radioimaging, genotyping of cysts, and antibody, antigen, and nucleic acid detection in body fluids.

Giardia and Cryptosporidium are both parasites of considerable global interest due to the gastrointestinal problems the organisms can cause in humans as well as domestic and wild animals. This book presents a comprehensive overview of recent research. Chapters discuss topics from taxonomy, nomenclature and evolution to molecular epidemiology, advances in diagnostics and zoonotic, human and animal health issues.

Many invertebrates are serious pests of agriculture (e.g., mites and locusts), vectors of disease (e.g., mosquitoes and aquatic snails) and venomous (e.g., scorpions), whilst others are beneficial to humans as pollinators, food sources, and detritivores. Despite their obvious ecological, medical, and economic importance, this is the first comprehensive review of invertebrate diseases to be available within a single volume. Concurrent molecular and bioinformatics developments over the last decade have catalysed a renaissance in invertebrate pathology. High-throughput sequencing, handheld diagnostic kits, and the move to new technologies have rapidly increased our understanding of invertebrate diseases, generating a large volume of fundamental and applied research on the topic. An overview is now timely and this authoritative work assembles an international team of the leading specialists in the field to review the main diseases and pathologic manifestations of all the major invertebrate groups. Each chapter adopts a common plan in terms of its scope and approach to achieve a succinct and coherent synthesis. Invertebrate Pathology is aimed at graduate students and researchers in the fields of disease ecology, invertebrate biology, comparative immunology, aquaculture, fisheries, veterinary science, evolution, and conservation. It will be particularly useful for readers new to the field as well as a broader interdisciplinary audience of practitioners and resource managers.

Emerging infectious diseases pose an increasingly serious threat to a number of endangered or sensitive species and are increasingly recognized as one of the major factors driving species extinction. Despite the significant impact of pathogens on conservation, no single book has yet integrated the theoretical principles underlying disease transmission with the practical health considerations for helping wildlife professionals and conservation biologists to manage disease outbreaks and conserve biodiversity. This novel and accessible book starts with a foundational section focusing on the role of pathogens in natural ecosystems, the dynamics of transmission in different environments, and the factors driving wildlife disease outbreaks. It then moves on to more applied issues concerned with the acquisition of field data including sampling, experimental design and analysis, as well as diagnostic analyses in both the laboratory and field. Guidelines for effective modelling and data analysis follow, before a final section is devoted to disease prevention and control including the prevention of novel outbreaks, the use of diseases as biocontrol agents, and the associated issues of ethics, public communication, and outreach. Infectious Disease Ecology and Conservation is primarily aimed at advanced undergraduates, graduate students, and established researchers in the fields of conservation biology, disease ecology, population ecology, and veterinary science. It will also be a valuable reference for conservation practitioners, land managers, and wildlife professionals who are required to deal with disease outbreak problems.

Population Biology of Vector-Borne Diseases is the first comprehensive survey of this rapidly developing field. The chapter topics provide an up-to-date presentation of classical concepts, reviews of emerging trends, synthesis of existing knowledge, and a prospective agenda for future research. The contributions offer authoritative and international perspectives from leading thinkers in the field. The dynamics of vector-borne diseases are far more intrinsically ecological compared with their directly transmitted equivalents. The environmental dependence of ectotherm vectors means that vector-borne pathogens are acutely sensitive to changing environmental conditions. Although perennially important vector-borne diseases such as malaria and dengue have deeply informed our understanding of vector-borne diseases, recent emerging viruses such as West Nile virus, Chikungunya virus, and Zika virus have generated new scientific questions and practical problems. The study of vector-borne disease has been a particularly rich source of ecological questions, while ecological theory has provided the conceptual tools for thinking about their evolution, transmission, and spatial extent. Population Biology of Vector-Borne Diseases is an advanced textbook suitable for graduate level students taking courses in vector biology, population ecology, evolutionary ecology, disease ecology, medical entomology, viral ecology/evolution, and parasitology, as well as providing a key reference for researchers across these fields.

