Two to three decades ago, multiple primary malignancies (MPM) were
considered to be simply a clinical curiosity, with sporadic
reports, mostly single case descriptions, found in the literature.
While in the last few years, analyses of larger series have been
published, the number of cases has still been relatively small and
most of the reports have addressed a single type of primary tumor
and its associations. With the improved prognosis and survival of
cancer patients, MPM is becoming increasingly prevalent in this
population, necessitating a better understanding of the
characteristics and associations of the malignancies involved.
Thus, as a prerequisite, a universal definition and an
internationally accepted classification system, based on
chronological, pathological, clinical, and other parameters, are
needed. Moreover, much remains to be learned about the etiology of
MPM, whether genetic, iatrogenic, or environmental. Several of the
hereditary syndromes, such as familial adenomatous polyposis,
hereditary non-polyposis colorectal cancer, hereditary
breast-ovarian cancer, and multiple endocrine neoplasia, are
already well-known and their characteristics in relation to MPM
must be kept in mind. Nonetheless, along with these syndromes,
there are sporadic and apparently casual associations between
primary neoplasms that can involve almost any part of the body.
This volume points out the clinical aspects of MPM and discusses
the diagnostic and therapeutic problems that are encountered in
treating these patients. "DNA-guided" surgery, currently confined
to the treatment of patients with hereditary syndromes, will, along
with other novel treatment strategies, no doubt play an
increasingly greater role in the therapy of MPM. This work presents
state-of-the-art information about MPM that is aimed at a broad
range of medical specialists, including surgeons, endoscopists,
oncologists, and geneticists, . The goal is to improve our
understan
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