"Manual of Trauma Management in the Dog and Cat" provides quick access to clinically relevant information on stabilizing, diagnosing, and managing the trauma patient. The book uses an outline format to provide fast access to essential information, focusing on practical advice and techniques for treating traumatic injuries. "Manual of Trauma Management in the Dog and Cat" is an ideal handbook for quickly and confidently managing this common presenting complaint.

Beginning with a concise summary of the global assessment of traumatized patients, the heart of the book is devoted to guidance on managing specific types of trauma following definitive diagnosis. "Manual of Trauma Management in the Dog and Cat" is a valuable quick-reference guide to treating canine and feline trauma patients for general practitioners and emergency specialists alike.

Proceedings of the XIth European Conference on Animal Blood Groups and Biochemical Polymorphism Held in Warsaw, July 2-6, 1968 Organized by European Society for Animal Blood Group Research

Biofilms are implicated in many common medical problems including urinary tract infections, catheter infections, middle-ear infections, dental plaque, gingivitis, and some less common but more lethal processes such as endocarditis and infections in cystic fibrosis. However, the true importance of biofilms in the overall process of disease pathogenesis has only recently been recognized. Bacterial biofilms are one of the fundamental reasons for incipient wound healing failure in that they may impair natural cutaneous wound healing and reduce topical antimicrobial efficiency in infected skin wounds. Their existence explains many of the enigmas of microbial infection and a better grasp of the process may well serve to establish a different approach to infection control and management. Biofilms and their associated complications have been found to be involved in up to 80% of all infections. A large number of studies targeted at the bacterial biofilms have been conducted, and many of them are referred to in this book, which is the first of its kind. These clinical observations emphasize the importance of biofilm formation to both superficial and systemic infections, and the inability of current antimicrobial therapies to 'cure' the resulting diseases even when the in vitro tests suggest that they should be fully effective. In veterinary medicine the concept of biofilms and their role in the pathogenesis of disease has lagged seriously behind that in human medicine. This is all the more extraordinary when one considers that much of the research has been carried out using veterinary species in experimental situations. The clinical features of biofilms in human medicine is certainly mimicked in the veterinary species but there is an inherent and highly regrettable indifference to the failure of antimicrobial therapy in many veterinary disease situations, and this is probably at its most retrograde in veterinary wound management. Biofilms and Veterinary Medicine is specifically focused on discussing the concerns of biofilms to health and disease in animals and provides a definitive text for veterinary practitioners, medical and veterinary students, and researchers.

The Fifth Chinese Peptide Symposium, hosted by Lanzhou University, was held at Lanzhou, China July 14-17, 1998, with 156 participants, including 30 scientists from abroad, representing nine countries. The four-day conference was both intense and spiritually rewarding. Our goal for CPS-98 was to provide a forum for the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities, and we believe this goal was met. The symposium consisted of 8 sessions with 42 oral and 90 poster presentations, including synthetic methods, molecular diversity and peptide libraries, structure and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo design and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry-biology-interface and challenging problems in peptides. The enthusiastic cooperation and excellent contributions were gratifying and the active response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science. Dr. Kit Lam of the University of Arizona and Dr. Yun-Hua Ye of Peking University were the recipients of "The Cathay Award" sponsored by the H. H. Liu Education Foundation, offered for their seminal contribution in peptide science and the Chinese Peptide Symposium. Four outstanding young scientists were selected by the organizing committee to receive awards sponsored by Haikou Nanhai Pharmaceutical Industry Co. Ltd. (Zhong He Group).

This engaging, informative text provides a thorough introduction to equine care and management. EQUINE SCIENCE, Fifth Edition, features a full-color layout, numerous photos, and vivid illustrations that help bring chapter material to life, as well as a logical, easy-to-understand sequence of topics. Following an introduction to the equine industry, you'll learn about horses' unique anatomy and needs; how to care for, train, and manage horses; and key business aspects of the industry. This all-new edition also clearly connects text content to National AFNR (Agriculture, Food, and Natural Resources) Standards, key math and science concepts, and current references, helping prepare you for success in the classroom and beyond.

