Rectal Cancer: International Perspectives on Multimodality Management is a timely analysis of the diagnosis, staging, pathology, and therapy of cancer of the rectum. This book is intended as a useful resource for physicians, scientists, medical students, and allied health personnel in the disciplines of radiology, gastroenterology, surgical oncology, medical onc- ogy, radiation oncology, and pathology. Renowned contributors from different medical d- ciplines have written their chapters in a thoughtful, provocative, and visual fashion. Importantly, these chapters highlight the controversies in the diagnostic, staging, and the- peutic management of patients with rectal cancer while providing practical management recommendations. This book is divided into 18 chapters. Early chapters address the diagnosis and staging of rectal cancer, highlighting the critical role of contemporary imaging in guiding treatment. The remaining chapters focus on the multimodality management of rectal cancer from the vantage points of surgery, pathology, chemotherapy, and radiation therapy. The major dev- opments in surgery are reviewed first, including contemporary roles of local excision, total mesorectal excision, lateral pelvic lymph node dissection, organ preservation approaches, as well as the management of advanced, recurrent, and metastatic disease. Following is a ch- ter describing the pathologic evaluation of rectal cancer specimens, with emphasis on proper methodology and its clinical relevance to overall disease management. The final chapters review the contemporary roles of chemotherapy (including with radiation therapy, adjuvant and neoadjuvant settings without radiation therapy, as well as in metastatic disease) as well as radiation therapy (including adjuvant and neoadjuvant approaches, short vs.

Endoscopic ultrasound has revolutionized the approach to lesions inside and outside the gastrointestinal tract. It has opened the door for gastroenterologists to explore organs outside of the GI lumen, such as the lymph nodes, lung, pancreas, and liver. Endoscopic Ultrasound covers all aspects of endoscopic ultrasound, from the basics to the interventional indications. Richly detailed chapters describe the utility of EUS in different parts of the body and are organized based on body site Pioneers in the field summarize new studies, and the direction of EUS in practice. Endoscopic Ultrasound provides a ready reference that will help physicians and support staff that are beginning EUS, as well as trained ultrasonographers who wish to arm themselves with a comprehensive reference and explore the future of the field.

Colorectal cancer is one of the most frequent human tumors. Despite tremendous advances in our knowledge about the pathogenesis of the disease, the prognosis remains poor for almost half of the individuals affected. This volume provides an updated and comprehensive description of the most relevant features of colorectal cancer - from molecular biology to prevention, from hereditary syndromes to new treatment modalities. It represents an invaluable source for clinicians who deal with colorectal neoplasms and for all those who wish to increase their knowledge of these malignancies.

This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.

This atlas describes and illustrates in detail the surgical procedures employed in laparoscopic anatomical liver resection, according to tumor location. The surgical approach and techniques are explained for each type of laparoscopic liver resection based on the involved anatomical segment, section, and hemi-liver. Attention is also drawn to potential complications and the means of preventing and managing them. Beyond anatomical liver resection, guidance is provided on non-anatomical resections that do not pay regard to segmental, sectional, or lobar anatomy. The coverage is completed by the inclusion of useful information on instruments and energy devices as well as the basic skills required for laparoscopic liver resection. In presenting a clear practical approach to each laparoscopic anatomical major and minor resection, the Color Atlas of Laparoscopic Liver Resection will be an invaluable guide for trainees. In addition, it will equip more experienced surgeons with much useful information that will enable them to further improve their technique.

The 24th volume of this highly successful series includes new contemporary topics such as corrosive injuries of the oesophagus, post-gastrectomy complications, advances in imaging of inflammatory bowel disease, unusual presentations of gallstones, gall bladder cancer with jaundice, minimally invasive pancreatic surgery, and enhanced recovery after surgery. Finally, the chapter on advances in GI surgery, like in each past volume, reviews important new developments in the field. The GI Surgery Annual 24th Volume provides an overall roundup of selected topics that were deemed particularly relevant and topical by the series editors.

This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I Conference in 2006. Written by experts in the field, it addresses a critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that these findings will help readers to prevent and treat the long-term side-effects of irradiation.

Use of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea and esophagus and miscellaneous items including the role of robotic surgery."

Managing urologic cancer by preserving, as opposed to removing, affected tissue, is rapidly becoming the favoured choice for urologists and oncologists. Discover all available options and how to achieve the best possible patient management with this expert guide to the area. The editor, Mark Schoenberg, is an internationally-renown expert in this exciting new area and has recruited an outstanding team featuring some of the leading urologists/oncologists in North America and Europe to assist him.

