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Books > Medicine > Other branches of medicine > Pharmacology
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Novel Anticancer Drug Protocols (Hardcover, 2003 ed.)
Loot Price: R4,629
Discovery Miles 46 290
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Novel Anticancer Drug Protocols (Hardcover, 2003 ed.)
Series: Methods in Molecular Medicine, 85
Expected to ship within 12 - 17 working days
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Donate to Against Period Poverty
Total price: R4,649
Discovery Miles: 46 490
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We are in an exciting era in the war against cancer, with real
prospects for novel anticancer drugs that are cancer cell-specific
without the toxicities that have been the hallmark of conventional
cytotoxic cancer chemotherapy. Advances in cancer cell biology
fueled by the molecular biology revolution have resulted in the
uncovering of many novel potential molecular targets for cancer
therapy. New anticancer drug discovery and development is now
largely focused on exploiting these new molecular targets, which
encompass oncogenes, tumor s- pressor genes, and their gene
products, as well as targets involved in tumor angiogenesis,
metastasis, survival, and longevity mechanisms. Exploitation of
some of these targets has already yielded fruits and introduced new
paradigms of molecularly targeted cancer therapy into the clinic,
namely, protein kinase in- bition by antibodies or small molecules,
exemplified by Herceptin (R) (trastuzumab), a humanized antibody
targeted against the HER-2 growth factor receptor tyrosine kinase
for the treatment of metastatic breast cancer; and Gleevec, a small
molecule bcr-abl kinase inhibitor for the treatment of chronic
myel- enous leukemia.
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