The immune systems of human and non-human primates have diverged over time, such that some species differ considerably in their susceptibility, symptoms, and survival of particular infectious diseases. Variation in primate immunity is such that major human pathogens - such as immunodeficiency viruses, herpesviruses and malaria-inducing species of"Plasmodium"- elicit striking differences in immune response between closely related species and within primate populations. These differences in immunity are the outcome of complex evolutionary processes that include interactions between the host, its pathogens and symbiont/commensal organisms. The success of some pathogens in establishing persistent infections inhumans and other primateshas been determined not just by the molecular evolution of the pathogen and its interactions with the host, but also by the evolution of primate behavior and ecology, microflora, immune factors and the evolution of other biological systems.

To explore how interactions between primates and their pathogenshave shaped their mutual molecular evolution, "Primates, Pathogens and Evolution"brings together research that explorescomparativeprimate immune function, the emergence of major and neglected primatediseases, primate-microorganism molecular interactions, and related topics. Thisbookwill be of interest to anyone curious as to why infectious diseases manifest differently in humans and their closest relatives. It will be of particular interest to scholars specializing in humanand non-human primate evolution, epidemiology and immunology, and disease ecology."Primates, Pathogens and Evolution"offers anoverview and discussion of current findings on differences in the molecular mechanics of primate immune response, as well as on pathogen-mediated primate evolution and human and non-human primate health."

This collection of reviews will be of considerable interests to biologists and MDs working on any aspect of cardiovascular function. With state-of-the-art reviews written by competent experts in the field, the content is also of interest for MSc and PhD students in most fields of cardiovascular physiology.

"Oryzias latipes," known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

Intertidal Fishes describes the fishes inhabiting the narrow strip of habitat between the high and low tide marks along the rocky coastlines of the world. It analyzes the specialized traits of these fishes that have adapted to living in the dynamic and challenging space where they are alternately exposed to the air and submerged in water with the ebb and flow of the tides. This book provides a comprehensive account of fishes largely overlooked in many previous studies of intertidal organisms and emphasizes how they differ from fishes living in other deeper-water habitats. Coverage includes air breathing, movements and homing, sensory systems, spawning and parental care, feeding habits, community structure, systematic relationships, distribution patterns, and the fossil record in the intertidal zone.
Key Features
* Written by an international team of 21 experts on intertidal fish biology
* Worldwide coverage of intertidal fishes
* Comprehensive phylogenetic listing of all fish families with intertidal members
* Global biogeographic analysis involving over 700 species from 86 sites
* Outlines field and laboratory methods pertinent to studying intertidal fishes
* Thorough ecological coverage with chapters on vertical distribution, movements and homing, reproduction, feeding, and community structure
* Covers the physiology of aerial and aquatic respiration, osmoregulation, and sensory systems

The basic goal of the volume is to compile the most up to date research on how high altitude affects the behavior, ecology, evolution and conservation status of primates, especially in comparison to lowland populations. Historically, the majority of primate studies have focused on lowland populations. However, as the lowlands have been disappearing, more and more primatologists have begun studying populations located in higher altitudes. High altitude populations are important not only because of their uniqueness, but also because they highlight the range of primate adaptability and the complex variables that are involved in primate evolution. These populations are good examples of how geographic scales result in diversification and/or speciation. Yet, there have been very few papers addressing how this high altitude environment affects the behavior, ecology, and conservation status of these primates. "

This text is dedicated to the contributions of women ichthyologists. Three colleagues were selected to represent all women ichthyologists, Ethelwynn Trewavas (ET), Rosemary Lowe-McConnell (Ro) and Eugenie Clark (Genie). All have had distinguished professional careers and have contributed in their own ways to their science. The career of each is highlighted by a personal interview with one of the editors of the volume, a bibliography of their lifetime publications, and a biography of their careers. Questions of historical inequities and current controversies in the treatment of women ichthyologists by their peers are raised and addressed by the women themselves. The personal and professional influences of these three women, and other women ichthyologists, are highlighted. A survey article by Pat Brown brings a number of women ichthyologists to the attention of a broader audience, and points the way for a more comprehensive historical consideration of the accomplishments and contributions of women ichthyologists. The volume continues with 16 solicited and contributed papers. ET's studies of taxonomy and life history are echoed in papers on the taxonomy and systematics of marine angelfishes, and of freshwater bitterlings, a review of reproduction in the North Atlantic ichthyofauna, and a comparison of reproductive styles and systematics of African minnows. Ro's studies on ecology, life history and behaviour are paralleled by papers on growth and metabolism in piranha, the community structure in tide pool fishes, and the social system and reproductive patterns in groupers. Genie's pioneering work on sexual roles and sex change, and her field studies of the behaviour of marine fishes are reflected in papers on gonadal structure and environmental sex determination in brook lamprey, sexual patterns in hawkfish, reproduction and systematics in phallostethids, gonadal structure and systematics in gobiids, reproductive and predator avoidance behaviour in razorfish, early ontogeny of an African mouth brooder, and alternative life histories in killifish.