Dickson D. Despommier's vivid, visceral account of the biology, behavior, and history of parasites follows the interplay between these fascinating life forms and human society over thousands of years. Despommier focuses on long-term host-parasite associations, which have evolved to avoid or even subvert the human immune system. Some parasites do great damage to their hosts, while others have signed a kind of "peace treaty" in exchange for their long lives within them. Many parasites also practice clever survival strategies that medical scientists hope to mimic as they search for treatments for Crohn's disease, food allergies, type 1 diabetes, organ transplantation, and other medical challenges. Despommier concentrates on particularly remarkable and often highly pathogenic organisms, describing their lifecycles and the mechanisms they use to avoid elimination. He details their attack and survival plans and the nature of the illnesses they cause in general terms, enabling readers of all backgrounds to steal a glimpse into the secret work of such effective invaders. He also points to the cultural contexts in which these parasites thrive and reviews the current treatments available to defeat them. Encouraging scientists to continue to study these organisms even if their threat is largely contained, Despommier shows how closer dissection of the substances parasites produce to alter our response to them could help unravel some of our most complex medical conundrums.

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.

Reflecting the enormous advances made in the field over the past ten years, this text synthesizes the latest developments in the ecology and evolution of animal parasites against a backdrop of parallel advances in parasite systematics, biodiversity and life cycles. This second edition has been thoroughly revised to meet the needs of a new generation of parasitology students. Balancing traditional approaches in parasitology with modern studies in parasite ecology and evolution, the authors present basic ecological principles as a unifying framework to help students understand the complex phenomenon of parasitism. Richly illustrated with over 250 figures, the text is accompanied by case study boxes designed to help students appreciate the complexity and diversity of parasites and the scientists who study them. This unique approach, presented clearly and with a minimum of jargon and mathematical detail, encourages students from diverse backgrounds to think generally and conceptually about parasites and parasitism.

Biogeography has renewed its concepts and methods following important recent advances in phylogenetics, macroecology, and geographic information systems. In parallel, the evolutionary ecology of host-parasite interactions has attracted the interests of numerous studies dealing with life-history traits evolution, community ecology, and evolutionary epidemiology.
The Biogeography of Host-Parasite Interactions is the first book to integrate these two fields, using examples from a variety of host-parasite associations in various regions, and across both ecological and evolutionary timescales. Besides a strong theoretical component, there is a bias towards applications, specifically in the fields of historical biogeography, palaeontology, phylogeography, landscape epidemiology, invasion biology, conservation biology, human evolution, and health ecology. A particular emphasis concerns emerging and re-emerging infectious diseases linked to global changes.

For several years there has been a growing interest in understanding the dynamics of parasites in ecosystems, as well as the diversity of ways in which they influence ecosystem functioning through their effects on host populations and communities. Ecologists, epidemiologists, evolutionary biologists, and other scientists are increasingly coming to realise that parasites must be taken into account when studying ecosystems. Parasitism and Ecosystems summarizes current knowledge on this topic, providing a comprehensive overview for researchers and students. It represents the first synthesis of both the roles and the consequences of pathogens in ecosystems, utilizing well-documented case-studies to illustrate the main issues as well as identifying prospects for future research.

An extraordinary array of infectious agents affects humans; from worms, arthopods, and fungi to bacteria, viruses, and prions. In this compendium of the curious and fascinating organisms that cause disease, including Legionnaire's disease, mumps, CJD, and chlamydia, David I. Grove provides a lively, fact-filled account of the nature of each organism, their life cycle, the ingenious ways in which they infect humans, and the human stories behind their discovery.

This is a question-oriented volume with a solid organismal foundation that will help to bridge the gap between evolutionary ecologists and parasitologists. A range of experts have written chapters that review general concepts and provide a detailed survey of the parasites of a major group of hosts. The book concludes with extensive reviews of methods used to study bird parasites. It is a novel and valuable tool for anyone interested in understanding host-parasite interactions, particularly from an evolutionary perspective.