"Home-Prepared Dog and Cat Diets, Second Edition" provides an introduction to nutrition of the healthy dog and cat and an extensive discussion of medical disorders that can be managed in part through diet. Presenting easy-to-follow recipes that can be prepared at home, this new edition of Donald Strombeck's classic handbook has been completely rewritten by new author Patricia A. Schenck to reflect the latest nutritional recommendations based on current research. New chapter topics include feeding the puppy and kitten; feeding the pregnant or lactating dog or cat; feeding the senior pet; feeding the performance dog; and the role of diet in pets with cancer.

Diets are now listed together in a cookbook style for ease of use, and recipes are adjustable for any size dog or cat, allowing exact nutritional values to be calculated. Nutrient content for protein, fat, carbohydrate, and fiber have been provided for every diet, along with the nutrient density. A companion website features downloadable spreadsheets with complete nutritional breakdowns for each recipe.

Useful for both veterinarians and pet owners alike, "Home-Prepared Dog and Cat Diets, Second Edition" is a unique handbook written by an expert in the field providing an introduction to the nutritional management of dogs and cats with easy-to-use recipes for home-prepared diets.

Clarification: Calcium Carbonate

We've had some questions from readers regarding the use of the term "calcium carbonate," which is listed as an ingredient in a number of the diets found in this book, and therefore wanted to clarify what is meant by this ingredient. Baking soda comes in two forms: sodium bicarbonate and calcium carbonate. The sodium bicarbonate version is widely available as "baking soda" and is commonly used in baking, but none of the recipes in this book use it as an ingredient. The calcium carbonate version of baking soda is sometimes sold as "baking soda substitute" and sometimes referred to as simply "baking soda."

To avoid confusing sodium bicarbonate and calcium carbonate, any time the calcium carbonate type of baking soda has been used in a diet in this book, the ingredient includes the specific term "calcium carbonate." There are several manufacturers of calcium carbonate baking soda; for example, Amazon carries the Ener-G Foods product baking soda substitute. Calcium carbonate can also be sold for garden use, which is non-food-grade, so to avoid the use of the garden product in foods, the term "baking soda" was used in this book instead to indicate that readers should be sure to select a food-appropriate ingredient.

Swine can be infected with many different mycoplasmas. Some are important pathogens, causing significant health and welfare issues in pigs and major losses to the swine industry worldwide. Other mycoplasmas are not pathogenic for swine and can be considered commensals. This book provides up-to-date scientific, clinical and practical information of the most important pathogenic mycoplasmas in swine. Most emphasis has been placed on Mycoplasma hyopneumoniae as the most economically important, but other pathogenic species like Mycoplasma hyorhinis, Mycoplasma hyosynoviae and Mycoplasma suis are also discussed. Written by internationally renowned scientists and clinicians from all over the world, this book draws together in depth knowledge, expertise and experience in swine mycoplasmas to provide an evidence-based, academically rigorous and practical collection. It aims to serve the scientific and veterinary community and the swine industry worldwide.

"Decision Making in Small Animal Oncology" is a practical manual for the increasing number of veterinarians called upon to treat patients with cancer. This case-based quick reference leads practitioners through diagnosis, treatment, and management decisions, offering reliable guidance for more effective management of cancer care. With easy-to-follow algorithms to assist the reader through the critical thinking process, "Decision Making in Small Animal Oncology" answers the questions most commonly asked in daily practice to provide the cancer knowledge practitioners and students need in general practice.

This issue will explore the latest research and clinical information concerning endocrinology of exotic pet species. The articles will cover thyroid disease in rodent species, deslorelin implants in birds, pathology of the avian panceas, non-surgical management of ferret adrenal endocrinopathy, medical management of reproductive disorders in birds, neuroendocrine regulation of calcium metabolism in reptiles, clinical aspects of the avian hypothalamic/pituitary axis, and more!

