Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field.
Key Features
* Comprehensive protocols included for
* Detection of NO and related compounds by chemical, immunohistochemical, and "in situ" hybridization techniques
* Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression
* Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone
* Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution

The last few years have seen a dramatic increase in the number of areas known to be involved in mammalian vision. It has also seen a far greater understanding of the importance of reciprocal connections, intrinsic connections, structure-specific modules and modules which span different structures, as well as the introduction of parallel processing models within the thalamocortical and corticocortical streams.

The body of knowledge has become so vast, and is growing so rapidly, that periodic updates are essential even for experts in the field. This volume is based on a satellite meeting of an international group of researchers. It emphasizes the most current information regarding midbrain and extrastriate mechanisms underlying vision and visually-guided behavior. The book also places these data into the larger context of how interrelated components of the visual system function to produce coherent visual experiences and behavior. New research findings are presented that are unavailable elsewhere, as well as reviews and broad perspectives in which existing data from multiple sources are brought together in order to help understand the structure and function of extrageniculostriate visual areas.

Many of the processes influencing recruitment to an adult fish population or entry into a fishery occur very early in life. The variations in life histories and behaviours of young fish and the selective processes operating on this variation ultimately determine the identities and abundance of survivors. This important volume brings together contributions from many of the world's leading researchers from the field of fish ecology. The book focuses on three major themes of pressing importance in the analysis of the role that the early life history of fishes plays in the number and quality of recruits: the selective processes at play in their early life history; the contributions of early life history to the understanding of recruitment.

The Dodo went from being newly discovered to extinction in less than a hundred years. The flightless, odd-looking bird was seen for the first time by Europeans and then annihilated by Europeans in the course of the seventeenth century. And by the end of the nineteenth century, all that remained of what Portuguese explorers called the ¿crazy bird¿ was a patchwork of tall tales, contradictory reports, incompatible illustrations, and fragments of feather and bone. The dodo had become, in short, an unsolvable puzzle, but a puzzle that persisted in art, literature, and scientific speculation.|Best-selling author Clara Pinto-Correia, in following the bird¿s re-creation, shows in this remarkable book how the human intellect and the human imagination prey on sketchy facts and images, how missing pieces and incomplete lines are merged and fused to make a cohesive whole. By considering the incredibly strong hold of this bumbling, ungainly, and ill-fated creature on our collective scientific and literary imagination, Pinto-Correia teaches us not just about the ill-fated bird from the island paradise of Mauritius, but about our own abiding need to make sense of the world around us.|Clara Pinto-Correia is the author of the best-selling The Ovary of Eve. She has taught in the Department of Veterinary and Animal Sciences at the University of Massachusetts at Amherst; served as a research assistant at Harvard University in the Museum of Comparative Zoology; and is currently Professor and Director of the Masters Degree Program in Developmental Biology at the Universidade Lusofona de Humanidades e Tecnologias, Lisbon, Portugal.

Vertebrate embryos develop from a single cell via a complex succession of cell divisions, movements and inductive interactions. The zebrafish, Danio rerio, emerged in recent years as an excellent system in which to study genetic underpinnings of normal human development and its pathologies. Large-scale genetic screens identified thousands of mutant variants that allow in vivo dissection of developmental processes at single cell and molecular resolution. This book provides the first comprehensive overview of zebrafish embryogenesis: formation and patterning of germ layers, gastrulation movements, and aspects of organogenesis, including formation of somites, cardiovascular system, pronephros and eyes.

The development of vertebrate muscle has long been a major area of research in developmental biology. During the last decade, novel technical approaches have allowed us to unravel to a large extent the mechanisms underlying muscle formation, and myogenesis has become one of the best-understood paradigms for cellular differentiation. This book concisely summarizes our current knowledge about muscle development in vertebrates, from the determination of muscle precursors to terminal differentiation. Each chapter has been written by an expert in the field, and particular emphasis has been placed on the different developmental and molecular pathways followed by the three types of vertebrate musculature - skeletal, heart and smooth muscle.

