Features Provides a comprehensive review of all aspects of skin cancer management. Edited by experts in the area, with interdisciplinary and international collaborators. Promotes a 'Bigger picture' approach to the topic with multidisciplinary insight.

Cryosurgery is a surgical technique that employs freezing to destroy undesirable tissue. From as early as 3500 BC, there is evidence for the use of cold in medicine for the treatment of infected wounds of the chest, fracture of the skull and various injuries. However, the history of "modern" cryosurgery is relatively short and is closely intertwined with the development in low temperature physics, engineering, and instrumentation during the last century. From the early 21st century, advanced helium-based cryosurgery has been applied worldwide. More than ten thousand patients with malignant and benign tumors have received cryosurgery. It is specially noted that in most cases cryosurgery, as a mini-invasive ablation technique, was performed with percutaneous approach under guidance of CT or ultrasound. Cryosurgery is now one of the more popular techniques in China, with nearly 6000 cases of tumors receiving cryosurgery in the author's institution alone. This book summarizes the experimental and clinical experience and practice of cryosurgery, and describes the basics of cryosurgery and its use in the treatment of various tumors.

We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin (R) (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.

*takes a patient centred approach * reflects contemporary multi-disciplinary team approach * assesses breast cancer in specialist circumstances eg very young, pregnant, very old * clearly illustrated to highlight key issues

This issue of Surgical Clinics of North America focuses on Advances in Colorectal Neoplasia, and is edited by Dr. Sean J. Langenfeld. Articles will include: Colorectal cancer screening; Imaging for colon and rectal cancer; The difficult colorectal polyp; Emergency presentations of colorectal cancer; Advances in laparoscopic colorectal surgery; Robotic colorectal surgery; Local excision of rectal cancer; New strategies in rectal cancer; Hereditary colorectal cancer syndromes; Dysplasia and cancer in inflammatory bowel disease; Atypical colorectal neoplasms; Resection of the primary tumor in stage IV colorectal cancer: when is it necessary?; Cytoreduction and HIPEC for colorectal cancer; Molecular markers for colorectal cancer, and more!

This book identifies key treatment challenges and unique care considerations in patients with head and neck cancers, providing a comprehensive guide to patient management that illustrates the critical importance of a multidisciplinary approach in achieving optimal oncological, functional, and survival outcomes. It covers all relevant specialties, including dental and oral medicine, medical oncology, radiation oncology, surgical oncology, and reconstructive surgery. It highlights the vital role played by ancillary head and neck cancer services, such as speech and swallowing therapy, occupational and physical therapy, and nutritional therapy in offering essential physical and psychological support from the time of diagnosis onward. The closing chapters address post-treatment issues, including those relating to survivorship, surveillance, and end-of-life care. Multidisciplinary care is perhaps even more important for patients with head and neck cancers than for other cancer patients, and in addressing all its aspects this book is invaluable for a wide range of practitioners.

Uncommon tumors of the pancreas are of increasing interest for clinicians: cross imaging techniques development makes it possible to detect small lesions in the pancreatic gland of asymptomatic patients, and in the last decades a more detailed and specific pathological classification definitivelyopened an unexpected world of more or less rare pancreatic tumors. As a matter of fact, nowadays most surgical procedures deal with these so called uncommon pancreatic tumors such as cystic, endocrine and others unfrequent histotypes, and many patientsexperiencing an accidental discovery of this type of tumor need therefore a specialistic evaluation. The concept behind this volume is the need to give the correct clinical relevance to these "uncommon" tumors, that are ranked at the first place among pancreatic tumors, and that are definitively curable with a multimodal approach. Aim of the book is therefore to get clinicians closer to these pathologies, describing their complexity and the current state of the art in diagnostic, therapeutic and pathological classification strategy, thus providing them with the tools for a modern and updated clinical management of these patients.

This volume provides the most comprehensive and complete resource available on all aspects of gastric cancer and it's management. The book covers topics such as oncologic approaches to staging, treating, and following patients, filling a critical need for resource materials on these areas. As multidisciplinary care is an integral part of gastric cancer treatment, this text is unique in including a renowned group of expert authors from a variety of disciplines, including pathology, gastroenterology, medical oncology, surgery and clinical genetics. In addition, authors from an international pool of gastric cancer experts have covered the breadth of practice and understanding globally. Edited and organized by an expert from one of the most highly respected cancer institutions in the country, Gastric Cancer: Principles and Practice is an expert review of this field, serving as a valuable reference for physicians in training and in practice, as well as for researchers who are interested in the scope of issues and advances in this important malignancy.

Self-Assessment in Head and Neck Surgery and Oncology is a one-of-a-kind, comprehensive medical reference book that showcases international, expert knowledge and judgment in the practice of head and neck surgery and oncology. It offers a variety of true/false statements and multiple-choice questions, as well as patient and case histories, coverage of the newest technologies, and much more. This brand-new resource is perfectly suited for otolaryngology residents, oncologists, and surgeons who wish to measure their understanding of how to effectively manage the day-to-day problems and issues arising in patients with neoplasms of the head and neck. Test your expertise. Various forms of self-assessment include true/false statements and multiple-choice questions throughout. Take advantage of patient and case histories accompanied by real-life photographs and scans. Reference the correct answer to every question, which is followed by a bulleted list of the minimum core knowledge required for that particular area. Access the most current information on new technologies, outcomes data, results of clinical trials, and future directions. Further your research with a list of suggested readings included in each chapter. Search the full text online at Expert Consult.