This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

The field of genito-urinary oncology is rapidly evolving at virtually every level. Significant advances have been made in our understanding of the molecular and cellular events which contribute to the generation of GU malignancies. At the same time, similar advances have been made in the clinical arena which have improved the diagnosis and treatment of urologic cancers. This volume attempts to summarize those advances which most impact us as clinicians, and has been divided into three sections. Section One, 'Diagnostic advances: the use of molecular medicine in the diagnosis and prognosis of GU malignancies', details how epidemiologic studies and new molecular techniques are impacting our ability to diagnose and treat GU tumors. Section Two, 'Surgical and radiation advances', details the recent major advances in the treatment of organ-confined cancers. Section Three, 'Medical advances', addresses major issues in the treatment of metastatic disease. This volume will serve as a compendium of the advances, both at the basic science and clinical levels, which are currently impacting practicing oncologists and urologists.

Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.

Many students have only a limited knowledge of biology before starting a variety of equine courses, from BHS stages to National Certificate and Diploma and HND/degree. Introduction to Horse Biology provides all the information students of equine subjects require, particularly those without a GCSE or A level in biology.

This book will be invaluable to all students of equine subjects including First Diploma, National Diploma, National Certificate, Higher National Diploma and Higher National Certificate and all students studying for BHS or other equine related examinations. It is also ideal for serious horse owners searching for a better understanding of horses and how they function.

The Author

Zoe Davies is a former lecturer in equine science, a consultant equine nutritionist, author and external examiner for higher education courses. She has substantial experience in equine management and training.

Also from Blackwell Publishing

Horse and Stable Management

Fourth Edition

Jeremy Houghton Brown, Sarah Pilliner and Zoe Davies

1 4051 0007 9

Horse Nutrition and Feeding

Second Edition

Sarah Pilliner

0 632 05016 0

Teaching Jumping

Jane Houghton Brown

0 632 04127 7

Equine Science

Second Edition

Sarah Pilliner and Zoe Davies

1 4051 1944 6

Tasks for the Veterinary Assistant is the definitive, practical guide to the vital skills and techniques used in daily practice--bringing together all the information necessary to succeed as a veterinary assistant in one reader-friendly volume. Now in its fourth edition, this classic text has been completely revised to adopt a concise approach to learning that is ideally suited for modern readers. More and improved images, streamlined chapters, and easily-referenced key topics help readers understand the important aspects of real-world practice. Updated chapters cover infectious disease protocols, clinical procedures, and patient care and management. New chapters cover exam and treatment room skills, and present information on small animals, laboratory animals, and large animals. This re-envisioned new edition: Covers every task and technique that veterinary assistants encounter daily Offers step-by-step guidance for fundamental veterinary skills, procedures, and practices Provides quick and easy reference to a comprehensive range of central topics Uses a new, larger page size to better fit content and enhance searching for information when on the job Includes access to a companion website presenting instructor resources, skills evaluations, and PowerPoint slides Tasks for the Veterinary Assistant, Fourth Edition continues to be the definitive text for trainee and practicing veterinary assistants in clinical, laboratory, or research settings.

During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentionally pronounced visual disability and blindness.

Murdering Animals confronts the speciesism underlying the disparate social censures of homicide and "theriocide" (the killing of animals by humans), and as such, is a plea to take animal rights seriously. Its substantive topics include the criminal prosecution and execution of justiciable animals in early modern Europe; images of hunters put on trial by their prey in the upside-down world of the Dutch Golden Age; the artist William Hogarth's patriotic depictions of animals in 18th Century London; and the playwright J.M. Synge's representation of parricide in fin de siecle Ireland. Combining insights from intellectual history, the history of the fine and performing arts, and what is known about today's invisibilised sites of animal killing, Murdering Animals inevitably asks: should theriocide be considered murder? With its strong multi- and interdisciplinary approach, this work of collaboration will appeal to scholars of social and species justice in animal studies, criminology, sociology and law.

In February 2001, Foot and Mouth Disease arrived in Cumbria. At its peak Cumbria was the worst affected county in Britain with a staggering 41 per cent of all cases. For the local community, the environmental and social consequences were to prove devastating. As a local resident, leading UK photographer John Darwell found himself surrounded by the effects of the disease. Over the next twelve months, he committed himself to recording what was taking place. Despite government reports to the contrary, the Cumbrian countryside became largely a 'no-go area', whilst on the farms thousands of animals were destroyed, their bodies burnt on the now notorious pyres. The ultimate clean-up of the infected farms led to extraordinary lengths being taken to eradicate the virus. "Dark Days" represents, perhaps, the most complete record of this time and provides a powerful and emotive insight into one of the most dramatic and destructive periods in British farming history. It is published in association with Littoral Arts.

