This Atlas presents a state-of-the-art review of VATS and robotic approaches to managing lung and esophageal cancers. It discusses cancer staging, physiological evaluation of patients, and patient selection for minimally invasive surgery. The atlas offers detailed descriptions of individual operations accompanied by anatomic drawings, intraoperative images, and 3-dimensional anatomic reconstructions. Written by recognized experts in the field, it provides readers with an unparalleled resource for advancing their skills in managing these cancers. It is a valuable reference work for thoracic surgeons in training as well as in practice who want to pursue minimally invasive surgery. It is unique in offering fully illustrated, step-by-step descriptions of the operative procedures.

Digestive Endoscopic Resection provides a minimally invasive method of diagnosing and treating gastrointestinal cancer. This book contains a comprehensive and detailed introduction to this technique. It includes preoperative preparation, surgical methods, intraoperative complications and postoperative management of advanced endoscopic procedures. It mainly focuses on endoscopic submucosal dissection (ESD) and endoscopic submucosal tunneling technologies, such as peroral endoscopic myotomy (POEM) and submucosal tunneling endoscopic resection (STER). This book presents essential surgical steps and diagnostic illustrations of these fast developing techniques. It provides a theoretical basis and valuable technical guidance for experts to perform ESD and summarizes this new treatment of gastrointestinal disease not only early cancers but also other gastrointestinal disorders including esophageal achalasia, etc. The Atlas of Digestive Endoscopic Resection will serve as an ideal reference for physicians and surgeons involved in endoscopic minimally invasive surgery. Editors Pinghong Zhou, Liqing Yao and Xinyu Qin are professors at Zhongshan Hospital affiliated to Fudan University, Shanghai, China.

This book provides a comprehensive, up-to-date review of the pathology of the neoplastic and non-neoplastic diseases that occur in the mediastinum. The pathologic and relevant clinical features are discussed, and detailed diagnostic criteria for various diseases are given, along with information about the most relevant laboratory tests. The features of thymomas, thymic carcinomas, neuroendocrine carcinomas and germ cell tumors are discussed in detail, including the utilization of immunostains and other ancillary tests in diagnosing these diseases. An algorithmic approach to the differential diagnosis of mediastinal lymphomas is given, and a novel clinico-pathologic classification helps readers diagnose and treat thymomas. Cardiac lesions, mesothelioma and other intrathoracic lesions are also reviewed. The book features more than 650 images, and downloadable copies of these are included on a CD-ROM, packaged with the print book. Pathology of the Mediastinum will be of interest to practising surgical pathologists, thoracic surgeons, oncologists and radiologists.

Manfred Georg Krukemeyer first describes magnetic drug targeting, by which is meant the focused application of drugs, e.g. the introduction of a cytostatic, and which is aimed at optimising its locally therapeutic effect. The author thus achieves a high concentration of cytostatic at the site of the tumour. The particles have to be large enough to be attracted by a magnetic field and so find their way into the tumour, where they release their active ingredient. The aim of the hypothesis formed by one of the author's study groups was to show in a scientific experiment that in this case cytostatics coupled with iron particles [Fe3O4] can be introduced into a tumour. The focused introduction of drugs - magnetic drug targeting - results in faster arrival of the active ingredient at the target site together with a reduced quantity of active substances. For this reason magnetic drug targeting is also interesting from an economic point of view.

The risk of cancer increases with age, and the number of older adults seeking treatment is increasing dramatically in line with the aging population. The care of older patients differs from that of younger adults because of differences in the biology of the tumor, age-related differences in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. This book focuses on the management of hematological cancer and provides guidance on the management issues specific to older patients, spanning background and epidemiology, special considerations in the management of older people, therapeutics and psychosocial considerations.

