This issue of Thoracic Surgery Clinics, Guest Edited by Drs. Jean Deslauriers, F.G. Pearson, and Farid Shamji, is devoted to surgery and chemotherapy for lung cancer. This issue was written as a tribute to Dr. Robert J. Ginsberg, and will include articles on: Contemporary results of surgical resection of NSCLC after induction therapy; Prediction of operative morbidity and mortality before operation; Limited resection for small diameter tumors; Management of tumors involving the chest wall, including Pancoast tumors and tumors invading the spine; Role of surgery in patients with clinical N2 disease; Reconstruction of the bronchus and pulmonary artery; Current status of systematic lymph node dissection versus lymph node sampling; Intraoperative nodal staging: Role of sentinel node technology; Stereotactic body radiation therapy (SBRT) in early stage tumors; Palliative resection; Adjuvant chemotherapy after pulmonary resection for lung cancer; Targeted therapy and new anti-cancer drugs in advanced disease; Biologic approaches to drug selection and targeted therapies; Cost effective methods for follow-up after lung cancer surgery; Quality of life after pulmonary resection; and Principles of palliative care.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older lung cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

Covers all aspects of gastrointestinal and liver malignancies (epidemiology, pathophysiology, screening where appropriate, symptoms and clinical signs, diagnostic studies, staging and classification, treatment, prognosis, follow-up, future perspectives). The text is addressed to those involved in the multidisciplinary approach to the gastrointestinal cancer patient (gastroenterologists, medical oncologists, radiation therapists, surgeons, interventional radiologists, pathologists, nurses, and physicians-in-training). The book provides in-depth information, illustrated by numerous color/black-and-white pictures. Selective reading for a quick reference is made possible by introducing text elements such as summaries, tables, listing and treatment algorithms.

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. Greg Masters, will highlight the multi-disciplinary approach to a variety of common malignancies, focusing on how surgical oncologists work together with medical oncologists and radiation oncologists to provide the most up-to-date management for many different malignancies. It will focus on the latest data from updates in basic science and clinical trials, including the importance of new technology and surgical techniques, new radiation techniques and the latest in chemotherapy, biologic, and targeted drug development in the multidisciplinary care of cancer patients.

A comprehensive and important issue devoted to multidisciplinary breast management Topics will include neoadjuvant chemotherapy, pathology of invasive breast disease, management of high risk lesions, genetic predisposition syndromes, radiation therapy, surgical management of the breast-mastectomy and breast conservation, management of the axilla, management of ductal carcinoma in situ, breast reconstruction, adjuvant therapy, screening, imaging, and image guided biopsy techniques for breast cancer, benign breast disease, and much more

This book provides a unique and comprehensive overview of minimally invasive (MI) surgical options for the treatment of pancreatic diseases. The opening chapters present the state of the art of MI pancreatic resection according to the 2016 IHPBA Conference, offer information on the safe dissemination of MI pancreatic surgical techniques, and discuss preoperative evaluations protocols and surgical planning options. The book subsequently investigates the full range of currently available minimally invasive techniques, which includes: biliary and gastric bypass, ampullectomy, central and distal pancreatectomy, laparoscopic and robotic pancreatoduodenectomy, and robotic pancreas transplantation. Combining the acknowledged expertise of the Italian school in pancreatic surgery and the contributions of many leading international experts, the book offers a valuable guide for all surgeons who perform this complex surgery, as well as for residents and fellows-in-training.

This issue of Surgical Oncology Clinics of North America, Guest Edited by John M. Kane III, MD, is devoted to Sarcomas.? Articles in this issue include: Prognostic Factors and Staging for Soft Tissue Sarcomas; Margin Status and Local Recurrence: Correlation or Causation?; Systemic Chemotherapy in the Adjuvant and Clinical Metastatic Setting; Pulmonary Metastasectomy; Regional Therapy for Advanced Extremity Sarcomas; Current Approaches to Retroperitoneal Sarcomas; Updates on the Management of Gastrointestinal Stromal Tumors (GIST); Soft Tissue Sarcoma: Immunologic Implications; Atypical Lipomatous Tumor/Well Differentiated Liposarcoma: What is it?; Modern Surgical Therapy: Limb Salvage and the Role of Amputation; Adjuvant Radiation Therapy: and Preoperative, Postoperative, or Not at All.

New research has shown that neuroendocrine tumors are more common than previously thought. Progress in our understanding of the molecular pathogenesis of these not-so-rare cancers has resulted in renewed interest in developinginnovative therapeutic options. In particular, novel molecular targeted agents have been shown to have significant anti-tumor activity, and integration of these therapies has led to critical advances in management.

