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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)
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Ribonucleases (Hardcover, 2011)
Loot Price: R5,644
Discovery Miles 56 440
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Ribonucleases (Hardcover, 2011)
Series: Nucleic Acids and Molecular Biology, 26
Expected to ship within 10 - 15 working days
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Ribonucleases are a ubiquitous and functionally diverse group of
enzymes that have a common ability to cleave RNA. Either through
scission of internal phosphodiesters, or removal of nucleotides
from RNA 5' or 3' ends, ribonucleases perform essential roles in
gene expression and regulation, genome replication and maintenance,
host defense, stress response, and viral strategies of infection.
Ribonucleases have also served as highly informative models to
understand virtually every aspect of biomolecular structure and
function. The fifteen chapters in this volume are written by
recognized researchers in the field, and provide in-depth analyses
of the major ribonuclease families. Particular focus is given to
the relation of ribonuclease structure and mechanism to biological
function, as well as ribonuclease dysfunction in certain disease
states. Other topics include the evolutionary genetics and
functional diversification of ribonucleases, engineered
ribonucleases as anti-cancer agents, the mechanisms of action of
artificial ribonucleases, and ribonucleases as models to understand
protein folding and stability. This volume should serve as an
essential reference for a broad range of researchers and educators
with interests in RNA metabolism, enzymology, and gene regulation.
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