This book aims to equip readers with a better understanding of neuroendocrine tumors of the abdomen and explains how to manage them optimally by making use of novel therapeutic options that represent major advances on previous treatments. The most recent advances in epidemiology, genetics, molecular biology, biomarkers, pathology, diagnostics, clinical assessment, medical therapy, and surgical treatment are presented. The information and data provided will stimulate readers to develop their personal opinions on significant issues and assist in decision making in individual patients during routine clinical practice. The book features a multidisciplinary approach and is designed to meet the needs of all physicians seeking comprehensive guidance from experts on the management of patients with neuroendocrine tumors. It will also be of value for researchers wishing to acquaint themselves with the state of the art in the field and emerging research avenues. Abdominal Neuroendocrine Tumors is published in Springer's highly successful Updates in Surgery series, which now comprises more than 20 titles.

This issue of Surgical Clinics of North America focuses on Advances in Colorectal Neoplasia, and is edited by Dr. Sean J. Langenfeld. Articles will include: Colorectal cancer screening; Imaging for colon and rectal cancer; The difficult colorectal polyp; Emergency presentations of colorectal cancer; Advances in laparoscopic colorectal surgery; Robotic colorectal surgery; Local excision of rectal cancer; New strategies in rectal cancer; Hereditary colorectal cancer syndromes; Dysplasia and cancer in inflammatory bowel disease; Atypical colorectal neoplasms; Resection of the primary tumor in stage IV colorectal cancer: when is it necessary?; Cytoreduction and HIPEC for colorectal cancer; Molecular markers for colorectal cancer, and more!

This book provides a unique and comprehensive overview of minimally invasive (MI) surgical options for the treatment of pancreatic diseases. The opening chapters present the state of the art of MI pancreatic resection according to the 2016 IHPBA Conference, offer information on the safe dissemination of MI pancreatic surgical techniques, and discuss preoperative evaluations protocols and surgical planning options. The book subsequently investigates the full range of currently available minimally invasive techniques, which includes: biliary and gastric bypass, ampullectomy, central and distal pancreatectomy, laparoscopic and robotic pancreatoduodenectomy, and robotic pancreas transplantation. Combining the acknowledged expertise of the Italian school in pancreatic surgery and the contributions of many leading international experts, the book offers a valuable guide for all surgeons who perform this complex surgery, as well as for residents and fellows-in-training.

This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

Single-access laparoscopic surgery (SALS), performed using a single transumbilical access, has recently proved to bring advantages over other forms of laparoscopic surgery due to the reduction in the number of incisions and the consequent decrease in morbidity, less blood loss and postoperative pain. Furthermore, cosmesis may be improved because incision within the umbilicus renders surgery virtually scarless. Nevertheless, as with all new surgical concepts, questions may be raised regarding safety, usefulness and appropriateness. This book analyzes the use of SALS for different indications and abdominal surgical procedures based on a careful literature review of the experience of the most important surgical teams employing this approach and also the authors' personal observations. The coverage is broad, encompassing, for example, the role of SALS in appendectomy, repair of abdominal wall defects, cholecystectomy, gastric surgery, nephrectomy, splenectomy, hemicolectomy and pancreatic, liver and gynecological surgery.

This book comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It closes by discussing animal models of gastrointestinal malignancies and examining the significance of the Ras superfamily of GTPases. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

This book provides a thorough background to the emerging field of medical robotics. It covers the mathematics needed to understand the use of robotic devices in medicine, including but not limited to robot kinematics, hand-eye and robot-world calibration, reconstruction, registration, motion planning, motion prediction, motion correlation, motion replication and motion learning. Additionally, basic methods behind state-of-the art robots like the DaVinci system, the CyberKnife, motorized C-arms and operating microscopes as well as stereotactic frames are presented. The book is a text book for undergraduates in computer science and engineering. The main idea of the book is to motivate the methods in robotics in medical applications rather than industrial applications. The book then follows the standard path for a robotics textbook. It is thus suitable for a first course in robotics for undergraduates. It is the first textbook on medical robotics.

This book offers a complete overview on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history and diagnosis. NCRNNE liver metastases are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.