This book focuses on the use of molecular tools to study small populations of rare and endangered mammals, and presents case studies that apply an evolutionary framework to address innovative questions in the emerging field of mammalian conservation genomics using a highly diverse set of novel molecular tools. Novel and more precise molecular technologies now allow experts in the field of mammology to interpret data in a more contextual and empirical fashion and to better describe the evolutionary and ecological processes that are responsible for the patterns they observe. The book also demonstrates how recent advances in genetic/genomic technologies have been applied to assess the impact of environmental/anthropogenic changes on the health of small populations of mammals. It examines a range of issues in the field of mammalian conservation genomics, such as the role that the genetic diversity of the immune system plays in disease protection and local adaptation; the use of noninvasive techniques and genomic banks as a resource for monitoring and restoring populations; the structuring of population by physical barriers; and genetic diversity. Further, by integrating research from a variety of areas - including population genetics, molecular ecology, systematics, and evolutionary and conservation biology - it enables readers to gain a deeper understanding of the conservation biology of mammals that are at increasing risk of extinction at local, regional and global scales. As such, it offers a unique resource for a broad readership interested in the conservation biology of mammals and conservation management strategies to better preserve biodiversity.

This book is written to serve as a general reference for biologists and resource managers with relatively little statistical training. It focuses on both basic concepts and practical applications to provide professionals with the tools needed to assess monitoring methods that can detect trends in populations. It combines classical finite population sampling designs with population enumeration procedures in a unified approach for obtaining abundance estimates for species of interest. The statistical information is presented in practical, easy-to-understand terminology.
Key Features
* Presented in practical, easy-to-understand terminology
* Serves as a general reference for biologists and resource managers
* Provides the tools needed to detect trends in populations
* Introduces a unified approach for obtaining abundance estimates

* Comprehensive and an easily accessible reference volume for developing, running, and analyzing biomedical research using the rat as model system Grown exponentially by the genomic revolution, the use of the rat as a model of choice for physiological studies continues in popularity and at a much greater depth of understanding. In Rat Genomics: Methods and Protocols, world-wide experts provide both practical information for researchers involved in genomic research in the rat along with a more contextual discussion about the usefulness of the rat in physiological or translational research in different organs and systems. The volume extensively covers topics including genome sequencing, quantitative trait loci mapping, and the identification of single nucleotide polymorphisms as well as the development of transgenic technologies such as nuclear cloning, lentiviral-mediated transgenesis, gene knock-down using RNA interference, gene knock-out by mutagenesis, and zinc finger nucleases plus exciting advances in the obtention of rat embryonic cell lines. As a volume in the highly successful Methods in Molecular BiologyT series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Comprehensive and up-to-date, Rat Genomics: Methods and Protocols thoroughly covers the current techniques used in labs around the world and overviews the applications of the data obtained, making it certain to be useful to the scientific community as a key source of references and methods.

WINNER OF THE JOHN AVERY AWARD AT THE ANDRE SIMON AWARDS If we can save the salmon, we can save the world Over the centuries, salmon have been a vital resource, a dietary staple and an irresistible catch. But there is so much more to this extraordinary fish. As international bestseller Mark Kurlansky reveals, salmon persist as a barometer for the health of our planet. Centuries of our greatest assaults on nature can be seen in their harrowing yet awe-inspiring life cycle. Full of all Kurlansky's characteristic curiosity and insight, Salmon is a magisterial history of a wondrous creature. 'An epic, environmental tragedy' Spectator 'These creatures have nurtured our imagination as surely as our bodies. This book does them justice!' Bill McKibben

This book summarizes the key adaptations enabling extremophile fishes to survive under harsh environmental conditions. It reviews the most recent research on acidic, Antarctic, cave, desert, hypersaline, hypoxic, temporary, and fast-flowing habitats, as well as naturally and anthropogenically toxic waters, while pointing out generalities that are evident across different study systems. Knowledge of the different adaptations that allow fish to cope with stressful environmental conditions furthers our understanding of basic physiological, ecological, and evolutionary principles. In several cases, evidence is provided for how the adaptation to extreme environments promotes the emergence of new species. Furthermore, a link is made to conservation biology, and how human activities have exacerbated existing extreme environments and created new ones. The book concludes with a discussion of major open questions in our understanding of the ecology and evolution of life in extreme environments.