In this volume, an outstanding group of the world s leaders in the field have assembled to convey their knowledge of the epidemiology, biology, and management of allthemajor types of neuroendocrine tumors. The book takes a multi-modality approach to understanding disease processes and therapeutics, including chapters on medical and surgical treatment as well as a chapter devoted to imaging. Throughout, the authors emphasize recent advances in our understanding of molecular biology and the subsequent emerging therapeutic options.

Benign esophageal diseases are common problems treated by thoracic surgeons.? This issue includes articles on the diagnosis and management of several motility and reflux disorders that are considered benign, with an emphasis on the use of cutting-edge technology.

This volume of the Urologic Clinics covers the indications, controversies, and complications of Lymphadenectomy in Urologic Oncology.? Cancer of the prostate, bladder, testicles, and kidney are covered, along with new imaging modalities and complications of open and minimally invasive lymphadenectomy.

In this issue of Surgical Oncology Clinics of North America, Guest Editor Mark Krasna and colleagues discuss a wide range of topics devoted to lung cancer.? Articles focus on pathology; updated staging systems; epidemiology of lung cancer - smoking, second hand smoke, and genetics; molecular markers for incidence, prognosis, and response to therapy; screening; diagnostic work-up; non-invasive staging techniques; surgical resection; the role of surgery following induction therapy for stage III NSCLC; the role of adjuvant chemotherapy in NSCLC (stages I-III); and much more.

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Frederick Greene, focuses on Surgical Oncology in the Community Cancer Center. An array of experts have come together to explore topics on Sarcoma Management, Minimally Invasive Esophagectomy, Multidisciplinary Clinics and the Surgeon's Role in the Hospital Cancer Program, Breast Cancer Care in the Community Cancer Center, Lumpectomy versus Mastectomy Rates in the Community Setting, American College of Surgeons Oncology Group trials and the Community Surgeon, Quality Surgical Oncology Care in the Community: Training versus Hospital Volume, The Impact of Dedicated Tumor Boards in Clinical Trials, The National Accreditation Program for Breast Centers: Quality Improvement Through Standard Setting, and much more.

This book aims to equip readers with a better understanding of neuroendocrine tumors of the abdomen and explains how to manage them optimally by making use of novel therapeutic options that represent major advances on previous treatments. The most recent advances in epidemiology, genetics, molecular biology, biomarkers, pathology, diagnostics, clinical assessment, medical therapy, and surgical treatment are presented. The information and data provided will stimulate readers to develop their personal opinions on significant issues and assist in decision making in individual patients during routine clinical practice. The book features a multidisciplinary approach and is designed to meet the needs of all physicians seeking comprehensive guidance from experts on the management of patients with neuroendocrine tumors. It will also be of value for researchers wishing to acquaint themselves with the state of the art in the field and emerging research avenues. Abdominal Neuroendocrine Tumors is published in Springer's highly successful Updates in Surgery series, which now comprises more than 20 titles.

Mohs Surgery is reviewed in this issue of Dermatologic Clinics, guest edited by Drs. Allison Vidimos, Christine Poblete-Lopez, and Christopher Gasbarre. Expert contributors offer reviews on topics including the history of Mohs surgery, Techniques, Mohs surgery for melanoma in situ, Flaps and grafts reconstruction, Transplant patients, Imaging, Histologic pitfalls, Special stains and Mohs, Special considerations: Eyes, lips, nailbed, and genitalia, Multidisciplinary approach to large tumors, Prosthetic rehabilitation, Setting up a Mohs surgery lab, and Coding for Mohs surgery.

This issue of Surgical Oncology Clinics, Guest Edited by Dr. Steven Curley, presents various articles on the subject of Ablative Procedures. Articles include: The History of Ablation; Radiofrequency Ablation (RFA) of Hepatocellular Carcinoma (HCC); RFA of Colorectal Cancer; RFA of Neuroendocrine Metastases; Basic Science Research; Ablation Kidney Lesions; High Intensity Focused Ultrasound (HIFU); Microwave Coagulation; Ablation of Bone Metastases; Ablation Breast; Ablation Lung Lesions; and Planning and Follow-up After Ablation.

This issue of Surgical Oncology Clinics, Guest Edited by Dr. Jeffrey Gershenwald, presents various articles on the subject of Melanoma. Articles include: Pathologic Evaluation of the Primary Tumor and Sentinel Lymph Nodes; Staging and Prognosis; Management of Primary Melanoma; Management of the Clinically Uninvolved Nodal Basin in Cutaneous Melanoma; Evidence-based Approach to Imaging and Follow-up Guidelines for the Melanoma Patient; Treatment Strategies for the Intransit Melanoma Metastasis; Adjuvant Therapy for Stage III Melanoma; Role of Radiotherapy; Targeted Therapy; Immunotherapy; Assessment of Melanoma-specific Patient Reported Outcomes (PRO); and Metastasectomy for Stage IV Melanoma.