Written by some of the most experienced surgeons in the United States, Contemporary Transoral Surgery for Primary Head and Neck Cancer is a distinct resource for surgeons and oncologists interested in transoral surgery. This text gives readers current, thoroughly illustrated, and data-driven information on all aspects of transoral surgery. The authors are pioneers in the field, having performed thousands of transoral surgery cases and publishing and lecturing extensively on the subject. Opening with the history of transoral surgery, the book goes on to address endoscopic anatomy, general techniques, as well as tips for analysis and pathologic considerations, and provides comprehensive coverage of surgeries for the head and neck subsites. Also included are valuable chapters on surgery for chemoradiation failures, reconstruction techniques for surgical defects, and oncologic and functional outcomes using open surgery, chemoradiation, and transoral surgery.To supplement the text and provide additional visualization of the concepts described, readers can access a companion website that contains video footage of transoral surgery techniques for various head and neck primary cancer sites. Through this highly relevant text, physicians not only learn the technical aspects of transoral surgery for head and neck cancer, but also its importance in the treatment of these patients.

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Breast Cancer: The Facts provides essential, easy to follow information on all aspects of the diagnosis and management of breast cancer. It provides essential background information on the disease, from the ways breast problems are investigated, through treatment options and new therapies, to follow-up processes after remission. Fully updated to cover new and emerging therapies in breast cancer, this second edition also features new chapters on treating special or unusual types of breast cancer; surviving and thriving post-treatment; and coping and support strategies for the partners, families, friends, and colleagues of the person diagnosed with breast cancer. Each chapter is enriched with resources such as websites, links to videos, and care plans so the reader can explore relevant topics in greater detail. Written by specialists in breast cancer, the focus is on the whole patient, their family, and social networks, to make this book a holistic guide to better health at and after diagnosis with the disease, equipping patients affected by breast cancer and their families to be able to ask their health care team the questions they need to have answered to make informed decisions about their treatment.

This book provides a thorough overview of the detection of PCNs using modern imaging techniques and a clear guide to the recognition of the different subtypes of PCN based on their radiologic and histopathologic features. This volume will serve as an excellent aid to the selection of optimal therapeutic strategies based on preoperative diagnosis. A further important feature is the emphasis placed on radiologic, clinical, and surgical correlations. Pancreatic cystic neoplasms (PCNs) have been increasingly recognized during the past decade, mainly because of the widespread use of modern imaging modalities for the investigation of often unrelated abdominal symptoms. The three most common subtypes of PCN are serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. These subtypes have distinct radiologic and histopathological features, and their biological behavior differs greatly. Accurate preoperative diagnosis is of prime importance in selecting the optimal therapeutic strategy: while serous cystic neoplasms are almost always benign, and may be treated conservatively, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms have malignant potential, warranting an aggressive surgical approach, i.e., pancreatectomy. Pancreatic Cystic Neoplasms will be of great interest to surgeons, gastroenterologists, radiologists, oncologists, and pathologists, and also to internists and residents in these specialties.

This third edition text provides a completely revised and updated new version of this unique, modern, practical text that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert colorectal surgeons caring for patients with complex problems-whether they result from underlying colorectal disease or from complications arising from previous surgical therapy. The format follows that of both a "how to" manual as well as an algorithm-based guide to allow the reader to understand the thought process behind the proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides a narrative by the author on his/her operative technical details and perioperative "tips and tricks" that they utilize in the management of these complex surgical challenges. Distinctive to this book, is the reliance on experts in the field including past presidents of the ASCRS, as well as multiple other national and internationally recognized surgeons, to lend their personal insight into situations where data may be more sparse, but individual and collective experience is paramount to making sound decisions and thereby optimizing patient outcomes. The text includes chapters on the assessment of risk and methods utilized to minimize perioperative complications. In addition, it incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Moreover, the technical challenges of managing complications resulting from the original or subsequent operations is addressed. The underlying focus throughout the text is on providing pragmatic and understandable solutions that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems. However, it also goes beyond the technical aspects of colorectal surgery and includes special sections highlighting the essence of a surgeon; covering aspects involving the medical-legal, ethical, and economic challenges confronting surgeons. Throughout the text, each author provides an ongoing narrative of his/her individual surgical techniques along with illustrations and diagrams to "personally" take the reader through the crucial steps of the procedure, and key points of patient care inherent to that topic. Additionally, where appropriate, links to online videos give the reader an up-front look into technical aspects of colorectal surgery.

The widespread acceptance among the oncology community at large of cytoreductive surgery and HIPEC as a potentially curative treatment for peritoneal metastases has paved the way for innovative new therapies that could benefit a larger proportion of patients. Much has been and continues to be published on this subject. This book provides comprehensive reviews on the various aspects of managing peritoneal metastases. The authors highlight essential practical issues that surgical oncologists encounter in their day-to-day practice, and try to before provide evidence based answers to address them. All chapters were written and/or reviewed by leading experts in this field.