In this volume contemporary methods designed to provide insights into, mathematical structure for, and predictive inferences about neuroendocrine control mechanisms are presented.
Key Features
* Collates an array of contemporary techniques for analysis of neuroendocrine data
* Discusses current problems in and solutions to neurohormone pulse analysis
* Identifies relevant software available

A world of categones devmd of spirit waits for life to return. Saul Bellow, Humboldt's Gift The stock-in-trade of communicating hypotheses about the historical path of evolution is a graphical representation called a phylogenetic tree. In most such graphics, pairs of branches diverge from other branches, successively marching across abstract time toward the present. To each branch is tied a tag with a name, a binominal symbol that functions as does the name given to an individual human being. On phylogenetic trees the names symbolize species. What exactly do these names signify? What kind of information is communicated when we claim to have knowledge of the following types? "Tetonius mathewzi was ancestral to Pseudotetonius ambiguus. " "The sample of fossils attributed to Homo habzlis is too variable to contain only one species. " "Interbreeding populations of savanna baboons all belong to Papio anubis. " "Hylobates lar and H. pileatus interbreed in zones of geographic overlap. " While there is nearly universal agreement that the notion of the speczes is fundamental to our understanding of how evolution works, there is a very wide range of opinion on the conceptual content and meaning of such particular statements regarding species. This is because, oddly enough, evolutionary biolo gists are quite far from agreement on what a species is, how it attains this status, and what role it plays in evolution over the long term."

This is a companion volume to World Animal Science C4, The Production of Aquatic Animals (Crustaceans, Molluscs, Amphibians and Reptiles). It describes the production of fishes, particularly the most important species or species groups farmed in both marine and fresh waters throughout the world. The volume emphasizes all the systems and practices currently used for production, aspects which are unusual or constrain further development, and key areas of present research.

Many marine mammals communicate by emitting sounds that pass through water. Such sounds can be received across great distances and can influence the behavior of these undersea creatures. In the past few decades, the oceans have become increasingly noisy, as underwater sounds from propellers, sonars, and other human activities make it difficult for marine mammals to communicate. This book discusses, among many other topics, just how well marine mammals hear, how noisy the oceans have become, and what effects these new sounds have on marine mammals. The baseline of ambient noise, the sounds produced by machines and mammals, the sensitivity of marine mammal hearing, and the reactions of marine mammals are also examined.
An essential addition to any marine biologist's library, Marine Mammals and Noise will be especially appealing to marine mammalogists, researchers, policy makers and regulators, and marine biologists and oceanographers using sound in their research.

It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen- dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri- mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The sigma receptor was originally thought to be a subset of the opioid receptor family, and it is less than 10 years since it was recognized that this receptor represents unique binding sites in mammalian brain and peripheral organs, distinct from any other known neurotransmitter receptor. Since the sigma receptors exhibit high affinity for members of diverse classes of psychotropic drugs, and have been postulated to be involved in various central nervous disorders, neuroscientists have demonstrated a great deal of interest in the elucidation of these receptor sites and their biological relevance. Relatively little is known about the precise role of sigma receptors in normal brain function and in CNS disorders, despite an overwhelming research effort. This research has resulted in many controversies, some of which have been reconciled while others have not. This volume aims to update the reader on the current situation, and deals with the potential functional significance of these receptors in the brain and peripheral organs and, where appropriate, makes reference to the clinical potential of these sites.

In this text, ornithologist John Terres explains the process by which eagles, hawks, hummingbirds, and other birds fly, soar and hover.

The contributors to this volume have provided a detailed and integrated introduction to the behavioural, anatomical, and physiological changes that occur in the auditory system of developing animals. Edwin W Rubel is Virginia Merrill Bloedel Professor of Hearing Sciences at the Virginia Merrill Bloedel Hearing Research Center at the University of Washington, Arthur N. Popper is Professor and Chair of the Department of Zoology at the University of Maryland, while Richard R. Fay is Associate Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago. Each volume in this series is independent and authoritative; taken as a set, the series will be the definitive resource in the field.