We first discussed the possibility of organizing a symposium on helminth communities in June, 1986. At that time, we were engaged in writing a joint paper on potential structuring mechanisms in helminth communities; we disagreed on a number of issues. We felt the reason for such debate was because the discipline was in a great state of flux, with many new concepts and approaches being introduced with increasing frequency. After consider able discussion about the need, scope and the inevitable limitations of such a symposium, we decided that the time was ripe to bring other ecologists, engaged in similar research, face-to-face. There were many individuals from whom to choose; we selected those who were actively publishing on helminth communities or those who had expertise in areas which we felt were particularly appropriate. We compiled a list of potential participants, contacted them and received unanimous support to organize such a symposium. Our intent was to cover several broad areas, fully recognizing that breadth negates depth (at least with a publisher's limitation on the number of pages). We felt it important to consider patterns amongst different kinds of hosts because this is where we had disagreed among ourselves."

Acanthocephalans, or spiny-headed worms, are endoparasites found in almost all marine, freshwater and terrestrial systems. They infect a huge range of definitive and intermediate hosts during their life cycles, including both vertebrates and arthropods. This volume, first published in 2006, examines the distribution and abundance of the Acanthocephala, and uses this ecological information to reveal the group's enormous survival success. It discusses how the acanthocephalans have evolved differently to all other groups of parasites, and represent a distinct and alternative pathway of parasite evolution and host parasite-interactions. Written for graduate students and researchers in parasitology, ecology and zoology or anyone interested in reading about parasite ecology and evolution.

Interactions between competitors, predators and their prey have traditionally been viewed as the foundation of community structure. Parasites - long ignored in community ecology - are now recognized as playing an important part in influencing species interactions and consequently affecting ecosystem function. Parasitism can interact with other ecological drivers, resulting in both detrimental and beneficial effects on biodiversity and ecosystem health. Species interactions involving parasites are also key to understanding many biological invasions and emerging infectious diseases. This book bridges the gap between community ecology and epidemiology to create a wide-ranging examination of how parasites and pathogens affect all aspects of ecological communities, enabling the new generation of ecologists to include parasites as a key consideration in their studies. This comprehensive guide to a newly emerging field is of relevance to academics, practitioners and graduates in biodiversity, conservation and population management, and animal and human health.

This volume was first published in 1985. A knowledge of this phylum of parasitic worms is essential for helminthologists and instructive for all research workers investigating the principles of parasitism. Each of the chapters is written by a specialist on the biology of the Acanthocephala. Systematics, functional morphology, feeding, nutrition, metabolism, reproduction, embryology, development, epizootiology, life-history patterns and population ecology are reviewed and analysed in detail; problems for further investigation are identified. Special features of the book include a taxonomic revision and list of valid species, anatomical illustrations and extensive tables covering morphological terms, host-parasite associations, life-history parameters and reproductive biology. The three indices (parasite, author and subject) and the comprehensive list of over a thousand references help the reader to use this major source of reference on a fascinating group of parasites.

One of the most studied fields within the discipline of parasitology is immunoparasitology. The main emphasis is understanding the interaction between the host immune system and the invading parasite in order that information can be gained to aid parasite control and hence improve human health. The articles contained within this volume were produced by speakers (and their colleagues) at the 2004 British Society for Parasitology Autumn Symposium on "Subversion of immune cell signalling by parasites." Together they provide an introduction to the topic as well as detailed insights into the immune subversion mechanisms employed by eukaryotic parasites.