Interventional oncology (IO) consists of the use of image-guided minimally invasive techniques to diagnose and treat patients with cancer. Alongside medical, surgical and radiation oncology this constitutes an important approach with potential to improve cancer treatment and care. A team of experts in interventional oncology and cancer care have created a new introduction that may be used by any professional involved in the planning and delivery of interventional oncology care around the world. The text is particularly helpful and timely, and will again serve as a valuable resource for those who develop new interventional oncology services, as well as provide a source of training and an update for clinicians working in this challenging clinical area. This title is formally supported by the Association of Cancer Physicians.

Now fully revised and in its fourth edition, the Oxford Handbook of Oncology has been the essential go-to guide for students and practitioners in oncology for over a decade. The scientific basis and diagnosis of cancers is covered, as well as drugs, biomarkers, and the presentation and psychosocial aspects of oncology. Concise, practical, and comprehensive, there is no better companion for both common conditions and challenging emergencies. The field of oncology has surged forward since the last edition was published and the Oxford Handbook of Oncology has been fully revised and updated to reflect these recent advances so you can be sure that the vital information you need is in your hands. This handbook incorporates changes such as the understanding of the science of cancer, novel therapies in breast, lung, renal, and melanoma, molecular sub-classification of common solid cancers, personalized therapy approaches, new agents in hard to treat cancers, the benefits of new technologies in radiotherapy, and the emerging data on the importance of the immune response. Written by experts in the field to ensure that it is grounded in real life clinical practice, this handbook provides a concise guide to all aspects of oncology for all students, nurses, and junior faculty responsible for the care of cancer patients, while also providing further reading and highlighting areas of controversy for those who need a more detailed understanding.

Hepatocellular Carcinoma: Targeted Therapy provides a detailed repository of the latest information regarding HCC epidemiology, diagnosis, imaging, pathology, staging, and treatment options. This volume also provides an up-to-date guide for treatment that explores not only traditional treatments, but newer investigational treatment options including, surgical resection, liver transplantation, ablation (radiofrequency, microwave), percutaneous ethanol or acetic acid injection, transarterial chemoembolization (TACE), intra-arterial radiation therapy, and systemic chemotherapy. Heptocellular Carcinoma: Targeted Therapy will be of great value to all health care professionals and trainees worldwide who have an interest in the diagnosis and treatment of HCC, including surgeons, medical oncologists, radiologists, radiation oncologists, and pathologists.

Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

This monograph summarizes the data of the prospective study on the immunological characteristics of cancer patients with sepsis and septic shock developed after surgery. Patients without signs of infectious complications and symptoms of organ failure, as well as a group of healthy donors, were considered as references. The comparative analysis of blood parameters that characterized humoural and cell immunity (concentrations of cytokines and their receptors, immunoglobulins, lipopolysaccharide and other active biomolecules) has been performed. An estimation of diagnostic and prognostic significances of these parameters has been performed as well. In the final chapters, the properties of the new perspective hypercrosslinked polymeric hemosorbents are presented. The monograph could be interesting for a wide array of specialists in the fields of resuscitation, healthcare therapy, oncology and surgery, as well as for researchers aimed toward the development of new types of biocompatible materials.

Breast cancer affects 1 in 10 women and the majority of UK women will attend a breast clinic at least once during their lives. The patient's journey through assessment and management is one that involves a huge range of healthcare professionals, in which the truly multidisciplinary management style required has previously been only sparsely addressed. This book provides a practical guide on how to investigate and manage common breast problems for all members of the breast disease team, whether surgeons, nurses, pathologists or support workers. Its focus is on providing easy access to the most up-to-date evidence, allowing healthcare workers to make the best decisions possible and encouraging a team approach to patient support.
26 chapters cover the whole of the patient journey from assessment through to surgery and adjuvant treatments, giving a practical overview of the whole process of care. The coverage guides the reader from clinical examination and investigation of the breast patient to pre-operative workup and post-operative complication guidance. To enable swift and effective decision-making, clear management plans are provided for common breast problems. The book also includes the latest evidence, guidance and references on breast disease, together with discussions on current controversies in the field including the management of margins, management of the axilla and the evidence surrounding the NHS Breast Screening Programme. To give practical advice on the realities of being part of a breast care team, the book also has several chapters devoted to leadership and management including MDT requirements, audit and research, avoiding complaints and the organisation of a breast unit.
Enabling every healthcare professional to respond to patients' needs accurately and knowledgeably, Breast Disease Management is a practical guide for the whole team in providing truly patient-centred, effective care.

Management of Soft Tissue Sarcoma addresses the diagnosis and best current management of adult soft tissue sarcomas. Edited by world renowned experts, this book delineates and discusses each different sarcoma subtype individually. Both clinical and molecular diagnoses are addressed, and tumor histopathology is employed as the basis of treatment recommendations including surgery, radiation therapy, systemic therapy and novel therapeutics.