The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.

During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it."

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica tion of several families of adhesion molecules, well conserved throughout evolu tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi gration, or differentiation depends on both cell surface adhesion properties and acti vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.

The objective of this book is to provide recent information on neural regulation in the endocrine system in vertebrates. Classical studies have revealed that certain neurons synthesize and release chemical messengers into the vascular system. These neurons are endocrine devices that link the brain with the endocrine glands and other target organs. In vertebrates, the hypothalamus is the seat for chemical coordination and integration of en- vironmental and hormonal cues to modulate function of the pituitary gland, and conse- quently, the functions of other endocrine glands. Exciting information generated during the past few decades has resulted in profound alterations in the conceptual fabric of endo- crinology. From the wealth of information that emerged on neuropeptides of the central nervous system, and on the other connectivities of various brain centers, its has become clear that several extra-hypothalamic sites are also involved in regulation of hypophysial hormones. The brain has assumed a greater importance in the regulation of the endocrine sys- tem. However, recent studies have revealed varying degrees of functional autonomy in hy- pophysial hormone secretion, which may be due to intrapituitary cytokines. Although gonadotropin-releasing hormone (GnRH) is a key regulator of gonadotropin secretion, there exists a GnRH receptor diversity in vertebrates such as the receptor presence in can- cer cells. Recent studies have demonstrated the multifactorial nature of the neuroendo- crine factors involved in growth hormone regulation in fish. On the other hand, in birds, thyrotropin-releasing hormone plays a major role in growth hormone release.

This volume, Biological and Hormonal Therapies of Cancer, which is part of the series Cancer Treatment and Research, presents selected new information concerning biologic and hormonal therapy of cancer. We have attempted to provide the reader with topics of major interest in a timely fashion. There is renewed interest in biologic therapy of cancer. Two chapters review the role of interferon in the hematologic malignancies and in solid tumors. Vaccine therapies have come to the forefront of cancer therapy re cently, and two chapters approach different strategies of vaccine therapies; one reviews the cellular vaccine therapies and another the anti-idiotype ap proach. The hormonal therapy chapters focus on current uses of endocrine therapy in endometrial, breast, and prostate cancer. In addition, hormonal strategies for the prevention of breast cancer and endometrial cancer, including excit ing information relating to phytochemicals, are presented. The effects of tamoxifen on endometrium is a topic of major interest and is discussed in detail. Finally, there is a chapter on estrogen receptor expression and regula tion in human breast cancer. These chapters are all written by experts in the field and contain timely and relevant information of interest to laboratory and clinical scientists and practitioners alike. Biologic and endocrine therapies represent major areas of cancer research interest. The advent of newer biologic therapies, including new antibody targeted treatments, and the use of biologics as tumor modulators to enhance the effects of other treatment regimens is an exploding avenue of research.

Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.

Andrew Arnold The past several years have been a time of intense excitement and have brought major advances in the understanding and treatment of endocrine neoplasms. This is therefore an excellent point at which to undertake a broad based overview of the state of the art in endocrine neoplasia for the Cancer Treatment and Research series. Because of the wide and interdisciplinary readership of this series, our aim for each chapter has been to provide ample background for those not highly familiar with the topic, while emphasizing the most recent advances. Furthermore, the chapters have been written with the clinician in mind, whether she or he is an oncologist, endocrinologist, surgeon, generalist, pathologist, or radiologist. As such, the authors' mission has been to focus on clinically relevant issues and to present the scientific basis of current or potential future advances in a manner easily digestible to the nonexpert. Endocrine tumors often cause problems for the patient by virtue of their hormonal activity, which may frequently (but certainly not always) over shadow the adverse consequences related to their mass per se. In fact, it is important to keep in mind that endocrine tumors can manifest two biologically separable but often intertwined properties, namely, increased cell mass and abnormal hormonal function. These need not go hand in hand, and their distinction has definite clinical relevance in, for example, the increasingly recognized problem of incidentally discovered adrenal or pituitary masses.