Blood-sucking insects transmit many of the most debilitating diseases to man including malaria, sleeping sickness, filariasis, dengue, typhus and plague. Additionally these insects cause major economic losses in agriculture by direct damage to livestock. This new edition of The Biology of Blood-Sucking in Insects has been fully updated since it was first published in 1991. It provides a unique, topic-led commentary on the biological aspects that are common to blood-sucking insects. This account focuses on the biological adaptations that clearly suit the blood-sucking habit and further discusses host-insect interactions and the transmission of parasites by blood-sucking insects. It also outlines the medical, social and economic impact of blood-sucking insects. The final chapter is designed as a useful quick-reference section. Written in a clear, concise fashion and well illustrated throughout, the text will be of direct interest to advanced undergraduate and postgraduate students of medical and veterinary entomology and parasitology.

This volume is a republication in one volume of the 10 part "CIH Keys to the Nematode Parasites of Vertebrates," first published between 1974 and 1983. For many years the "Keys" have provided a working tool to those within the field and laboratory needing to know "what is this worm?" Now due to popular demand and to coincide with the long awaited publication of the supplement volume, the "Keys" will be presented as one volume, refreshed and reformatted with the additional convenience of reordering in to superfamily. As an indispensable guide the "Keys" shall continue to be an essential resource to those working within medical, veterinary and biological departments worldwide for many more years to come.

In "What's Eating You?" Eugene Kaplan recounts the true and harrowing tales of his adventures with parasites, and in the process introduces readers to the intimately interwoven lives of host and parasite.

Kaplan has spent his life traveling the globe exploring oceans and jungles, and incidentally acquiring parasites in his gut. Here, he leads readers on an unforgettable journey into the bizarre yet oddly beautiful world of parasites. In a narrative that is by turns frightening, disgusting, and laugh-out-loud funny, Kaplan describes how drinking contaminated water can cause a three-foot-long worm to burst from your arm; how he "gave birth" to a parasite the size and thickness of a pencil while working in Israel; why you should never wave a dead snake in front of your privates; and why fleas are attracted to his wife. Kaplan tells stories about leeches feasting on soldiers in Vietnam; sea cucumbers with teeth in their anuses that seem to encourage the entry of symbiotic fish; the habits of parasites that cause dysentery, river blindness, and other horrifying diseases--and much, much more. Along the way, he explains the underlying science, including parasite evolution and host-parasite physiology.

Informative, frequently lurid, and hugely entertaining, this beautifully illustrated book is a must-read for health-conscious travelers, and anyone who has ever wondered if they picked up a tapeworm from that last sushi dinner.

This volume presents ecological consequences and evolutionary mechanisms that may be associated with behavioral alterations in parasitized hosts. Alterations may result from natural selection favoring the host or parasite, or there may be side effects of physiological changes associated with symbiosis. This book summarizes the literature in this area, showing that reports of alteration may frequently be consistent with more than one evolutionary explanation and that rigorous tests are needed before the phenomenon can be understood and placed in a predictive framework. Such understanding is important, because these behavioral alterations have been shown to have the potential to affect the distribution of animals in nature and their interactions with predators and competitors, and the alterations may have implications for vector biology.

This introductory undergraduate textbook provides a concise, clear and affordable overview of parasite biology for students and nonspecialists, preparing them for more technical and detailed literature. Using examples from all groups of animal parasites, the text considers the various stages of a parasite's life cycle from finding hosts to surviving within the host. The author discusses the significance of damage caused by parasites and approaches to control, giving the book a well-rounded scope for those new to the subject or desiring a review of key points. A key feature of the book is its comparative rather than systematic approach. Suitable for all introductory parasitology courses in biology, zoology and human and veterinary medicine.

This introductory undergraduate textbook provides a concise, clear and affordable overview of parasite biology for students and nonspecialists, preparing them for more technical and detailed literature. Using examples from all groups of animal parasites, the text considers the various stages of a parasite's life cycle from finding hosts to surviving within the host. The author discusses the significance of damage caused by parasites and approaches to control, giving the book a well-rounded scope for those new to the subject or desiring a review of key points. A key feature of the book is its comparative rather than systematic approach. Suitable for all introductory parasitology courses in biology, zoology and human and veterinary medicine.