The extremely potent substance botulinum neurotoxin (BoNT) has
attracted much interest in diverse fields. Originally identified as
cause for the rare but deadly disease botulism, military and
terrorist intended to misuse this sophisticated molecule as
biological weapon. This caused its classification as select agent
category A by the Centers for Diseases Control and Prevention and
the listing in the Biological and Toxin Weapons Convention. Later,
the civilian use of BoNT as long acting peripheral muscle relaxant
has turned this molecule into an indispensable pharmaceutical world
wide with annual revenues >$1.5 billion. Also basic scientists
value the botulinum neurotoxin as molecular tool for dissecting
mechanisms of exocytosis. This book will cover the most recent
molecular details of botulinum neurotoxin, its mechanism of action
as well as its detection and application.
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