This text provides a comprehensive overview of orthopaedic oncology – the field of orthopaedic surgery that specializes in the evaluation and treatment of bone and soft tissue tumors of the musculoskeletal system. The opening chapters cover musculoskeletal imaging interpretation and the principles of musculoskeletal biopsy. Assessment and treatment of the full range of tumors are then described in a series of well-illustrated chapters. Detailed consideration is given to benign tumors, osteosarcomas, Ewing sarcomas, chondrosarcomas, metastatic bone disease of the axial and appendicular skeleton, and soft tissue sarcomas. This book will be invaluable for both orthopaedic surgeons and medical oncologists, providing a framework for understanding the fundamentals of these tumors and a sound basis for their treatment.

This book provides an up-to-date review of current management techniques for Non-Small Cell Lung Cancer. It addresses all of the latest issues that have been raised by the discovery of oncogenic drivers and the improvement of diagnosis and therapeutic methods, including new radiotherapy techniques and anticancer strategies like immunotherapy. New strategies for patients with molecular alterations and the management of particular types of cases are also highlighted. Written by recognized experts in their field, the book represents a unique and valuable resource in the field of lung cancer, both for those currently in training and for those already in clinical or research practice.

This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful.

This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authors’ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.

This book describes the current applications of the robotic system in general surgery, focusing on the technical aspects of the procedures most commonly performed by this means. It provides a comprehensive overview of the state of the art in robotic surgery and presents the most recently available evidence as documented in the literature. The opening chapters review robotic platforms, discuss the general advantages, limitations, and strategies of robotic surgery, and identify challenges and critical elements when setting up a robotic program. The full range of applications of the robotic system is then covered, encompassing thoracic, esophageal, gastric, hepatobiliopancreatic, splenic, colorectal, endocrine, and transplantation surgery. Detailed attention is also paid to innovative applications and future trends in the robotic platform, with inclusion of a special chapter on fluorescence imaging during robotic procedures. The book closes by considering aspects related to credentialing and privileging, such as mentoring, proctoring, and teaching modules for residents and fellows. Against the background of increasing acceptance of the robotic surgery system across the globe, this book will be invaluable for all general surgeons. There is no doubt that within general surgery the system will continue to flourish on account of its undoubted technical advantages, which minimize most of the intrinsic shortcomings of laparoscopy.

This book presents the most recent developments in oncologic breast surgery and takes full account of diagnostic, pathologic, and radiologic inputs. It is divided into three parts, the first of which discusses the premises underlying the modern surgical approach to breast cancer. The second part is devoted to what might be termed the conservative program, i.e., breast conservation and oncoplastic surgery, conservative mastectomy, and sentinel node biopsy and axillary dissection. The final part of the book covers different forms of surgery and other treatments in particular settings. Topics include plastic and reconstructive surgery, DCIS surgery, radio-guided surgery, adjuvant systemic therapy, intraoperative radiotherapy, and the role of surgery in locally advanced and metastatic disease. The detailed descriptions of techniques are accompanied by numerous high-quality illustrations. This book will be of value to both experienced practitioners and surgical trainees.    ​

The purpose of this book is twofold: First, it provides an up-to-date overview of the field of surgical oncology for surgeons in training. Particular attention is devoted to the principles of surgery, but important aspects of radiation and medical oncology are also discussed. Furthermore, diagnostic, staging, and treatment algorithms are presented that will offer invaluable assistance in management decision making. The second aim of the book is to offer a comprehensive reference source on the role of surgery in curative and palliative management for medical and radiation oncologists (in practice and in training) and other healthcare professionals involved in the care of cancer patients. The full range of cancer types is covered in a practical, multidisciplinary approach, and additional chapters are devoted to pediatric malignancies, the role of new surgical technologies, and surgical emergencies.

This is a novel text that highlights the controversial areas in the management of gynecological cancers. None of the topics in this book have definitive answers; they represent the everyday decision-making facing gynecologists, oncologists, radiologists, pathologists and other health professionals treating women with these conditions. This book is not to be used as a traditional textbook; it is a text that specialists and trainees will use to help them weigh up the arguments that exist in a variety of areas in the treatment of gynecological cancers. Each chapter will have two or more authors, selected either for their opposing views or for their ability to provide an opposite view or opinion to the other. The content will be evidence-based, illustrating contrasting evidence and scientific opinion in the literature. Each chapter will close on a summary indicating the direction of research needed to address the issues being discussed.