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Minimal Residual Disease in Acute Leukemia 1986 (Paperback, Softcover reprint of the original 1st ed. 1986)
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Minimal Residual Disease in Acute Leukemia 1986 (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: Developments in Oncology, 45
Expected to ship within 9 - 17 working days
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Relapse of leukemia following successful remission-induction
therapy remains a major obstacle in the treatment of patients with
acute leukemia. Leukemia recurs most frequently in patients with
acute myeloblastic leukemia (AML) and high risk acute lymphoblastic
leukemia (ALL) following chemotherapy and less often in patients
with low risk ALL and particularly in patient groups> submitted
to allogeneic marrow transplantation. ' It is likely that the great
majority of these recurrences originate from residual leukemic
cells that survive initial remission-induction chemotherapy. Today,
several research groups throughout the world place emphasis on
studies concerned with the detection and treatment of 'minimal
residual disease' (MRD). These investigations are conducted with
the common objective to tackle the remaining cells. 'Minimal
Residual Disease in Acute Leukemia: 1986' summarizes the fast
advancements in this area. Several disciplines are concerned with
the analysis of leukemic cells. The perspectives of cytogenetic and
molecular genetic approaches for applica tion in the detection of
MRD are reviewed. In this respect, modern cyto genetics provide
highly specific tumor markers. The resolution of cyto genetic
methods can be particularly improved when combined with other
techniques which select relevant subpopulations of cells.
Characterization of oncogenes and gene rearrangements, including
those of immunoglobulin and T-cell receptor genes, and the
measurement of gene products, have been established. Techniques
based on these approaches offer interesting tools for the detection
of MRD. New possibilities of employing monoclonal anti bodies are
also presented.
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