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Antimalarial Natural Products (Hardcover, 1st ed. 2022)
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Antimalarial Natural Products (Hardcover, 1st ed. 2022)
Series: Progress in the Chemistry of Organic Natural Products, 117
Expected to ship within 10 - 15 working days
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This volume begins with a short history of malaria and follows with
a summary of its biology. It then traces the fascinating history of
the discovery of quinine for malaria treatment, and then describes
quinine's biosynthesis, its mechanism of action, and its clinical
use, concluding with a discussion of synthetic antimalarial agents
based on quinine's structure. It also covers the discovery of
artemisinin and its development as the source of the most effective
current antimalarial drug, including summaries of its synthesis and
biosynthesis, its mechanism of action, and its clinical use and
resistance. A short discussion of other clinically used
antimalarial natural products leads to a detailed treatment of
additional natural products with significant antiplasmodial
activity, classified by compound type. Although the search for new
antimalarial natural products from Nature's combinatorial library
is challenging, it is very likely to yield new antimalarial drugs.
This book thus ends by identifying ten natural products with
development potential as clinical antimalarial agents.
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