This book emphasizes on clinical, radiological and laboratory assessment of operative surgery in common head and neck surgical procedures. It provides a systematic and rational operative approach to management in day-to-day practice. A photographic style is used, wherein high-quality photographs provide visual details to reveal each step of the procedure. This photographic content of each surgical step on patient or cadaver makes this book a valuable resource for surgical residents, fellows, junior consultants, and general surgeons who manage head and neck cases and would learn to deftly perform the procedures. Key Features * Incorporates a unique photographic style enumerating the step-by-step surgical procedures. * Provides a crisp and to the point approach towards common head and neck surgical management, helpful for surgery residents and trainees. * Fills a significant gap for a text that adequately describes the wide variety of procedures performed by head and neck surgeons.

This book emphasizes on clinical, radiological and laboratory assessment of operative surgery in common head and neck surgical procedures. It provides a systematic and rational operative approach to management in day-to-day practice. A photographic style is used, wherein high-quality photographs provide visual details to reveal each step of the procedure. This photographic content of each surgical step on patient or cadaver makes this book a valuable resource for surgical residents, fellows, junior consultants, and general surgeons who manage head and neck cases and would learn to deftly perform the procedures. Key Features * Incorporates a unique photographic style enumerating the step-by-step surgical procedures. * Provides a crisp and to the point approach towards common head and neck surgical management, helpful for surgery residents and trainees. * Fills a significant gap for a text that adequately describes the wide variety of procedures performed by head and neck surgeons.

This volume provides a comprehensive perspective on surgical oncologic diseases that are relevant to those who have an interest in surgical oncology. Its purpose is to distill a voluminous amount of information to readers so they will have the opportunity to apply relevant information and knowledge to their particular needs. Each chapter is written by experts in their field who provide concise and in-depth information on their topic and supply references to key articles. Illustrations, diagrams and photographs are included to assist the visual learners. Each chapter begins with bulleted key points to focus the readers on the material that will be covered and concludes with an appendix that summarizes the salient points. This unique set-up can be used as a tool to quickly review the topic at hand. The text also includes a set of short questions and answers at the end of each chapter to reinforce the salient points. Surgical Oncology: A Practical and Comprehensive Approach is a valuable resource for Medical students, surgical oncology fellows, general surgeons and educators.

Written by internationally acclaimed specialists, Breast, Endocrine and Surgical Oncology provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated throughout by photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Breast, Endocrine and Surgical Oncology provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.

This issue of the Surgical Oncology Clinics will focus on new advances in Breast Cancer Surgery, and will include articles on Chemoprevention, Breast MRI, Genomics, Sentinel Node Biopsy, Extra-axillary Sentinel Nodes, Skin-Sparing and Nipple Sparing Mastectomy, Oncoplastic Techniques, Neoadjuvant Hormonal Therapy, Neoadjuvant Chemotherapy, Adjuvant Hormonal Therapy, Adjuvant Chemotherapy, and Biologic Targeted Therapies.

This issue of the Surgical Oncology Clinics will cover the following topics: imaging for pancreatic cancer, EUS staging and novel therapeutics for pancreatic cancer, management of cystic tumors, management of IPMN, laparoscopic surgery for pancreatic tumors, current concepts in the surgical management of pancreatic cancer, management of borderline resectable pancreatic cancer, regionalization of pancreatic surgery, update on adjuvant trials for pancreatic cancer, neoadjuvant therapy for pancreatic cancer, novel targets for pancreatic cancer therapy, and new frontiers in pancreatic cancer.

In the 10 years since malignant melanoma was last covered in Clinics in Plastic Surgery, significant changes have occurred in the diagnosis and treatment of this disease.? Sentinel lymph node biopsy has now become the standard of care in melanoma. The staging system was totally revamped in 2002, taking into account the significance of ulceration and the information gained during sentinel node biopsy.? With more than 60,000 patients diagnosed each year with malignant melanoma, the plastic surgeon must continue to be pivotal in the management of patients with this disease, coordinating care among the specialists and being integral in all aspects of surgery and follow-up.

This issue of the Surgical Oncology Clinics will review the important clinical trials from the past eight years in following topics: breast cancer, soft tissue sarcoma, rectal and anal carcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma, gastric cancer, esophageal cancer, colon cancer, advanced and metastatic colorectal carcinoma, gastrointestinal stromal tumors, and melanoma.