Shrimps are subject to great consumer demand in the United States. However, more than #1 billion worth of shrimp is now imported; more than twice the amount produced domestically. Domestic shrimp production, mostly from the trawler fleet in the Gulf of Mexico, is thought to be at its maximum sustainable yield of 91,000 MT (heads-off). Increased production of shrimp in the U.S. through mariculture has been motivated by the increasing demand for this product.
The biology of penaeid shrimp and lack of technology for their culture present special problems in fisheries science, reproductive biology, endocrinology, nutrition, pathology, culture science and future research. The purpose of the Frontiers of Shrimp Research symposium was to assess the status of shrimp research in these areas and to further foster the scientific collaboration vital for significant research advances. The participants included representatives of the science funding agencies, the mariculture industry and representatives of both the scientific research and science policy communities.
The subject matter should be of interest to a variety of readers. Advanced undergraduate/graduate students, mariculturists and research workers will find this volume both interesting and informative.

This volume comprises the edited proceedings of the International Taurine Sympo sium held in Osaka, Japan, in June 1995, as a Satellite Symposium of the 15th Biennial of the International Society for Neurochemistry. This Taurine Symposium was the Meeting latest in a series held since 1975 at approximately two-year intervals by an informal group of international researchers. It attracted contributions from 20 countries, ranging from Armenia via Finland and Spain to the United States. Some 121 participants attended. The Symposium was organized and chaired by Junichi Azuma, University of Osaka. Other members of the Organizing Committee in Japan consisted of Kinya Kuriyama and Masao Nakagawa, both from the Kyoto Prefectural University of Medicine, and Akemichi Baba, from Osaka University. The Committee had to contend with the disaster of the Kobe earthquake, which struck on January 21. The epicenter was only around 25 miles from the meeting site, and the quake demolished the home of one Committee member. Despite this unnaturally natural handicap, the participants experienced a superbly organized meeting, one which more than maintained the high social and scientific standards established for this series. In his Welcome Message, Dr. Azuma listed a threefold objective for the Symposium: To provide a forum for the interdisciplinary exchange of information on taurine; to give an opportunity for renewing old friendships and making new friends; and to promote coopera tion among participants from around the world."

New species of animal and plant are being discovered all the time. When this happens, the new species has to be given a scientific, Latin name in addition to any common, vernacular name. In either case the species may be named after a person, often the discoverer but sometimes an individual they wished to honour or perhaps were staying with at the time the discovery was made. Species names related to a person are 'eponyms'. Many scientific names are allusive, esoteric and even humorous, so an eponym dictionary is a valuable resource for anyone, amateur or professional, who wants to decipher the meaning and glimpse the history of a species name. Sometimes a name refers not to a person but to a fictional character or mythological figure. The Forest Stubfoot Toad Atelopus farci is named after the FARC, a Colombian guerrilla army who found refuge in the toad's habitat and thereby, it is claimed, protected it. Hoipollo's Bubble-nest Frog Pseudophilautus hoipolloi was named after the Greek for 'the many', but someone assumed the reference was to a Dr Hoipollo. Meanwhile, the man who has everything will never refuse an eponym: Sting's Treefrog Dendropsophus stingi is named after the rock musician, in honour of his 'commitment and efforts to save the rainforest'. Following the success of their Eponym Dictionary of Reptiles, the authors have joined forces to give amphibians a similar treatment. They have tracked down 1,609 honoured individuals and composed for each a brief, pithy biography. In some cases these are a reminder of the courage of scientists whose dedicated research in remote locations exposed them to disease and even violent death. The eponym ensures that their memory will survive, aided by reference works such as this highly readable dictionary. Altogether 2,668 amphibians are listed.

This book evaluates the reputation of the coelacanth, presenting up-to-date accounts of the structure of fossil coelacanths, and suggests a family history to show that there have been subtle but significant changes in coelacanth history.

