The topic of biological response modifiers has attracted the
attention of many biomedical investigators, including
immunologists, oncologists, pharmacologists, microbiologists, and
biochemists, as well as clinical practitioners of medicine. This
has occurred mainly because of the realization that the complex
system of cellular and humoral interactions culminating in a
productive immune response is under exquisite regulatory control
for normal immune responses and that loss of control may markedly
influence the capability of a host to respond in a productive
manner to the numerous immunologic "insults" encountered in the
environment. Furthermore, biological response modification is
considered by many to be a natural offshoot of the relatively new
application of "immunotherapy" to cancer. It is widely recognized
that "immunotherapy" was practiced at the end of the last century
and the beginning of this century when it was recognized that
microbial infections were caused by distinct species of bacteria
and that passive administration of serum con taining antibody to
these microbes or their products could, in many cases, favorably
influence the outcome of an infectious process."
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