To escape the constraints of water-bound reproduction, the first terrestrial vertebrates evolved a group of membranes that surround and protect developing embryos. The "amnion" is one of these membranes. It surrounds and protects in amniotic fluid, the developing embryos of birds, reptiles and mammals. Terrestrial vertebrates began to diversify and exploit their new habitats when the need to reproduce in water no longer dictated the course of their lives. Occurring in conjunction with this reproductive freedom was the evolution of non-permeable skin (to avoid cutaneous water loss), different less toxic forms of nitrogen waste and more efficient forms of locomotion and feeding. This text gives a detailed treatment of these and other changes that occurred as vertebrates completed the transition from aquatic to terrestrial life. It integrates modern systematic methods with studies of functional and physiological processes, and illustrates how studies of paleobiology can be illuminated by studies of neontology.

Elwyn Simons has held professional appointments at Yale University (1960-1977), Duke University (1977-present), and was the Director of the Duke Primate Center (1977-1991) and Scientific Director (1991-2001). He has authored nearly 300 scientific publications and is the holder of many high honors. He is a member of the United States National Academy of Sciences, the American Philosophical Society, as well as many other professional associations. He was elected a Knight of the National Order by the government of Madagascar and has been the recipient of many awards including the prestigious Charles R. Darwin Award for Lifetime Achievement from the American Association of Physical Anthropologists. For nearly a half century, Dr. Simons has dominated the study of primate evolution. The volume summarizes the current state of knowledge in many aspects of primate and human evolution that have been studied by Simons and his colleagues and place it in a broader paleontological and historical perspective. Elwyn Simons: A Search for Origins contains the results of new research and reviews of many of the critical issues in primate and human evolution during the last half of the twentieth century as well as aspects of African paleontology and primate conservation in Madagascar. The authors are an extremely distinguished group of international authorities on all aspects of primate and human evolution and primate behavior. Although linked primarily by their connection to Simons? own career, the chapters include a wide range of important new works that are valuable contributions to the field of physical anthropology and paleontology and are certain to be widely cited and used in teaching.Several of the papers (Simons et al., Wing et al., Seiffert et al., Gingerich, O?Conner) are broad reviews of the history of research and discoveries in the fossil deposits of the Fayum, Egypt that have formed the background of our understanding of anthropoid evolution for over a century and will be important researchers for students and researchers in primate evolution and African paleontology. Similarly, broad reviews of the history of primate paleontology and human evolution (Rasmussen, Pilbeam, Wood; Sussman and Hart) will be essential reading in courses in primate and human evolution as well as the history of physical anthropology. Other authors describe new research results on early anthropoid fossils from Egypt (Kay and Simons) Tanzania (Stevens) and Myanmar (Gunnell and Ciochon). The chapter by John Oakley, Professor of Law at the University of California addresses the challenges to the teaching of evolution in schools- both public and universities world wide. Another major focus of several chapters are the primates of Madagascar. Two chapters are reviews of the extraordinary radiation of fossil lemurs (Godfrey et al, Jungers et al.). Two review the behavior and conservation of living lemurs (Taylor and Wright) and the chapter by Tattersall bridges the two major sections of the book by discussing about the biogeographic history of Malagasy mammals.

This second volume in the series covers such topics as DNA fingerprinting of fishes, the cytochromes P450 in fish, the molecular biology of bacterial fish diseases, and new insights into the origins of the diversity and distribution of fish antifreeze proteins. The book will be of great value to fisheries scientists, animal biochemists, physiologists and endocrinologists, and aquaculturists. It will provide researchers and students alike with a pertinent information source from theoretical and experimental angles.

Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century. The achievement itself was celebrated at the highest levels (President and Prime Minister) on both sides of the Atlantic, and rightly so. DNA sequencing has become sufficiently c- mon now, even to the extent of being used in law courts, that it is easy to forget how technically difficult it was and how cleverly the sequencing teams solved those problems in the exciting race to finish by the turn of the century [1, 2]. The fanfares were misplaced, however, in an important respect. The metaphors used to describe the project and its biological significance gave the impression to the public at large, and to many scientists themselves, that this sequence would reveal the secrets of life. DNA had already been likened to a computer program [3]. The "genetic program" for life was therefore to be found in those sequences: A kind of map that had simply to be unfolded during development. The even more colo- ful "book of life" metaphor gave the promise that reading that book would lead to a veritable outpouring of new cures for diseases, hundreds of new drug targets, and a brave new world of medicine.