Foreword by Phillip V. Tobias The introduction of rhesus macaques to Cayo Santiago, Puerto Rico in 1938, and the subsequent development of the CPRC for biomedical research, continues its long history of stimulating studies in physical anthropology. The CPRC monkey colonies, and the precise demographic data on the derived skeletal collection in the Center's Laboratory of Primate Morphology and Genetics (LPMG), provide rare opportunities for morphological, developmental, functional, genetic, and behavioral studies across the life span of rhesus macaques as a species, and as a primate model for humans. The book grows out of a symposium Wang is organizing for the 78th annual meeting of the American Association of Physical Anthropologists to be held in April 2009. This symposium will highlight recent and ongoing research in, or related to, physical anthropology, and reveal the numerous research opportunities that still exist at this unusual rhesus facility. Following an initial historical review of CPRC and its research activities, this book will emphasize recent and current researches on growth, function, genetics, pathology, aging, and behavior, and the impact of these researches on our understanding of rhesus and human morphology, development, genetics, and behavior. Fourteen researchers will present recent and current studies on morphology, genetics, and behavior, with relevance to primate and human growth, health, and evolution. The book will include not only papers presented in the symposium, but also papers from individuals who could not present their work at the meeting due to limitations in the maximum number (14) of permitted speakers.

The Springer Handbook of Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modern auditory research. It is aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes will introduce new investigators to important aspects of hearing science and will help established inves tigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The series focusses on topics that have developed a solid data and con ceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature."

In a flurry of post-war productivity, Niko Tinbergen re-established his lab in Leiden, wrote landmark papers and his famous book The Study of Instinct, and founded the journal Behaviour to serve the burgeoning field of ethology. Tinbergen and his senior assistant, Jan van Iersel, published their classic paper, "Displacement reactions in the three-spined stickleback," in the first issue of his new journal in 1948. Stickleback are now a powerful model in the fields of behavioural ecology, evolutionary biology, developmental genetics, and ecotoxicology - an extraordinary development for a small fish that began its modeling career among an enthusiastic core of Tinbergen students in the 1930s. From a series of clever experiments with painted model fish to the use of the sequenced genome to analyze the genetic basis of courtship, stickleback science progressed in leaps and bounds, often via seminal studies published in the pages of "Behaviour." "Tinbergen s Legacy in Behaviour" traces sixty years in the development of science using stickleback as a model, with 34 original articles covering topics ranging from homosexuality and cannibalism to genetics and speciation. Desmond Morris, Theo Bakker, Robert Wootton, Michael Bell, Tom Reimchen, Boyd Kynard, Harman Peeke, and Iain Barber provide fresh retrospectives on their republished works. Commentary by Frank von Hippel accompanies the articles and explains the roles they played in the frontiers of science as researchers falsified or expanded upon one another s ideas.

The papers in this volume are representative of those presented at a conference entitled "Creatures of the Dark: The Nocturnal Prosimians," held at Duke University, June 9-12, 1993. The purpose of the conference, attended by more than 100 scientists, was to assemble, for the ftrst time ever, scholars from diverse ftelds with a common interest in the nocturnal prosimian primates. The history of the precursors of this meeting are outlined in the Historical Perspective by Doyle (this volume). Most of the invited papers are presented here in modified form, as are several papers originally presented as posters. Two papers are included that were not presented, due to scheduling conftcts and health considerations. Some papers, delivered from the podium, are not included in this volume. Interactions among conference participants resulted in many revisions to the contributions, as did the comments of reviewers and the editors. Several papers which contained new data or new interpretations of familiar phenomena met with constructive criticism, resulting in modification of the original papers. We thank all of the contributors for their patience and cooperation, and commend the numerous reviewers who generously donated their time and expertise. We greatly appreciate funding from the National Institutes of Health, the Wenner Gren Foundation for Anthropological Research, the Duke University Center for International Studies, the Duke University Primate Center, and Drs. Charles Putman of Duke University and Malcolm Gillis, currently of Rice Universtiy.

Infrastructure development in Africa and Asia is expanding at breakneck speed, largely in biodiversity-rich developing nations. The trend reflects governments' efforts to promote economic growth in response to increasing populations, rising consumption rates and persistent inequalities. Large-scale infrastructure development is regularly touted as a way to meet the growing demand for energy, transport and food - and as a key to poverty alleviation. In practice, however, road networks, hydropower dams and 'development corridors' tend to have adverse effects on local populations, natural habitats and biodiversity. Such projects typically weaken the capacity of ecosystems to maintain ecological functions on which wildlife and human communities depend, particularly in the face of climate change. This title is also available as Open Access via Cambridge Core.