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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Advances in Nitrate Therapy (Paperback, 2nd ed. 1990. Softcover reprint of the original 2nd ed. 1990)
Loot Price: R2,280
Discovery Miles 22 800
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Advances in Nitrate Therapy (Paperback, 2nd ed. 1990. Softcover reprint of the original 2nd ed. 1990)
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Nitrates have been for many years the cornerstone of cardiovascular
therapy for various indications. Not only have nitrates stood the
test of time for treatment of chronic stable angina pectoris, but
the indications for them have markedly ex panded. They now include
all forms of angina pectoris and myocardial ischemia, congestive
heart failure and hypertensive emergencies. The beneficial effects
of nitrates in all these conditions result from their vasodilatory
properties, but it is still unclear whether the central or
peripheral effects predominate in the thera peutic mechanism.
Recently nitrates have been shown to fulfill the most important
requirement for each and every drug - to reduce mortality. A large
scale study revealed that isosorbide dinitrate, combined with
hydralazine, reduced long-term mortality by 28% in patients with
congestive heart failure. This finding will certainly stimulate
research on nitrates, and it might be expected that interest in
these drugs will markedly increase. The primarily used nitrates in
clinical practice are nitroglycerin and the com plex organic
nitrates, mainly isosorbide dinitrate. The organic mononitrates are
now under clinical investigation, and isosorbide-5-mononitrate
(IS-5-MN) appears to be especially promising.
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