Topics include: Evaluation and initial management of the patient with facial skin cancer; Nonmelanomatous skin cancer; Mohs, Malignant melanoma; Local flaps - bilobed, rhombic, forehead, melolabial; Options for the management of scalp defects; Defects of the nose; Eyelid defects; Ear defects; Defects of the lips; Cheek defects; Secondary procedures to improve flap appearance.

Intraductal papillary mucinous neoplasms (IPMNs) represent an opportunity to treat pancreatic tumors before they develop into aggressive, hard-to-treat cancers. Beginning with morphological classification and its clinical significance, natural history, and malignant change of both main duct and branch duct IPMNs, this book covers the whole field of IPMNs of the pancreas. It reviews the various methods of investigation: imaging, diagnostic investigation of cyst fluid, and those using pancreatic juice; and also examines aspects ranging from the development of malignancy to the timing and method of resection, focusing on both main duct and branch duct IPMNs.

Aimed at residents, clinical fellows, and pancreatologists who treat patients with this common disease of the pancreas, this book is a landmark in the current understanding and future perspectives of IPMNs of the pancreas.

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While many comprehensive texts have been written on the treatment of breast cancer, the most common cancer among women, there are relatively few which cover in depth the prevention and early detection of the disease. The goal of this work is to present what experts in the ?eld feel is the current knowledge and future direction of breast cancer prevention and early detection. We begin Part I of the book with a review of risk factors, both genetic and environmental. We next review progress in the use of chemoprevention. Notably, chemoprevention risk reduction studies have led to FDA approval of two medications which measurably reduce disease incidence among women at increased risk, although with some risk of treatment related side effects. Newer agents in the pipeline, which may also reduce risk among normal risk women, are also discussed. Surgical risk reducing strategies complete the section on prevention, including both the bene?ts and downsides to this more aggressive approach. Even with aggressive prevention strategies, some women will develop breast cancer. For these women, early detection is critical to minimize disease spread and maximize long term survival. Part II of this book reviews current and upcoming approaches to early detection. Imaging strategies, including mammography, breast ultrasound, MRI, and PET imaging are reviewed. The potential for molecular tumor targeting to detect disease prior to the formation of a mass visible by anatomic imaging is presented.

Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances brings together the three main pelvic specialties (Urology, Gynecological Oncology and Colorectal Surgery) into one volume. Patients have been shown to benefit from a multidisciplinary approach since it allows surgeons of different specialties to learn from one another therefore enhancing the treatment for the patient. Pelvic cancer outcomes are poor in low volume centres. These centres account for 80% of the global centres dealing with these cancers. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances is a much needed book that can focus training and assist health professionals in their care of patients with pelvic dysfunction. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advance is complete with full color illustrations and schematic diagrams and makes use of key points and stepwise figures for an enhanced learning experience.

This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world s leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful."

General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology brings together the world's leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.

Oncological surgeons are often requested in their clinical practice to identify and manage uncommon and complex situations. It is therefore of the utmost importance that they are well aware of the most recent technological evolutions, in order to achieve the best possible results in term of oncological outcome, with a concern on quality of life and economical issues. Furthermore, new techniques can give a fundamental contribution in overcoming the limitations of standard approaches.

An essential aim of this book is to underline the great importance and the need of an effective coordination of multi-disciplinary care among surgeons, medical oncologists, radiation therapists, plastic surgeons and ancillary services, in order to optimise patient outcome.

Rectal Cancer: International Perspectives on Multimodality Management is a timely analysis of the diagnosis, staging, pathology, and therapy of cancer of the rectum. This book is intended as a useful resource for physicians, scientists, medical students, and allied health personnel in the disciplines of radiology, gastroenterology, surgical oncology, medical onc- ogy, radiation oncology, and pathology. Renowned contributors from different medical d- ciplines have written their chapters in a thoughtful, provocative, and visual fashion. Importantly, these chapters highlight the controversies in the diagnostic, staging, and the- peutic management of patients with rectal cancer while providing practical management recommendations. This book is divided into 18 chapters. Early chapters address the diagnosis and staging of rectal cancer, highlighting the critical role of contemporary imaging in guiding treatment. The remaining chapters focus on the multimodality management of rectal cancer from the vantage points of surgery, pathology, chemotherapy, and radiation therapy. The major dev- opments in surgery are reviewed first, including contemporary roles of local excision, total mesorectal excision, lateral pelvic lymph node dissection, organ preservation approaches, as well as the management of advanced, recurrent, and metastatic disease. Following is a ch- ter describing the pathologic evaluation of rectal cancer specimens, with emphasis on proper methodology and its clinical relevance to overall disease management. The final chapters review the contemporary roles of chemotherapy (including with radiation therapy, adjuvant and neoadjuvant settings without radiation therapy, as well as in metastatic disease) as well as radiation therapy (including adjuvant and neoadjuvant approaches, short vs.

Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.