The second edition of Endocrine Surgery is a comprehensive update of the previous edition published in 2003. Edited by three leading authorities in the field of surgical endocrinology, the book encompasses the clinical, imaging, nuclear, molecular, technological and evidence-based principles that are applied in the diagnosis and treatment of all categories of endocrine tumors. Authored by experts from across the globe, this textbook reflects the best international clinical practice and also provides an outstanding educational resource. With full color illustrations throughout, the new edition emphasizes contemporary approaches in successive stages including: pituitary endocrine tumors; pathology and pathophysiology of pulmonary neuroendocrine cells; surgery of endocrine tumors of the lungs and thymus; robotic endocrine surgery; molecular testing of thyroid nodules; pediatric surgery for neuroblastoma and ganglioneuroma; multiple endocrine neoplasia; retroperitoneoscopic adrenalectomy; radionuclide imaging of carcinoid tumors, pancreas and adrenals; serotonin-induced cardiac valvular disease and surgical treatment; multimodal management of primary and metastatic neuroendocrine tumors; pathophysiology and surgery of Type II diabetes; post-bariatric surgery hyperinsulinemic hypoglycemia; and surgical management of metabolic syndrome. Endocrine Surgery 2e provides the clinician with a definitive resource to reach curative outcomes in the treatment of patients with endocrine pituitary, thyroid, and parathyroid entities. Further coverage of broncho-pulmonary, adrenal, pancreatic, and intestinal neoplasia is also included, making this the definitive textbook on the subject. Demetrius Pertsemlidis, MD FACS The Bradley H. Jack Professor of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA William B. Inabnet III, MD FACS Professor of Surgery and Chief, Division of Metabolic, Endocrine and Minimally Invasive Surgery, Icahn School of Medicine at Mount Sinai, New York, USA Michel Gagner, M.D. FRCSC, FACS, FASMBS Clinical Professor of surgery, Herbert Wertheim School of Medicine, Florida International University, Miami, FL and Senior consultant, Hôpital du Sacre Coeur, Montreal, Quebec, Canada Print Versions of this book also include access to the ebook version.

Surgery continues to be the most effective treatment of solid tumors in terms of recovery, while its combination with other treatments improves the survival curves especially in the advanced forms of the disease. The aim of my task first of all has been to provide readers with both the current and constantly evolving pathophysiologic knowledge required for building the foundation of a specific education enabling surgeons to meet the fundamental targets in surgical oncology. Secondly, this volume aims to present an update on the real possibilities offered by the cooperation between surgeon and pathologist and by chemotherapy, radiotherapy and gene therapy in the treatment of tumors in the light of the most recent scientific achievements. Lastly, the report presents the experiences and cases drawn mostly from our School regarding some of the major issues in oncologic surgery. This overview does not pretend to elucidate or to summarize all aspects of oncologic surgery, but rather to be the result of a general consideration on cancer surgery, on its rational bases, on its interaction with other treatment modalities, on its desirable and expected developments and on its probable future evolution.

"Radical Prostatectomy: Surgical Perspectives" provides surgeons with a comprehensive overview of the anatomical approach to radical prostatectomy, whether done through an open (retropubic) or robotic-assisted laparoscopic approach. All chapters are structured to provide a step-by-step approach to the most technically demanding and most common oncologic procedure in urology surgery. The book includes highly practical presentations of typical surgical patients seen in the clinical practice of urology and relies heavily on illustrations and intraoperative photographs to clearly complement the text. In addition, the book includes a detailed description of the management of uncommon but potentially serious intraoperative complications, including major vascular injury, ureteral transaction, and rectotomy.

Written by authors from a variety of integrated disciplines, including anesthesia, cardiology, and nursing "Radical Prostatectomy: Surgical Perspectives" is a unique and valuable resource in the field of urology both for those currently in training and for those already in surgical practices."

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.

Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge.

Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities.

By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology. "

Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authors' very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.

An easy to follow step-by-step guide to the most useful surgical skills from knot tying to simple procedures. Illustrated with colour photographs and video clips to demonstrate techniques, this book makes these practical skills as clear and easy to follow as possible. Including coverage of surgical instruments, wound management and suturing, and minor surgical procedures, it also explains how to use these essential surgical skills to make the most of a surgical placement. Healthcare students or junior professionals undertaking a placement in surgery or emergency medicine will feel confident and capable, and will be able to take an active role in surgical placements. Learning basic surgical skills is important for such placements, as well as for undertaking exams such as the Membership of the Royal College of Surgeons (MRCS).

A new revision guide designed to help candidates prepare for the first part of the FRCS general surgery exam. Due to a lack of preparatory resources for the exam, this book bridges the gap, offering updated guidelines and information which will help candidates succeed. It acts as a supportive revision guide which will enrich other FRCS exam resources. This resource provides an updated approach to the FRCS exam. Using questions written by practicing surgeons, the book offers more contemporary revision materials, touching on topics not widely covered in other FRCS revision aids. Readers will gain a familiarity with the style of the FRCS exam, as Higher FRCS uses a style reflective of the exam to enhance the candidate's knowledge, confidence, and preparation. The audience for this book includes general surgery trainees who are preparing for their higher exams (including FRCS), alongside surgical trainees taking the MRCS. It is also a beneficial resource for students in other medical courses studying for surgical exams.